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  • 1
    In: Aktuelle Urologie, 2017, Vol.48(05)
    In: Aktuelle Urologie, 2017, Vol.48(05), pp.e6-e9
    Keywords: Ejaculation ; Humans ; Magnetic Resonance Imaging ; Male ; Prostatic Neoplasms ; Seminal Vesicles;
    ISSN: 0001-7868
    E-ISSN: 1438-8820
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  • 2
    Article
    Article
    Language: German
    In: Uro-News, 5/2018, Vol.22(5), pp.32-38
    ISSN: 1432-9026
    E-ISSN: 2196-5676
    Source: Springer (via CrossRef)
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  • 3
    Language: German
    In: Uro-News, 2/2017, Vol.21(2), pp.18-20
    ISSN: 1432-9026
    E-ISSN: 2196-5676
    Source: Springer (via CrossRef)
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  • 4
    In: TumorDiagnostik & Therapie, 2017, Vol.38(07)
    In: TumorDiagnostik & Therapie, 2017, Vol.38(07), pp.433-435
    ISSN: 0722-219X
    E-ISSN: 1439-1279
    Source: Thieme Publishing Group
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  • 5
    Language: German
    In: Uro-News, 6/2018, Vol.22(6), pp.27-27
    ISSN: 1432-9026
    E-ISSN: 2196-5676
    Source: Springer (via CrossRef)
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  • 6
    Language: English
    In: PLoS ONE, 2011, Vol.6(9), p.e25341
    Description: In order to generate genomic signals, the androgen receptor (AR) has to be transported into the nucleus upon androgenic stimuli. However, there is evidence from in vitro experiments that in castration-resistant prostate cancer (CRPC) cells the AR is able to translocate into the nucleus in a ligand-independent manner. The recent finding that inhibition of the glycogen-synthase-kinase 3β (GSK-3β) induces a rapid nuclear export of the AR in androgen-stimulated prostate cancer cells prompted us to analyze the effects of a GSK-3β inhibition in the castration-resistant LNCaP sublines C4-2 and LNCaP-SSR. Both cell lines exhibit high levels of nuclear AR in the absence of androgenic stimuli. Exposure of these cells to the maleimide SB216763, a potent GSK-3β inhibitor, resulted in a rapid nuclear export of the AR even under androgen-deprived conditions. Moreover, the ability of C4-2 and LNCaP-SSR cells to grow in the absence of androgens was diminished after pharmacological inhibition of GSK-3β in vitro . The ability of SB216763 to modulate AR signalling and function in CRPC in vivo was additionally demonstrated in a modified chick chorioallantoic membrane xenograft assay after systemic delivery of SB216763. Our data suggest that inhibition of GSK-3β helps target the AR for export from the nucleus thereby diminishing the effects of mislocated AR in CRPC cells. Therefore, inhibition of GSK-3β could be an interesting new strategy for the treatment of CRPC.
    Keywords: Research Article ; Vladislav V. Glinsky ; University Of Missouri-columbia, United States Of America ; Medicine ; Diabetes And Endocrinology ; Urology ; Oncology
    E-ISSN: 1932-6203
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  • 7
    Language: English
    In: Clinical chemistry, July 2011, Vol.57(7), pp.995-1004
    Description: To date, no published nomogram for prostate cancer (PCa) risk prediction has considered the between-method differences associated with estimating concentrations of prostate-specific antigen (PSA). Total PSA (tPSA) and free PSA were measured in 780 biopsy-referred men with 5 different assays. These data, together with other clinical parameters, were applied to 5 published nomograms that are used for PCa detection. Discrimination and calibration criteria were used to characterize the accuracy of the nomogram models under these conditions. PCa was found in 455 men (58.3%), and 325 men had no evidence of malignancy. Median tPSA concentrations ranged from 5.5 μg/L to 7.04 μg/L, whereas the median percentage of free PSA ranged from 10.6% to 16.4%. Both the calibration and discrimination of the nomograms varied significantly across different types of PSA assays. Median PCa probabilities, which indicate PCa risk, ranged from 0.59 to 0.76 when different PSA assays were used within the same nomogram. On the other hand, various nomograms produced different PCa probabilities when the same PSA assay was used. Although the ROC curves had comparable areas under the ROC curve, considerable differences were observed among the 5 assays when the sensitivities and specificities at various PCa probability cutoffs were analyzed. The accuracy of the PCa probabilities predicted according to different nomograms is limited by the lack of agreement between the different PSA assays. This difference between methods may lead to unacceptable variation in PCa risk prediction. A more cautious application of nomograms is recommended.
    Keywords: Prostate-Specific Antigen -- Blood ; Prostatic Neoplasms -- Diagnosis
    ISSN: 00099147
    E-ISSN: 1530-8561
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  • 8
    Language: English
    In: Psychology and Aging, 2014, Vol.29(4), pp.787-792
    Description: Following tumor surgery, urinary incontinence challenges prostate cancer patients’ functional health. Adjustments of functional goals (lines of defense [LoDs]) were examined during rehabilitation from incontinence. A conceptual model proposing stepwise and distinct upward adjustments of LoDs, ranging from minimizing discomfort (lowest LoD) to protecting self-reliance (highest LoD), was investigated. Within 7 months following the onset of incontinence, 175 patients completed questionnaires at 4 occasions. A theory-based hierarchy was imposed on time-invariant latent classes of LoD-endorsements. As incontinence receded, patients transitioned upward through the hierarchy of LoD-classes, matched LoDs to concurrent incontinence levels, and thus promptly claimed independent functioning with physical improvements.
    Keywords: Lines Of Defense ; Rehabilitation ; Prostate Cancer ; Urinary Incontinence
    ISSN: 0882-7974
    E-ISSN: 1939-1498
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  • 9
    Language: German
    In: Der Onkologe, 2017, Vol.23(2), pp.97-101
    Description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00761-016-0149-7 Byline: Mark Schrader (1), Friedemann Zengerling (2) Keywords: Keimzelltumoren; Carboplatin-Monotherapie; Surveillance; Patientenpraferenz; Adjuvante Therapie; Testicular cancer; Carboplatin monotherapy; Surveillance; Patient preference; Adjuvant therapy Abstract (German): Hintergrund In den letzten Jahren hat sich die Therapie von Hodentumoren im klinischen Stadium I stark verandert. Einige Autoren fordern, die adjuvante Therapie im klinischen Stadium I unabhangig vom Risikoprofil der Tumoren ganz zu verlassen. Dieses Vorgehen wird bei Keimzelltumoren durch eine Reihe von Studien unterstutzt, die eine exzellente Uberlebensrate im Rahmen einer Surveillance-only-Strategie zeigen. Generell ist eine in diesem Stadium zunehmende Therapiereduktion zu verzeichnen. Ziel Fragestellung der folgenden Arbeit war eine Evaluation der Vor- und Nachteile eines solchen Vorgehens. Material und Methoden Es erfolgten eine selektive Literaturrecherche sowie die Auswertung des eigenen Patientenkollektivs. Ergebnisse Der Artikel gibt einen Uberblick uber aktuelle Behandlungsstrategien sowie Nachsorgeempfehlungen und diskutiert die moglichen Indikationen fur eine adjuvante Therapie bei Hodentumoren im klinischen Stadium I. Schlussfolgerung Aufgrund der exzellenten Heilungsraten und potenziellen Vorteile fur individuelle Patienten sollten die Vor- und Nachteile einer Surveillance-Strategie jedem Patienten zumindest dargestellt werden. Abstract: Background The therapy of clinical stage I testicular cancer has radically changed during the last few years. Some authors demand that adjuvant therapy in clinical stage I is omitted regardless of the risk profile of the tumor. This approach to germ cell tumors is underlined by several studies, which show an excellent survival rate regarding surveillance only strategies. In general, in this stage a reduction in therapy is becoming more frequent. Aim The main question of the study was the evaluation of the advantages and disadvantages concerning a surveillance only strategy. Material and methods A selective review of the literature and additional evaluation of data from our own patient collective. Results The article gives an overview on current treatment strategies as well as recommendations on follow-up regimens and discusses the possible indications for adjuvant therapy of clinical stage I testicular tumors. Conclusion Based on the excellent success rate and the potential advantages for individual patients, the advantages and disaadvantages of a surveillance only strategy should at least be discussed with each patient. Author Affiliation: (1) Klinik fur Urologie, Heliosklinikum Berlin Buch, Schwanbecker Chaussee 50, 13125, Berlin, Deutschland (2) Klinik fur Urologie, Universitatsklinik Ulm, Prittwitzstr. 43, 89075, Ulm, Deutschland Article History: Registration Date: 27/10/2016 Online Date: 23/11/2016
    Keywords: Testicular cancer ; Carboplatin monotherapy ; Surveillance ; Patient preference ; Adjuvant therapy
    ISSN: 0947-8965
    E-ISSN: 1433-0415
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  • 10
    Article
    Article
    Language: English
    In: Karger Kompass Onkologie, October 2014, Vol.1(2), pp.58-59
    Keywords: Editorial
    ISSN: 2296-5416
    E-ISSN: 2296-5386
    Source: Karger Journals (S. Karger AG)
    Source: Karger (S. Karger AG)
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