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  • 1
    Language: English
    In: European Radiology, Jan, 2013, Vol.23(1), p.198(7)
    Description: Byline: Boris Schulz (1,3), Katrin Eichler (1), Petra Siebenhandl (1), Tatjana Gruber-Rouh (1), Christoph Czerny (2), Thomas Josef Vogl (1), Stephan Zangos (1) Keywords: Flat-panel computed tomography; Interventional CT; Percutaneus biopsy; Robot; Robotic device Abstract: Objective To analyse the feasibility and accuracy of robotic aided interventions on a phantom when using a modern C-arm-mounted cone beam computed tomography (CBCT) device in combination with needle guidance software. Methods A small robotic device capable of holding and guiding needles was attached to the intervention table. After acquiring a 3D data set the access path was planned on the CBCT workstation and shown on the intervention monitor. Then the robot was aligned to the live fluorosopic image. A total of 40 punctures were randomly conducted on a phantom armed with several targets (diameter 2 mm) in single and double oblique trajectory (n=20 each). Target distance, needle deviation and time for the procedures were analysed. Results All phantom interventions (n=40) could be performed successfully. Mean target access path within the phantom was 8.5 cm (min 4.2 cm, max 13.5 cm). Average needle tip deviation was 1.1 mm (min 0 mm, max 4.5 mm), time duration was 3:59 min (min 2:07 min, max 10:37 min). Conclusion When using the proposed robot device in a CBCT intervention suite, highly accurate needle-based interventional punctures are possible in a reasonable timely manner in single as well as in double oblique trajectories. Key Points aC/ Percutaneous image-guided biopsy is an important contribution of modern radiology. aC/ A compact robotic device has been developed which may facilitate such procedures. aC/ Accurate needle-based interventions are possible in a timely manner. aC/ Complex trajectories and even deep access paths are possible. Author Affiliation: (1) Institute for Diagnostic and Interventional Radiology, Goethe University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany (2) Department of Trauma Surgery, Goethe University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany (3) Department of Diagnostic and Interventional Radiology, Goethe University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany Article History: Registration Date: 30/06/2012 Received Date: 10/05/2012 Accepted Date: 22/06/2012 Online Date: 21/07/2012
    Keywords: Robots ; Cat Scans
    ISSN: 0938-7994
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  • 2
    In: International Journal of Cancer, 01 March 2014, Vol.134(5), pp.1225-1231
    Description: The aims of the study were to evaluate therapeutic efficacy and to determine the prognostic factors for treatment success in patients with liver metastases from colorectal cancer (CRC) treated with transarterial chemoembolization (TACE). A total of 564 patients (mean age, 60.3 years) with liver metastases of CRC were repeatedly treated with TACE. In total, 3,384 TACE procedures were performed (mean, six sessions per patient). The local chemotherapy protocol consisted of mitomycin C alone (43.1%), mitomycin C with gemcitabine (27.1%), mitomycin C with irinotecan (15.6%) or mitomycin C with irinotecan and cisplatin (15.6%). Embolization was performed with lipiodol and starch microspheres. Tumor response was evaluated using magnetic resonance imaging or computed tomography. The change in tumor size was calculated and the response was evaluated according to the RECIST‐Criteria. Survival rates were calculated according to the Kaplan–Meier method. Prognostic factors for patient's survival were evaluated using log‐rank test. Evaluation of local tumor control showed partial response in 16.7%, stable disease in 48.2% and progressive disease in 16.7%. The 1‐year survival rate after chemoembolization was 62%, the 2‐year survival rate was 28% and the 3‐year survival rate was 7%. Median survival from the start of chemoembolization treatment was 14.3 months. The indication ( = 0.001) and initial tumor response ( = 0.015) were statistically significant factors for patient's survival. TACE is a minimally invasive therapy option for controlling local metastases and improving survival time in patients with hepatic metastases from CRC. TN stage, extrahepatic metastases, number of lesions, tumor location within the liver and choice of chemotherapy protocol of TACE are none significant factors for patient's survival. What's new? About two‐thirds of colorectal cancer patients develop life‐threatening liver metastases, for which the only potentially curative therapy is resection. But only a small proportion of patients are candidates for resection, and those who undergo resection may suffer from intrahepatic recurrence. Here, transarterial chemoembolization (TACE), a minimally invasive procedure, was explored for colorectal cancer liver metastases. TACE was performed repeatedly for each of more than 560 patients. Following treatment, 48.2 percent of patients had stable disease, and the 1‐year survival rate was 62 percent. Initial tumor response was a significant prognostic factor for patient survival after TACE.
    Keywords: Chemoembolization ; Liver Metastases ; Colorectal Cancer
    ISSN: 0020-7136
    E-ISSN: 1097-0215
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  • 3
    Language: English
    In: 2012, Vol.7(11), p.e47452
    Description: Polyglutamine (polyQ) diseases represent a neuropathologically heterogeneous group of disorders. The common theme of these disorders is an elongated polyQ tract in otherwise unrelated proteins. So far, only symptomatic treatment can be applied to patients suffering from polyQ diseases. Despite extensive research, the molecular mechanisms underlying polyQ-induced toxicity are largely unknown. To gain insight into polyQ pathology, we performed a large-scale RNAi screen in Drosophila to identify modifiers of toxicity induced by expression of truncated Ataxin-3 containing a disease-causing polyQ expansion. We identified various unknown modifiers of polyQ toxicity. Large-scale analysis indicated a dissociation of polyQ aggregation and toxicity.
    Keywords: Research Article ; Biology ; Genetics And Genomics ; Molecular Biology ; Cell Biology ; Neuroscience
    E-ISSN: 1932-6203
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  • 4
    In: Advances in Computed Tomography, 2014, Vol.03(04), pp.51-58
    ISSN: 2169-2475
    E-ISSN: 2169-2483
    Source: CrossRef
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  • 5
    Language: English
    In: Forensic Science, Medicine, and Pathology, Dec, 2014, Vol.10(4), p.607(6)
    Description: Byline: Mattias Kettner (1,2), Stefan Potente (2), Boris Schulz (3), Peter Knauff (4), Peter H. Schmidt (5), Frank Ramsthaler (5) Keywords: Forensic medicine; Forensic radiology; Micro-CT; Manual strangulation; Decomposition Abstract: Postmortem computed tomography (CT) is now routinely performed in forensic autopsies. Microfocus computed tomography (mfCT) has attracted recent attention because it can provide more detailed information than routine postmortem CT can. This feasibility study evaluated the usefulness of mfCT for examination of the hyoid bone and thyroid cartilage in cases of suspected strangulation, where advanced decomposition precludes detection of petechial hemorrhages and hemorrhages adjacent to fractures. The results show that mfCT was useful for identification of thin fracture lines in the fragile laryngeal structures. We suggest that mfCT should be considered for forensic autopsies in cases of suspected strangulation with advanced decomposition. Author Affiliation: (1) Department of Experimental Forensic Medicine, Institute of Forensic Medicine, Saarland University Medical School, Kirrbergerstr. 100/Building 42, 66424, Homburg/Saar, Germany (2) Institute of Forensic Medicine, Frankfurt University Medical School, Frankfurt/M., Germany (3) Department of Diagnostic and Interventional Radiology, Frankfurt University Medical School, Frankfurt/M., Germany (4) Ctm-do GmbH, Dortmund, Germany (5) Department of Forensic Medicine, Institute of Forensic Medicine, Saarland University Medical School, Homburg/Saar, Germany Article History: Registration Date: 06/06/2014 Accepted Date: 06/06/2014 Online Date: 15/08/2014
    Keywords: Cat Scans -- Analysis
    ISSN: 1547-769X
    Source: Cengage Learning, Inc.
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  • 6
    Language: English
    In: European radiology, July 2014, Vol.24(7), pp.1725-34
    Description: To investigate the impact of automated attenuation-based tube potential selection on image quality and exposure parameters in polytrauma patients undergoing contrast-enhanced thoraco-abdominal CT. One hundred patients were examined on a 16-slice device at 120 kV with 190 ref.mAs and automated mA modulation only. Another 100 patients underwent 128-slice CT with automated mA modulation and topogram-based automated tube potential selection (autokV) at 100, 120 or 140 kV. Volume CT dose index (CTDI(vol)), dose-length product (DLP), body diameters, noise, signal-to-noise ratio (SNR) and subjective image quality were compared. In the autokV group, 100 kV was automatically selected in 82 patients, 120 kV in 12 patients and 140 kV in 6 patients. Patient diameters increased with higher kV settings. The median CTDI(vol) (8.3 vs. 12.4 mGy; -33%) and DLP (594 vs. 909 mGy cm; -35%) in the entire autokV group were significantly lower than in the group with fixed 120 kV (p 〈 0.05 for both). Image quality remained at a constantly high level at any selected kV level. Topogram-based automated selection of the tube potential allows for significant dose savings in thoraco-abdominal trauma CT while image quality remains at a constantly high level. • Automated kV selection in thoraco-abdominal trauma CT results in significant dose savings • Most patients benefit from a 100-kV protocol with relevant DLP reduction • Constantly good image quality is ensured • Image quality benefits from higher kV when arms are positioned downward.
    Keywords: Image Processing, Computer-Assisted ; Abdominal Injuries -- Diagnostic Imaging ; Multidetector Computed Tomography -- Instrumentation ; Multiple Trauma -- Diagnostic Imaging ; Thoracic Injuries -- Diagnostic Imaging
    ISSN: 09387994
    E-ISSN: 1432-1084
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  • 7
    Language: English
    In: Journal of Magnetic Resonance Imaging, Feb, 2014, Vol.39(2), p.434(6)
    Description: Byline: Nagy N.N. Naguib, Kevin Bohrt, Nour-Eldin A. Nour-Eldin, Boris Schulz, Ahmed M. Tawfik, Petra Siebenhandel, Boris Bodelle, Katrin Eichler, Anton Moritz, Thomas J. Vogl, Stephan Zangos Keywords: whole-body MRA; Tim-CT; single contrast injection Purpose To assess image quality, presence of artifacts, arterial stenosis, and interobserver agreement of Tim-CT in assessment of the arterial system using contrast-enhanced whole-body-MRA (CE-Wb-MRA) with a single contrast-medium injection in patients with arteriosclerosis. Materials and Methods The retrospective study included 18 patients (mean age, 68 years). A total of 468 arteries were evaluated. CE-Wb-MRA was performed using Tim-CT technology on a 1.5 Tesla (T) MRI after injecting a single dose of Vasovist. Evaluations were independently performed by two radiologists. The arterial system was divided into seven anatomic locations. Each radiologist assessed the image quality, degree of artifacts, and arterial stenosis in different locations. Results All Wb-MRA examinations were technically successful. Image quality: 28.42% arteries were excellent, 29.17% were good, 22.54% were satisfactory, 9.40% were poor, and 5.13% of insufficient quality. Occurrence of artifacts: 37.25% were free of artifacts, 49.44% minimal artifacts not affecting diagnosis, and 13.31% strong artifacts not permitting a diagnosis. A total of 60.00% arteries showed no stenosis, 8.76% were [less than or equal to]50% stenotic, 5.17% were 51-75% stenotic, 4.38% were 76-99%, and 8.54% total occlusion. The interobserver agreement was good for supra-aortic, pelvic, and upper and lower leg regions. Conclusion CE-Wb-MRA using the TimCT technology and with a single contrast injection is a feasible tool for whole-body MRA. J. Magn. Reson. Imaging 2014;39:434-439. [c] 2013 Wiley Periodicals, Inc.
    Keywords: Angiography
    ISSN: 1053-1807
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  • 8
    Language: English
    In: AJR. American journal of roentgenology, November 2012, Vol.199(5 Suppl), pp.S34-9
    Description: Dual-energy scanning is a breakthrough in CT technology that has several applications in chest and abdominal imaging. Dual-energy CT also has potential for head and neck imaging. This review describes the role of dual-energy CT in head and neck imaging. As with other body regions, both image fusion and material characterization dual-energy applications can be used for head and neck imaging. Early results are promising, and further research is encouraged.
    Keywords: Head -- Diagnostic Imaging ; Head and Neck Neoplasms -- Diagnostic Imaging ; Neck -- Diagnostic Imaging ; Radiographic Image Interpretation, Computer-Assisted -- Methods ; Radiography, Dual-Energy Scanned Projection -- Methods ; Tomography, X-Ray Computed -- Methods
    E-ISSN: 1546-3141
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  • 9
    Language: English
    In: Forensic Science, Medicine, and Pathology, 2014, Vol.10(4), pp.607-612
    Description: Postmortem computed tomography (CT) is now routinely performed in forensic autopsies. Microfocus computed tomography (mfCT) has attracted recent attention because it can provide more detailed information than routine postmortem CT can. This feasibility study evaluated the usefulness of mfCT for examination of the hyoid bone and thyroid cartilage in cases of suspected strangulation, where advanced decomposition precludes detection of petechial hemorrhages and hemorrhages adjacent to fractures. The results show that mfCT was useful for identification of thin fracture lines in the fragile laryngeal structures. We suggest that mfCT should be considered for forensic autopsies in cases of suspected strangulation with advanced decomposition.
    Keywords: Forensic medicine ; Forensic radiology ; Micro-CT ; Manual strangulation ; Decomposition
    ISSN: 1547-769X
    E-ISSN: 1556-2891
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  • 10
    In: Open Journal of Radiology, 2015, Vol.05(02), pp.84-91
    Description: Purpose: To investigate a robot assistance device for CT-guided percutan liver biopsy. Materials and Methods: The liver of a corpse was equipped with target dummies. Four radiologists used a 16 G needle to perform biopsy of the target region in standard free hand technique and then used a robot system which allowed planning and aligning the trajectory path. Accuracy in terms of needle tip deviation, and time efficiency and radiation exposure in terms of effective dose for the radiologists were measured. Results: For in plane procedures, there was no significant benefit in accuracy when using the robot versus standard technique (4 mm vs. 5.6 mm, p = 0.11); timely effort was worse (443 sec vs. 405 sec, p = 0.64). For angulated punctures, a needle tip of 3.7 mm was measured by using the robotic device (vs. 10.8 mm, p
    Keywords: Medicine;
    ISSN: 2164-3024
    E-ISSN: 2164-3032
    Source: CrossRef
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