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  • 1
    Language: English
    In: Cancer Research, 04/15/2012, Vol.72(8 Supplement), pp.3847-3847
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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  • 2
    Language: English
    In: Journal of the American College of Cardiology, 27 March 2012, Vol.59(13), pp.E1700-E1700
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0735-1097(12)61701-X Byline: Mohsen Sharifi, Curt Bay, Todd Schuster, Navid Mehdipour Author Affiliation: Arizona Cardiovascular Consultants, Mesa, AZ, USA, A.T. Still University, Mesa, AZ, USA Article Note: (footnote) ACC Moderated Poster Contributions McCormick Place South, Hall A Sunday, March 25, 2012, 9:30 a.m.-10:30 a.m. Session Title: Prevention: Clinical Current Topics in Anticoagulation/Antiplatelet Therapies Abstract Category: 9. Prevention: Clinical Presentation Number: 1192-603
    Keywords: Medicine
    ISSN: 0735-1097
    E-ISSN: 1558-3597
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  • 3
    Language: English
    In: Cancer Research, 07/15/2016, Vol.76(14 Supplement), pp.1821-1821
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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  • 4
    Language: English
    In: Cancer Research, 07/01/2018, Vol.78(13 Supplement), pp.LB-332-LB-332
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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  • 5
    Language: English
    In: Cancer Research, 07/01/2018, Vol.78(13 Supplement), pp.5851-5851
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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  • 6
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 01 June 1993, Vol.90(11), pp.4777-4778
    Description: We report on the preliminary result of a search for anisotropy in the cosmic background radiation (CBR). Our receiver operates with four equally spaced channels from 25 to 35 GHz with a beam size of ≈1.5 ⚬ full width at half maximum. The system operated successfully for 500 hr at the South Pole during 1990-1991 austral summer. The data from one region, representing 25 hr after editing, are presented here. A strong signal is present in the lower-frequency channels with a spectrum unlike CBR fluctuations. The highest-frequency channel has the smallest contribution from this signal and has been used to set a 95% confidence level upper limit ΔT/T ≤ 1.4 10 -5 .
    Keywords: Physical sciences -- Astronomy -- Astronomical cosmology ; Applied sciences -- Materials science -- Material properties ; Physical sciences -- Astronomy -- Astronomical cosmology ; Physical sciences -- Astronomy -- Astronomical instrumentation ; Physical sciences -- Earth sciences -- Geography
    ISSN: 00278424
    E-ISSN: 10916490
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  • 7
    Language: English
    In: International Journal of Cancer, 01 October 2012, Vol.131(7), pp.1720-1731
    Description: Activated Kras gene coupled with activation of Akt and nuclear factor‐kappa B (NF‐κB) triggers the development of pancreatic intraepithelial neoplasia, the precursor lesion for pancreatic ductal adenocarcinoma (PDAC) in humans. Therefore, intervention at premalignant stage of disease is considered as an ideal strategy to delay the tumor development. Pancreatic malignant tumor cell lines are widely used; however, there are not relevant cell‐based models representing premalignant stages of PDAC to test intervention agents. By employing a novel Kras‐driven cell‐based model representing premalignant and malignant stages of PDAC, we investigated the efficacy of ACTICOA‐grade cocoa polyphenol (CP) as a potent chemopreventive agent under and conditions. It is noteworthy that several human intervention/clinical trials have successfully established the pharmacological benefits of cocoa‐based foods. The liquid chromatography (LC)–mass spectrometry (MS)/MS data confirmed epicatechin as the major polyphenol of CP. Normal, nontumorigenic and tumorigenic pancreatic ductal epithelial (PDE) cells (exhibiting varying Kras activity) were treated with CP and epicatechin. CP and epicatechin treatments induced no effect on normal PDE cells, however, caused a decrease in the () proliferation, () guanosine triphosphate (GTP)‐bound Ras protein, () Akt phosphorylation and () NF‐κB transcriptional activity of premalignant and malignant Kras‐activated PDE cells. Further, oral administration of CP (25 mg/kg) inhibited the growth of Kras‐PDE cell‐originated tumors in a xenograft mouse model. LC–MS/MS analysis of the blood showed epicatechin to be bioavailable to mice after CP consumption. We suggest that () Kras‐driven cell‐based model is an excellent model for testing intervention agents and () CP is a promising chemopreventive agent for inhibiting PDAC development.
    Keywords: Kras ; Preneoplastic ; Cocoa Polyphenol ; Epicatechin ; Pancreatic Cancer
    ISSN: 0020-7136
    E-ISSN: 1097-0215
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  • 8
    In: Nature, 1982, Vol.299(5878), p.32
    Description: The binding of trinucleoside diphosphates to long helical rods of tobacco mosaic virus (TMV) protein is shown to depend on base sequence, 5' AAG 3' binding being the strongest of the 25 trinucleoside diphosphate sequences measured. As TMV has a stoichiometry of three nucleotides per protein subunit, the sequence of TMV RNA suggested to be the nucleation site for self-assembly of the virus has three possible binding frames. From our binding constant data the most likely frame is predicted and shown to have two contiguous AAG sequences in a hairpin loop region.
    Keywords: Oligonucleotides -- Metabolism ; Tobacco Mosaic Virus -- Ultrastructure ; Viral Proteins -- Metabolism;
    ISSN: 0028-0836
    E-ISSN: 1476-4687
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  • 9
    Language: English
    In: International Journal of Oncology, February 2010, Vol.36(2), pp.421-426
    Description: Pomegranate extracts have been used as anticancer agents and they contain a large number of potentially bioactive substances. Punicic acid is an ω-5 long chain polyunsaturated fatty acid found in Punica granatum (pomegranate) seed oil. A number of long chain fatty acids have been reported to have cancer preventive actions. Here we investigated the potential ability of punicic acid to affect growth of both an estrogen insensitive breast cancer cell line (MDA-MB-231) and an estrogen sensitive cell line developed from the MDA-MB-231 cells (MDA-ERα7). Proliferation was inhibited 92 and 96% for MDA-MB-231 and MDA-ERα7 cells, respectively compared to untreated cells by 40 µM punicic acid. Furthermore, punicic acid induced apoptosis in the MDA-MB-231 and MDA-ERα7 cells by 86 and 91%, respectively compared to untreated control cells and disrupted cellular mitochondrial membrane potential. We also investigated whether lipid oxidation was required for the function of punicic acid by adding 20 µM of the antioxidant tocotrienol to the assays. This resulted in reversal of the effects of punicic acid on proliferation inhibition, apoptosis and disruption of the mitochondrial membrane potential. Finally, we evaluated the role of PKC signaling in the anti-cancer effects of punicic acid by performing proliferation assays in the presence of the PKC inhibitor bisindolymaleimide I. Proliferation inhibition by punicic acid was partially blocked in both the MDA-MB-231 and MDA-ERα7 cells. These results suggest that punicic acid has breast cancer inhibitor properties that are dependent on lipid peroxidation and the PKC pathway.
    Keywords: Antineoplastic Agents -- Pharmacology ; Antioxidants -- Pharmacology ; Breast Neoplasms -- Metabolism ; Cell Proliferation -- Drug Effects ; Linolenic Acids -- Pharmacology ; Plant Extracts -- Pharmacology;
    ISSN: 1019-6439
    E-ISSN: 17912423
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  • 10
    Language: English
    In: HortScience : a publication of the American Society for Horticultural Science, 2010, Vol.45(8), pp.1188-1191
    Description: Glucosinolates (GSL) are bioactive compounds found in cruciferous vegetables that have been shown to have chemopreventive benefits for human health. The objective of this study was to determine whether foliar application of jasmonic acid (JA) increases glucosinolate accumulation and yield in cabbage (Brassica oleracea L. Capitata group). Field studies were conducted in 2004 and 2005 with a green (‘Quisto’) and red (‘Ruby Perfection’) cabbage cultivar. Foliar JA application rates were 0.1 mM, 0.2 mM, and split application of 0.2 mM JA with surfactant, surfactant control, and water control. Yield of both cabbage cultivars was not changed by JA application in both years of the study. In both years, ‘Ruby Perfection’ had significantly higher glucosinolate concentrations than ‘Quisto’ with sinigrin being the predominant glucosinolate in both varieties. JA application consistently increased sinigrin, gluconapin, and glucoiberin concentrations across cultivars and years of the study. JA application also increased progoitrin and total GSL concentrations, but the effect was inconsistent between years and cultivars. In most cases, a split application of 0.2mM JA resulted in the highest GSL accumulation. GSL accumulation was significantly higher in 2005 than 2004 for both cultivars. Climatic data suggest that annual differences in temperature may have influenced the variability in glucosinolate concentration in cabbage. ; Includes references ; p. 1188-1191.
    Keywords: Glucosinolates ; Foliar Application ; Application Rate ; Air Temperature ; Crop Yield ; Field Experimentation ; Jasmonic Acid ; Temporal Variation ; Medicinal Properties ; Food Composition ; Cabbage ; Phytochemicals ; Brassica Oleracea Var. Capitata ; Surfactants ; Cultivars ; Sinigrin ; Progoitrin ; Glucoiberin ; Gluconapin
    ISSN: 0018-5345
    E-ISSN: 23279834
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