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  • 1
    Language: English
    In: Journal of Tax Practice and Procedure, 2013, Vol.15(1), p.33(5)
    Keywords: Tax Administration – Laws, Regulations and Rules
    ISSN: 1529-9279
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  • 2
    In: Transplantation, 2015, Vol.99(11), pp.2239-2240
    Keywords: Allergy and Immunology -- History ; Biomedical Research -- History ; Immunosuppression -- History;
    ISSN: 0041-1337
    E-ISSN: 15346080
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  • 3
    In: Medicine & Science in Sports & Exercise, 2017, Vol.49(4), pp.641-645
    Description: INTRODUCTION: Marathon running is presumed to improve cardiovascular risk, but health benefits of high volume running are unknown. High-resolution coronary computed tomography angiography and cardiac risk factor assessment were completed in women with long-term marathon running histories to compare to sedentary women with similar risk factors. METHODS: Women who had run at least one marathon per year for 10–25 yr underwent coronary computed tomography angiography, 12-lead ECG, blood pressure and heart rate measurement, lipid panel, and a demographic/health risk factor survey. Sedentary matched controls were derived from a contemporaneous clinical study database. CT scans were analyzed for calcified and noncalcified plaque prevalence, volume, stenosis severity, and calcium score. RESULTS: Women marathon runners (n = 26), age 42–82 yr, with combined 1217 marathons (average 47) exhibited significantly lower coronary plaque prevalence and less calcific plaque volume. The marathon runners also had less risk factors (smoking, hypertension, and hyperlipidemia); significantly lower resting heart rate, body weight, body mass index, and triglyceride levels; and higher high-density lipoprotein cholesterol levels compared with controls (n = 28). The five women runners with coronary plaque had run marathons for more years and were on average 12 yr older (65 vs 53) than the runners without plaque. CONCLUSION: Women marathon runners had minimal coronary artery calcium counts, lower coronary artery plaque prevalence, and less calcified plaque volume compared with sedentary women. Developing coronary artery plaque in long-term women marathon runners appears related to older age and more cardiac risk factors, although the runners with coronary artery plaque had accumulated significantly more years running marathons.
    Keywords: Women'S Health – Research ; Marathon Running – Health Aspects ; Marathon Running – Research ; Coronary Heart Disease – Research ; Coronary Heart Disease – Prevention ; Sedentary Behavior – Health Aspects;
    ISSN: 0195-9131
    E-ISSN: 15300315
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  • 4
    In: The New England Journal of Medicine, 2017, Vol.376(25), pp.2486-2488
    Description: Two studies provide some answers to the question of why cells in neoplastic lesions in the epithelial lining of ducts in the breast are more likely to disseminate than are cells in established breast tumors. In 2015, almost 232,000 women in the United States received a diagnosis of invasive breast cancer, and approximately 40,000 women died of metastatic breast cancer. The leading cause of these deaths was metastatic spread. The timing and distribution of breast-cancer metastases vary considerably. In approximately 5% of women with breast cancer, metastases are clinically evident at the time of diagnosis. In other women, metastases become apparent years or even decades after the initial diagnosis. Moreover, the number of metastases varies considerably. The mechanisms that account for the wide variability in the propensity of breast cancer to metastasize are unknown, although . . .
    Keywords: Medicine;
    ISSN: 0028-4793
    E-ISSN: 1533-4406
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  • 5
    Language: English
    In: New England Journal of Medicine, 02/17/2011, Vol.364(7), pp.656-665
    Description: The article discusses the regulation of immune responses by hypoxia-induced signaling and the link between hypoxia and inflammation in inflammatory bowel disease, certain cancers and infections. Hypoxia and inflammation are intertwined at the molecular, cellular and clinical levels.
    Keywords: Inflammatory Bowel Diseases -- Diagnosis ; Inflammatory Bowel Diseases -- Care And Treatment ; Anoxia -- Genetic Aspects ; Anoxia -- Diagnosis ; Anoxia -- Care And Treatment ; Transcription Factors -- Research ; Immune Response -- Analysis ; Hydroxylases -- Health Aspects;
    ISSN: 0028-4793
    E-ISSN: 1533-4406
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  • 6
    Language: English
    In: The New England Journal of Medicine, June 22, 2017, Vol.376(25), p.2486(3)
    Description: The article discusses the key role that the timing of metastatis plays in the spread of breast cancer among women. Recent studies have highlighted the importance of increased scrutiny of cells of the early lesion and of the establishment and proliferation of these cells at the site of metastatis.
    Keywords: Breast Cancer – Diagnosis ; Cancer Cells – Research ; Women – Health Aspects
    ISSN: 0028-4793
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  • 7
    Language: English
    In: The American Journal of Cardiology, 2011, Vol.107(10), pp.1541-1546
    Description: Multidetector computed tomographic angiography defines anatomy in complex congenital heart disease, but radiation exposure and general anesthesia requirements limit its application. The aim of this study was to compare radiation exposure, anesthesia use, and diagnostic accuracy between standard-pitch, single-source computed tomography and high-pitch, dual-source computed tomography for image quality and risk in a clinical pediatric population. Consecutive computed tomographic scans were evaluated in patients aged 〈2 years with complex congenital heart disease. Two groups were compared on the basis of standard- versus high-pitch scans. High-pitch scans were further divided into variable pitch (2.25 to 3.0) and highest pitch (3.4) groups. Image quality, radiation exposure, anesthesia use, and diagnostic confidence and accuracy were determined. Sixty-one scans were reviewed (29 at standard pitch, 32 at high pitch). Body surface area, scan length, and indications were similar. The median dose-length product for standard-pitch scans was 66 mGy · cm (range 29 to 372) compared to 7 mGy · cm (range 3 to 50) in all high-pitch scans. The median dose-length product was 28 mGy · cm (range 8 to 50) for variable high-pitch scans and 5 mGy · cm (range 3 to 12) for the highest fixed-pitch scans. Diagnostic confidence was similar, although high-pitch scans had higher image noise and lower contrast-to-noise ratios. All high-pitch scans were performed under sedation with free breathing, and all standard-pitch scans required general anesthesia. Diagnostic accuracy was 100% in the 2 groups, with 17 standard-pitch and 16 high-pitch patients undergoing procedural validation. In conclusion, high-pitch, dual-source computed tomography provides excellent diagnostic accuracy and markedly reduces radiation dose, although image quality is mildly reduced.
    Keywords: Medicine
    ISSN: 0002-9149
    E-ISSN: 1879-1913
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  • 8
    In: The New England Journal of Medicine, 2009, Vol.360(3)
    Description: This interactive feature presented the case a 63-year-old man with a normal digital rectal examination but a prostate-specific antigen level that has been increasing over a 3-year period. Readers were invited to vote for one of three possible treatment options. In early December, we presented the case of a 63-year-old man with a rising prostate-specific antigen (PSA) level in Clinical Decisions,1 an interactive feature designed to assess how readers would manage a clinical problem for which there may be more than one appropriate treatment. The patient had no symptoms and was physically and sexually active. Biopsy of the prostate revealed adenocarcinoma with a Gleason score of 6 in 2 of 12 biopsy cores. Among the 3720 votes cast, 29% were for expectant management, 33% for radiotherapy, and 39% for radical prostatectomy. The votes that could be attributed to a continent . . .
    Keywords: Humans–Methods ; Male–Radiotherapy ; Middle Aged–Surgery ; Prostatectomy–Therapy ; Prostatectomy–Therapy ; Prostatic Neoplasms–Therapy ; Prostatic Neoplasms–Therapy ; Prostatic Neoplasms–Therapy ; Prostate Cancer ; Radiation Therapy ; Health Care ; Clinical Trials;
    ISSN: 0028-4793
    E-ISSN: 1533-4406
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  • 9
    Language: English
    In: New England Journal of Medicine, 05/20/2010, Vol.362(20), pp.1909-1919
    Description: The study of rare genetic diseases can lead to insights into the cause and treatment of common diseases. An example is the rare chromosomal instability disorder, Fanconi Anemia (FA). Studies of this disease have elucidated general mechanisms of bone marrow failure, cancer pathogenesis, and resistance to chemotherapy. The principal features of FA are aplastic anemia in childhood, susceptibility to cancer or leukemia, and hypersensitivity of FA cells to DNA cross-linking agents. There are thirteen FA genes, and one of these genes is identical to the well known breast cancer susceptibility gene, BRCA2. The corresponding FA proteins cooperate in the recognition and repair of damaged DNA. Inactivation of FA genes occurs not only in FA patients but also in a variety of cancers in the general population. These findings have broad implications for predicting the sensitivity and resistance of tumors to conventional anti-cancer agents, to inhibitors of poly-ADP ribose polymerase 1, an enzyme involved in DNA repair, and to other inhibitors of DNA repair.
    Keywords: Medicine;
    ISSN: 0028-4793
    E-ISSN: 1533-4406
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  • 10
    Language: English
    In: New England Journal of Medicine, 06/24/2010, Vol.362(25), pp.2399-2409
    Description: This review recounts the molecular mechanisms that control serum phosphate levels and describes the clinical consequences of abnormalities of these mechanisms. Several proteins in the kidney participate in reabsorption of urinary phosphate; the review describes mutations in the genes that encode these proteins, and the syndromes they produce.
    Keywords: Animals–Metabolism ; Biological Transport–Genetics ; Bone Demineralization, Pathologic–Physiopathology ; Calcinosis–Physiology ; Homeostasis–Genetics ; Humans–Physiology ; Kidney–Metabolism ; Kidney Calculi–Physiology ; Metabolism, Inborn Errors–Genetics ; Metabolism, Inborn Errors–Genetics ; Mutation–Genetics ; Parathyroid Hormone–Genetics ; Phosphate Transport Proteins–Genetics ; Phosphate Transport Proteins–Genetics ; Phosphates–Genetics ; Phosphoproteins–Genetics ; Phosphorus Metabolism Disorders–Genetics ; Phosphates ; Kidneys ; Proteins ; Rodents ; Urine ; Parathyroid Hormone ; Phosphate Transport Proteins ; Phosphates ; Phosphoproteins;
    ISSN: 0028-4793
    E-ISSN: 1533-4406
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