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  • 1
    Language: English
    In: Materials Today: Proceedings, 2017, Vol.4, pp.S188-S192
    Description: In order to prepare doxorubicin-loaded nanoparticles three different preparation techniques (emulsion diffusion, solvent displacement, and double emulsion) were compared in terms of particle diameter, polydispersity, zeta potential, drug load, and drug release. The particle size and polydispersity were measured by photon correlation spectroscopy (PCS), while the amount of entrapped doxorubicin was determined by HPLC-UV. The drug release profiles were observed over 24 h at 37°C in phosphate buffered saline (PBS) containing 5% bovine serum albumin (BSA). Nanoparticles with the highest quality were obtained by using emulsion diffusion yet drug release behaviour needs to be improved.
    Keywords: Nanoparticles ; Doxorubicin ; Poly(Lactic-Co-Glycolic Acid) (Plga) ; Emulsion Diffusion ; Solvent Displacement ; Double Emulsion
    ISSN: 2214-7853
    E-ISSN: 2214-7853
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  • 2
    In: Journal of Antimicrobial Chemotherapy, 2017, Vol. 72(4), pp.1109-1117
    Description: Objectives: This study evaluated the in vitro pharmacodynamics of combinations of ceftazidime and the non-β-lactam β-lactamase inhibitor, avibactam, against ceftazidime-, piperacillin/tazobactam- and meropenem-multiresistant Pseudomonas aeruginosa by a quantitative time–kill method. Methods : MICs of ceftazidime plus 0–16 mg/L avibactam were determined against eight isolates of P. aeruginosa . Single-compartment, 24 h time–kill kinetics were investigated for three isolates at 0–16 mg/L avibactam with ceftazidime at 0.25–4-fold the MIC as measured at the respective avibactam concentration. Ceftazidime and avibactam concentrations were measured by LC-MS/MS during the time–kill kinetic studies to evaluate drug degradation. Results: Avibactam alone displayed no antimicrobial activity. MICs of ceftazidime decreased by 8–16-fold in the presence of avibactam at 4 mg/L. The changes in log 10 cfu/mL at both the 10 h and 24 h timepoints (versus 0 h) revealed bacterial killing at ≥1-fold MIC. Significantly higher concentrations of ceftazidime alone, as compared with those of ceftazidime in combination, were required to produce any given kill. Without avibactam, ceftazidime degradation was significant (defined as degradation t 1/2  〈   24 h), with as little as 19%   ±   18% of the original concentration remaining at 8 h for the most resistant strain. In combination with avibactam, ceftazidime degradation at ≥ 1-fold MIC was negligible. Conclusion: The addition of avibactam protected ceftazidime from degradation in a dose-dependent manner and restored its cidal and static activity at concentrations in combination well below the MIC of ceftazidime alone.
    Keywords: Medicine ; Pharmacy, Therapeutics, & Pharmacology;
    ISSN: 0305-7453
    E-ISSN: 1460-2091
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  • 3
    Book chapter
    Book chapter
    Language: German
    In: Reflexiv-strategische Beratung : Gewerkschaften und betriebliche Interessenvertretungen professionell begleiten, pp. 47-58
    Keywords: Organisationsberatung ; Betriebsrat ; Deutschland
    ISBN: 3-531-17955-1
    Source: Deutsche Zentralbibliothek für Wirtschaftswissenschaften
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  • 4
    Language: German
    In: Praxis der Personalisierung im Handel : mit zeitgemäßen E-Commerce-Konzepten Umsatz und Kundenwert steigern, pp. 25-45
    Keywords: Online-Handel ; Online-Handel ; Kundenservice
    ISBN: 3-658-16243-0
    Source: Deutsche Zentralbibliothek für Wirtschaftswissenschaften
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  • 5
    Language: German
    In: Marketingexzellenz im Tourismus : Konzepte - Fallstudien - Best Practices, pp. 193-212
    Keywords: Tourismus ; It-Gestütztes Marketing
    ISBN: 3-503-17102-9
    Source: Deutsche Zentralbibliothek für Wirtschaftswissenschaften
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  • 6
    Language: English
    In: Haas, S., H. ten Cate, G. Accetta, P. Angchaisuksiri, J. Bassand, A. J. Camm, R. Corbalan, et al. 2016. “Quality of Vitamin K Antagonist Control and 1-Year Outcomes in Patients with Atrial Fibrillation: A Global Perspective from the GARFIELD-AF Registry.” PLoS ONE 11 (10): e0164076. doi:10.1371/journal.pone.0164076. http://dx.doi.org/10.1371/journal.pone.0164076.
    Description: Aims Vitamin K antagonists (VKAs) need to be individually dosed. International guidelines recommend a target range of international normalised ratio (INR) of 2.0–3.0 for stroke prevention in atrial fibrillation (AF). We analysed the time in this therapeutic range (TTR) of VKA-treated patients with newly diagnosed AF in the ongoing, global, observational registry GARFIELD-AF. Taking TTR as a measure of the quality of patient management, we analysed its relationship with 1-year outcomes, including stroke/systemic embolism (SE), major bleeding, and all-cause mortality. Methods and Results: TTR was calculated for 9934 patients using 136,082 INR measurements during 1-year follow-up. The mean TTR was 55.0%; values were similar for different VKAs. 5851 (58.9%) patients had TTR〈65%; 4083 (41.1%) TTR≥65%. The proportion of patients with TTR≥65% varied from 16.7% in Asia to 49.4% in Europe. There was a 2.6-fold increase in the risk of stroke/SE, 1.5-fold increase in the risk of major bleeding, and 2.4-fold increase in the risk of all-cause mortality with TTR〈65% versus ≥65% after adjusting for potential confounders. The population attributable fraction, i.e. the proportion of events attributable to suboptimal anticoagulation among VKA users, was 47.7% for stroke/SE, 16.7% for major bleeding, and 45.4% for all-cause mortality. In patients with TTR〈65%, the risk of first stroke/SE was highest in the first 4 months and decreased thereafter (test for trend, p = 0.021). In these patients, the risk of first major bleed declined during follow-up (p = 0.005), whereas in patients with TTR≥65%, the risk increased over time (p = 0.027). Conclusion: A large proportion of patients with AF had poor VKA control and these patients had higher risks of stroke/SE, major bleeding, and all-cause mortality. Our data suggest that there is room for improvement of VKA control in routine clinical practice and that this could substantially reduce adverse outcomes. Trial Registration ClinicalTrials.gov NCT01090362
    Keywords: Medicine And Health Sciences ; Diagnostic Medicine ; Signs And Symptoms ; Hemorrhage ; Pathology And Laboratory Medicine ; Vascular Medicine ; Pharmaceutics ; Drug Therapy ; Antiplatelet Therapy ; People And Places ; Demography ; Death Rates ; Biology And Life Sciences ; Population Biology ; Population Metrics ; Neurology ; Cerebrovascular Diseases ; Stroke ; Ischemic Stroke ; Geographical Locations ; Asia ; Cardiology ; Arrhythmia ; Atrial Fibrillation ; Hemorrhagic Stroke ; Physical Sciences ; Chemistry ; Chemical Compounds ; Organic Compounds ; Vitamins ; B Vitamins ; Vitamin K ; Organic Chemistry
    ISSN: 1932-6203
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  • 7
    Language: German
    In: Supervision : Mensch, Arbeit, Organisation : die Zeitschrift für Berater/innen, 2008, pp. 18-24
    Keywords: Gewerkschaft ; Unternehmenskultur ; Betriebsrat ; Organisationsberatung ; Coaching ; Deutschland
    ISSN: 14317168
    Source: Deutsche Zentralbibliothek für Wirtschaftswissenschaften
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  • 8
    Language: English
    In: BMC Health Services Research, Jan 27, 2009, Vol.9, p.17
    Description: Background Crohn's disease (CD) and ulcerative colitis (UC) are the most frequent inflammatory bowel disorders (IBD). IBD cause a significant burden to society due to extensive health care utilization from the first clinical symptoms until diagnosis and thereafter due to direct and indirect costs. Besides the socio-economic impact of CD and UC, gastrointestinal and extraintestinal symptoms affect quality of life, but there is remarkably little data about the quality of treatment as assessed by patient satisfaction, quality of life and adherence to guidelines. Thus the aim of this study was to identify variables that influence quality of treatment and quality of life as well as patient satisfaction. Methods The Essener Zirkel Study was a cross sectional study of 86 IBD-patients with a confirmed diagnosis of CD or UC. They were recruited at primary, secondary and tertiary care settings. Quality of treatment, quality of life and patient satisfaction were evaluated. Consulting behaviour and number of examinations, duration of disease and variables regarding adherence to guidelines were evaluated, too. Results 59 (69%) patients had CD and 27 had UC (31%). 19% spent more than four years until the suspected diagnosis of IBD was confirmed and visited more than five physicians. All patients showed a significantly reduced quality of life compared to the 1998 German normative population. In spite of being under medical treatment, nearly half of the patients suffered from strong quality of life restricting symptoms. Over all, 35% described their treatment as moderate or bad. Patients who consulted psychotherapists and non-medical practitioners suffered significantly less from depression. Conclusion Besides structural deficiencies due to the health care policy, we revealed the adherence to guidelines to be a problem area. Our findings support the assumption, that providing better health care and especially maintaining constant patient-physician communication improves patient satisfaction.
    Keywords: Inflammatory Bowel Diseases -- Causes Of ; Inflammatory Bowel Diseases -- Diagnosis ; Inflammatory Bowel Diseases -- Care And Treatment ; Inflammatory Bowel Diseases -- Patient Outcomes ; Patient Satisfaction -- Psychological Aspects ; Physician-patient Relations -- Psychological Aspects ; Physician-patient Relations -- Research
    ISSN: 1472-6963
    Source: Cengage Learning, Inc.
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  • 9
    Language: English
    In: BMC Health Services Research, Jan 27, 2009, Vol.9, p.17
    Description: Background Crohn's disease (CD) and ulcerative colitis (UC) are the most frequent inflammatory bowel disorders (IBD). IBD cause a significant burden to society due to extensive health care utilization from the first clinical symptoms until diagnosis and thereafter due to direct and indirect costs. Besides the socio-economic impact of CD and UC, gastrointestinal and extraintestinal symptoms affect quality of life, but there is remarkably little data about the quality of treatment as assessed by patient satisfaction, quality of life and adherence to guidelines. Thus the aim of this study was to identify variables that influence quality of treatment and quality of life as well as patient satisfaction. Methods The Essener Zirkel Study was a cross sectional study of 86 IBD-patients with a confirmed diagnosis of CD or UC. They were recruited at primary, secondary and tertiary care settings. Quality of treatment, quality of life and patient satisfaction were evaluated. Consulting behaviour and number of examinations, duration of disease and variables regarding adherence to guidelines were evaluated, too. Results 59 (69%) patients had CD and 27 had UC (31%). 19% spent more than four years until the suspected diagnosis of IBD was confirmed and visited more than five physicians. All patients showed a significantly reduced quality of life compared to the 1998 German normative population. In spite of being under medical treatment, nearly half of the patients suffered from strong quality of life restricting symptoms. Over all, 35% described their treatment as moderate or bad. Patients who consulted psychotherapists and non-medical practitioners suffered significantly less from depression. Conclusion Besides structural deficiencies due to the health care policy, we revealed the adherence to guidelines to be a problem area. Our findings support the assumption, that providing better health care and especially maintaining constant patient-physician communication improves patient satisfaction.
    Keywords: Inflammatory Bowel Diseases -- Causes Of ; Inflammatory Bowel Diseases -- Diagnosis ; Inflammatory Bowel Diseases -- Care And Treatment ; Inflammatory Bowel Diseases -- Patient Outcomes ; Patient Satisfaction -- Psychological Aspects ; Physician-patient Relations -- Psychological Aspects ; Physician-patient Relations -- Research
    ISSN: 1472-6963
    Source: Cengage Learning, Inc.
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  • 10
    Language: English
    In: Oncology Research and Treatment, December 2008, Vol.31(12), pp.657-663
    Description: Background: Ewing’s tumors (ET) are rare in patients over the age of 40 years. Published data on presentation, treatment, and clinical outcome are limited. Patients and Methods: We present a retrospective analysis of data from 47 patients in this age group diagnosed with ET and enrolled in the 2 consecutive trials, EICESS 92 and EURO-E.W.I.N.G. 99. The median age at diagnosis was 47.7 years (range, 40–68.6 years). Results: The median follow-up was 2.23 years from diagnosis (range, 0.35–12.92 years). 72.3% of patients were found to have localized disease, and 27.7% had primary metastases. Good clinical response to induction therapy was observed in 55%, and 73% of patients showed good histological response. The event-free survival was 0.77 at 1 year and 0.50 at 3 years (n = 44). Conclusion: ET are rare in patients over the age of 40 years. With adequate multimodal therapy, the results in terms of survival are comparable to those in adolescence. Specific age-adapted treatment regimens are not established. Patients should be enrolled in international trials, and if necessary treatment should be adjusted for lower tolerance and co-morbidity.
    Keywords: Original Article · Originalarbeit ; Surgery ; Adults ; Chemotherapy ; Ewing'S Tumor ; Radiotherapy ; Medicine
    ISSN: 2296-5270
    ISSN: 0378584X
    E-ISSN: 2296-5262
    E-ISSN: 14230240
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