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  • 1
    Language: English
    In: Journal of the American College of Cardiology, 17 March 2015, Vol.65(10), pp.A2130-A2130
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0735-1097(15)62130-1 Byline: Mohsen Sharifi, Wilbur Freeman, Curt Bay, Mirali Sharifi, Jean Chatham, Frederic Schwartz Author Affiliation: Arizona Cardiovascular Consultants & Vein Clinic, Mesa, AZ, USA A.T. Still University, Mesa, AZ, USA Article Note: (footnote) Poster Contributions Poster Hall B1 Monday, March 16, 2015, 9:45 a.m.-10:30 a.m. Session Title: Advanced in Pharmacomechanical Therapy for Deep Vein Thrombosis Abstract Category: 46. Vascular Medicine: Venous Disease Presentation Number: 1258-333
    Keywords: Medicine
    ISSN: 0735-1097
    E-ISSN: 1558-3597
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  • 2
    Language: English
    In: Journal of the American College of Cardiology, 01 April 2014, Vol.63(12), pp.A2096-A2096
    Keywords: Medicine
    ISSN: 0735-1097
    E-ISSN: 1558-3597
    Source: ScienceDirect Journals (Elsevier)
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  • 3
    Language: English
    In: Journal of the American College of Cardiology, 01 April 2014, Vol.63(12), pp.A1475-A1475
    Keywords: Medicine
    ISSN: 0735-1097
    E-ISSN: 1558-3597
    Source: ScienceDirect Journals (Elsevier)
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  • 4
    Language: English
    In: Journal of the American College of Cardiology, 16 September 2014, Vol.64(11), pp.B140-B141
    Description: Low molecular weight heparins ( LMWH) are considered the standard of care due to their superiority over warfarin. New oral anticoagulants (NOAC) are promising drugs which can simplify long term care of cancer patients with DVT.
    Keywords: Medicine
    ISSN: 0735-1097
    E-ISSN: 1558-3597
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  • 5
    Language: English
    In: Thrombosis Research, April 2015, Vol.135(4), pp.607-609
    Description: Heparin induced thrombocytopenia (HIT) is a potentially catastrophic syndrome with a high incidence of vascular thrombosis. There are little data on the efficacy of new oral anticoagulants (NOAC) in this setting. This study reports on the outcome of patients with HIT, treated with NOAC. We retrospectively identified 22 patients with HIT who were treated by our group with a combination of NOAC and a short course of argatroban. These patients were evaluated in a prospective fashion for development of outcomes at a mean follow up of 19 ± 3 months. There were a total of 5 deep and 2 superficial vein thromboses diagnosed at index hospitalization. No patient developed arterial thrombosis. All patients tolerated NOAC and their platelet count normalized before discharge. At 19 months of follow-up, 6 patients had died of non-thrombotic causes. There was no bleeding, limb loss or recurrent venous thromboembolism in any patient. In patients with HIT, a short course of parenteral treatment with argatroban followed by administration of a NOAC is highly safe and effective in prevention of thrombosis and normalization of platelet count. Development of HIT however, portends a poor prognosis independent of vascular thrombosis.
    Keywords: Heparin- Induced Thrombocytopenia ; New Oral Anticoagulants ; Deep Venous Thrombosis ; Medicine
    ISSN: 0049-3848
    E-ISSN: 1879-2472
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  • 6
    Language: English
    In: Lung, 2015, Vol.193(3), pp.369-374
    Description: Background Administration of systemic thrombolysis in pulmonary embolism (PE) has been limited to severe forms due to the risk of intracerebral hemorrhage (ICH). There is growing evidence from small studies that low-dose systemic thrombolysis has equal efficacy to standard dose, while eliminating the risk of ICH. Little data exists on the combined use of low-dose systemic thrombolysis and new oral anticoagulants (NOAC). We evaluated the clinical and echocardiographic outcome of patients treated with low or "safe dose" thrombolysis (SDT) and NOAC at intermediate term. Methods We retrospectively identified 159 patients with massive and submassive PE who were treated with SDT and NOAC over a 2-year period by our group. They were followed prospectively for PE-related mortality, recurrent PE, bleeding, change in right/left ventricle (RV/LV) size, pulmonary artery systolic pressure (PASP), and clinical improvement at a mean follow-up of 18 #177; 3 months. Results At 6 months, the RV/LV size was reduced from 1.29 #177; 0.28 to 0.89 #177; 0.03 (p 0.001). The PASP dropped from 53.12 #177; 3.85 mmHg to 30.39 #177; 3.93 mmHg (p 0.001). There was no ICH or in-hospital major or minor bleeding. At 18 months, three patients died of cancer. Recurrent PE developed in one patient who had been later switched to warfarin. The duration of hospitalization was 1.8 #177; 0.3 days. Conclusion With combination of SDT and NOAC, treatment of massive and submassive PE becomes identical and is transformed from an "anticoagulation first" to a "thrombolysis first" approach, thereby making treatment streamlined, simple, safe and effective, accessible and inexpensive.
    Keywords: Safe dose thrombolysis ; Pulmonary embolism ; New oral anticoagulants ; Pulmonary hypertension
    ISSN: 0341-2040
    E-ISSN: 1432-1750
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  • 7
    Language: English
    In: Vascular Medicine, April 2015, Vol.20(2), pp.112-116
    Description: Post-thrombotic syndrome (PTS) is a common complication of deep venous thrombosis (DVT) of the iliofemoral venous system leading to significant morbidity and high health care costs. It has been recently shown that percutaneous endovenous intervention (PEVI) can effectively reduce the incidence of PTS. The role of new oral anticoagulants (NOACs) in combination with PEVI in the reduction of PTS has not been previously studied. This report sought to evaluate the role of PEVI plus NOACs in the reduction of PTS in acute symptomatic femoropopliteal and iliac DVT. We studied 127 patients with acute lower extremity DVT who had undergone PEVI plus administration of NOACs. All had received a minimum of 3 months of anticoagulation with a NOAC following PEVI. The mean follow-up was 22±5 months. The patients were evaluated for development of PTS, bleeding, recurrent venous thromboembolism (VTE), duration of hospitalization and mortality. There was no in-hospital bleeding. The mean duration of hospitalization was 46±9 hours. DVT occurred in two patients who had been later switched to warfarin. There were four non-VTE-related deaths. PTS developed in five patients (3%), two of whom were those who had been switched to warfarin. Their mean Villalta score was 6.2±0.9. We conclude that the combination of PEVI plus NOAC and low dose aspirin is associated with a very low rate of PTS with the severity being only mild. This approach leads to very low rates of bleeding and recurrent VTE and promotes early discharge.
    Keywords: Deep Vein Thrombosis ; Endovenous Intervention ; New Oral Anticoagulants ; Post-Thrombotic Syndrome ; Medicine
    ISSN: 1358-863X
    E-ISSN: 1477-0377
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  • 8
    Language: English
    In: 13 January 2012, Vol.8350, pp.83500D-83500D-5
    Description: From locating techniques in the wireless sensors networks two groups based on harbor and without it can be referred to. Firstly, the harbor nodes distribute the local information in the network and through that the average distance between two groups or the average length of a step is identified. Non-harbor nodes know the shortest path as the number of steps to each of the harbors and determine their distance to the harbors by understanding this average step length and using this estimation compute their location distance. Firstly, the network nodes are clustered. Each harbor is a cluster head and the cluster members using information derived from this cluster head begin locating. This process starts by the nodes located in the common field between two clusters. Although algorithm comparability based on harbor is increased by the nodes clustering, but the algorithm precise and efficiency is still dependent on the number of harbor nodes. Using harbor in all of the conditions causes its usage limitation in the wireless sensor networks. Regarding the algorithms without needing to harbor, algorithm is the first case. This algorithm has invented a new method to make a local graph in the network which is applicable in computing the relative features of nodes. Firstly, each node makes a graph with its own axis. Then the general graph of network is made and each node changes its coordinates by using an algorithm. Because of the current limitations in the trigonometry method used in this algorithm, the computed coordinates are not reliable and face difficulties in many cases. The other algorithms being needless to harbor try to use another methods instead of trigonometry methods in locating. For instance, among these methods, those ones based on graph drawing or mass and coil algorithms can be referred to. These kinds of algorithms take much time and use a lot of energy. In order to upgrade the algorithm results quality and prevent the fault distribution, we define a secondary parameter called the computed location accuracy. This parameter indicates location accuracy and can be a value between zero and one.
    Keywords: Engineering
    ISBN: 9780819490261
    ISBN: 0819490261
    ISSN: 0277786X
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