UID:
almahu_9949697971802882
Format:
1 online resource (439 pages)
ISBN:
0-323-90655-9
Series Statement:
Woodhead Publishing Series in Biomaterials
Content:
Protein-Based Biopolymers: From Source to Biomedical Applications provides an overview on the development and application of protein biopolymers in biomedicine. Protein polymers have garnered increasing focus in the development of biomedical materials, devices and therapeutics due to their intrinsic bioactivity, biocompatibility and biodegradability. This book comprehensively reviews the latest advances on the synthesis, characterization, properties and applications of protein-based biopolymers. Each chapter is dedicated to a single protein class, covering a broad range of proteins including silk, collagen, keratin, fibrin, and more. In addition, the book explores the biomedical potential of these polymers, from tissue engineering, to drug delivery and wound healing. This book offers a valuable resource for academics and researchers in the fields of materials science, biomedical engineering and R&D groups working in pharmaceutical and biomedical industries.
Note:
Front Cover -- Protein-Based Biopolymers -- Copyright Page -- Contents -- List of contributors -- Preface -- 1 An introduction to protein-based biopolymers -- 1.1 Introduction -- 1.2 Protein and its biopolymers -- 1.2.1 Structure and properties of proteins -- 1.2.2 Origin and types -- 1.2.2.1 Collagen -- 1.2.2.2 Gelatin -- 1.2.2.3 Keratin -- 1.2.2.4 Fibrin -- 1.2.2.5 Silk fibroin -- 1.2.2.6 Elastin -- 1.2.2.7 Resilin -- 1.2.2.8 Reflectin -- 1.2.2.9 Casein -- 1.2.2.10 Whey -- 1.2.2.11 Albumin -- 1.2.2.12 Zein -- 1.2.2.13 Gluten -- 1.2.3 Synthetic protein material products in the industry -- 1.2.4 Reinforcement and modification techniques -- 1.3 Applications -- 1.3.1 Soil Strengthening -- 1.3.2 Food packaging: films and coatings -- 1.3.3 Protein purification -- 1.3.4 PBBM in healthcare: tissue engineering, drug delivery, surface engineering -- 1.3.5 Recombinant protein polymers -- 1.4 Protein-based biopolymers nanoparticles -- 1.5 Challenges and future prospects -- Acknowledgments -- References -- 2 Fabrication, properties and applications of gluten protein -- 2.1 Introduction -- 2.2 Methods of protein fabrication -- 2.2.1 pH variation -- 2.2.2 Phase separation -- 2.2.3 Polymer chain collapse -- 2.2.4 Electron-beam lithography -- 2.2.5 Photolithography -- 2.2.6 Micro-contact printing -- 2.2.7 Colloidal lithography -- 2.2.8 Nanoimprinting lithography -- 2.3 Properties of wheat gluten -- 2.3.1 Gluten hydration or water retention property -- 2.3.2 Viscoelastic properties -- 2.3.3 Extensibility -- 2.3.4 Viscosity -- 2.4 Applications of gluten protein -- 2.4.1 Use of wheat protein isolate -- 2.4.2 Texturized protein -- 2.4.3 Use in meat industry -- 2.4.4 Use in vegetarian food substitutes -- 2.4.5 Hydrolyzed wheat protein -- 2.4.6 Uses in bakery -- 2.4.7 Uses in non-food products -- 2.4.8 Wheat gluten-based bioplastics -- 2.5 Conclusion -- References.
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3 Keratin for potential biomedical applications -- 3.1 Introduction -- 3.2 Keratin in the history -- 3.3 Structure and the characteristic features of keratin -- 3.3.1 Classification of keratins -- 3.3.2 Distribution of keratins -- 3.3.3 Chemical composition, physicochemical and biological properties of keratin -- 3.3.3.1 Biocompatibility -- 3.3.3.2 Biodegradability -- 3.3.3.3 Biological characteristics of keratins -- 3.4 Keratin-based biomaterials and their biomedical applications -- 3.4.1 Keratin films -- 3.4.2 Biomedical applications of keratin films -- 3.4.3 Keratin hydrogels -- 3.4.4 Biomedical applications of keratin hydrogels -- 3.4.5 Keratin biofibers for biomedical applications -- 3.5 Conclusion -- References -- 4 Fabrication, properties, and biomedical applications of soy protein-based materials -- 4.1 Introduction -- 4.2 Soy protein properties -- 4.2.1 Surface properties -- 4.2.2 Mechanical properties -- 4.2.3 Biodegradability -- 4.3 Fabrication of soy protein-based biomaterials -- 4.3.1 Soy protein films -- 4.3.1.1 Solution casting -- 4.3.1.2 Film extrusion -- 4.3.2 Soy protein hydrogels -- 4.3.3 Soy protein microparticles -- 4.3.4 Advent of nanoscience -- 4.3.4.1 Soy protein nanoparticles -- Ionic gelation method -- Desolvation -- Microfluidics -- Ultrasonication -- Electrospraying -- Self-assembly -- 4.3.4.2 Soy protein nanoemulsions -- Microfluidics -- Ultrahigh pressure homogenization -- Ultrasonic homogenization -- 4.3.4.3 Soy protein nanofibers -- 4.3.4.4 Soy protein nanocomposites -- Soy protein-organic nanocomposites -- Soy protein-inorganic nanocomposites -- 4.4 Biomedical applications -- 4.4.1 Drug delivery -- 4.4.2 Wound dressing -- 4.4.3 Tissue engineering -- 4.5 Challenges and future prospects -- References -- 5 Sodium caseinate versus sodium carboxymethyl cellulose as novel drug delivery carriers -- 5.1 Introduction.
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5.2 Synthesis and characterization of biopolymer composites as hydrogels for controlling the release of drug -- 5.2.1 Synthesis and characterization of protein- and cellulose-based hydrogels -- 5.2.2 Evaluating composite hydrogels as drug delivery systems -- 5.2.3 Cytotoxicity assay of composite hydrogels -- 5.3 Effective role of protein-based composite hydrogel versus cellulose-based composite hydrogel -- 5.3.1 SC/Ch composite hydrogel characteristics versus CMC/Ch composite -- 5.3.1.1 FTIR analysis -- 5.3.1.2 Differential scanning calorimetry -- 5.3.1.3 Scanning electron microscopy -- 5.3.2 Characteristics of SC/Ch and CMC/Ch composite hydrogels as drug delivery system -- 5.3.2.1 Swelling test -- 5.3.2.2 Encapsulation efficiency and loading -- 5.3.2.3 In vitro release study -- 5.3.2.4 Kinetics and mechanism of drug release -- 5.3.3 Cytotoxicity assay of the prepared composite hydrogels -- 5.3.3.1 Neutral red uptake assay -- 5.3.3.2 Effect of composite gels on cell membrane integrity (LDH assay) -- 5.4 Conclusions -- Acknowledgments -- References -- 6 Silk-based biomaterials for biomedical applications -- 6.1 Introduction -- 6.2 Components of silk -- 6.2.1 Properties of silk fibroin -- 6.3 Development of silk-based biomaterials -- 6.4 Biomedical applications -- 6.4.1 Disease model -- 6.4.2 Tissue engineering -- 6.4.3 Gene therapy -- 6.4.4 Implantable devices -- 6.4.5 Drug delivery -- 6.5 Future prospective -- 6.6 Conclusions -- Acknowledgments -- References -- 7 Protein-based nanoparticles as drug delivery nanocarriers -- 7.1 Introduction -- 7.1.1 Nanotechnology, nanomaterials and medicinal aspects -- 7.1.2 Protein nanoparticles -- 7.1.3 Designing of nanoparticles -- 7.1.4 Preparation of Pr-NPs -- 7.2 Pr-NPs and drug delivery -- 7.2.1 Pr-NPs assisted drug delivery -- 7.2.2 Pr-NPs and drug -- 7.2.2.1 Drug encapsulation or drug loading.
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7.2.2.2 Drug release -- 7.2.2.2.1 In vitro drug release methods -- 7.2.2.2.2 Sample and separate -- 7.2.2.2.3 Continuous flow method -- 7.2.2.2.4 Dialysis method for drug release -- 7.2.2.2.5 Modified methods -- 7.3 Emerging research on Pr-NPs assisted drug delivery -- 7.3.1 Bioadhesive food Pr-NPs for pediatric oral drug delivery -- 7.3.2 Coiled-coil formation for targeted drug delivery (TDD) using Pr-NPs -- 7.3.3 Self-assembled protein shell lipophilic core nanoparticles for drug delivery -- 7.3.4 Drug delivery from nanoparticles derived from silk-elastin-like protein polymers -- 7.3.5 Dual-sensitive hydrogel nanoparticles with protein filaments for triggerable drug delivery -- 7.3.6 Blood−brain-barrier-penetrating albumin nanoparticles for biomimetic drug delivery -- 7.4 Future approach for Pr-NPs assisted drug delivery -- 7.4.1 Metal organic ionic framework assisted drug delivery -- 7.4.2 Protein nanoparticles conjugated metal organic ionic framework for drug delivery -- 7.5 Conclusions -- Acknowledgments -- References -- 8 Peptide and protein-based hydrogels for the encapsulation of bioactive compounds and tissue engineering applications -- 8.1 Introduction -- 8.2 Characteristics of gels -- 8.3 Gel formulation methods -- 8.4 Classification and types of gels -- 8.5 Hydrogels -- 8.5.1 Introduction to hydrogels -- 8.5.2 Classification of hydrogels -- 8.5.3 Biodegradability -- 8.5.4 Biomolecules -- 8.5.5 Proteins -- 8.6 Protein-based hydrogels -- 8.7 Peptide-based hydrogels -- 8.8 Synthesis of peptide-based hydrogels -- 8.9 Bioactive compounds -- 8.10 Encapsulation -- 8.11 Peptide hydrogels for encapsulating bioactive compounds -- 8.12 Tissue engineering -- 8.13 Keratin -- 8.14 Keratin-based hydrogel for wound healing -- 8.15 Regeneration of bone tissue engineering using Nap-FFY based hydrogels -- 8.16 Formation of a desired organ/tissue.
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8.17 Albumin based hydrogels for skin regeneration and wound healing -- 8.18 Blood vessels formation in damaged tissues with mussel adhesive protein -- 8.19 Heparin-mediated delivery of bone morphogenetic protein-2 improves spatial localization of bone regeneration -- 8.20 Cartilage tissue engineering using silk-based hydrogels -- 8.21 Conclusion -- Acknowledgments -- References -- 9 Silver nanoparticles and protein polymer-based nanomedicines -- 9.1 Introduction -- 9.2 Protein-based Ag nanoparticles -- 9.2.1 Study on the interaction of protein and Ag nanoparticles -- 9.2.2 Impact of surface coating/food-mimicking media on silver nanoparticle-protein interaction -- 9.2.3 Protein concentration effects on the silver nanoparticles surface -- 9.2.4 Impact of proteins on the aggregation of silver nanoparticles -- 9.2.5 Effects of surface modification on protein conformation -- 9.3 Collagen-based silver nanoparticles -- 9.3.1 Synthesis and characterization -- 9.3.2 Stability of collagen-silver nanoparticles-based materials -- 9.3.3 Biological applications of collagen-based silver nanoparticles -- 9.3.3.1 Antimicrobial activity -- 9.3.3.2 Wound healing -- 9.3.3.3 Bone healing -- 9.3.3.4 Other medical applications -- 9.4 Keratin-silver nanoparticles -- 9.4.1 Synthesis and characterization of keratin-silver nanoparticle-based materials -- 9.4.2 Stability of keratin protein-stabilized silver nanoparticles -- 9.4.3 Biomedical applications of keratin-silver nanoparticles-based materials -- 9.4.3.1 Antibacterial activity -- 9.4.3.2 Wound healing -- 9.5 Soy protein-silver nanoparticles-based materials -- 9.5.1 Synthesis and characterization of soy protein-silver nanoparticles-based materials -- 9.5.2 Stability of silver nanoparticles stabilized by soy protein -- 9.5.3 Biological applications of soy protein-silver nanoparticles-based materials.
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9.5.3.1 Antimicrobial activity.
Additional Edition:
Print version: Kalia, Susheel Protein-Based Biopolymers San Diego : Elsevier Science & Technology,c2022 ISBN 9780323905459
Language:
English
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