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  • 1
    Language: English
    In: Journal of Analytical Chemistry, 2013, Vol.68(3), pp.253-260
    Description: The transfer of aminoglycoside antibiotics streptomycin, kanamycin, and gentamycin induced by dibenzo-18-crown-6 is studied by voltammetry at the interface of two immiscible electrolyte solutions ( ITIES ). An assumption about the 1: 1 stoichiometry of the complexes formed is formulated. The method is proposed for use in the analysis of kanamycin and streptomycin in aqueous solutions. The optimal conditions of analysis of these aminoglycosides are found, the detection limits are 8.0 × 10 −5 M for streptomycin and 2.0 × 10 −4 M for kanamycin. The selectivity of streptomycin analysis by ITIES voltammetry in presence of potassium and sodium is studied. An amperometric ion-selective electrode is developed for the determination of streptomycin in drug formulations with a detection limit of 9.0 × 10 −5 M.
    Keywords: voltammetry at the interface of two immiscible electrolyte solutions ; aminoglycoside antibiotics ; streptomycin ; gentamycin ; kanamycin ; dibenzo-18-crown-6
    ISSN: 1061-9348
    E-ISSN: 1608-3199
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  • 2
    Language: English
    In: Die Pharmazie, July 2014, Vol.69(7), pp.518-24
    Description: Arylsulfatase A (ASA) deficiency is the cause of metachromatic leucodystrophy (MLD), a lysosomal storage disease associated with severe neurological disorders. Poly(butyl cyanoacrylate) (PBCA) nanoparticles overcoated with polysorbate 80 enabled the delivery of several drugs across the blood-brain barrier to the brain suggesting that these nanoparticles also may transport ASA across this barrier. The objective of this research, therefore, was to evaluate the feasibility of loading ASA onto PBCA nanoparticles. A stable ASA-loaded PBCA nanoparticle formulation was developed that could be easily freeze-dried and stored over a period of more than 8 weeks. The maximum loading capacity for this enzyme was -59 microg per 1 mg of PBCA. In the presence of 3% sucrose as a lyoprotector the activity of freeze-dried ASA was found to be 100% recoverable.
    Keywords: Cerebroside-Sulfatase -- Therapeutic Use ; Enbucrilate -- Chemistry ; Enzyme Replacement Therapy -- Methods
    ISSN: 0031-7144
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 3
    Language: English
    In: Russian Journal of Electrochemistry, 2011, Vol.47(3), pp.361-368
    Description: Transfer of complexes of josamycin, spyramycin, and erythromycin with alkali and alkali-earth metals was studied using the method of voltammetry at the interface of two immiscible electrolyte solutions. Standard energies and standard transfer potentials of the formed complexes and also the values of their stability constants were determined. Stoichiometry of the complexes formed was determined. Experimentally obtained detection limits of these macrolide antibiotics in the organic phase are presented.
    Keywords: voltammetry at the interface of two immiscible electrolyte solutions ; macrolide antibiotics ; josamycin ; spyramycin ; erythromycin ; alkali metals ; alkali—earth metals
    ISSN: 1023-1935
    E-ISSN: 1608-3342
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  • 4
    Language: English
    In: International Journal of Pharmaceutics, 2007, Vol.345(1), pp.154-162
    Description: Macrophages in the lungs are the most important cell type supporting replication of in humans. The objective of this study was to investigate whether the effect of moxifloxacin against residing in macrophages could be improved by encapsulation of the drug in the biodegradable nanoparticles, which are known to accumulate in macrophages upon intravenous administration. To accomplish this, moxifloxacin was encapsulated in poly(butyl cyanoacrylate) (PBCA) nanoparticles. Encapsulated moxifloxacin accumulated in macrophages approximately three-fold times more efficiently than the free drug, and was detected in the cells for at least six times longer than free moxifloxacin at the same extracellular concentration. Inhibition of intracellular growth with encapsulated moxifloxacin was achieved at the concentration of 0.1 μg/ml, whereas the same effect with free MX required a concentration of 1 μg/ml. Nanoparticles observed within the macrophage cytoplasm were distributed throughout the cytoplasm, sometimes in the vicinity of intracellular bacteria.
    Keywords: Macrophage ; Moxifloxacin ; M. Tuberculosis ; Nanoparticles ; Poly(Butyl Cyanoacrylate) ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0378-5173
    E-ISSN: 1873-3476
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  • 5
    Language: English
    In: Pharmaceutical Chemistry Journal, 2010, Vol.44(3), pp.151-156
    Description: The aim of the present work was to assess the influences of the parameters of the process of preparing polylactide-based nanosomal medicinal formulations of rifampicin (Rif) on nanoparticle size, the level of Rif sorption, and the kinetics of Rif release in vitro. The most effective Rif sorption in nanoparticles (up to 90%) was obtained using polylactides with additional terminal carboxyl groups. An increase in the initial Rif concentration in the organic phase from 1 to 5 mg/ml led to some decrease in the extent of sorption (from 89% to 76%) though it had no significant effect on the sizes of the resulting nanoparticles (190 – 260 nm). The rate of Rif release could be controlled by altering the composition of the polymer matrix of the nanoparticles; the presence of additional terminal carboxyl groups in polylactides gave slower antibiotic release, resulting from tighter interaction with the polymer matrix.
    Keywords: Nanoparticles ; polylactides ; rifampicin
    ISSN: 0091-150X
    E-ISSN: 1573-9031
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  • 6
    Language: English
    In: Russian Journal of Electrochemistry, 2014, Vol.50(10), pp.940-946
    Description: The transfer of alkali and alkaline earth metal ions and ammonium ions facilitated by the calixarenes 5,11,17,23-tetra(tert-butyl)-26,28-dihydroxycalix[4]-25,27-crown-5-ether, 5,11,17,23-tetra(tert-butyl)-26,28-di(ethoxycarbonylmethoxy)calix[4]-25,27-crown-5-ether, and 5,11,17,23-tetra(tert-butyl)-25,26,27,28-tetra(ethoxycarbonylmethoxy)-calix[4]arene was studied by voltammetry at the interface between two immiscible electrolyte solutions. The formal energies, transfer potentials, stoichiometry, and stability constants of the complexes were determined. The optimum conditions for determining the ammonium ion by voltammetry at the liquid-liquid interface were selected on the basis of these studies (the detection limit was 3.5 × 10 −6 M). The ammonium ion determination showed selectivity relative to the sodium ion.
    Keywords: voltammetry at the liquid-liquid interface ; calixarenes ; alkali metals ; alkaline earth metals ; ammonium ion
    ISSN: 1023-1935
    E-ISSN: 1608-3342
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  • 7
    Language: English
    In: Journal of Analytical Chemistry, 2010, Vol.65(7), pp.726-731
    Description: To establish the composition of the gentamicin complex ( GNMC ) of copper(II) in the polymer matrix of an ion-selective membrane ( ISM ), we investigated spectra of the ISM upon both incorporation of the GNMC and its complex with copper(II) by the IR spectrometry method. A number of spectral changes were revealed: the appearance and disappearance of some absorption bands and batho- and hypsochromic shifts accompanied by the substantial rearrangement of the bands’ intensities. The observed effects are indicative of the change of the distribution of the charge within the molecule, the formation of new bonds, and rotational transformation in the formation of a chelate cycle. This confirms not only the presence of a complex in the polymer matrix but also that its structure is identical to the one found in solution before.
    Keywords: Aminoglycosides -- Research ; Copper Compounds ; Infrared Spectroscopy ; Polymers;
    ISSN: 1061-9348
    E-ISSN: 1608-3199
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  • 8
    Language: English
    In: Pharmaceutical Chemistry Journal, 2016, Vol.50(6), pp.407-412
    Description: Parenteral formulations of the poorly soluble antituberculosis antibiotic rifapentine were developed. Proteins (human serum albumin, succinylated gelatin, and sodium caseinate) were used to produce water-soluble forms of rifapentine by precipitation or homogenization. Ultrasonic homogenization gave the best results, i.e., stable colloidal suspensions with 9 – 10 mg of rifapentine per mL (practically 100 times greater than its water solubility). Dilution of the suspensions led to dissociation of the aggregates formed during the solubilization and formation of a clear solution. The particle size decreased to 10 – 20 nm, which corresponded to the particle size in a solution of the proteins at the same concentration. This would not cause embolization upon infusion of such water-soluble forms of rifapentine. The results indicated that the selected approach was promising for designing parenteral formulations of rifapentine.
    Keywords: proteins ; complexation ; rifapentine ; solubilization ; tuberculosis
    ISSN: 0091-150X
    E-ISSN: 1573-9031
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  • 9
    Language: English
    In: Pharmaceutical Chemistry Journal, 2017, Vol.51(7), pp.616-621
    Description: Solubilization of rifapentine with human serum albumin (HSA) was used to produce a water-miscible form consisting of a colloidal suspension of particles of size 538 ± 9 nm. Dilution of the suspension more than 20-fold led to dissociation of the aggregates formed during solubilization procedure, producing a transparent solution. This was associated with a reduction in particle size to 10 – 20 nm, corresponding to the particle size in HSA solution at the same concentration. A fluorescence method showed that suspensions contained both free rifapentine and its complex with HSA. Studies of the activity against the pathogen of tuberculosis, Mycobacterium tuberculosis H37Rv, in a model of acute infection in Balb/c mice showed that the water-miscible form of rifapentine given intravenously had high activity against mycobacteria, comparable with the activity of rifapentine substance, decreasing mycobacterial loadings in the parenchymatous organs from 10 6 – 10 7 to 10 2 – 10 3 cfu/organ. Thus, use of HSA as solubilizer yielded an intravenous form of rifapentine retaining the activity of the antibiotic against Mycobacterium tuberculosis.
    Keywords: human serum albumin ; rifamycins ; rifapentine ; tuberculosis
    ISSN: 0091-150X
    E-ISSN: 1573-9031
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  • 10
    Language: English
    In: Pharmaceutical Chemistry Journal, 2013, Vol.46(10), pp.626-629
    Description: The aim of the present work was to develop methods for the preparation of a nanosomal form of low-sialylated recombinant human erythropoietin (ls-rhEPO), which has neurotropic antihemorrhagic activity. Measurements were made of the sorption of erythropoietin to nanoparticles made of lactic acid homopolymer or lactic acid/glycolic acid copolymer, mean nanoparticle size, and the resistance of the resulting complex to aggregation. The most effective sorption (greater than 80%) was achieved using a copolymer with equal proportions of lactic and glycolic acids (50:50). Experiments using an intracerebral post-traumatic hematoma model in rats demonstrated that nanosomal ls-rhEPO had neuroprotective actions, based on its ability to decrease death in the experimental animals (77.8% survived, which was 40% more than in the control group). Nanosomal ls-rhEPO was found to have no effect on hematopoiesis in conditions of chronic administration.
    Keywords: nanoparticles ; copolymer of lactic and glycolic acids ; erythropoietin ; neuroprotection ; intracerebral post-traumatic hematoma ; hematocrit
    ISSN: 0091-150X
    E-ISSN: 1573-9031
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