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  • 1
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 01 November 2011, Vol.108(44), pp.E998-1006
    Description: Toll-like receptors (TLRs) are expressed on innate immune cells and trigger inflammation upon detection of pathogens and host tissue injury. TLR-mediated proinflammatory-signaling pathways are counteracted by partially characterized anti-inflammatory mechanisms that prevent exaggerated inflammation and host tissue damage as manifested in inflammatory diseases. We biochemically identified a component of TLR-signaling pathways, A20-binding inhibitor of NF-κB (ABIN1), which recently has been linked by genome-wide association studies to the inflammatory diseases systemic lupus erythematosus and psoriasis. We generated ABIN1-deficient mice to study the function of ABIN1 in vivo and during TLR activation. Here we show that ABIN1-deficient mice develop a progressive, lupus-like inflammatory disease characterized by expansion of myeloid cells, leukocyte infiltrations in different parenchymatous organs, activated T and B lymphocytes, elevated serum Ig levels, and the appearance of autoreactive antibodies. Kidneys develop glomerulonephritis and proteinuria, reflecting tissue injury. Surprisingly, ABIN1-deficient macrophages exhibit normal regulation of major proinflammatory signaling pathways and mediators but show selective deregulation of the transcription factor CCAAT/enhancer binding protein β (C/EBPβ) and its target genes, such as colony-stimulating factor 3 (Csf3), nitric oxide synthase, inducible (Nos2), and S100 calcium-binding protein A8 (S100a8). Their gene products, which are intimately linked to innate immune cell expansion (granulocyte colony-stimulating factor), cytotoxicity (inducible nitric oxide synthase), and host factor-derived inflammation (S100A8), may explain, at least in part, the inflammatory phenotype observed. Together, our data reveal ABIN1 as an essential anti-inflammatory component of TLR-signaling pathways that controls C/EBPβ activity.
    Keywords: Adaptor Proteins, Signal Transducing -- Physiology ; Ccaat-Enhancer-Binding Protein-Beta -- Metabolism ; Lupus Erythematosus, Systemic -- Prevention & Control ; Nf-Kappa B -- Antagonists & Inhibitors ; Psoriasis -- Prevention & Control ; Toll-Like Receptors -- Physiology
    ISSN: 00278424
    E-ISSN: 1091-6490
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  • 2
    Article
    Article
    In: Journal of Biomolecular Techniques : JBT, 4/2013, Vol.24(1), pp.50-56
    Keywords: Biology;
    ISSN: 1524-0215
    E-ISSN: 1943-4731
    Source: CrossRef
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  • 3
    Article
    Article
    In: Journal of Biomolecular Techniques : JBT, 9/2012, Vol.23(3), pp.115-121
    ISSN: 1524-0215
    E-ISSN: 1943-4731
    Source: CrossRef
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  • 4
    Article
    Article
    In: Journal of Biomolecular Techniques : JBT, 12/2012, Vol.23(4), pp.147-152
    ISSN: 1524-0215
    E-ISSN: 1943-4731
    Source: CrossRef
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  • 5
    Article
    Article
    In: Journal of Biomolecular Techniques : JBT, 4/2012, Vol.23(1), pp.31-36
    Description: This column highlights recently published articles that are of interest to the readership of this publication. We encourage ABRF members to forward information on articles they feel are important and useful to Clive Slaughter, Georgia Health Sciences University-University of Georgia Medical Partnership, 279 William St., Athens GA 30607-1777. Phone: 706-369-5945; Fax: 706-369-5936; E-mail: ude.agu@thgualsc; or to any member of the editorial board. Article summaries reflect the reviewer's opinions and not necessarily those of the association.
    Keywords: Biology;
    ISSN: 1524-0215
    E-ISSN: 1943-4731
    Source: CrossRef
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  • 6
    Article
    Article
    In: Journal of Biomolecular Techniques : JBT, 7/2012, Vol.23(2), pp.78-82
    Description: This column highlights recently published articles that are of interest to the readership of this publication. We encourage ABRF members to forward information on articles they feel are important and useful to Clive Slaughter, GHSU-UGA Medical Partnership, 279 William St., Athens, GA 30607-1777. Phone: 706-369-5945; Fax: 706-369-5936; E-mail: ude.agu@thgualsc; or to any member of the editorial board. Article summaries reflect the reviewer's opinions and not necessarily those of the association.
    Keywords: Biology;
    ISSN: 1524-0215
    E-ISSN: 1943-4731
    Source: CrossRef
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  • 7
    Article
    Article
    In: Journal of Biomolecular Techniques : JBT, 7/2014, Vol.25(2), pp.61-66
    ISSN: 1524-0215
    E-ISSN: 1943-4731
    Source: CrossRef
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  • 8
    Article
    Article
    Language: English
    In: Journal of biomolecular techniques : JBT, December 2018, Vol.29(4), pp.105-112
    Description: This column highlights recently published articles that are of interest to the readership of this publication. We encourage ABRF members to forward information on articles they feel are important and useful to Clive Slaughter, MCG-UGA Medical Partnership, 1425 Prince Ave., Athens, GA 30606, USA. Tel: (706) 713-2216; Fax: (706) 713-2221; E-mail: cslaught@uga.edu, or to any member of the editorial board. Article summaries reflect the reviewer's opinions and not necessarily those of the association.
    E-ISSN: 1943-4731
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 9
    Article
    Article
    Language: English
    In: Journal of biomolecular techniques : JBT, September 2016, Vol.27(3), pp.119-24
    Description: This column highlights recently published articles that are of interest to the readership of this publication. We encourage ABRF members to forward information on articles they feel are important and useful to Clive Slaughter, AU-UGA Medical Partnership, 1425 Prince Ave., Athens, GA 30606, USA. Tel: (706) 713-2216; Fax: (706) 713-2221; E-mail: cslaught@uga.edu, or to any member of the editorial board. Article summaries reflect the reviewer's opinions and not necessarily those of the association.
    Keywords: Biology;
    E-ISSN: 1943-4731
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  • 10
    Article
    Article
    In: Journal of Biomolecular Techniques : JBT, 7/2018, p.jbt.18-2902-004
    ISSN: 1524-0215
    E-ISSN: 1943-4731
    Source: CrossRef
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