Kooperativer Bibliotheksverbund

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Format: 1 online resource (426p.)

ISBN: 9783110260373

Series Statement: Kallikrein-related peptidases ; Volume 1

Content: The KLK proteins and their encoding genes are increasingly attracting attention among scientists and clinicians worldwide as they represent interesting and functionally distinct biomarkers both under physiological and pathophysiological conditions. This volume on kallikrein-related peptidases (KLKs) reviews the characterization, regulation, and interactions of these proteases within the protease web.

Note: Frontmatter -- , Preface -- , List of contributing authors -- , Table of Contents -- , Introduction to Volume 1: Kallikrein-related Peptidases. Characterization, Regulation, and Interactions Within the Protease Web -- , 1 Genomic Structure of the KLK Locus -- , 2 Single Nucleotide Polymorphisms in the Human KLK Locus and Their Implication in Various Diseases -- , 3 Evolution of Kallikrein-related Peptidases -- , 4 Structural Aspects of Kallikrein-related Peptidases -- , 5 Molecular Recognition Properties of Kallikrein-related Peptidases on Synthetic and Endogenous Substrates -- , 6 Natural, Engineered and Synthetic Inhibitors of Kallikrein-related Peptidases -- , 7 Kallikrein-related Peptidases as Pharmaceutical Targets -- , 8 Expression of Kallikrein-related Peptidases under (Patho-)Physiological Conditions -- , 9 Kallikrein-related Peptidases within the Proteolytic Web -- , 10 Kallikrein-Kinin Cascade: Bioregulation by Human Tissue Kallikrein 1 (hK1, KLK1) -- , 11 Role of KLK4 in Dental Enamel Formation -- , 12 Kallikrein-related Peptidases and Semen -- , 13 Kallikrein-related Peptidases and Inhibitors of the Skin -- , 14 Physiological and Pathophysiological Roles of Kallikrein-related Peptidases in the Central Nervous System -- , 15 Kallikrein-related Peptidases (KLKs), Proteinase-mediated Signaling and Proteinase-activated Receptors (PARs) -- , Index , In English.

Additional Edition: ISBN 978-3-11-026036-6

Language: English

DOI: 10.1515/9783110260373

URL: https://doi.org/10.1515/9783110260373

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Format: 1 online resource (241p.)

ISBN: 9783110303667

Series Statement: Kallikrein-related peptidases ; Volume 2

Content: This volume on kallikrein-related peptidases (KLKs) reviews the role of these proteases as biomarkers in a wide range of malignancies including cancers of the lung, prostate, breast, ovary, kidney, stomach, and colon. It provides clinicians, physician scientists, and cancer researchers with in-depth overviews on the emerging clinical relevance of KLK protein or gene expression in these malignancies.

Note: Frontmatter -- , Preface -- , List of contributing authors -- , Table of Contents -- , Introduction to Volume 2: Kallikrein-related Peptidases. Novel Cancer-related Biomarkers -- , 1 Pathophysiology of Kallikrein-related Peptidases in Lung Cancer -- , 2 Clinical Relevance of Kallikrein-related Peptidases in Gastric and Colorectal Cancer -- , 3 Pathophysiology of Kallikrein-related Peptidases in Head and Neck Cancer -- , 4 PSA (Prostate-Specific Antigen) and other Kallikrein-related Peptidases in Prostate Cancer -- , 5 Cellular Model Systems to Study the Tumor Biological Role of Kallikrein-related Peptidases in Ovarian and Prostate Cancer -- , 6 Clinical Relevance of Kallikrein-related Peptidases in Breast Cancer -- , 7 Clinical Relevance of Kallikrein-related Peptidases in Ovarian Cancer -- , 8 microRNAs: A New Control Mechanism for Kallikrein-related Peptidases in Kidney and Other Cancers -- , 9 Genomic Instability of the KLK-locus in Cancer -- , 10 Kallikrein-related Peptidases as Biomarkers in Personalized Cancer Medicine -- , Index , In English.

Additional Edition: ISBN 978-3-11-030358-2

Language: English

DOI: 10.1515/9783110303667

URL: https://doi.org/10.1515/9783110303667

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Language: English