Format:
Online-Ressource (XIV, 238p. 120 illus, digital)
ISBN:
9781441979643
Series Statement:
SpringerLink
Content:
This book is intended as a communication platform to bridge the cultural, conceptual, and technological gap among the key systems biology disciplines of biology, mathematics, and information technology. To support this goal, contributors were asked to adopts an approach that appeals to audiences from different backgrounds.
Content:
This book is intended as a communication platform to bridge the cultural, conceptual, and technological gap among the key systems biology disciplines of biology, mathematics, and information technology. To support this goal, contributors were asked to adopts an approach that appeals to audiences from different backgrounds
Note:
Includes bibliographical references and index
,
Understanding the Dynamics of Biological Systems; Preface; Contents; Contributors; Chapter 1 Effects of Protein Quality Control Machinery on Protein Homeostasis; 1.1 Protein Folding is Catalyzed by a Complex Network of Reactions; 1.1.1 Disruptions to the Protein Folding Network are Associated with Disease; 1.1.2 The ER Functions as a Protein Folding Factory; 1.1.3 Mathematical Models of Protein Quality Control Provide Novel Insights into the Regulation of Protein Assembly; 1.2 Case Studies; 1.2.1 Case Study I: Protein Folding Without Quality Control; 1.2.1.1 Assumptions
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1.2.1.2 Analytical Solution1.2.1.3 Timescale Analysis; 1.2.1.4 Conclusions for Case Study I; 1.2.2 Case Study II: Protein Folding with Quality Control; 1.2.2.1 Assumptions; 1.2.2.2 Qualitative Dynamical Behavior and Equilibrium Points; 1.2.2.3 Timescale Analysis; 1.2.2.4 Parametric Sensitivity Analysis; 1.2.2.5 Conclusions for Case Study II; 1.3 Lessons Learned; Appendix; References; Chapter 2 Metabolic Network Dynamics: Properties and Principles; 2.1 Introduction; 2.2 Dynamic Mass Balances and Fundamental Subspaces; 2.2.1 Key Considerations in Networks; 2.2.2 Properties of Dynamic Systems
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2.2.2.1 Underlying Structure of the Jacobian2.2.2.2 Structural Similarity; 2.2.2.3 Flux-Concentration Duality; 2.2.2.4 Hierarchical Dynamics; 2.3 Dual Jacobian Matrices; 2.4 Stoichiometry Versus Gradients; 2.5 Example: Folate Metabolism; 2.5.1 Constituent Matrices and Subspaces; 2.5.2 Hierarchical Pooling of Metabolites; 2.5.3 Environmental Perturbations; 2.6 Conclusions; 2.6.1 Future Directions: Constructing Genome-Scale Models; References; Chapter 3 A Deterministic, Mathematical Modelfor Hormonal Control of the Menstrual Cycle; 3.1 Introduction and Biological Background
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3.2 The Pituitary and Ovarian Models3.3 Fitting Parameters; 3.4 Parameter Sensitivity and Bifurcations; 3.5 Exogenous Hormone Effects; 3.6 Conclusion; References; Chapter 4 Modeling Transport Processes and Their Implications for Chemical Disposition and Action; 4.1 Introduction; 4.1.1 The Fate of Chemicals in the Body; 4.1.1.1 Absorption; 4.1.1.2 Distribution; 4.1.1.3 Metabolism; 4.1.1.4 Excretion; 4.1.2 Chemical and Pathophysiological-Mediated Alterations in Drug Disposition; 4.1.3 Extrapolation of Data Between Biological Scenarios
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4.2 Traditional Pharmacokinetic Approaches to Modeling Drug Disposition4.3 More Complex Models of Drug Movement Across Biological Membranes; 4.3.1 The Measurement of Chemical Movement Across Biological Membranes; 4.3.2 General Considerations for Measuring Movement of Drugs Across Biological Membranes; 4.3.2.1 Simple Versus Complex Measurement Systems; 4.3.2.2 Ionization Status of the Drug; 4.3.2.3 Heterogeneity in Drug Dispersion; 4.3.2.4 Chemical Sequestration; 4.3.2.5 Physico-Chemical Characteristics of the Chemical; 4.3.2.6 ATP Usage Within the Test System
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4.3.3 Measurement of Passive Diffusion
Additional Edition:
ISBN 9781441979636
Additional Edition:
Buchausg. u.d.T. ISBN 978-1-441-97963-6
Language:
English
Subjects:
Biology
DOI:
10.1007/978-1-4419-7964-3
URL:
Volltext
(lizenzpflichtig)
Author information:
Dubitzky, Werner 1958-
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