Kooperativer Bibliotheksverbund

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Format: XXI, 199 p. , online resource.

Edition: 1st ed. 2010.

ISBN: 9781441979131

Series Statement: Advances in Experimental Medicine and Biology, 706

Content: Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand-receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders. Phylogenetic analysis of GPCRs produced the GRAFS classification system, which subdivides GPCRs into five discrete families: glutamate, rhodopsin, adhesion, frizzled/taste2 and secretin receptors. The adhesion-GPCR family 2 can be further subdivided into eight groups. The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation.

Note: The Adhesion GPCRs; Gene Repertoire, Phylogeny and Evolution -- 7TM-Cadherins: Developmental Roles and Future Challenges -- Latrophilin Signalling in Tissue Polarity and Morphogenesis -- GPS Proteolytic Cleavage of Adhesion-GPCRs -- The Latrophilins, "Split-Personality" Receptors -- Studies on the Very Large G Protein-Coupled Receptor: From Initial Discovery to Determining its Role in Sensorineural Deafness in Higher Animals -- Adhesion-GPCRs in the CNS -- GPR56 Interacts with Extracellular Matrix and Regulates Cancer Progression -- Adhesion-GPCRs in Tumorigenesis -- Immunity and Adhesion-GPCRs -- CD97 in Leukocyte Trafficking -- The Role of CD97 in Regulating Adaptive T-Cell Responses -- F4/80: The Macrophage-Specific Adhesion-GPCR and its Role in Immunoregulation -- Signal Transduction Mediated through Adhesion-GPCRs -- Emerging Roles of Brain-Specific Angiogenesis Inhibitor 1 -- Adhesion-GPCRs in the Male Reproductive Tract.

In: Springer Nature eBook

Additional Edition: Printed edition: ISBN 9781441979148

Additional Edition: Printed edition: ISBN 9781441979124

Language: English

DOI: 10.1007/978-1-4419-7913-1

URL: https://doi.org/10.1007/978-1-4419-7913-1

UID:

Format: Online-Ressource , v.: digital

Edition: Online-Ausg. Springer eBook Collection. Biomedical and Life Sciences

ISBN: 9781441979131

Series Statement: Advances in Experimental Medicine and Biology 706

Content: The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs, there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation. This volume focuses on the recent advances in adhesion-GPCR biology.

Content: The field of adhesiona'GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesiona'GPCR biology, including the evolution and biochemistry of adhesiona'GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesiona'GPCR signalling, an area of intense investigation. This volume focuses on the recent advances in adhesiona'GPCR biology

Note: Description based upon print version of record , Title Page; Copyright Page; PREFACE; ABOUT THE EDITORS...; ABOUT THE EDITORS...; PARTICIPANTS; Table of Contents; CHAPTER 1 THE ADHESION GPCRs; GENE REPERTOIRE, PHYLOGENY AND EVOLUTION; INTRODUCTION; THE MOUSE GENE REPERTOIRE; THE RAT GENE REPERTOIRE; THE DOG GENE REPERTOIRE; THE CHICKEN GENE REPERTOIRE; FISH; THE AMPHIOXUS GENE REPERTOIRE; THE NEMATOSTELLA GENE REPERTOIRE; THE ADHESION FAMILY IS AN ANCESTOR OF THE SECRETIN FAMILY; CONCLUSION AND PERSPECTIVE; ACKNOWLEDGEMENTS; REFERENCES; CHAPTER 27TM-CADHERINS: Developmental Roles and Future Challenges , THE 7TM-CADHERINS: A UNIQUE GROUP OF ADHESION-GPCRsTHE FAMILY TREE; VERTEBRATE 7TM-CADHERINS ARE DEVELOPMENTALLY REGULATED; 7TM-CADHERINS PLAY PLEIOTROPIC ROLES DURING EMBRYONIC DEVELOPMENT; FUTURE DIRECTIONS: LINKING 7TM-CADHERIN STRUCTURE TO FUNCTION; CONCLUSION; ACKNOWLEDGEMENTS; REFERENCES; CHAPTER 3 LATROPHILIN SIGNALLING IN TISSUE POLARITY AND MORPHOGENESIS; INTRODUCTION; THE ROLE OF ADHESION-GPCRs IN DEVELOPMENT; LATROPHILINS AND TISSUE POLARITY; CONCLUSION; REFERENCES; CHAPTER 4 GPS PROTEOLYTIC CLEAVAGE OF ADHESION-GPCRs; INTRODUCTION , THE IDENTIFICATION OF GPS PROTEOLYTIC MODIFICATION IN ADHESION-GPCRsTHE MOLECULAR MECHANISM OF GPS PROTEOLYSIS; THE REGULATION OF GPS PROTEOLYSIS; THE ROLE OF GPS PROTEOLYSIS IN RECEPTOR FUNCTION AND HUMAN DISEASE; THE FATE AND FUNCTIONAL INTERACTION OF THE EXTRACELLULAR AND 7TM SUBUNITS FOLLOWING GPS PROTEOLYSIS; CONCLUSION; ACKNOWLEDGEMENTS; REFERENCES; CHAPTER 5 THE LATROPHILINS,"SPLIT-PERSONALITY" RECEPTORS; INTRODUCTION; THE ISOLATION OF LATROPHILIN; THE LATROPHILIN FAMILY; EXPRESSION PATTERNS OF LATROPHILINS; THE STRUCTURE OF LATROPHILIN; NTF; CTF; LATROPHILIN AS A GPCR , LIGANDS AND INTERACTING PARTNERS OF LATROPHILINSLATROPHILIN GENE KNOCKOUTS; LATROPHILINS IN DISEASE; CONCLUSION; REFERENCES; CHAPTER 6 STUDIES ON THE VERY LARGE G PROTEIN-COUPLED RECEPTOR: From Initial Discovery to Determining its Role in Sensorineural Deafness in Higher Animals; INTRODUCTION; GENE STRUCTURE; PROTEIN STRUCTURE; GENE EXPRESSION; MICE WITH MUTATIONS IN VLGR1; EXPRESSION IN THE COCHLEA AND RETINA; VLGR1 in Usher Syndrome; CONCLUSION; REFERENCES; CHAPTER 7 ADHESION-GPCRs IN THE CNS; INTRODUCTION; ADHESION-GPCRs IN BRAIN DEVELOPMENT; GPR56 IN BRAIN DEVELOPMENT AND MALFORMATION , CONCLUSIONACKNOWLEDGEMENTS; REFERENCES; CHAPTER 8 GPR56 INTERACTS WITH EXTRACELLULAR MATRIX AND REGULATES CANCER PROGRESSION; INTRODUCTION; THE PRIMARY STRUCTURE OF GPR56 GENE AND ITS ENCODED PROTEIN; FUNCTIONS OF GPR56 IN CANCER; SIGNALING PATHWAYS MEDIATED BY GPR56; CONCLUSION; ACKNOWLEDGEMENTS; REFERENCES; CHAPTER 9 ADHESION-GPCRs IN TUMORIGENESIS; DATABASES; OVERVIEW ON THE ADHESION-GPCR FAMILY; GROUP I: LATROPHILIN-LIKE (LATROPHILIN 1-3, ETL); GROUP II: EGF-LIKE (CD97, EMR1-4); GROUP III: IgG-LIKE (GPR123, GPR124, GPR125); GROUP IV: CELSR-LIKE (CELSR 1-3); GROUP V: GPR133 AND 144 , GROUP VI: GPR110, GPR111, GPR113, GPR115, GPR116

Additional Edition: ISBN 9781441979124

Language: English

DOI: 10.1007/978-1-4419-7913-1

URL: Volltext  (lizenzpflichtig)