Format:
1 Online-Ressource (VI, 138 Seiten, 6360 KB)
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Illustrationen, Diagramme
Content:
The increasing age of worldwide population is a major contributor for the rising prevalence of major pathologies and disease, such as type 2 diabetes, mediated by massive insulin resistance and a decline in functional beta-cell mass, highly associated with an elevated incidence of obesity. Thus, the impact of aging under physiological conditions and in combination with diet-induced metabolic stress on characteristics of pancreatic islets and beta-cells, with the focus on functionality and structural integrity, were investigated in the present dissertation. Primarily induced by malnutrition due to chronic and excess intake of high caloric diets, containing large amounts of carbohydrates and fats, obesity followed by systemic inflammation and peripheral insulin resistance occurs over time, initiating metabolic stress conditions. Elevated insulin demands initiate an adaptive response by beta-cell mass expansion due to increased proliferation, but prolonged stress conditions drive beta-cell failure and loss. Aging has been also shown to affect beta-cell functionality and morphology, in particular by proliferative limitations. [...]
Note:
Kumulative Dissertation
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Dissertation Universität Potsdam 2019
Additional Edition:
Erscheint auch als Druck-Ausgabe Kehm, Richard The impact of metabolic stress and aging on functionality and integrity of pancreatic islets and beta-cells Potsdam, 2019
Language:
English
Keywords:
Hochschulschrift
DOI:
10.25932/publishup-44109
URN:
urn:nbn:de:kobv:517-opus4-441099
URL:
https://nbn-resolving.org/urn:nbn:de:kobv:517-opus4-441099
URL:
https://d-nb.info/1218405449/34
Author information:
Stangl, Gabriele I. 1964-
Author information:
Grune, Tilman 1962-
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