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  • 1
    Language: English
    In: Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(6), pp.1990-1993
    Description: The synthesis and the ACE inhibitory activity of chalcones ( – ) and pyrazoles ( – ) are reported. A series of chalcones ( ) and pyrazoles ( ) was prepared to investigate their potential activity as Angiotensin I-Converting Enzyme (ACE) inhibitors. Their structures were verified by elemental analysis, UV, IR, MS, H NMR, C NMR, and 2D NMR experiments. Among tested compounds, chalcone exerted the highest activity with an IC value of 0.219 mM, while the most potent pyrazole was (IC value of 0.213 mM).
    Keywords: Chalcones ; Pyrazole Derivatives ; Hypertension ; ACE ; Medicine ; Chemistry ; Anatomy & Physiology
    ISSN: 0960-894X
    E-ISSN: 1464-3405
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  • 2
    Language: English
    In: Food Chemistry, 15 December 2011, Vol.129(4), pp.1413-1419
    Description: ► The consumption of non-cultivated botanicals play a central role in the diet. ► Twelve-one plant extracts were assayed for antioxidant/anti-inflammatory activity. ► Four extracts were selected for antiradical and anti-inflammatory properties. ► A relationship between radical scavenging activity and polyphenolic content was found. Hydroalcoholic extracts from 18 non-cultivated vegetables traditionally consumed in Southern Italy were tested for their free radical scavenging activity (FRSA) in the DPPH (1,1-diphenyl-2-picrylhydrazil radical) screening assay and for their inhibition of nitric oxide (NO) production. The strongest activity was shown for (leaves), subsp. (leaves) and subsp. (stems and leaves) with IC values of 5, 6, 8 μg/ml, respectively. Extracts from non-cultivated subsp. (seeds) (leaves) and subsp. (leaves) showed high inhibition of nitric oxide production, with an activity comparable to a reference drug, indomethacin. A significant cytotoxic effect was shown for the seeds of subsp. (leaves) presented the highest content in linoleic acid. and subsp. had relatively high polyphenols content, 482 and 334 mg/g of extract, respectively.
    Keywords: Antioxidant ; Food Plants ; Mediterranean ; Wild ; Nitric Oxide ; Chemistry ; Diet & Clinical Nutrition ; Economics
    ISSN: 0308-8146
    E-ISSN: 1873-7072
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  • 3
    Language: English
    In: Food Chemistry, 15 August 2013, Vol.139(1-4), pp.439-447
    Description: ► Cytotoxicity threshold of e.o. on Ames tester strains was determined. ► HCAs are toxic also as direct mutagens (without S9). ► HCAs (with S9) showed lower toxic concentration than that reported in the literature. ► e.o. showed anti-mutagenic activity against HCAs with and without S9. ► e.o. showed cytotoxic activity against human LoVo and HepG2 cell lines. The Amazonian stem bark essential oil was tested for its anti-mutagenic potential by performing the Ames test against heterocyclic amines (HCAs), in continuing research on applicative functional profile of this phytocomplex as food ingredient ( ). strain TA98 was used with and without metabolic activation (S9 mix). The anti-mutagenic properties was assayed with the following HCAs: 2-amino-3-methylimidazo-[4,5- ]quinoline (IQ), 2-amino-3,4-dimethylimidazo-[4,5- ]quinoline (MeIQ), 2-amino-3,8-dimethylimidazo-[4,5- ]quinoxaline (MeIQx), the imidazoles 2-amino-6-methyldipyrido-[1,2- :3′,2′- ]imidazole (Glu-P-1) and 2-aminodipirydo-[1,2- :3′,2′- ]imidazole (Glu-P-2). All HCAs with S9 induced mutagenicity at 10 mol/plate. Without S9, IQ and MeIQ showed mutagenicity at 10 mol/plate, MeIQx and Glu-P-1 at 10 mol/plate, while Glu-P-2 was inactive. In presence of HACs (10 mol/plate), essential oil was tested for mutagen-protective properties (concentration range: 0.01–0.10 mg/plate) taking the Highest Uneffective Dose (HUD) as threshold reference. With S9 mix, essential oil displayed a significant reduction of revertants at 0.05 mg/plate, from 21% to 34%. The essential oil showed mutagen-protective efficacy against IQ and MeIQ tested as direct mutagens (10 mol/plate), with a revertants percentage reduction of 39% and 40%, respectively. No anti-mutagen capacity was noted for MeIQx and Glu-P-1 (10 mol/plate). Since HACs are known as possible colon and liver cancer inducers, essential oil was tested for its cytotoxicity and anti-proliferative capacity against LoVo and HepG2 cancer cell lines showing IC of 74.95 ± 0.05 μg/ml (LoVo) and 82.28 ± 0.03 μg/ml (HepG2), displaying a promising role of this essential oil as a functional food ingredient with interesting mutagen preventing properties.
    Keywords: Croton Lechleri ; Essential Oils ; Heterocyclic Amines ; Quinolines ; Ames Test ; Mutagenic Activity ; Anti-Mutagenic Activity ; Antiproliferative Activity ; Lovo ; Hepg2 ; Chemistry ; Diet & Clinical Nutrition ; Economics
    ISSN: 0308-8146
    E-ISSN: 1873-7072
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  • 4
    In: Phytotherapy Research, June 2015, Vol.29(6), pp.857-863
    Description: Indian Sarsaparilla ( R. Br.) is widely used in Indian traditional medicine. In the present work, we explored the effects of decoction, traditional Ayurvedic preparation, and hydroalcoholic extract, a phytocomplex more traditionally studied and commercialized as food supplement in western medicine, from the roots as possible source of chemicals with new functional potential linked to their nutritional uses. The antiproliferative and antioxidant properties were assayed. To test antiproliferative affects, different cancer cell lines, growing both as monolayers (CaCo2, MCF‐7, A549, K562, MDA‐MB‐231, Jurkat, HepG2, and LoVo) and in suspension (K562 and Jurkat) were used. The decoction showed strong activity on HepG2 cells, while the hydroalcoholic extracts were active on HepG2, LoVo, MCF‐7, K562, and Jurkat cell lines. Weak inhibition of cancer cell proliferation was observed for the principal constituents of the preparations: 2‐hydroxy‐4‐methoxybenzaldehyde, 2‐hydroxy‐4‐methoxybenzoic acid, and 3‐hydroxy‐4‐methoxybenzaldehyde that were tested alone. The antiradical activity was tested with 2,2‐diphenyl‐1‐picrylhydrazyl and 2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid)diammonium salt tests and inhibition of nitric oxide production in lipopolysaccharide‐stimulated RAW 264.7 macrophages. Interesting result has also been obtained for hydroalcoholic extract regarding genoprotective potential (58.79% of inhibition at 37.5 µg/mL). Copyright © 2015 John Wiley & Sons, Ltd.
    Keywords: Ayurveda ; Antitumor Activity ; Genoprotective Potential ; Antioxidants ; Nitric Oxide Inhibitors
    ISSN: 0951-418X
    E-ISSN: 1099-1573
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  • 5
    In: Journal of Agriculture and Ecology Research International, 01/10/2016, Vol.6(3), pp.1-9
    ISSN: Journal of Agriculture and Ecology Research International
    E-ISSN: 23941073
    Source: CrossRef
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  • 6
    Language: English
    In: Molecules, 01 October 2016, Vol.21(10), p.1404
    Description: Obesity is one of the greatest public health problems. This complex condition has reached epidemic proportions in many parts of the world, and it constitutes a risk factor for several chronic disorders, such as hypertension, cardiovascular diseases and type 2 diabetes. In the last few decades,...
    Keywords: Lipid Metabolism ; Medicinal Plant ; Obesity ; Phytochemicals ; Saponins ; Chemistry
    E-ISSN: 1420-3049
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  • 7
    Language: English
    In: Phytochemistry Reviews, 2018, Vol.17(4), pp.873-888
    Description: The purpose of this review is to provide an overview of most recent studies about potential pharmaceutical applications of plants belonging to Origanum genus. Oregano is one of the most famous and economically important culinary herbs in the world. The genus Origanum includes more than 70 species mainly distributed around the Mediterranean region. The vernacular name “oregano” is attributed to a vast number of species. O. vulgare L. is the most variable species of the genus and the most commonly known as oregano in most countries. Today, it is generally accepted that oregano is a characteristic flavour produced by a number of plant species that yield carvacrol-rich essential oils. The genus Origanum is characterised by a large morphological and chemical diversity. Because of their several biological activities, such as antimicrobial, expectorant, antispasmodic and carminative, Origanum species have been used in traditional medicine to treat various diseases. The botany and chemotaxonomy of the species are thoroughly reported, along with chemical constituents. The in vitro and in vivo effects of Origanum extracts are presented and discussed.
    Keywords: Biological activity ; Essential oil ; sp. ; Phenols ; Terpenes
    ISSN: 1568-7767
    E-ISSN: 1572-980X
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  • 8
    Language: English
    In: Molecules, 01 December 2018, Vol.24(1), p.119
    Description: Common onion (Allium cepa L.) is one of the oldest cultivated plants, utilized worldwide as both vegetable and flavouring. This species is known to contain sulphur amino acids together with many vitamins and minerals. A variety of secondary metabolites, including flavonoids, phytosterols and...
    Keywords: Allium ; Bioactive Compounds ; Diabetes ; Hyperlipidaemia ; Obesity ; Onion ; Organosulfur Compounds ; Quercetin ; Chemistry
    E-ISSN: 1420-3049
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  • 9
    Language: English
    In: Mini-Reviews in Medicinal Chemistry, 2016, Vol.16(9), p.710-720
    Description: The genus Hypericum includes more than 450 species distributed in Europe, North America, North Africa and West Asia. These plants are widely used in folk medicine for the treatment of inflammation, bacterial and viral infections, burns and gastric disorders. The use for alleviating inflammation and promoting wound healing is well known for H. Perforatum L. (St. John's wort) and other species. Because of its pharmacological activity, H. perforatum L. is one of the most important species of this genus. This plant has been largely utilized for its efficacy in the treatment of mild to moderate depression. However, some other species have been utilized in traditional medicine and have been studied for their phytochemical composition and for their biological activities to date. Hypericum species contain biologically active secondary metabolites belonging to at least ten different classes, with prevalence of naphthodianthrones (hypericin and pseudohypericin), phloroglucinols (hyperforin), flavonoids (rutin, hyperoside, isoquercitrin, quercitrin, quercetin, amentoflavone) and phenylpropanoids (chlorogenic acid). However, great variations in contents have been reported for wild populations worldwide. The purpose of this review is to provide an overview of most recent studies about potential pharmaceutical applications of plants belonging to Hypericum genus. The most interesting isolated active principles and both in vitro and in vivo effects of Hypericum extracts are presented and discussed.
    Keywords: Anticancer Activity Antimicrobial Activity Biological Activities Extract Hypericum Natural Compounds.
    ISSN: 1389-5575
    E-ISSN: 1875-5607
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  • 10
    Language: English
    In: Acta Physiologiae Plantarum, 2013, Vol.35(6), pp.1979-1988
    Description: Calamintha nepeta L. (Savi), known as Lesser Catmint, is a Mediterranean species belonging to the Labiatae family, considered an important source of natural compounds. Since little is known about phytotoxic potential of Lesser Catmint, the bio-guided fractionation method was employed to isolate and identify some compounds, prerequisite for their possible future use in weed management. Leaves and stems of catmint were extracted with methanol and fractionated using n -hexane, chloroform, ethyl acetate and n -butanol, solvents with different polarity. The potential phytotoxicity of the methanolic extract and its fractions, evaluated by ED 50 values comparison, was assayed in vitro on seed germination and root growth of lettuce ( Lactuca sativa L.). Germination and root growth of lettuce were strongly inhibited by catmint methanolic extract and its fractions, showing the following hierarchy of phytotoxicity for both physiological processes: ethyl acetate ≥  n -hexane 〉 chloroform ≥  n -butanol. In the most active fraction, analyzed by HPLC, 5 poliphenols, gallic, vanillic, syringic, p -coumaric and ferulic acids, were identified and quantified. Whereas, the n -hexane fraction was a mixture of 32 chemicals, mainly composed of terpenoids and fatty acids, as analyzed by gas chromatography–mass spectrometry (GC–MS). Further, GC analysis allowed to quantify 5 compounds: camphor, trans -caryophyllene, menthol, farnesene and pulegone. Furthermore, both fractions inhibited seed germination and root growth of two of the most common weeds, Amaranthus retroflexus and Echinochloa crus-galli . The results confirmed the phytotoxic activity of C. nepeta L. (Savi) due to the presence of different molecule classes with biological activity and their potential future application as bio-herbicides.
    Keywords: Lesser catmint ; L. ; Root growth ; Seed germination ; Amaranthus retroflexus ; Echinochloa crus-galli
    ISSN: 0137-5881
    E-ISSN: 1861-1664
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