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  • 1
    Language: English
    In: Neuroscience Letters, 10 February 2012, Vol.509(1), pp.9-12
    Description: ► Interaction of cellular LINGO-1 with the amyloid precursor protein. ► The LRRs of LINGO-1 are not required for interaction with APP or self-interaction. ► Corroborates finding that LRRs are not required for inhibition of differentiation. LINGO-1 (leucine rich repeat and Ig domain containing Nogo receptor interacting protein-1) is a central nervous system transmembrane protein which simultaneously interacts with the Nogo-66 receptor and p75 or TROY on neurons to form a receptor complex responsible for myelin-mediated neurite outgrowth inhibition. On oligodendroglial cells, LINGO-1 interacts with p75 to constitutively inhibit multiple aspects of oligodendrocyte differentiation. Recently, LINGO-1 was identified as an in vivo interacting partner of the amyloid precursor protein (APP) and, correspondingly, cellular LINGO-1 expression was found to augment the release of the Abeta peptide, the potential causative agent of Alzheimer's disease. In addition, the recombinant LINGO-1 ectodomain has been shown to self-interact in solution and after crystallisation. Here, we have used deletional mutagenesis to identify the regions on LINGO-1 that are involved in homo- and heterotypic interactions. We have found that the N-terminal region containing the leucine-rich repeats along with the transmembrane and cytoplasmic domains of LINGO-1 are not required for self-interaction or interaction with APP.
    Keywords: Amyloid Precursor Protein ; Leucine-Rich Repeats ; Lingo-1 ; Self-Interaction ; Medicine ; Anatomy & Physiology
    ISSN: 0304-3940
    E-ISSN: 1872-7972
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  • 2
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 14 February 2012, Vol.109(7), pp.2573-8
    Description: After the emergence of pandemic influenza viruses in 1957, 1968, and 2009, existing seasonal viruses were observed to be replaced in the human population by the novel pandemic strains. We have previously hypothesized that the replacement of seasonal strains was mediated, in part, by a population-scale boost in antibodies specific for conserved regions of the hemagglutinin stalk and the viral neuraminidase. Numerous recent studies have shown the role of stalk-specific antibodies in neutralization of influenza viruses; the finding that stalk antibodies can effectively neutralize virus alters the existing dogma that influenza virus neutralization is mediated solely by antibodies that react with the globular head of the viral hemagglutinin. The present study explores the possibility that stalk-specific antibodies were boosted by infection with the 2009 H1N1 pandemic virus and that those antibodies could have contributed to the disappearance of existing seasonal H1N1 influenza virus strains. To study stalk-specific antibodies, we have developed chimeric hemagglutinin constructs that enable the measurement of antibodies that bind the hemagglutinin protein and neutralize virus but do not have hemagglutination inhibition activity. Using these chimeric hemagglutinin reagents, we show that infection with the 2009 pandemic H1N1 virus elicited a boost in titer of virus-neutralizing antibodies directed against the hemagglutinin stalk. In addition, we describe assays that can be used to measure influenza virus-neutralizing antibodies that are not detected in the traditional hemagglutination inhibition assay.
    Keywords: Antibodies, Viral -- Biosynthesis ; Hemagglutinin Glycoproteins, Influenza Virus -- Immunology ; Influenza A Virus, H1n1 Subtype -- Growth & Development
    ISSN: 00278424
    E-ISSN: 1091-6490
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  • 3
    Language: German
    In: Der Betrieb : Betriebswirtschaft, Steuerrecht, Wirtschaftsrecht, Arbeitsrecht, 2012, Vol.65(28), pp. 1529-1533
    ISSN: 00059935
    Source: Deutsche Zentralbibliothek für Wirtschaftswissenschaften
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  • 4
    Language: English
    In: 2012, Vol.7(11), p.e48502
    Description: Analysis of in vitro samples with high salt concentrations represents a major challenge for fast and specific quantification with liquid chromatography-tandem mass spectrometry (LC-MS/MS). To investigate the intestinal permeability of opioids in vitro employing the Ussing chamber technique, we developed and validated a fast, sensitive and selective method based on LC–MS/MS for the determination of loperamide in HEPES-buffered Ringer's solution. Chromatographic separation was achieved with an Atlantis dC18 column, 2.1 mm×20 mm, 3 µm particle size and a gradient consisting of methanol/0.1% formic acid and ammonium acetate. The flow rate was 0.7 ml/min, and the total run time was 3 min. For quantification, two mass transitions for loperamide and a deuterated internal standard (methadone-d 3 ) were used. The lower limit of loperamide quantification was 0.2 ng/ml. This new LC-MS/MS method can be used for the detection of loperamide in any experimental setup using HEPES-buffered Ringer's solution as a matrix compound.
    Keywords: Research Article ; Biology ; Chemistry ; Medicine ; Chemistry ; Physiology ; Anesthesiology And Pain Management ; Biochemistry
    E-ISSN: 1932-6203
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  • 5
    Language: English
    In: The American Journal of Sports Medicine, August 2010, Vol.38(8), pp.1542-1548
    Description: Background: The influence of standard meniscus treatment strategies regarding osteoarthritic progress, function, and sports activity has not been estimated in a direct long-term comparison. Hypothesis: Meniscal repair compared with partial meniscectomy (partial meniscal resection)...
    Keywords: Meniscal Repair ; Long-Term Results ; Osteoarthritis ; Arthroscopic Surgery ; Medicine
    ISSN: 0363-5465
    E-ISSN: 1552-3365
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  • 6
    Language: English
    In: The Journal of Urology, April 2013, Vol.189(4), pp.e491-e491
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Source: ScienceDirect Journals (Elsevier)
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  • 7
    Language: English
    In: Diabetes, 05/2018, Vol.67(Supplement 1), p.225-OR
    ISSN: 0012-1797
    E-ISSN: 1939-327X
    Source: CrossRef
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  • 8
    Language: English
    In: Journal of the American Chemical Society, 06 March 2013, Vol.135
    Description: The mixed-valence diiron hydrido complex (μ-H)Fe2(pdt)(CO)2(dppv)2 ([H1](0), where pdt =1,3-propanedithiolate and dppv = cis-1,2-C2H2(PPh2)2), was generated by reduction of the differous hydride [H1](+) using decamethylcobaltocene. Crystallographic analysis shows that [H1](0) retains the stereochemistry of its precursor, where one dppv ligand spans two basal sites and the other spans apical and basal positions. The Fe---Fe bond elongates to 2.80 from 2.66 Å, but the Fe-P bonds only change subtly. Although the Fe-H distances are indistinguishable in the precursor, they differ by 0.2 Å in [H1](0). The X-band electron paramagnetic resonance (EPR) spectrum reveals the presence of two stereoisomers, the one characterized crystallographically and a contribution of about 10% from a second symmetrical (sym) isomer wherein both dppv ligands occupy apical-basal sites. The unsymmetrical (unsym) arrangement of the dppv ligands is reflected in the values of A((31)P), which range from 31 MHz for the basal phosphines to 284 MHz for the apical phosphine. Density functional theory calculations were employed to rationalize the electronic structure of [H1](0) and to facilitate spectral simulation and assignment of EPR parameters including (1)H and (31)P hyperfine couplings. The EPR spectra of [H1](0) and [D1](0) demonstrate that the singly occupied molecular orbital is primarily localized on the Fe center with the longer bond to H, that is, Fe(II)-H···Fe(I). The coupling to the hydride is A((1)H) = 55 and 74 MHz for unsym- amd sym-[H1](0), respectively. Treatment of [H1](0) with H(+) gives 0.5 equiv of H2 and [H1](+). Reduction of D(+) affords D2, leaving the hydride ligand intact. These experiments demonstrate that the bridging hydride ligand in this complex is a spectator in the hydrogen evolution reaction.
    Keywords: Catalysis (Homogeneous), Catalysis (Heterogeneous), Solar (Photovoltaic), Solar (Fuels), Photosynthesis (Natural and Artificial), Bio-Inspired, Hydrogen and Fuel Cells, Electrodes - Solar, Defects, Charge Transport, Spin Dynamics, Membrane, Materials and Chemistry By Design, Optics, Synthesis (Novel Materials), Synthesis (Self-Assembly)
    ISSN: 00027863
    E-ISSN: 15205126
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  • 9
    Book
    Book
    S.l. : Peter Lang AG, Internationaler Verlag der Wissenschaften
    Language: English
    Description: Questo lavoro da uno sguardo minuzioso sulla ricezione teatrale dei maggiori episodi della Gerusalemme Liberata, studiata qui di riflesso attraverso il successo delle sue riscritture per il palco in Italia ed Europa. Frutto di un'indagine paziente sulla miriade di forme drammatiche musical-teatrali del...
    Keywords: Italian poetry -- 16th century ; Tasso, Torquato, -- 1544-1595 -- Criticism and interpretation;
    ISBN: 9783034311601
    E-ISSN: 97830343
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  • 10
    Language: English
    In: The American Journal of Sports Medicine, November 2011, Vol.39(11), pp.2404-2414
    Description: Background: Reports of return to shoulder-dependent sport after surgical stabilization previously underestimated impairments, which were not reflected in the score systems used. Hypothesis: Return to shoulder-dependent sport depends on the type of sport performed. Study Design: Case series; Level of evidence, 4. Methods: Forty-seven athletes (26.9 years of age at surgery) who underwent isolated arthroscopic Bankart repair were longitudinally monitored by shoulder-dependent sport-specific activity (Shoulder Sport Activity Score [SSAS]) and ability (Athletic Shoulder Outcome Scoring System [ASOSS]) scores and visual analog scales for reachieved proficiency level, sport-specific shoulder pain, and functional deficits. Data were assessed at 4 points of treatment: preoperatively, and postoperatively after 6, 16, and 32 months (P0-P3). Athletes were analyzed separately according to shoulder sport: noncollision/nonoverhead (G1), collision (G2), overhead (G3), and martial arts (G4). Results: The G1 and G2 athletes had reachieved the preinjury sport activity and sport proficiency status and excellent ASOSS scores after 32 months (SSASG1 = 7.2, SSASG2 = 8.1, ASOSSG1 = 94.4, ASOSSG2 = 95.2), whereas G3 and G4 athletes remained at an inferior activity level (SSASG3 = 8.0, SSASG4 = 8.3) and proficiency level. The ASOSS documented a prolonged period of shoulder rehabilitation for G3 and G4 athletes to reach a good shoulder-dependent sport ability outcome after 32 months (ASOSSG3 = 89.0, ASOSSG4 = 93.1). All groups recorded persisting limitations in visual analog scales for sport-specific shoulder function and pain. The established scores (Rowe = 95.9, Walch-Duplay = 93.3, Constant = 94.0) did not reflect these sport-specific impairments. Athletes with 5 or more preoperative dislocations had significantly longer surgery-to-sport resumption intervals with a prolonged proficiency recovery. Conclusion: The athletes’ shoulder stabilization resulted in a prolonged rehabilitation depending on the functional demand of the performed shoulder-dependent sport, as shown by the specific shoulder sport score systems.
    Keywords: Shoulder Instability ; Athletes ; Arthroscopic Bankart Repair ; Rehabilitation ; Knotless Suture Anchor ; Medicine
    ISSN: 0363-5465
    E-ISSN: 1552-3365
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