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  • 1
    Language: English
    In: The Journal of nutrition, July 2010, Vol.140(7), pp.1390S-4S
    Description: This summary addresses the progress and limitations of existing research on the physiologic properties of the isoflavone daidzein metabolite equol. Previous research demonstrating that physiological equol is its S-enantiomer has led to the preparation of S-(-)equol-enriched products formed by the bacterial fermentation of soy germ. Although this product has interesting properties as described in this workshop, the following important issues must be addressed: 1) the product should be evaluated against a preparation containing an equal amount of pure S-(-)equol to determine whether other components resulting from the fermentation are contributing to the physiological effects; 2) evaluation of the cellular mechanisms of S-(-)equol using cell culture methods should be conducted at concentrations consistent with those encountered physiologically (in the nmol/L range) and in several cell lines representing a target tissue; and 3) in follow-up studies in animal models and in human clinical trials, standardized preparations of S-(-)equol should be made available. Research opportunities now exist to determine whether equol's apparent effects on menopausal symptoms (hot flashes, sleep disturbances, bone health) in equol producers can be extended to equol nonproducers. It will be important to ensure that such research is not complicated by cultural differences, differences in lifetime exposure to soy products, experimental techniques, and other variables. Further areas of research that would benefit from the availability of S-(-)equol preparations include its use in skin care (either as an antioxidant or as an estrogen receptor agonist) and in the treatment of brain injury as well as postmenopausal cognitive decline.
    Keywords: Isoflavones ; Leadership ; Menopause ; Soybeans
    ISSN: 00223166
    E-ISSN: 1541-6100
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  • 2
    Language: English
    In: The Journal of the Acoustical Society of America, 2011, Vol.129(2), p.1142
    ISSN: 00014966
    Source: CrossRef
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  • 3
    Language: English
    In: The Explicator, 02 October 2015, Vol.73(4), pp.312-315
    Description: Chapter 1 of Wendell Berry's "Remembering" opens with the recollection of a nightmare. Berry's small masterpiece calls to mind, then, not only the biblical tradition, by way of allusions to Milton and Dante, but also pagan mythology, by echoing tales from Homer and Ovid. Hence, "Remembering" proves a novella more comprehensive of -- and more dependent upon -- the two great literary strands comprised within Berry's imaginative cosmos.
    Keywords: Wendell Berry ; Erisychthon ; Homer ; Mythology ; Odyssey ; Ovid ; Languages & Literatures
    ISSN: 0014-4940
    E-ISSN: 1939-926X
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  • 4
    Language: English
    In: The American Journal of Surgery, August 2016, Vol.212(2), pp.366-366
    Description: [...]my cousin, a woman, was fully trained in Canada and currently practices there. [...]my family has generational, geographical, and gender diversity regarding surgical training including experience with, or in one case as, women surgeons.
    Keywords: Canada ; United States–Us ; Women ; Surgery ; Gender ; Response Rates;
    ISSN: 0002-9610
    E-ISSN: 1879-1883
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  • 5
    Language: English
    In: Journal of the American Dietetic Association, 2008, Vol.108(11), pp.1888-1895
    Description: Nutritional genomics offers a way to optimize human health and the quality of life. It is an attractive endeavor, but one with substantial challenges. It encompasses almost all known aspects of science, ranging from the genomes of humans, plants, and microorganisms, to the highest levels of food science, analytical science, computing, and statistics of large systems, as well as human behavior. This paper describes the underlying biochemistry that is targeted by the principal issues in nutritional genomics, which entails genomics, transcriptomics, proteomics, and metabolomics. A major feature relevant to nutritional genomics is the single nucleotide polymorphisms in genes that interact with nutrients and other bioactive food components. These genetic changes may lead to alterations in absorption, metabolism, and functional responses to bioactive nutritional factors. Bioactive food components may also regulate gene expression at the transcriptome, protein abundance, and/or protein turnover levels. Even if all of these variables are known, additional variables to be considered include the nutritional variability of the food (unprocessed and processed), the amount that is actually eaten, and the eating-related behaviors of those consuming the food. These challenges are explored within the context of soy intake. Finally, the importance of international cooperation in nutritional genomics research is presented.
    Keywords: Diet & Clinical Nutrition
    ISSN: 0002-8223
    E-ISSN: 1878-3570
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  • 6
    Language: English
    In: The Lancet, May 23, 2015, Vol.385(9982), p.2024(3)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0140-6736(14)61934-6 Byline: Jacob A Quick, Stephen L Barnes Author Affiliation: (a) Department of Surgery, Division of Acute Care Surgery, University of Missouri, Columbia, MO 65212, USA
    ISSN: 0140-6736
    Source: Cengage Learning, Inc.
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  • 7
    Language: English
    In: The Journal of the Acoustical Society of America, 2010, Vol.128(1), p.517
    ISSN: 00014966
    Source: CrossRef
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  • 8
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 07 March 2017, Vol.114(10), pp.2485-2490
    Description: The largest mass extinction event in Earth's history marks the boundary between the Permian and Triassic Periods at circa 252 Ma and has been linked with the eruption of the basaltic Siberian Traps large igneous province (SLIP). One of the kill mechanisms that has been suggested is a biogenic methane burst triggered by the release of vast amounts of nickel into the atmosphere. A proposed Ni source lies within the huge Noril'sk nickel ore deposits, which formed in magmatic conduits widely believed to have fed the eruption of the SLIP basalts. However, nickel is a nonvolatile element, assumed to be largely sequestered at depth in dense sulfide liquids that formed the orebodies, preventing its release into the atmosphere and oceans. Flotation of sulfide liquid droplets by surface attachment to gas bubbles has been suggested as a mechanism to overcome this problem and allow introduction of Ni into the atmosphere during eruption of the SLIP lavas. Here we use 2D and 3D X-ray imagery on Noril'sk nickel sulfide, combined with simple thermodynamic models, to show that the Noril'sk ores were degassing while they were forming. Consequent "bubble riding" by sulfide droplets, followed by degassing of the shallow, sulfide-saturated, and exceptionally volatile and Cl-rich SLIP lavas, permitted a massive release of nickel-rich volcanic gas and subsequent global dispersal of nickel released from this gas as aerosol particles.
    Keywords: Noril'Sk Ni–Cu–Pge Deposits ; Permian–Triassic Mass Extinction ; Sulfide Flotation
    ISSN: 00278424
    E-ISSN: 1091-6490
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  • 9
    Language: English
    In: Geochimica et Cosmochimica Acta, 2011, Vol.75(13), pp.3645-3661
    Description: The distinction between Ru in solid solution and Ru-bearing inclusions is essential for the predictive modeling of platinum-group element (PGE) geochemistry in applications such as the lithogeochemical exploration for magmatic sulfide deposits in komatiites. This study investigates the role of chromite in the fractionation of Ru in ultramafic melts by analyzing chromite grains from sulfide-undersaturated komatiites and a komatiitic basalt from the Yilgarn Craton in Western Australia. In situ analysis using laser ablation ICP-MS yields uniform Ru concentrations in chromites both within-grain and on a sample scale, with concentrations between 220 and 540 ppb. All other platinum-group elements are below the detection limit of the laser ablation ICP-MS analysis. Carius tube digestion isotope dilution ICP-MS analysis of chromite concentrates confirms the accuracy of the in-situ method. Time resolved laser ablation ICP-MS analyses have identified the presence of sub-micron Ir-bearing inclusions in some chromite grains from the komatiitic basalt. However, Ru-bearing inclusions have not been recognized in the analyzed chromites and this combined with the in situ data suggests that Ru exists in solid solution in the crystal lattice of chromite. These results show that chromite can control the fractionation and concentration of Ru in ultramafic systems.
    Keywords: Geology
    ISSN: 0016-7037
    E-ISSN: 1872-9533
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  • 10
    Language: English
    In: The Lancet, 23 May 2015, Vol.385(9982), pp.2024-2026
    Description: Goldstein and colleagues' study6 adds to the growing body of evidence supporting directed factor replacement with prothrombin complex concentrate in emergency clinical situations.8 Goldstein and colleagues' findings reaffirm the ability of 4F-PCC to decrease INR rapidly in a wide range of patient groups, including in those who need emergency reversal.9-12 In terms of financial viability, PCC has routinely been shown to be more cost effective than plasma or recombinant factor VIIa.12,13 Additionally, the risk of fluid overload, cardiac events, stroke, and viral transmission is low with PCC.7 Although early formulations were associated with increased risk of thromboembolic events, currently available formulations have rates of thrombosis similar to that of plasma.7 PCC dosing regimens vary across studies, and some investigators have suggested concomitant use with vitamin K to prolong its mechanism of action, although there is no consensus about the added benefit of vitamin K.8,9 PCC remains an effective, rapid, economically sound, and safe way to correct anticoagulation resulting from administration of vitamin K antagonist rapidly, and should be used as first-line treatment for emergency correction of therapeutic anticoagulation.
    Keywords: Medicine
    ISSN: 0140-6736
    E-ISSN: 1474-547X
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