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  • 1
    Language: English
    In: Neuron, 2003, Vol.40(3), pp.447-449
    Description: In a widely held view of vertebrate CNS development, neurons, astrocytes, and oligodendrocytes arise from a common tripotent progenitor cell. However, tripotent progenitors have never been detected in developing embryos. In this issue of Neuron, Gabay et al. show that tripotent progenitors can be created in vitro by deregulation of normal dorsoventral positional cues.
    Keywords: Biology ; Anatomy & Physiology
    ISSN: 0896-6273
    E-ISSN: 1097-4199
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  • 2
    Language: English
    In: Neuron, 20 September 2012, Vol.75(6), pp.940-942
    Description: In this issue of , show that the neuron/glia cell fate switch of cortical progenitors is regulated by MEK1 and MEK2. The observations resonate with recent studies on the genesis of low-grade astrocytomas and highlight neuronal support functions of astrocytes in the postnatal brain.
    Keywords: Biology ; Anatomy & Physiology
    ISSN: 0896-6273
    E-ISSN: 1097-4199
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  • 3
    Language: English
    In: Neuron, 03 May 2017, Vol.94(3), pp.415-417
    Description: During central nervous system development, oligodendrocytes must be formed in proportion to the number of neurons requiring their services. In this issue of , show how cortical interneurons modulate oligodendrogenesis through a cytokine-mediated paracrine interaction. During central nervous system development, oligodendrocytes must be formed in proportion to the number of neurons requiring their services. In this issue of , Voronova et al. show how cortical interneurons modulate oligodendrogenesis through a cytokine-mediated paracrine interaction.
    Keywords: Biology ; Anatomy & Physiology
    ISSN: 0896-6273
    E-ISSN: 1097-4199
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  • 4
    In: Nature Neuroscience, 2013, Vol.16(12), p.1710
    Description: The cerebellum, with its stereotypic anatomy, has served as an engine of discovery for developmental neurobiologists and cancer biologists alike. However, new findings reported in this issue of Nature Neuroscience suggest that its anatomy and cellular specification, and by extension, its tumor biology, may be less simple than previously believed.
    Keywords: Intermediate Filament Proteins -- Health Aspects ; Intermediate Filament Proteins -- Research ; Neurosciences -- Research ; Cerebellum -- Research ; Cerebellum -- Physiological Aspects;
    ISSN: 1097-6256
    E-ISSN: 15461726
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  • 5
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 19 July 1994, Vol.91(15), pp.7061-7065
    Description: Receptors for the platelet-derived growth factors (PDGFs) are expressed conditionally in developing embryos and adult tissues. Aberrant expression of PDGF receptors is a molecular marker for proliferative disorders such as atherosclerosis, myofibrosis, and malignant astrocytoma. We isolated genomic clones that encompass the 5' end of the mouse PDGF α receptor mRNA transcript and extend 10 kb into the upstream flanking region of the gene. Using these clones, we constructed a partial genomic map that locates the promoter and transcription start sites of the gene. One of our genomic clones contains cis-acting regulatory elements that drive expression of reporter gene constructs selectively in cells that express PDGF α receptors.
    Keywords: Physical sciences -- Chemistry -- Chemical compounds ; Biological sciences -- Biology -- Cytology ; Biological sciences -- Biology -- Cytology ; Biological sciences -- Biology -- Genetics ; Biological sciences -- Biology -- Cytology ; Biological sciences -- Biology -- Genetics ; Biological sciences -- Biology -- Genetics ; Applied sciences -- Laboratory techniques -- Culture techniques ; Biological sciences -- Biology -- Genetics ; Biological sciences -- Biology -- Genetics
    ISSN: 00278424
    E-ISSN: 10916490
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  • 6
    Language: English
    In: Cancer Research, 12/01/2015, Vol.75(23 Supplement), pp.B20-B20
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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  • 7
    Language: English
    In: Cancer Cell, 12 October 2015, Vol.28(4), pp.403-404
    Description: The multiple cell types of brain and blood arise from pluripotent stem cells via progressively more committed downstream progenitors. In this issue of , Alcantara Llaguno and colleagues show that identical genetic drivers give rise to distinct glioma subtypes within differentially committed neural progenitors—a paradigm well established for leukemias. The multiple cell types of brain and blood arise from pluripotent stem cells via progressively more committed downstream progenitors. In this issue of , Alcantara Llaguno and colleagues show that identical genetic drivers give rise to distinct glioma subtypes within differentially committed neural progenitors—a paradigm well established for leukemias.
    Keywords: Medicine
    ISSN: 1535-6108
    E-ISSN: 1878-3686
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  • 8
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 14 May 2013, Vol.110(20), pp.8188-93
    Description: Pediatric low-grade gliomas (PLGGs) are among the most common solid tumors in children but, apart from BRAF kinase mutations or duplications in specific subclasses, few genetic driver events are known. Diffuse PLGGs comprise a set of uncommon subtypes that exhibit invasive growth and are therefore especially challenging clinically. We performed high-resolution copy-number analysis on 44 formalin-fixed, paraffin-embedded diffuse PLGGs to identify recurrent alterations. Diffuse PLGGs exhibited fewer such alterations than adult low-grade gliomas, but we identified several significantly recurrent events. The most significant event, 8q13.1 gain, was observed in 28% of diffuse astrocytoma grade IIs and resulted in partial duplication of the transcription factor MYBL1 with truncation of its C-terminal negative-regulatory domain. A similar recurrent deletion-truncation breakpoint was identified in two angiocentric gliomas in the related gene v-myb avian myeloblastosis viral oncogene homolog (MYB) on 6q23.3. Whole-genome sequencing of a MYBL1-rearranged diffuse astrocytoma grade II demonstrated MYBL1 tandem duplication and few other events. Truncated MYBL1 transcripts identified in this tumor induced anchorage-independent growth in 3T3 cells and tumor formation in nude mice. Truncated transcripts were also expressed in two additional tumors with MYBL1 partial duplication. Our results define clinically relevant molecular subclasses of diffuse PLGGs and highlight a potential role for the MYB family in the biology of low-grade gliomas.
    Keywords: A-Myb ; Acgh ; Cancer ; Brain Neoplasms -- Genetics ; Glioma -- Genetics ; Proto-Oncogene Proteins -- Genetics ; Trans-Activators -- Genetics
    ISSN: 00278424
    E-ISSN: 1091-6490
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  • 9
    Language: English
    In: Neuron, 26 June 2008, Vol.58(6), pp.832-846
    Description: Several years ago, the discovery of a highly tumorigenic subpopulation of stem-like cells embedded within fresh surgical isolates of malignant gliomas lent support to a new paradigm in cancer biology—the cancer stem cell hypothesis. At the same time, these “glioma stem cells” seemed to resolve a long-standing conundrum on the cell of origin for primary cancers of the brain. However, central tenets of the cancer stem cell hypothesis have recently been challenged, and the cellular origins of stem-like cells within malignant glioma are still contended. Here, we summarize the issues that are still in play with respect to the cancer stem cell hypothesis, and we revisit the developmental origins of malignant glioma. Do glioma stem cells arise from developmentally stalled neural progenitors or from dedifferentiated astrocytes? Five separate predictions of a neural progenitor cell of origin are put to the test.
    Keywords: Biology ; Anatomy & Physiology
    ISSN: 0896-6273
    E-ISSN: 1097-4199
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  • 10
    Language: English
    In: Science, 27 November 1987, Vol.238(4831), pp.1269-1271
    Description: In density-arrested monolayer cultures of Balb/c 3T3 cells, platelet-derived growth factor (PDGF) stimulates expression of the c-myc and c-fos proto-oncogenes, as well as the functionally uncharacterized genes, JE, KC, and JB. These genes are not coordinately regulated. Under ordinary conditions, c-fos, JE, KC, and JB respond to PDGF only when the cells are in a state of G$_{0}$ growth arrest at the time of PDGF addition. The c-myc gene is regulated in opposition to the other genes, responding best to PDGF in cycling cultures.
    Keywords: Biological sciences -- Biology -- Cytology -- Lymphocytes ; Applied sciences -- Laboratory techniques -- Culture techniques -- Lymphocytes ; Physical sciences -- Chemistry -- Chemical compounds -- Lymphocytes ; Biological sciences -- Biology -- Physiology -- Lymphocytes ; Biological sciences -- Biology -- Physiology -- Lymphocytes ; Biological sciences -- Biology -- Cytology -- Lymphocytes ; Biological sciences -- Biology -- Cytology -- Lymphocytes ; Biological sciences -- Biology -- Cytology -- Lymphocytes ; Physical sciences -- Chemistry -- Chemical compounds -- Lymphocytes ; Biological sciences -- Biology -- Cytology -- Lymphocytes
    ISSN: 00368075
    E-ISSN: 10959203
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