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  • 1
    Language: English
    In: Schizophrenia Research, April 2014, Vol.153, pp.S68-S68
    ISSN: 0920-9964
    E-ISSN: 1573-2509
    Source: ScienceDirect Journals (Elsevier)
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  • 2
    Language: English
    In: Journal of Substance Abuse Treatment, Oct, 2011, Vol.41(3), p.225(8)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jsat.2011.03.005 Byline: Marius Suter, Werner Strik, Franz Moggi Keywords: Depression; Alcohol relapse; Residential treatment programs; Predictor; Naturalistic multisite study Abstract: Alcohol use disorder (AUD) and depressive disorders often co-occur. Findings on the effects of major depressive disorder (MDD) or depressive symptoms on posttreatment alcohol relapse are controversial. The study's aim is to examine the association of MDD and depressive symptoms with treatment outcomes after residential AUD programs. In a naturalistic-prospective, multisite study with 12 residential AUD treatment programs in the German-speaking part of Switzerland, 64 patients with AUD with MDD, 283 patients with AUD with clinically significant depressive symptoms at admission, and 81 patients with AUD with such problems at discharge were compared with patients with AUD only on alcohol use, depressive symptoms, and treatment service utilization. MDD was provisionally identified at admission and definitively defined at discharge. Whereas patients with MDD did not differ from patients with AUD only at 1-year follow-up, patients with AUD with clinically significant depressive symptoms had significantly shorter time-to-first-drink and a lower abstinence rate. These patients also had elevated AUD indices and treatment service utilization for psychiatric disorders. Our results suggest that clinically significant depressive symptoms are a substantial risk factor for relapse so that it may be important to treat them during and after residential AUD treatment programs. Article History: Received 16 July 2010; Revised 26 February 2011; Accepted 28 March 2011
    Keywords: Recurrence (Disease) -- Psychological Aspects ; Drinking (Alcoholic beverages) -- Psychological Aspects ; Depression (Mood disorder) -- Psychological Aspects ; Substance Abuse Treatment -- Psychological Aspects
    ISSN: 0740-5472
    Source: Cengage Learning, Inc.
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  • 3
    Language: English
    In: Neuropsychologia, November 2013, Vol.51(13), pp.2674-2678
    Description: Schizophrenia patients frequently present with subtle motor impairments, including higher order motor function such as hand gesture performance. Using cut off scores from a standardized gesture test, we previously reported gesture deficits in 40% of schizophrenia patients irrespective of the gesture content. However, these findings were based on normative data from an older control group. Hence, we now aimed at determining cut-off scores in an age and gender matched control group. Furthermore, we wanted to explore whether gesture categories are differentially affected in Schizophrenia. Gesture performance data of 30 schizophrenia patients and data from 30 matched controls were compared. Categories included meaningless, intransitive (communicative) and transitive (object related) hand gestures, which were either imitated or pantomimed, i.e. produced on verbal command. Cut-off scores of the age matched control group were higher than the previous cut-off scores in an older control group. An ANOVA tested effects of group, domain (imitation or pantomime), and semantic category (meaningless, transitive or intransitive), as well as their interaction. According to the new cut-off scores, 67% of the schizophrenia patients demonstrated gestural deficits. Patients performed worse in all gesture categories, however meaningless gestures on verbal command were particularly impaired ( =0.008). This category correlated with poor frontal lobe function ( 〈0.001). In conclusion, gestural deficits in schizophrenia are even more frequent than previously reported. Gesture categories that pose higher demands on planning and selection such as pantomime of meaningless gestures are predominantly affected and associated with the well-known frontal lobe dysfunction.
    Keywords: Meaningless ; Transitive ; Intransitive ; Hand Gestures ; Action Planning ; Medicine
    ISSN: 0028-3932
    E-ISSN: 1873-3514
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  • 4
    Language: English
    In: Journal of Affective Disorders, 01 December 2015, Vol.188, pp.167-172
    Description: Psychomotor disturbances are a main clinical feature of major depressive disorder (MDD) but little is known about their EEG signature. One of the most replicated EEG findings in MDD is resting frontal asymmetry in the alpha band (FAA), which is thought to be a correlate of withdrawal behavior and reduced approach motivation. The purpose of this study was to assess psychomotor alterations, alpha band power, FAA and investigate the association between them. 20 MDD patients and 19 healthy subjects were enrolled. Alpha power and FAA scores were calculated from a resting state EEG. Wrist actigraphy was recorded from the non-dominant arm for 24 h and activity level scores (AL) were extrapolated from the wakeful periods. MDD patients had a left-lateralized frontal alpha activity and lower AL scores when compared to healthy subjects. A significant correlation was found between mean FAA and AL scores. A negative covariance between power in the lower alpha range and AL scores over the motor cortex bilaterally was detected. Relatively small sample size. Patients were pharmacologically treated with antidepressants. This study replicates the finding of left-lateralized FAA and lower AL scores in MDD patients, and establishes the first evidence of significant correlations between alpha power, FAA scores and measures of motor activity, which may be interpreted as an expression of impaired motivational drive in MDD.
    Keywords: Major Depression ; Psychomotor Disturbances ; Actigraphy ; EEG ; Frontal Alpha Asymmetry ; Alpha Oscillations
    ISSN: 0165-0327
    E-ISSN: 1573-2517
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  • 5
    Language: English
    In: Schizophrenia Research, April 2014, Vol.153, pp.S68-S68
    ISSN: 0920-9964
    E-ISSN: 1573-2509
    Source: ScienceDirect Journals (Elsevier)
    Library Location Call Number Volume/Issue/Year Availability
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  • 6
    Language: English
    In: Journal of Substance Abuse Treatment, 2011, Vol.41(3), pp.225-232
    Description: Alcohol use disorder (AUD) and depressive disorders often co-occur. Findings on the effects of major depressive disorder (MDD) or depressive symptoms on posttreatment alcohol relapse are controversial. The study's aim is to examine the association of MDD and depressive symptoms with treatment outcomes after residential AUD programs. In a naturalistic-prospective, multisite study with 12 residential AUD treatment programs in the German-speaking part of Switzerland, 64 patients with AUD with MDD, 283 patients with AUD with clinically significant depressive symptoms at admission, and 81 patients with AUD with such problems at discharge were compared with patients with AUD only on alcohol use, depressive symptoms, and treatment service utilization. MDD was provisionally identified at admission and definitively defined at discharge. Whereas patients with MDD did not differ from patients with AUD only at 1-year follow-up, patients with AUD with clinically significant depressive symptoms had significantly shorter time-to-first-drink and a lower abstinence rate. These patients also had elevated AUD indices and treatment service utilization for psychiatric disorders. Our results suggest that clinically significant depressive symptoms are a substantial risk factor for relapse so that it may be important to treat them during and after residential AUD treatment programs.
    Keywords: Depression ; Alcohol Relapse ; Residential Treatment Programs ; Predictor ; Naturalistic Multisite Study ; Social Welfare & Social Work
    ISSN: 0740-5472
    E-ISSN: 1873-6483
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  • 7
    Language: English
    In: Psychiatry Research, 30 August 2013, Vol.209(1), pp.114-117
    Description: One Hertz (1 Hz) repetitive transcranial magnetic stimulation (rTMS) is an effective therapy for auditory verbal hallucinations (AVH). Theta burst protocols (TBS) show longer after-effects. This single-blind, randomized controlled study compared continuous TBS with 1 Hz rTMS in a 10-day treatment. Patients were diagnosed with schizophrenia or schizoaffective disorder. TBS demonstrated equal clinical effects compared to 1 Hz TMS.
    Keywords: Transcranial Magnetic Stimulation ; Auditory Hallucination ; Theta Burst ; Medicine
    ISSN: 0165-1781
    E-ISSN: 1872-7123
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  • 8
    Language: English
    In: Psychiatry Research, 30 December 2011, Vol.190(2-3), pp.212-216
    Description: Despite the use of actigraphy in depression research, the association of depression ratings and quantitative motor activity remains controversial. In addition, the impact of recurring episodes on motor activity is uncertain. In 76 medicated inpatients with major depression (27 with a first episode, 49 with recurrent episodes), continuous wrist actigraphy for 24 h and scores on the Hamilton Depression Rating Scale (HAMD) were obtained. In addition, 10 subjects of the sample wore the actigraph over a period of 5 days, in order to assess the reliability of a 1-day measurement. Activity levels were stable over 5 consecutive days. Actigraphic parameters did not differ between patients with a first or a recurrent episode, and quantitative motor activity failed to correlate with the HAMD total score. However, of the motor-related single items of the HAMD, the item was associated with motor activity parameters, while the items and were not. Actigraphy is consistent with clinical observation for the item . Expert raters may not correctly rate the motor aspects of retardation and agitation in major depression.
    Keywords: Validity ; Motor Retardation ; Recurrent Episodes ; Medicine
    ISSN: 0165-1781
    E-ISSN: 1872-7123
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  • 9
    In: Psychophysiology, September 2013, Vol.50(9), pp.909-919
    Description: The present study investigates the relation of perceived arousal (continuous self‐rating), autonomic nervous system activity (heart rate, heart rate variability) and musical characteristics (sound intensity, musical rhythm) upon listening to a complex musical piece. Twenty amateur musicians listened to two performances of hopin's “Tristesse” with different rhythmic shapes. Besides conventional statistical methods for analyzing psychophysiological reactions (heart rate, respiration rate) and musical variables, semblance analysis was used. Perceived arousal correlated strongly with sound intensity; heart rate showed only a partial response to changes in sound intensity. Larger changes in heart rate were caused by the version with more rhythmic tension. The low‐/high‐frequency ratio of heart rate variability increased—whereas the high frequency component decreased—during music listening. We conclude that autonomic nervous system activity can be modulated not only by sound intensity but also by the interpreter's use of rhythmic tension. Semblance analysis enables us to track the subtle correlations between musical and physiological variables.
    Keywords: Music ; Subjective Arousal ; Sound Intensity ; Heart Rate ; Heart Rate Variability ; Respiration Rate ; Tempo Rubato ; Semblance Analysis
    ISSN: 0048-5772
    E-ISSN: 1469-8986
    E-ISSN: 15405958
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  • 10
    Language: English
    In: NeuroImage, 01 January 2010, Vol.49(1), pp.1073-1079
    Description: Commonality of activation of spontaneously forming and stimulus-induced mental representations is an often made but rarely tested assumption in neuroscience. In a conjunction analysis of two earlier studies, brain electric activity during visual-concrete and abstract thoughts was studied. The conditions were: in study 1, spontaneous stimulus-independent thinking (post-hoc, visual imagery or abstract thought were identified); in study 2, reading of single nouns ranking high or low on a visual imagery scale. In both studies, subjects' tasks were similar: when prompted, they had to recall the last thought (study 1) or the last word (study 2). In both studies, subjects had no instruction to classify or to visually imagine their thoughts, and accordingly were not aware of the studies' aim. Brain electric data were analyzed into functional topographic brain images (using LORETA) of the last microstate before the prompt (study 1) and of the word-type discriminating event-related microstate after word onset (study 2). Conjunction analysis across the two studies yielded commonality of activation of core networks for abstract thought content in left anterior superior regions, and for visual-concrete thought content in right temporal-posterior inferior regions. The results suggest that two different core networks are automatedly activated when abstract or visual-concrete information, respectively, enters working memory, without a subject task or instruction about the two classes of information, and regardless of internal or external origin, and of input modality. These core machineries of working memory thus are invariant to source or modality of input when treating the two types of information.
    Keywords: Medicine
    ISSN: 1053-8119
    E-ISSN: 1095-9572
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