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  • 1
    Online Resource
    Online Resource
    Totowa, NJ : Springer Science+Business Media, LLC
    UID:
    gbv_1651286973
    Format: Online-Ressource (XII, 217p. 18 illus., 12 illus. in color, digital)
    ISBN: 9781617794711
    Series Statement: Stem Cell Biology and Regenerative Medicine
    Content: Regenerative medicine is the emerging science of how we can support our body to repair itself and encompasses innovative strategies to facilitate recovery after organ injury. Several types of blood-derived stem cells can be easily procured and have the potential to facilitate this repair process. Our understanding of the various cell types and precise mechanisms of repair are evolving quickly. In this book, several key types of blood-derived stem cells that participate in the repair of organ damage are reviewed and specific examples of how stem cells may improve heart damage and neurological injury are addressed. Practical approaches to preparing cellular products and regulatory issues that will govern translational studies in patients are also covered. Regenerative Therapy Using Blood-Derived Stem Cells is a timely publication of a fast-moving field that will stimulate further research and enquiry into the promising field of regenerative medicine
    Content: Blood has long been viewed as a conduit for therapy, stemming from the ancient days of phlebotomy to remove evil humors to the development of successful blood transfusions to replace missing blood components. The identification and characterization of hematopoietic stem cells by Drs. Till and McCulloch revolutionized the field and soon after, non-hematopoietic stem and progenitor cells were characterized from the blood and bone marrow. Some of these cell types and various blood-derived cell lineages are involved in the repair of various types of tissue damage that span the spectrum of medical
    Note: Description based upon print version of record , Regenerative Therapy Using Blood-DerivedStem Cells; Preface; Contents; Contributors; Chapter 1: Undertaking Regenerative Medicine Studies with Blood Stem Cells; 1.1 Cells, Secreted Factors, and Mechanisms of Repair; 1.2 Tracking the Cells That Facilitate Repair; 1.3 Building on the Experience in Hematopoietic Stem Cell Therapy; 1.4 Promise for the Future; References; Chapter 2: Defining Endothelial Progenitor Cells; 2.1 Introduction; 2.2 Methods to Identify Human EPC; 2.3 Summary Statement with Call for New Definition of an EPC; References , Chapter 3: Blood-Derived ALDH hi Cells in Tissue Repair3.1 Introduction; 3.2 FACS Purification of Multiple Human Progenitor Subtypes Using ALDH Activity; 3.3 ALDH -Purified Cells Possessing Hematopoietic Repopulating Capacity; 3.4 ALDH-Purified Cells Stimulating Vascular Regeneration; 3.5 Roles of ALDH-Purified MSC in Vascular Regeneration; 3.6 ALDH-Purified Cells Stimulating Islet Revascularization and Repair; 3.7 Roles of ALDH-Purified MSC in Islet Regeneration; 3.8 Future Perspectives; References; Chapter 4: Mesenchymal Stem Cells and Tissue Repair; 4.1 Introduction , 4.2 Mesenchymal Stem Cells: Identification and Characterization4.3 Ontogeny of Bone Marrow-Derived Mesenchymal Stem Cells; 4.4 Alternative Mesenchymal Stem Cell Sources; 4.4.1 Adipose Tissue; 4.4.2 Peripheral Blood; 4.4.3 Umbilical Cord Blood; 4.5 Trafficking and Homing of MSCs; 4.6 Tissue Repair Mechanisms; References; Chapter 5: Animal Protein-Free Expansion of Human Mesenchymal Stem/Progenitor Cells; 5.1 Introduction; 5.2 Isolation and Bioprocessing of MSPCs; 5.2.1 MSPC Sources and Starting Material; 5.2.2 Coating of Culture Vessels; 5.2.3 Cell Culture Medium and Seeding Density , 5.3 Human Alternatives to Fetal Bovine Serum5.3.1 Human Serum; 5.3.2 Serum-Free Media; 5.3.3 Platelet-Derived Growth Factors; 5.4 MSPC Harvest and Immunophenotyping; 5.5 Differentiation Potential In Vitro; 5.6 Genomic Stability of MSPCs; 5.7 Conclusion; References; Chapter 6: Defining Hierarchies of Unrestricted Somatic Stem Cells and Mesenchymal Stem Cells in Cord Blood; 6.1 Why Do We Find Nonhematopoietic Progenitors in Cord Blood?; 6.2 Isolation, Expansion, and Characterization of Cord Blood-Derived Adherent Cells , 6.2.1 GMP-Conform Generation and Cultivation of USSC and MSC from Fresh Cord Blood6.2.2 Generation of Cell Clones and Clonal Populations; 6.3 Hematopoiesis-Supporting Activity of GMP-Grade-Produced USSC and MSC from Cord Blood In Vitro and In Vivo; 6.4 Differentiation Potential of USSC and CBMSC; 6.4.1 In Vitro Differentiation into Osteoblasts and Chondroblasts; 6.4.2 Adipogenic Differentiation as a Distinguishing Feature Between USSC and CB MSC; 6.5 Definition of Differences Between USSC and CB MSC on the Basis of DLK; 6.6 Endodermal Differentiation , 6.7 A Hierarchy Based on the Specific HOX Expression Pattern
    Additional Edition: ISBN 9781617794704
    Additional Edition: Druckausg. Regenerative therapy using blood-derived stem cells New York, N.Y. : Humana Press, Springer, 2012 ISBN 9781617794704
    Additional Edition: Buchausg. u.d.T. Regenerative therapy using blood-derived stem cells New York, N.Y. : Humana Press, Springer, 2012 ISBN 9781617794704
    Language: English
    Subjects: Medicine
    RVK:
    Keywords: Blutstammzelle ; Therapie ; Blutstammzelle ; Regenerative Medizin ; Aufsatzsammlung
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 2
    UID:
    b3kat_BV024930044
    Format: 51, 3 Bl. , graph. Darst.
    Note: Berlin, Humboldt-Univ., Diss. A, 1989
    Language: German
    Keywords: Hochschulschrift
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  • 3
    UID:
    gbv_340180331
    ISBN: 344702769X
    In: Prinzipien der Literaturgeschichtsschreibung, Wiesbaden : Harrassowitz, 1988, (1988), Seite 175-186, 344702769X
    In: year:1988
    In: pages:175-186
    Language: German
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