Format:
Online-Ressource (XX, 318p. 77 illus., 45 illus. in color, digital)
ISBN:
9781461416890
Series Statement:
SpringerLink
Content:
This book is written by leading researchers in the fields about the intersection of genetics and metabolomics which can lead to more comprehensive studies of inborn variation of metabolism.
Content:
Addresses a selected aspect of the genetic background to a metabolic phenotype All chapters refer to one or more published experimental datasets Looks at research about the intersection of genetics and metabolomics which can lead to more comprehensive studies of inborn variation of metabolism
Note:
Description based upon print version of record
,
Genetics Meets Metabolomics; Preface; Contents; Contributors; Chapter 1: Introduction; 1 Chapters on Experiment Related Questions; 2 Chapters on Unicellular Organisms and Animal Models; 3 Chapters on Human Health Related Topics; 4 Chapters That Take a Systems Approach; Chapter 2: Pre-conditions for High Quality Biobanking in Large Human Epidemiological Cohorts for Metabolomics and Other - Omics Studies; 1 New Generation, Large-Scale Cohort Studies Around the World; 2 The German National Cohort (GNC): An Example for High Quality Sample Collection in a Large Epidemiological Setting
,
3 Collection and Storage of Biological Materials in the GNC to Reach High Sample Quality4 Sample Types Collected in the German National Cohort; 5 Conclusion; References; Chapter 3: Assay Tools for Metabolomics; 1 Metabolomics Is a Multidisciplinary Approach; 1.1 Why Do Metabolomics?; 1.2 De fi nitions; 1.3 Challenges of Metabolomics; Box 3.1 Metabolomics Terms; 1.4 Critical Elements of Metabolomics; 1.4.1 Experimental Design; 1.4.2 Sample Preparation; Collection; Extraction; Matrix Effects; 1.4.3 Analytical Approaches; Different Types of Metabolomics
,
Major Features of Technologies for Metabolomics1.4.4 Large Scale Bioinformatics; 2 Principles of Mass Spectrometry Assay Technologies; 2.1 Separation Technologies; 2.1.1 Gas Chromatography (GC); 2.1.2 Liquid Chromatography (LC); 2.2 Mass Spectrometry; 2.2.1 Ionization; Box 3.2 Mass Spectrometry; 2.2.2 Principles of Mass Analyzers; Quadrupole; Ion-trap; 2.2.3 Example of Flow Injection Analysis (FIA); 2.2.4 Example of Targeted LC-MS/MS Analysis; 2.2.5 Challenges of Non-Targeted LC-MS Analyses; 2.3 Detectors; 3 Requirements for Quanti fi cation; 3.1 Method Validation; 3.2 Sensitivity of Method
,
3.3 Standard Operating Procedures (SOPs)References; Chapter 4: Statistical Methods in Genetic and Molecular Epidemiology and Their Application in Studies with Metabolic Phenotypes; 1 Basic Genetics; 2 Basic Statistical Concepts; 2.1 Allele Frequency; 2.2 Linkage Disequilibrium; 2.3 Hardy-Weinberg-Equilibrium; 2.4 Testing for Violation of Hardy-Weinberg-Equilibrium; 2.5 Design of Genetic Association Studies; 2.6 Genetic Models and Single Locus Testing; 2.7 Multiple Testing; 3 Genome-Wide Association Studies (GWAS); 4 Candidate-Gene Association Studies Versus Genome-Wide Association Studies
,
5 Meta-analysis of Genome-Wide Association Studies6 Population Strati fi cation; 7 Case Study: Genetic Determinates of Uric Acid Levels and Their Associations with Gout; 8 Missing Heritability; References; Chapter 5: Ultrahigh Resolution Mass Spectrometry Based Non-targeted Microbial Metabolomics; 1 Microorganisms and Their Role in the Environment and Human Health; 2 Review of Current Advances in Microbial Metabolomics; 3 Non-targeted Metabolomics Using Ultrahigh-Resolution Analytical Platforms
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Box 5.1 Theory of ICR-FT/MS, Mass Resolution, Mass Accuracy and Calculation of Possible Formulas Out of Exact Masses
Additional Edition:
ISBN 9781461416883
Additional Edition:
Druckausg. Genetics meets metabolomics New York : Springer, 2012 ISBN 1461416884
Additional Edition:
ISBN 9781461416883
Language:
English
Subjects:
Biology
Keywords:
Metabolom
;
Genetik
;
Metabolom
;
Genetik
;
Aufsatzsammlung
DOI:
10.1007/978-1-4614-1689-0
URL:
Volltext
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