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Berlin Brandenburg

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  • 1
    In: Chemical Communications, 2016, Vol.52(80), pp.11931-11934
    Description: A simple, straightforward and efficient method for the synthesis of [ 18 F]CF 4 and [ 18 F]SF 6 based on an ion beam-induced isotopic exchange reaction is presented. Positron emission tomography ventilation studies in rodents using [ 18 F]CF 4 showed a uniform distribution of the radiofluorinated gas within the lungs and rapid elimination after discontinuation of the administration.
    Keywords: Chemistry;
    ISSN: 1359-7345
    E-ISSN: 1364-548X
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  • 2
    Language: English
    In: Macromolecules, 2010, Vol.43, pp.9488-9494
    Keywords: Life Sciences ; Biochemistry, Molecular Biology ; Life Sciences ; Cellular Biology ; Chemistry
    ISSN: 0024-9297
    E-ISSN: 1520-5835
    Source: Hyper Article en Ligne (CCSd)
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  • 3
    Language: English
    In: Journal of Neuroscience, 04/15/2015, Vol.35(15), pp.5998-6009
    Description: PET imaging of nicotinic acetylcholine receptors (nAChRs) could become an effective tool for the diagnosis and therapy evaluation of neurologic diseases. Despite this, the role of nAChRs α4β2 receptors after brain diseases such as cerebral ischemia and its involvement in inflammatory reaction is still largely unknown. To investigate this, we performed in parallel in vivo magnetic resonance imaging (MRI) and positron emission tomography (PET) with 2[(18)F]-fluoro-A85380 and [(11)C]PK11195 at 1, 3, 7, 14, 21, and 28 d after middle cerebral artery occlusion (MCAO) in rats. In the ischemic territory, PET with 2[(18)F]-fluoro-A85380 and [(11)C]PK11195 showed a progressive binding increase from days 3-7, followed by a progressive decrease from days 14-28 after cerebral ischemia onset. Ex vivo immunohistochemistry for the nicotinic α4β2 receptor and the mitochondrial translocator protein (18 kDa) (TSPO) confirmed the PET findings and demonstrated the overexpression of α4β2 receptors in both microglia/macrophages and astrocytes from days 7-28 after experimental ischemic stroke. Likewise, the role played by α4β2 receptors on neuroinflammation was supported by the increase of [(11)C]PK11195 binding in ischemic rats treated with the α4β2 antagonist dihydro-β-erythroidine hydrobromide (DHBE) at day 7 after MCAO. Finally, both functional and behavioral testing showed major impaired outcome at day 1 after ischemia onset, followed by a recovery of the sensorimotor function and dexterity from days 21-28 after experimental stroke. Together, these results suggest that the nicotinic α4β2 receptor could have a key role in the inflammatory reaction underlying cerebral ischemia in rats.
    Keywords: 2[18f]-Fluoro-A85380 ; Pet ; Tspo ; [11c]Pk11195 ; Cerebral Ischemia ; Α4β2 ; Positron-Emission Tomography ; Encephalitis -- Diagnostic Imaging ; Infarction, Middle Cerebral Artery -- Complications ; Receptors, Nicotinic -- Metabolism;
    ISSN: 0270-6474
    E-ISSN: 1529-2401
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  • 4
    Language: English
    In: Journal of Controlled Release, 28 September 2015, Vol.214, pp.76-84
    Description: Highly aggressive cancer types such as pancreatic cancer possess a mortality rate of up to 80% within the first 6 months after diagnosis. To reduce this high mortality rate, more sensitive diagnostic tools allowing an early stage medical imaging of even very small tumours are needed. For this purpose, magnetic, biodegradable nanoparticles prepared using recombinant human serum albumin (rHSA) and incorporated iron oxide (maghemite, -Fe O ) nanoparticles were developed. Galectin-1 has been chosen as target receptor as this protein is upregulated in pancreatic cancer and its precursor lesions but not in healthy pancreatic tissue nor in pancreatitis. Tissue plasminogen activator derived peptides (t-PA-ligands), that have a high affinity to galectin-1 have been chosen as target moieties and were covalently attached onto the nanoparticle surface. Improved targeting and imaging properties were shown in mice using single photon emission computed tomography–computer tomography (SPECT–CT), a handheld gamma camera, and magnetic resonance imaging (MRI).
    Keywords: Rhsa Nanoparticles ; Maghemite ; T-PA-Ligands to Galectins ; T-Papeptide1lac ; Single Photon Emission Computed Tomography–Computer Tomography (Spect–CT) ; Handheld Gamma Camera ; Magnetic Resonance Imaging (Mri) ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0168-3659
    E-ISSN: 1873-4995
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  • 5
    Language: English
    In: Chemical communications (Cambridge, England), 29 September 2016, Vol.52(80), pp.11931-11934
    Description: A simple, straightforward and efficient method for the synthesis of [F]CF and [F]SF based on an ion beam-induced isotopic exchange reaction is presented. Positron emission tomography ventilation studies in rodents using [F]CF showed a uniform distribution of the radiofluorinated gas within the lungs and rapid elimination after discontinuation of the administration.
    E-ISSN: 1364-548X
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 6
    Language: English
    In: Journal of Fluorescence, 2010, Vol.20, pp.719-731
    Keywords: Life Sciences ; Biochemistry, Molecular Biology ; Life Sciences ; Cellular Biology ; Chemistry ; Physics
    ISSN: 1053-0509
    E-ISSN: 1573-4994
    Source: Hyper Article en Ligne (CCSd)
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  • 7
    In: Journal of Materials Chemistry B, 2015, Vol.3(30), pp.6293-6300
    Description: The determination of nanoparticle (NP) stability and degradation in vivo is essential for the accurate evaluation of NP biodistribution in medical applications and for understanding their toxicological effects. Such determination is particularly challenging because NPs are extremely difficult to detect and quantify once distributed in a biological system. Radiolabelling with positron or gamma emitters and subsequent imaging studies using positron emission tomography (PET) or single-photon emission computerised tomography (SPECT) are some of the few valid alternatives. However, NPs that degrade or radionuclides that detach or are released from the NPs can cause artefact. Here, submicron-sized poly(lactide- co -glycolide) nanoparticles (PLGA-NPs) stabilised with bovine serum albumin (BSA) were dual radiolabelled using gamma emitters with different energy spectra incorporated into the core and coating. To label the core, 111 In-doped iron oxide NPs were encapsulated inside PLGA-NPs during NP preparation, and the BSA coating was labelled by electrophilic substitution using 125 I. After intravenous administration into rats, energy-discriminant SPECT resolved each radioisotope independently. Imaging revealed different fates for the core and coating, with a fraction of the two radionuclides co-localising in the liver and lungs for long periods of time after administration, suggesting that NPs are stable in these organs. Organ harvesting followed by gamma counting corroborated the SPECT results. The general methodology reported here represents an excellent alternative for visualising the degradation process of multi-labelled NPs in vivo and can be extended to a wide range of engineered NPs.
    Keywords: Coating ; Degradation ; Tomography ; Emitters ; Positron Emission ; Imaging ; Organs ; Nanostructure ; Miscellaneous Sciences (So) ; Surveying, Theory, and Analysis (CE);
    ISSN: 2050-750X
    E-ISSN: 2050-7518
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  • 8
    Language: English
    In: Catalysis Today, Sept 1, 2015, Vol.252, p.136(7)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cattod.2014.10.038 Byline: E. Kowalska, Z. Wei, B. Karabiyik, A. Herissan, M. Janczarek, M. Endo, A. Markowska-Szczupak, H. Remita, B. Ohtani Abstract: Author Affiliation: (a) Catalysis Research Center, Hokkaido University, N21, W10, 001-0021 Sapporo, Japan (b) Laboratoire de Chimie Physique, Universite de Paris-Sud, Batiment 349, 91405 Orsay, France (c) Department of Chemical Technology, Gdansk University of Technology, ul. Narutowicza 11/12, 80-233 Gdansk, Poland (d) Institute of Chemical and Environmental Engineering, West Pomeranian University of Technology, ul. Pulaskiego 10, 70-322 Szczecin, Poland Article History: Received 12 July 2014; Revised 23 October 2014; Accepted 29 October 2014
    Keywords: Catalysis
    ISSN: 0920-5861
    Source: Cengage Learning, Inc.
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  • 9
    Language: English
    In: Catalysis Today, 01 September 2015, Vol.252, pp.136-142
    Description: Commercial titania photocatalysts were modified with 2 wt% of silver by photodeposition. The properties of the samples were characterized by DRS, XPS, XRD, FE-SEM and STEM. The modified samples exhibited activity under visible light and enhanced activity under UV irradiation for 2-propanol and acetic acid oxidation, respectively. The time-resolved microwave conductivity (TRMC) analysis indicated that enhanced activity (2.5–8-fold enhancement depending on titania) under UV irradiation was caused by an electron storage in metallic nanoparticles (NPs), and therefore decreasing the recombination between charge carriers. The action spectrum (AS) analysis proved that localized surface plasmon resonance (LSPR) of silver NPs induced the photocatalytic activity under visible light irradiation. The increase of antimicrobial properties under visible light irradiation indicated that not only intrinsic properties of silver in the dark, but also plasmonic properties of Ag@TiO were responsible for overall bacteria killing. The evolution of carbon dioxide under both irradiation ranges indicated mineralization of bacteria cells, and therefore possible application of silver-modified titania for decomposition of chemical and biological pollutants.
    Keywords: Plasmonic Photocatalysts ; Silver Nanoparticles ; Action Spectra ; Time-Resolved Microwave Conductivity ; Antimicrobial Properties ; Engineering ; Chemistry
    ISSN: 0920-5861
    E-ISSN: 1873-4308
    Source: ScienceDirect Journals (Elsevier)
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  • 10
    In: Laryngoscope, December 2016, Vol.126(12), pp.2699-2704
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1002/lary.26035/abstract Byline: Monika E. Freiser, Erin R. Cohen, Mikhaylo Szczupak, Dipan D. Desai, Kaming Lo, Chetan Nayak, Donald T. Weed, Zoukaa B. Sargi Objectives/Hypothesis Early detection is essential in head and neck cancer treatment as prognosis varies greatly with stage at diagnosis. Underserved populations often present with advanced disease, and individuals with tobacco and heavy alcohol use demonstrate a higher head and neck cancer incidence. This study aims to evaluate whether various promotional methods differentially recruited behavioral risk factor positive and/or underserved populations to our screening event. Study Design Prospective cross-sectional study. Methods A hospital-based, medical student-run, free head and neck cancer screening event for 187 participants was held in April 2015. Medical campus-based, community-based, and media-based promotions were implemented to recruit participants. Event participants filled out questionnaires to determine how they were recruited, their risk-factor history, and their socioeconomic status. Prevalence of the higher-risk population across the various promotional methods was analyzed. Results Community-based promotions were significantly associated with the recruitment of participants in the underserved subgroups, namely uninsured (P = .019), unemployed (P = .006), and those with an annual household income 〈$20,000 (P 〈 .001). Although not statistically significant, participants with behavioral risk factors reported a higher percentage of recruitment by media-based promotions. Campus-based promotions led to the highest absolute number, but not percentage, of higher-risk participants. Conclusions Community-based promotions most efficiently recruit underserved guests to participate in a hospital-based head and neck cancer screening event as compared to media and campus-based promotions. Institutions interested in recruiting higher proportions of underserved guests to these screening events should consider focusing attention and allocation of resources to community-based promotions. Level of Evidence 4 Laryngoscope, 126:2699-2704, 2016 Article Note: This work was performed at the University of Miami Miller School of Medicine. This work was supported by a 2014 Prevention and Early Detection Community Service Grant by the American Head and Neck Society awarded to Monika Freiser, the University of Miami Department of Otolaryngology, Sylvester Comprehensive Cancer Center, University of Miami Hospital, and Jackson Memorial Hospital. The sponsor and hospitals reviewed the original project proposal but were not otherwise involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
    Keywords: Head And Neck Malignancy ; Cancer Prevention ; High‐Risk Behavior ; Early Detection
    ISSN: 0023-852X
    E-ISSN: 1531-4995
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