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  • 1
    Language: English
    In: The Journal of the Japanese Society of Clinical Cytology, 2014, Vol.53(6), pp.515-520
    ISSN: 0387-1193
    E-ISSN: 1882-7233
    Source: CrossRef
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  • 2
    In: PLoS ONE, 2013, Vol.8(1)
    Description: During the process of tumor invasion, cells require footholds on extracellular matrices (ECM) that are created by forming focal adhesions (FAs) using integrins. On the other hand, cells must degrade the ECM barrier using extracellular proteases including MMPs in the direction of cell movement. Degradation occurs at the leading edges or invadopodia of cells, which are enriched in proteases and adhesion molecules. Recently, we showed that the phosphoinositide-binding protein ZF21 regulates FA disassembly. ZF21 increased cell migration by promoting the turnover of FAs. In addition, ZF21 promotes experimental tumor metastasis to lung in mice and its depletion suppresses it. However, it is not known whether ZF21 regulates cancer cell invasion in addition to its activity on FAs. In this study, we demonstrate that ZF21 also regulates invasion of tumor cells, whereas it does not affect the overall production of MMP-2, MMP-9, and MT1-MMP by the cells. Also, we observe that the ECM-degrading activity specifically at the invadopodia is severely abrogated. In the ZF21 depleted cells MT1-MMP cannot accumulate to the invadopodia and thereby cannot contribute to the ECM degradation. Thus, this study demonstrates that ZF21 is a key player regulating multiple aspects of cancer cell migration and invasion. Possible mechanisms regulating ECM degradation at the invadopodia are discussed.
    Keywords: Research Article ; Biology ; Medicine
    E-ISSN: 1932-6203
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  • 3
    Language: Japanese
    In: 日本臨床細胞学会雑誌, 2014, Vol.53(1), pp.51-52
    Description: Tubular adenoma of the breast is a rare benign tumor with cytological findings similar to those of fibroadenoma. We report a case of tubular adenoma of the mammary gland in a 23-year-old female, with emphasis on the cytological findings. The cytological smears show abundant benign bimodal ductal cells arranged mainly in tubular structures as in pericanalicular fibroadenoma, and also small amounts of condensed secretions in the ductal lumen or in the background. Such secretions may be one of the important findings for the differential diagnosis between fibroadenoma and tubular adenoma of the breast by fine needle aspiration cytology.
    ISSN: 0387-1193
    E-ISSN: 18827233
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  • 4
    Language: Japanese
    In: 日本臨床細胞学会雑誌, 2018, Vol.57(3), pp.151-158
    Description: 〈p〉〈b〉目的〈/b〉 : 甲状腺髄様癌の細胞診所見について検者間誤差の生じにくい細胞所見と核の計測値を用いて診断に有用な所見を検索し, 診断率向上と診断のアルゴリズムの提案を検討する.〈/p〉〈p〉〈b〉方法〈/b〉 : 髄様癌 78 例, 乳頭癌 20 例, 低分化癌 20 例, 濾胞癌 20 例の細胞診標本を対象に, 細胞形態学的鑑別, 細胞計測, 統計学的解析を行い, 髄様癌の鑑別に有用な項目を求めた.〈/p〉〈p〉〈b〉成績〈/b〉 : 髄様癌の診断に有用な所見は, 1) 粗顆粒状のクロマチン, 2) 4 核以上の多核腫瘍細胞, 3) アミロイド, 4) 核の縦横比 1.6 以上, 5) 核の縦横比 CV 25%以上, 6) 核の長径の最小値と最大値の比 3.7 以上であった. これらの所見は髄様癌 59 例に認められ, 乳頭癌, 濾胞癌, 低分化癌には認められなかった. さらに, ロジスティック回帰分析により髄様癌 7 例を推定した.〈/p〉〈p〉〈b〉結論〈/b〉 : 検者間誤差が生じにくい細胞所見および計測値を用いたアルゴリズムを用いることにより, 髄様癌の 84.6%が診断可能であった.〈/p〉
    Description: 〈p〉〈i〉〈b〉Objective〈/b〉〈/i〉 : We examined the cytological features of medullary carcinoma (MC) of the thyroid gland, including the nuclear dimensions, in order to identify useful diagnostic features for MC that are unlikely to be beset by errors arising from inter-examiner differences, and propose a diagnostic algorithm for improvement of the diagnosis rate.〈/p〉〈p〉〈i〉〈b〉Study Design〈/b〉〈/i〉 : Using cytological specimens obtained from 78 cases of MC, 20 cases of papillary carcinoma, 20 cases of follicular carcinoma and 20 cases of poorly differentiated carcinoma of the thyroid gland, we compared the rates of detection of salt and pepper chromatin, nuclear grooves, nuclear cytoplasmic inclusion bodies and multinucleated carcinoma cells, the amyloid and nuclear areas, the nuclear aspect ratio (ratio of the major axis diameter to minor axis diameter?), and the long diameter of the nuclei in order to identify features useful for the diagnosis of MC.〈/p〉〈p〉〈i〉〈b〉Results〈/b〉〈/i〉 : Diagnosis of MC was confirmed in 59 cases. It was estimated by logistic regression analysis in a further 7 cases. Based on our findings, we suggest the following as useful features for the diagnosis of MC : 1) salt and pepper appearance of the nuclear chromatin ; 2) 4 or more multinucleated carcinoma cells ; 3) presence of amyloid ; 4) nuclear aspect ratio≥1.6 ; 5) CV of the nuclear aspect ratio≥25%, 6) ratio between the minimum and maximum longest diameters of the nuclei≥3.7.〈/p〉〈p〉〈i〉〈b〉Conclusion〈/b〉〈/i〉 : Among the 78 specimens of MC, the diagnosis could be made by cytologic examination in 66 cases (84.6%).〈/p〉
    Keywords: Thyroid ; Aspiration ; Algorithm ; Medullary carcinoma ; Thyroid ; Aspiration ; Algorithm ; Medullary Carcinoma
    ISSN: 0387-1193
    E-ISSN: 18827233
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  • 5
    Language: English
    In: The Journal of the Japanese Society of Clinical Cytology, 2015, Vol.54(6), pp.396-397
    ISSN: 0387-1193
    E-ISSN: 1882-7233
    Source: CrossRef
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  • 6
    Language: English
    In: Cancer Cytopathology, 25 April 2006, Vol.108(2), pp.114-118
    Description: CDX2 immunostaining can serve as a specific and sensitive marker to detect gastrointestinal and pancreatic malignancies in ascites cytology.
    Keywords: Ascites ; Gastrointestinal Cancer ; Cdx2 ; Immunocytochemistry
    ISSN: 0008-543X
    E-ISSN: 1097-0142
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  • 7
    Language: English
    In: Oncology Reports, 11/2012, Vol.28(5), pp.1606-1612
    Description: The Working Group of the Japanese Society of Clinical Cytology was assembled to assess the current status of breast cytology in Japan by conducting a large-scale survey regarding the accuracy of fine-needle aspiration biopsy (FNAB) in Japan. We collected data and investigated the status of breast cytological diagnosis at 12 different cooperating facilities in Japan, and re-evaluated their false-negative and false-positive cases. Among 30,535 individuals who underwent a breast cytological examination, analyses were conducted on 10,890 individuals (35.7%) in whom cytological diagnoses were confirmed by histology. Among these patients, the cytological diagnosis had an inadequate rate of 17.7%, an indeterminate rate of 7.8%, a positive predictive value of ‘malignancy suspected’ cells of 92.4%, an absolute sensitivity of 76.7%, a complete sensitivity of 96.7%, a specificity of 84.3%, a positive predictive value of ‘malignant’ cells of 99.5%, a false-negative value of 3.31%, a false-positive value of 0.25% and an accuracy rate of 88.0%. Subsequently, 297 false-negative and 23 false-positive cases were re-evaluated and several factors were characterized (i.e. histological type, tumor size and misread points). This survey collected data from a large number of cases for breast FNAB. Based on our survey, the accuracy of FNAB in Japan was relatively high compared with the goal of assessment of diagnostic accuracy. However, there were some false-negative and false-positive cases. Improvements in accuracy resulting from the learning points in the present study will lead to more useful and reliable diagnostic tools in clinical practice.
    Keywords: Breast ; Cytology ; Diagnostic Accuracy ; Breast Cancer Screening ; Accuracy Management ; Fine-Needle Aspiration Biopsy
    ISSN: 1021-335X
    E-ISSN: 1791-2431
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  • 8
    Language: Japanese
    In: 日本臨床細胞学会雑誌, 2014, Vol.53(5), pp.356-361
    Description: 〈b〉目的〈/b〉 : 甲状腺細胞診検査における偽陰性率を低減させることを目的として血中 TSH 値について検討した.〈br〉〈b〉方法〈/b〉 : 甲状腺穿刺細胞診検査が施行され, その後甲状腺切除術および病理組織検査が行われた 276 例を対象として, 術前の血中 TSH 値と病理診断との関係について総計学的に解析した.〈br〉〈b〉成績〈/b〉 : 病理診断が良性の 156 例と悪性の 120 例の間で TSH の平均値に有意差を認めた (p=0.011, t 検定). TSH 1.8μIU/m〈i〉l〈/i〉 以上の 79 例では 1.8 未満の 197 例に比べ有意に悪性が多く (p〈0.001, χ〈sup〉2〈/sup〉検定), オッズ比は 5.06 倍であった. 術前の細胞診検査が陰性であった 170 例においても, TSH 1.8 以上の 30 例では 1.8 未満の 140 例に比べ有意に悪性が多く (p=0.020, χ〈sup〉2〈/sup〉検定), オッズ比は 3.25 倍であった. 細胞診検査が陰性であった 170 例に対して TSH 1.8 以上を悪性の疑いと判定することにより偽陰性例は 19 例から 12 例に減少した.〈br〉〈b〉結論〈/b〉 : 細胞診検査が陰性の症例においても, TSH 1.8 以上は悪性を疑う所見として再検査や外科手術を促すことが細胞診検査の偽陰性率を低下させる有効な手段である.
    Description: 〈b〉〈i〉Objectives〈/i〉〈/b〉 : The serum levels of thyroid stimulating hormone (TSH) were investigated in relation to thyroid malignancy, in order to lower the false-negative rate in thyroid fine-needle aspiration cytology.〈br〉〈b〉〈i〉Study Design〈/i〉〈/b〉 : The preoperative serum TSH levels of 276 thyroid patients were tested. All patients had fine-needle aspiration cytology, then underwent surgical treatments, the histological diagnoses were confirmed, and the significance of the TSH levels was statistically investigated.〈br〉〈b〉〈i〉Results〈/i〉〈/b〉 : TSH levels were significantly different between benign and malignant thyroid diseases (p=0.011, t test). Thyroid cancers were more frequent in those with TSH levels of more than 1.8μIU/m〈i〉l〈/i〉 compared to those with TSH levels less than 1.8μIU/m〈i〉l〈/i〉 (p〈0.001, χ〈sup〉2〈/sup〉 test). The odds ratio was 5.06. Furthermore, even in 170 patients with a negative diagnosis based on the cytology, thyroid cancers were more frequent also in those with TSH levels of more than 1.8μIU/m〈i〉l〈/i〉 (p=0.020, χ〈sup〉2〈/sup〉 test), and the odds ratio was 3.25. By combining the serum TSH test for 170 patients with negative cytology diagnosis, false-negative cases were reduced to 12 cases from 19 cases.〈br〉〈b〉〈i〉Conclusion〈/i〉〈/b〉 : Even if the result of cytology examinations are negative, patients with TSH levels of more than 1.8μIU/m〈i〉l〈/i〉 have a higher risk of malignancy, and should be further examined or surgically treated. This may result in fewer false-negative cases in thyroid cytology.
    Keywords: Thyroid Cancer ; Fine-Needle Aspiration Cytology (Fna) ; Tsh ; False-Negative
    ISSN: 0387-1193
    E-ISSN: 18827233
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  • 9
    Language: English
    In: Bulletin of Shubun University, 2016, Issue 8, pp.1-9
    Description: [Abstract] Objectives : Serum levels of thyroid-stimulating hormone (TSH) and thyroglobulin (TG) were investigated in relation to thyroid malignancy to confirm the significance of both markers for cancer diagnosis, and also to decrease the false-negative rate in thyroid fine-needle aspiration (FNA) cytology. Methods : Preoperative serum levels of TSH and TG from 597 thyroid patients were statistically investigated. All patients had fine-needle aspiration cytology, then underwent surgical treatments, and their histological diagnoses were confirmed. The statistical significance of the TSH and TG levels was investigated. Results : TSH was significantly higher in cancer patients (P1.80 μIU/ml (P180 ng/ml (P1.80 μIU/ml have a higher risk of papillary carcinoma, and patients with TG〉180 ng/ml have a higher risk of follicular carcinoma. Even in patients with benign or inadequate results from FNA examinations, those with TSH〉1.80 μIU/ml have a higher risk of malignancy. Such patients should be further examined by repeat cytology or treated surgically to determine whether the lesion is malignant or not.
    ISSN: 1884-9806
    Source: Medical*Online (Meteo, Inc.)
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  • 10
    Language: English
    In: Bulletin of Shubun University, 2016, Issue 8, pp.1-9
    Description: [Abstract] Objectives : Serum levels of thyroid-stimulating hormone (TSH) and thyroglobulin (TG) were investigated in relation to thyroid malignancy to confirm the significance of both markers for cancer diagnosis, and also to decrease the false-negative rate in thyroid fine-needle aspiration (FNA) cytology. Methods : Preoperative serum levels of TSH and TG from 597 thyroid patients were statistically investigated. All patients had fine-needle aspiration cytology, then underwent surgical treatments, and their histological diagnoses were confirmed. The statistical significance of the TSH and TG levels was investigated. Results : TSH was significantly higher in cancer patients (P1.80 μIU/ml (P180 ng/ml (P1.80 μIU/ml have a higher risk of papillary carcinoma, and patients with TG〉180 ng/ml have a higher risk of follicular carcinoma. Even in patients with benign or inadequate results from FNA examinations, those with TSH〉1.80 μIU/ml have a higher risk of malignancy. Such patients should be further examined by repeat cytology or treated surgically to determine whether the lesion is malignant or not.
    ISSN: 1884-9806
    Source: Medical*Online-E (Meteo, Inc.)
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