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  • 1
    Language: German
    Keywords: Markenpolitik ; Krisenmanagement ; Markenimage ; Markenpolitik ; Krisenmanagement ; Markenimage ; Markenführung ; Krisenmanagement ; Theorie
    ISBN: 363155902X
    Source: Deutsche Zentralbibliothek für Wirtschaftswissenschaften
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  • 2
    In: EMBO Journal, 15 February 1998, Vol.17(4), pp.1040-1052
    Description: The retinoblastoma protein, pRb, controls entry into the S phase of the cell cycle and acts as a tumor suppressor in many tissues. Re‐introduction of pRb into tumor cells lacking this protein results in growth arrest, due in part to transcriptional repression of genes required for S phase. Several studies suggest that pRb may also be involved in terminal cell cycle exit as a result of the instigation of senescence or differentiation programs. To understand better these multiple growth‐inhibitory properties of pRb, a temperature‐sensitive mutant of pRb has been produced. This tspRb induces G arrest and morphological changes efficiently at the permissive temperature of 32.5°C, but is weakly functional at 37°C. Consistent with this, tspRb is compromised in nuclear association and E2F regulation at the non‐permissive temperature, but regains these properties at 32.5°C. Serial activation and inactivation of tspRb in SAOS‐2 cells does not allow proliferation, but rather leads to apoptotic cell death. Transient activation of pRb may kill tumor cells by establishing a conflict between persistent proliferation‐inhibitory signals and renewed deregulation of pRb targets such as E2F, and may thus be a more potent means of eliminating these cells than through simple re‐introduction of the tumor suppressor gene.
    Keywords: Apoptosis ; E2f ; Growth Suppression ; Prb ; Temperature‐Sensitive Mutant
    ISSN: 0261-4189
    E-ISSN: 1460-2075
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  • 3
    In: Nature Cell Biology, 2004, Vol.6(8), p.763
    Description: Epithelial cells have separate apical and basolateral plasma membrane domains with distinct compositions. After delivery to one surface, proteins can be endocytosed and then recycled, degraded or transcytosed to the opposite surface. Proper sorting into the transcytotic pathway is essential for maintaining polarity, as most proteins are endocytosed many times during their lifespan. The polymeric immunoglobulin receptor (pIgR) transcytoses polymeric IgA (pIgA) from the basolateral to the apical surface of epithelial cells and hepatocytes. However, the molecular machinery that controls polarized sorting of pIgR-pIgA and other receptors is only partially understood. The retromer is a multimeric protein complex, originally described in yeast, which mediates intracellular sorting of Vps10p, a receptor that transports vacuolar enzymes. The yeast retromer contains two sub-complexes. One includes the Vps5p and Vps17p subunits, which provide mechanical force for vesicle budding. The other is the Vps35p-Vps29p-Vps26p subcomplex, which provides cargo specificity. The mammalian retromer binds to the mannose 6-phosphate receptor, which sorts lysosomal enzymes from the trans-Golgi network to the lysosomal pathway. Here, we show a function for the mammalian Vps35-Vps29-Vps26 retromer subcomplex in promoting pIgR-pIgA transcytosis.
    Keywords: Immunoglobulin Receptors ; Epithelial Cells ; Mannose ; Immunoglobulin A ; Vesicles ; Hepatocytes ; Lysosomal Enzymes ; Protein Transport ; Antibody: Structure and Function;
    ISSN: 1465-7392
    E-ISSN: 14764679
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  • 4
    Language: English
    In: PDA journal of pharmaceutical science and technology, 2007, Vol.61(5), pp.411-20
    Description: A robust, real-time polymerase chain reaction (RT-PCR) system to universally detect microbes at a limit of 10 to 50 colony-forming units within 5-6 h was developed. Pre-treatment of RT-PCR master mixes with ethidiumbromide monoacide (EMA) facilitates the development of an RT-PCR assay with appropriate sensitivity, reproducibility, and recovery.The system is useful to replace conventional microbial plating techniques for the analysis of microbial contamination in liquids like water. This was statistically confirmed for eight different bacteria and two different fungi species. Finally a complete procedure including microbial lysis, DNA extraction, EMA treatment, and RT-PCR was developed and evaluated for three different bacteria and two fungi species.
    Keywords: Polymerase Chain Reaction ; Water Microbiology ; Bacteria -- Isolation & Purification ; Fungi -- Isolation & Purification ; Ribotyping -- Methods
    ISSN: 1079-7440
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 5
    Language: English
    Description: Epithelial cells have separate apical and basolateral plasma membrane domains with distinct compositions. After delivery to one surface, proteins can be endocytosed and then recycled, degraded or transcytosed to the opposite surface. Proper sorting into the transcytotic pathway is essential for maintaining polarity, as most proteins are endocytosed many times during their lifespan(1). The polymeric immunoglobulin receptor (pIgR) transcytoses polymeric IgA (pIgA) from the basolateral to the apical surface of epithelial cells and hepatocytes(2,3). However, the molecular machinery that controls polarized sorting of pIgR-pIgA and other receptors is only partially understood. The retromer is a multimeric protein complex, originally described in yeast, which mediates intracellular sorting of Vps10p, a receptor that transports vacuolar enzymes(4). The yeast retromer contains two sub-complexes. One includes the Vps5p and Vps17p subunits, which provide mechanical force for vesicle budding(5,6). The other is the Vps35p-Vps29p-Vps26p subcomplex, which provides cargo specificity(7). The mammalian retromer binds to the mannose 6-phosphate receptor, which sorts lysosomal enzymes from the trans-Golgi network to the lysosomal pathway(8,9). Here, we show a function for the mammalian Vps35-Vps29-Vps26 retromer subcomplex in promoting pIgR-pIgA transcytosis.
    Source: eScholarship
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  • 6
    Language: English
    In: The journal of physical chemistry. B, 23 November 2006, Vol.110(46), pp.23142-7
    Description: The growth of ZnS nanoparticles by precipitation from supersaturated aqueous solution is studied by stopped-flow UV absorption spectroscopy. The average size, size distribution, and concentration of the particles are monitored within the sub-second time regime with a resolution of 1.28 ms. Particle growth at these early stages is governed by pronounced ripening. The UV absorption data strongly suggest that growth occurs by preferential adsorption of HS- anions relative to Zn(2+) or ZnOH(+) cations. Correspondingly, the initial sulfide concentration has a much more pronounced influence on the growth kinetics than the initial zinc concentration. These findings are verified by zeta-potential measurements which confirm that the particle surfaces are negatively charged under near-neutral pH conditions.
    Keywords: Absorption Spectra -- Research ; Zinc Sulfate -- Spectra ; Aqueous Solution Reactions -- Research;
    ISSN: 1520-6106
    E-ISSN: 15205207
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  • 7
    Dissertation
    Dissertation
    Frankfurt am Main [u.a.] : Lang,
    Language: German
    Description: Univ., Diss.--Oldenburg, 2006.
    Keywords: Markenpolitik Krisenmanagement Markenimage Dissertation -- Thesis. Markenpolitik / Krisenmanagement / Theorie.
    Source: Networked Digital Library of Theses and Dissertations
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  • 8
    Language: English
    In: Annals of Hematology, 2007, Vol.86(7), pp.517-517
    Description: Byline: Christian Hallermann (1,2), Matthias Kaune Kjell (1), Markus Tiemann (3), Ekkehard Kunze (4), Frank Griesinger (5), Christina Mitteldorf (1), Hans-Peter Bertsch (1), Christine Neumann (1) Keywords: Hairy cell leukemia, Cutaneous T-cell lymphoma, Sezary syndrome Abstract: In patients suffering from primary cutaneous lymphomas, secondary malignancies of various origin may develop. However, the frequency of a second neoplasm deriving from another lymphoid lineage is still unclear and may be underestimated. We screened all our patients with primary cutaneous lymphomas from a 4-year recruitment period for a coexisting secondary lymphoproliferative disorder. The cohort comprised of a total of 82 patients with primary cutaneous lymphomas, 62 with primary cutaneous T-cell lymphoma (CTCL), 18 with primary cutaneous B-cell lymphomas, and two with CD4+/CD56+ hematodermic neoplasm/blastic lymphomas. Seven patients (8.5%) were identified with a coexisting lymphoma of a different lymphoid lineage. Four patients with Sezary syndrome (SS) suffered from systemic B-cell lymphoma. Two of these developed SS after chemotherapy of their B-cell lymphoma. The other three patients with various types of skin lymphomas (SS, Mycosis fungoides [MF], primary cutaneous marginal zone lymphoma) developed Hodgkin's disease (hairy cell leukemia). Our data indicate that patients with primary cutaneous lymphomas have an elevated risk for the development of a secondary lymphoproliferative disorder even without previous chemotherapy. Possible explanations for this association include a genetic predisposition, alterations in early progenitor cells, underlying viral infections, and/or stimulation of a B-cell clone by the malignant helper T cells of the primary CTCL and vice versa. Author Affiliation: (1) Department of Dermatology, University of Goettingen, Goettingen, Germany (2) Fachklinik Hornheide, Dorbaumstrasse 300, 48157, Muenster, Germany (3) Department of Haematopathology and Lymph Node Registry, University Hospitals of Schleswig-Holstein, Campus Kiel, Kiel, Germany (4) Department of Osteopathology and Haematopathology, University of Goettingen, Goettingen, Germany (5) Department of Haematology and Oncology, University of Goettingen, Goettingen, Germany Article History: Registration Date: 21/02/2007 Received Date: 31/10/2006 Accepted Date: 15/02/2007 Online Date: 06/03/2007
    Keywords: Tumors;
    ISSN: 0939-5555
    E-ISSN: 1432-0584
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  • 9
    Language: English
    In: International Journal of Hydrogen Energy, 2011, Vol.36(5), pp.3496-3504
    Description: A miniaturized fuel processor for LPG has been developed and put into operation as compact hydrogen supply system for low power applications. The fuel processor consists of an integrated micro-structured evaporator and a micro-structured reformer both integrated with micro-structured catalytic burners, heat exchangers, and a micro-structured water–gas shift (WGS) stage. In the current paper, performance data of a coupled LPG steam reformer/catalytic burner are presented, which has been running stably over 1060 h with repeated start-up and shut-down cycles. On top of that, some performance data of complete LPG fuel processors will be shown, which have been operated up to 3500 h in combination with high temperature PEM fuel cell stacks. These fuel processing systems are capable to convert LPG with a nominal hydrogen production rate of 0.263 Nm  h . It could be demonstrated, that the micro-structured devices are not only compact but show also high reliability and durability. ► Several LPG fuel processors were operated between 1000 h and 3500 h. ► Complete conversion of propane was observed for all operating conditions. ► During all experiments a good mechanical stability was observed as well. ► Fifty fuel processors have been fabricated and tested in field trials until 2009.
    Keywords: Micro-Structured Reactor ; Hydrogen Production ; Fuel Processor ; Lpg Steam Reforming ; Engineering
    ISSN: 0360-3199
    E-ISSN: 1879-3487
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  • 10
    Language: English
    In: International Journal of Cancer, 01 January 2010, Vol.126(1), pp.239-246
    Description: Nitrogen‐containing bisphosphonates (N‐BPs) are effective antiosteolytic agents in patients with multiple myeloma. Preclinical studies have also demonstrated that these agents have direct antitumor effects and can reduce tumor burden in a variety of animal models, although it is not clear whether such effects are caused by direct actions on tumor cells or by inhibition of bone resorption. N‐BPs prevent bone destruction in myeloma by inhibiting the enzyme farnesyl pyrophosphate synthase in osteoclasts, thereby preventing the prenylation of small GTPase signaling proteins. In this study, utilizing a plasmacytoma xenograft model without complicating skeletal lesions, treatment with zoledronic acid (ZOL) led to significant prolongation of survival in severe combined immunodeficiency mice inoculated with human INA‐6 plasma cells. Following treatment with a clinically relevant dose of ZOL, histological analysis of INA‐6 tumors from the peritoneal cavity revealed extensive areas of apoptosis associated with poly (ADP‐ribose) polymerase cleavage. Furthermore, Western blot analysis of tumor homogenates demonstrated the accumulation of unprenylated Rap1A, indicative of the uptake of ZOL by nonskeletal tumors and inhibition of farnesyl pyrophosphate synthase. These studies provide, for the first time, clear evidence that N‐BPs have direct antitumor effects in plasma cell tumors and this is executed by a molecular mechanism similar to that observed in osteoclasts.
    Keywords: ‐Bisphosphonates ; Prenylation Inhibitor ; Multiple Myeloma ; Animal Model
    ISSN: 0020-7136
    E-ISSN: 1097-0215
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