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  • 1
    In: Neurology: Clinical Practice, 2016, Vol.6(6), pp.468-469
    Description: I read the article by Soni et al.1 line by line. Because of my association with a hospital at the epicenter of the AIDS epidemic, I have performed many thousands of lumbar punctures (LPs) for all of the usual reasons. Many patients were tapped repeatedly. I am right-handed and so the LP is performed with the patient in the left lateral decubitus position. This is essential to measure the opening pressure. I mark the back in the usual fashion using the line between the superior iliac crests to identify the L4-L5 interspace. I prefer the L2-L3 interspace for the procedure. Once identified, I begin the procedure. I use the same words with each patient and prep and drape the patient in the same fashion each time. I use local anesthesia. Once I again have the L2 spinous process identified, I keep my left thumb firmly pressed there for guidance and support and to distract the patient. The needle is advanced perpendicular to the skin and once it has passed the bone is at times angled cephalad. What I have described is a ritual. It is the ritual that makes the successful LP and this can be taught.
    Keywords: Medicine;
    ISSN: 2163-0402
    E-ISSN: 21630933
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  • 2
    In: Neurology, 2012, Vol.78(1), pp.73-74
    Keywords: Medicine;
    ISSN: 0028-3878
    ISSN: 1526632X
    E-ISSN: 1526632X
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  • 3
    Language: English
    In: PMLA, Oct, 2009, Vol.124(5), p.1838-1841
    Keywords: War Stories -- Criticism And Interpretation ; Morality Of War -- Political Aspects ; Morality Of War -- Social Aspects ; Morality Of War -- Evaluation ; Literary Criticism -- Political Aspects ; Literary Criticism -- Social Aspects
    ISSN: 0030-8129
    E-ISSN: 19381530
    Source: Cengage Learning, Inc.
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  • 4
    In: Neurology, 2010, Vol.75(22), pp.2045-2045
    Keywords: Conflict of Interest ; Drug Industry ; Neurology ; Abridged;
    ISSN: 0028-3878
    E-ISSN: 1526632X
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  • 5
    In: Neurology, 2015, Vol.85(3), pp.e28-e28
    Description: A 32-year-old woman with episodic headaches presented with 1.5 months of continuous left frontotemporal headache, pain, and dragging sensation in the left eye. Red forehead dot was noted along with eyelid ecchymosis (figures 1 and 2). Family history of migraine was reported in the patient's father and grandmother. Neurologic examination and brain MRI, magnetic resonance angiography, and magnetic resonance venography had normal results and workup revealed no evidence for vasculitis. Activation of the trigeminovascular system leading to release of vasoactive peptides is the likely cause of the red forehead dot and eyelid ecchymosis seen in some migraine patients.1
    Keywords: Eyelid ; Angiography ; Neuroimaging ; Vasculitis ; Eye ; Migraine ; Magnetic Resonance Imaging ; Headache ; Pain Perception ; Brain ; N.M.R. ; Vasoactive Agents ; Neurology & Neuropathology;
    ISSN: 0028-3878
    E-ISSN: 1526632X
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  • 6
    Language: English
    In: Cephalalgia, February 2011, Vol.31(3), pp.377-377
    Keywords: Medicine
    ISSN: 0333-1024
    E-ISSN: 1468-2982
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  • 7
    Language: English
    In: Zeitschrift für Gerontologie und Geriatrie, 2013, Vol.46(7), pp.623-628
    Description: The microscopic worm Caenorhabditis elegans ( C. elegans ) is one of the most prominent animal models for aging studies. This is underscored by the fact that most of the genes and interventions that modulate the aging process, such as the insulin/IGF pathway, caloric restriction and mitochondrial signalling, were first identified in this organism. Remarkably, many features of the mammalian aging process are recapitulated in C. elegans : over time, damage to macromolecule accumulates, structural cellular components progressively deteriorate, physiological functions decline, resistance to stress and infections decreases, while morbidity and mortality rates increase. In humans, age represents risk factor number one for most diseases ultimately leading to death in industrialized countries, namely cardiovascular diseases, cancer and neurodegenerative disorders. Genes regulating aging in C. elegans are evolutionarily conserved and their deregulation is often involved in the development of age-associated diseases in humans. It is therefore likely that any intervention that extends C. elegans lifespan will indicate strategies to positively impact on healthy human longevity. Der mikroskopisch kleine Wurm () ist eines der bedeutendsten Tiermodelle für Alternsstudien. Dies wird dadurch unterstrichen, dass die meisten Gene und Interventionen, die den Alternsprozess modulieren, wie der Insulin-IGF-Signalweg, kalorische Restriktion und mitochondriale Signale, zuerst in diesem Organismus identifiziert wurden. Bemerkenswerterweise kommen viele Merkmale der Säugeralterung bei vor: Akkumulation geschädigter Makromoleküle, progressiver Zerfall struktureller Zellkomponenten, Nachlassen physiologischer Funktionen, Abnahme von Stress- und Infektionsresistenz, Zunahme von Morbidität und Mortalität. Beim Mensch ist Altern der Hauptrisikofaktor für die meisten letztlich zum Tod führenden Krankheiten, wie kardiovaskuläre und neurodegenerative Erkrankungen oder Krebs. Gene, die den Alternsprozess in regulieren, sind evolutionär konserviert, und ihre Deregulation ist häufig an der Entstehung alternsassoziierter Krankheiten beteiligt. Daher ist anzunehmen, dass Interventionen, die die Lebensspanne bei verlängern, Ansätze für Strategien zur Verlängerung der gesunden Lebensspanne beim Menschen liefern werden.
    Keywords: C. elegans ; Aging ; Age-associated diseases ; Signaling pathways ; Longevity
    ISSN: 0948-6704
    E-ISSN: 1435-1269
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  • 8
    In: Neurology, 2010, Vol.74(1), pp.92-93
    Keywords: Botulinum Toxins, Type A -- Therapeutic Use ; Diabetic Neuropathies -- Drug Therapy ; Neuromuscular Agents -- Therapeutic Use;
    ISSN: 0028-3878
    E-ISSN: 1526632X
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  • 9
    Language: English
    In: Neurology, 02/16/2016, Vol.86(7), pp.697.2-698
    ISSN: 0028-3878
    E-ISSN: 1526-632X
    Source: Wolters Kluwer - Ovid (via CrossRef)
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  • 10
    Language: English
    In: PMLA, 1 October 2009, Vol.124(5), pp.1838-1841
    Keywords: Political science -- Military science -- Armed conflict ; Political science -- Military science -- Armed conflict ; Political science -- Military science -- Armed forces ; Behavioral sciences -- Human behavior -- Violence ; Political science -- Military science -- Armed conflict ; Behavioral sciences -- Anthropology -- Ethnology ; Arts -- Literature -- Literary studies ; Arts -- Literature -- Literary studies ; Political science -- Military science -- Armed conflict ; Social sciences -- Population studies -- Human populations
    ISSN: 00308129
    E-ISSN: 19381530
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