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  • 1
    Language: English
    In: Antimicrobial agents and chemotherapy, April 2017, Vol.61(4)
    Keywords: Mtrcde Efflux Pump ; Neisseria Gonorrhoeae ; Mtra ; ATP-Binding Cassette Transporters -- Genetics ; Anti-Bacterial Agents -- Pharmacology ; Bacterial Proteins -- Genetics ; Drug Resistance, Multiple, Bacterial -- Genetics ; Neisseria Gonorrhoeae -- Drug Effects
    ISSN: 00664804
    E-ISSN: 1098-6596
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  • 2
    In: Pathogens and Disease, 2017, Vol. 75(4)
    Description: The development of resistance of Neisseria gonorrhoeae to available first-line antibiotics, including penicillins, tetracyclines, fluoroquinolones and cephalosporins, has led to the circulation of multidrug-resistant gonorrhea at a global scale. Advancements in high-throughput whole-genome sequencing (WGS) provide useful tools that can be used to enhance gonococcal detection, treatment and management capabilities, which will ultimately aid in the control of antimicrobial resistant gonorrhea worldwide. In this minireview, we discuss the application of WGS of N. gonorrhoeae to strain typing, phylogenomic, molecular surveillance and transmission studies. We also examine the application of WGS analyses to the public health sector as well as the potential usage of WGS-based transcriptomic and epigenetic methods to identify novel gonococcal resistance mechanisms. This minireview examines the application of whole-genome sequencing methodologies to respond to the urgent threat of antimicrobial-resistant gonorrhea.
    Keywords: 〈Kwd〉 〈Italic Toggle="Yes"〉Neisseria Gonorrhoeae〈/Italic〉 〈/Kwd〉 ; Gonorrhea ; Whole - Genome Sequencing ; Antimicrobial Resistance
    E-ISSN: 2049-632X
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  • 3
    Language: English
    In: Genome announcements, 10 September 2015, Vol.3(5)
    Description: Neisseria gonorrhoeae, the etiological agent that causes the sexually transmitted infection gonorrhea, is a significant public health concern due to the emergence of antimicrobial resistance. We report the complete genome sequences of three reference isolates with varied antimicrobial susceptibility that will aid in elucidating the genetic mechanisms that confer resistance.
    Keywords: Prokaryotes;
    ISSN: 2169-8287
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  • 4
    In: Clinical Infectious Diseases, 2017, Vol. 65(1), pp.92-99
    Description: BackgroundNeisseria meningitidis (Nm) is a Gram-negative diplococcus that normally colonizes the nasopharynx and rarely infects the urogenital tract. On Gram stain of urethral exudates, Nm can be misidentified as the more common sexually transmitted pathogen Neisseria gonorrhoeae. MethodsIn response to a large increase in cases of Nm urethritis identified among men presenting for screening at a sexually transmitted disease clinic in Columbus, Ohio, we investigated the epidemiologic characteristics of men with Nm urethritis and the molecular and phylogenetic characteristics of their Nm isolates. The study was conducted between 1 January and 18 November 2015. ResultsSeventy-five Nm urethritis cases were confirmed by biochemical and polymerase chain reaction testing. Men with Nm urethritis were a median age of 31 years (interquartile range [IQR] = 24-38) and had a median of 2 sex partners in the last 3 months (IQR = 1-3). Nm cases were predominantly black (81%) and heterosexual (99%). Most had urethral discharge (91%), reported oral sex with a female in the last 12 months (96%), and were treated with a ceftriaxone-based regimen (95%). A minority (15%) also had urethral chlamydia coinfection. All urethral Nm isolates were nongroupable, ST-11 clonal complex (cc11), ET-15, and clustered together phylogenetically. Urethral Nm isolates were similar by fine typing (PorA P1.5-1,10-8, PorB 2-2, FetA F3-6), except 2, which had different PorB types (2-78 and 2-52). ConclusionsBetween January and November 2015, 75 urethritis cases due to a distinct Nm clade occurred among primarily black, heterosexual men in Columbus, Ohio. Future urogenital Nm infection studies should focus on pathogenesis and modes of sexual transmission.
    Keywords: 〈Kwd〉 〈Italic Toggle="Yes"〉Neisseria Meningitidis〈/Italic〉 〈/Kwd〉 ; Urethritis ; Gram Stain ; 〈Kwd〉 〈Italic Toggle="Yes"〉Neisseria Gonorrhoeae〈/Italic〉 〈/Kwd〉
    ISSN: 1058-4838
    E-ISSN: 1537-6591
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  • 5
    Language: English
    In: Journal of Clinical Microbiology, 2017, Vol.55(5), pp.1454-1468
    Description: A curated Web-based user-friendly sequence typing tool based on antimicrobial resistance determinants in Neisseria gonorrhoeae was developed and is publicly accessible (https://ngstar.canada.ca). The N. gonorrhoeae Sequence Typing for Antimicrobial Resistance (NG-STAR) molecular typing scheme uses the...
    Keywords: Natural Sciences ; Biological Sciences ; Bioinformatics And Systems Biology ; Naturvetenskap ; Biologiska Vetenskaper ; Bioinformatik Och Systembiologi ; Natural Sciences ; Biological Sciences ; Genetics ; Naturvetenskap ; Biologiska Vetenskaper ; Genetik ; Neisseria Gonorrhoeae ; Antimicrobial Resistance ; Molecular Epidemiology ; Sequence Typing
    ISSN: 0095-1137
    E-ISSN: 1098660X
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  • 6
    In: Sexually Transmitted Diseases, 2017, Vol.44(8), pp.492-494
    Description: ABSTRACT: We report a case of Neisseria gonorrhoeae with a non-mosaic penA allele that exhibited decreased susceptibility to extended-spectrum cephalosporins, including a ceftriaxone minimum inhibitory concentration of 0.5 μg/mL. An analysis of resistance determinants suggested that the observed phenotype might have resulted from the combined effects of mutations in multiple genes.
    Keywords: Protein Binding -- Analysis ; Penicillins -- Analysis;
    ISSN: 0148-5717
    E-ISSN: 15374521
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  • 7
    Language: English
    In: International Journal of Antimicrobial Agents, February 2017, Vol.49(2), pp.252-254
    Description: The whole-genome sequences of 24 isolates of with elevated minimum inhibitory concentrations (MICs) to azithromycin (≥2.0 µg/mL) were analyzed against a modified sequence derived from the whole-genome sequence of FA1090 to determine, by signal ratio, the number of mutant copies of the 23S rRNA gene and the copy number effect on 50S ribosome-mediated azithromycin resistance. Isolates that were predicted to contain four mutated copies were accurately identified compared with the results of direct sequencing. Fewer than four mutated copies gave less accurate results but were consistent with elevated MICs.
    Keywords: Azithromycin ; Resistance ; Neisseria Gonorrhoeae ; 23s Rrna ; Biology ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0924-8579
    E-ISSN: 1872-7913
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  • 8
    Language: English
    In: Emerging Infectious Diseases, 01 May 2017, Vol.23(5), pp.830-832
    Description: During 2016, eight Neisseria gonorrhoeae isolates from 7 patients in Hawaii were resistant to azithromycin; 5 had decreased in vitro susceptibility to ceftriaxone. Genomic analysis demonstrated a distinct phylogenetic clade when compared with local contemporary strains. Continued evolution...
    Keywords: Neisseria Gonorrhoeae ; Gonorrhea ; Phylogenic Cluster ; Bacteria ; Bacterial Infection ; Antimicrobial Drug Resistance ; Public Health
    ISSN: 1080-6040
    E-ISSN: 1080-6059
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  • 9
    In: Journal of Clinical Microbiology, 2000, Vol. 38(8), p.2914
    Description: The pathogenic Neisseria species N. meningitidis and N. gonorrhoeae possess an outer membrane lipoprotein, designated Lip, which is present in all strains tested. The predicted protein sequence of Lip consists of a consensus AAEAP amino acid repeat. The objective of this study was to determine the feasibility of using the Lip repeat number and sequence for subtyping of Neisseria gonorrhoeae. The lip genes of each isolate were amplified by PCR and sequenced to determine the repeat number and sequence. Among the 46 strains we examined, eight different Lip repeat numbers were identified, with lengths of 11 (1 strain), 12 (14 strains), 13 (2 strains), 14 (10 strains), 15 (5 strains), 16 (10 strains), 17 (3 strains), and 20 (1 strain) repeats. Analysis indicated differences in the sequences within the repeats that resulted in amino acid alterations in repeat classes that contained multiple strains. Among the 46 isolates examined, we were able to identify 17 unique Lip subtyping patterns.
    Keywords: Bacterial Outer Membrane Proteins -- Chemistry ; Gonorrhea -- Microbiology ; Neisseria Gonorrhoeae -- Classification;
    ISSN: 0095-1137
    ISSN: 00951137
    E-ISSN: 1098660X
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  • 10
    Language: English
    In: The Journal of Infectious Diseases, 1 February 1990, Vol.161(2), pp.336-339
    Description: The development of vaccines to prevent Neisseria infections has been impeded by antigenic diversity of most Neisseria surface components. The lipid-modified azurin (Laz), one of two distinct surface proteins recognized by the H.8 monoclonal antibody, is present in all pathogenic Neisseria. The mature protein has two domains; one contains an H.8 epitope and the other has extensive homology to azurins, a class of bacterial copper-binding proteins. The cellular location of Laz and the serum immune response to Laz were examined in patients with disseminated Neisseria infections. The data demonstrated that Laz is probably contained in the Neisseria outer membrane, although unlike most outer membrane proteins it is Sarkosyl soluble. By probing recombinant bacteriophages encoding the H.8 and azurin domains of Laz, results showed that whereas the H.8 epitope is immunogenic in patients with disseminated Neisseria infections, the azurin domain of Laz plays little role in eliciting an antibody response in these patients.
    Keywords: Biological sciences -- Biology -- Microbiology -- Epitopes ; Physical sciences -- Chemistry -- Chemical compounds -- Polyclonal antibodies ; Health sciences -- Medical conditions -- Infections -- Monoclonal antibodies ; Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies ; Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies ; Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies ; Physical sciences -- Astronomy -- Astronomical cosmology -- Monoclonal antibodies ; Physical sciences -- Chemistry -- Chemical compounds -- Monoclonal antibodies ; Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies ; Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies
    ISSN: 00221899
    E-ISSN: 15376613
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