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  • 1
    In: Discourse-P, 12/01/2017, Vol.28-29(3-4), pp.191-198
    ISSN: 18179568
    Source: CrossRef
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  • 2
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 13 September 2005, Vol.102(37), pp.13164-9
    Description: 5-Lipoxygenase (5-LO) is a tightly regulated enzyme in the synthesis of bioactive lipids from arachidonic acid. Here, we demonstrate that 5-LO is regulated by caspases, which are signaling molecules that control critical biological processes by means of specific limited proteolysis. Cell splitting of the Epstein-Barr virus-transformed B lymphocytic cell line BL41-E95-A caused a pronounced, but transient, reduction of functional 5-LO protein, accompanied by the appearance of a 62-kDa 5-LO cleavage product. In parallel, splitting of BL41-E95-A cells induced activation of caspase-6 (casp-6) and casp-8. Caspase activation and 5-LO degradation were blocked by the protein-synthesis inhibitor cycloheximide, and cell-permeable peptide inhibitors of casp-6 and casp-8 prevented 5-LO cleavage. Activation of casp-6 and casp-8 was connected to subsequent enhancement of cell proliferation, whereas selective caspase inhibition blocked cell growth. Last, isolated human 5-LO was cleaved by recombinant casp-6 in vitro to a 58-kDa fragment. Based on site-directed mutagenesis studies, 5-LO is cleaved by casp-6 after Asp-170, which in a homology-based 3D model of 5-LO is located on the enzyme periphery. We suggest that splitting of BL41-E95-A cells induces de novo synthesis of a protein involved in the activation of casp-6, which cleaves 5-LO.
    Keywords: Arachidonate 5-Lipoxygenase -- Metabolism ; B-Lymphocytes -- Metabolism ; Caspases -- Metabolism
    ISSN: 0027-8424
    E-ISSN: 10916490
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  • 3
    Language: English
    In: Gondwana Research, February 2017, Vol.42, pp.126-132
    Description: Kimberlites are not only the most economically important source of diamonds; they also carry unique information encapsulated in rock fragments entrained as the magma traverses the whole thickness of the lithosphere. The Nurbinskaya pipe in the Siberian kimberlite province (Russia) is one of several intruded along the Vilyui Rift, a major terrane boundary. The pipe contains three populations of mantle-derived zircon xenocrysts: Archean (mean age 2709 ± 9 Ma), Devonian (mean age 371 ± 2.3 Ma), and a subset of grains with evidence of brittle deformation and rehealing, and a range of ages between 370 and 450 Ma. The Hf-isotope, O-isotope and trace-element signatures of the last group provide a link between the Archean and Devonian events, indicating at least three episodes of magmatic activity and zircon crystallization in the lithosphere beneath the pipe. The emplacement of the Nurbinskaya pipe 370 Ma ago was only the youngest activity in a magma plumbing system that has been periodically reactivated over at least 2.7 billion years, controlled by the lithosphere-scale structure of the Vilyui Rift. Mosaic zircons from the Nurbinskaya pipe as the link between Archean and Devonian populations of mantle-derived zircons
    Keywords: U-Pb Dating ; Hf-Isotopes ; Yakutian Kimberlite Province ; Siberian Craton ; Lithospheric Mantle ; Geology
    ISSN: 1342-937X
    E-ISSN: 1878-0571
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  • 4
    Language: English
    In: LITHOS, May 2018, Vol.308-309, pp.181-195
    Description: Cr-pyrope xenocrysts and associated inclusions of crichtonite-group minerals from the Internatsionalnaya kimberlite pipe were studied to provide new insights into processes in the lithospheric mantle beneath the Mirny kimberlite field, Siberian craton. Pyropes are predominantly of lherzolitic paragenesis (Cr O 2–6 wt%) and have trace-element spectra typical for garnets from fertile mantle (gradual increase in chondrite-normalized values from LREE to MREE-HREE). Crichtonite-group minerals commonly occur as monomineralic elongated inclusions, mostly in association with rutile, Mg-ilmenite and Cr-spinel within individual grains of pyrope. Sample INT-266 hosts intergrowth of crichtonite-group mineral and Cl-apatite, while sample INT-324 contains polymineralic apatite- and dolomite-bearing assemblages. Crichtonite-group minerals are Al-rich (1.1–4.5 wt% Al O ), moderately Zr-enriched (1.3–4.3 wt% ZrO ), and are Ca-, Sr-, and occasionally Ba-dominant in terms of A-site occupancy; they also contain significant amounts of Na and LREE. T-estimates and chemical composition of Cr-pyropes imply that samples represent relatively low-T peridotite assemblages with ambient T ranging from 720 to 820°С. Projected onto the 35 mW/m cratonic paleogeotherm for the Mirny kimberlite field (Griffin et al., 1999b. Tectonophysics 310, 1–35), temperature estimates yield a P range of ~34–42 kbar (~110–130 km), which corresponds to a mantle domain in the uppermost part of the diamond stability field. The presence of crichtonite-group minerals in Cr-pyropes has petrological and geochemical implications as evidence for metasomatic enrichment of some incompatible elements in the lithospheric mantle beneath the Mirny kimberlite field. The genesis of Cr-pyropes with inclusions of crichtonite-group minerals is attributed to the percolation of Ca-Sr-Na-LREE-Zr-bearing carbonate-silicate metasomatic agents through Mg- and Cr-rich depleted peridotite protoliths. The findings of several potentially new members of the crichtonite group as inclusions in garnet extend existing knowledge on the compositions and occurrences of exotic titanates stable in the lithospheric mantle.
    Keywords: Crichtonite-Group Minerals ; Inclusion ; Pyrope ; Kimberlite ; Mantle Metasomatism ; Siberian Craton ; Engineering ; Geology
    ISSN: 0024-4937
    E-ISSN: 1872-6143
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  • 5
    Language: English
    In: Apoptosis, 2008, Vol.13(1), pp.119-131
    Description: Myrtucommulone (MC) is a unique, nonprenylated acylphloroglucinol contained in the leaves of myrtle ( Myrtus communis ). Here, we addressed the potential of MC to induce apoptosis of cancer cells. MC potently induced cell death of different cancer cell lines (EC 50 3–8 μM) with characteristics of apoptosis, visualized by the activation of caspase-3, -8 and -9, cleavage of poly(ADP-ribose)polymerase (PARP), release of nucleosomes into the cytosol, and DNA fragmentation. MC was much less cytotoxic for non-transformed human peripheral blood mononuclear cells (PBMC) or foreskin fibroblasts (EC 50 cell death = 20–50 μM), and MC up to 30 μM hardly caused processing of PARP, caspase-3, -8 and -9 in human PBMC. MC-induced apoptosis was mediated by the intrinsic rather than the extrinsic death pathway. Thus, MC caused loss of the mitochondrial membrane potential in MM6 cells and evoked release of cytochrome c from mitochondria. Interestingly, Jurkat cells deficient in caspase-9 were resistant to MC-induced cell death and no processing of PARP or caspase-8 was evident. In cell lines deficient in either CD95 (Fas, APO-1) signalling, FADD or caspase-8, MC was still able to potently induce cell death and PARP cleavage. Conclusively, MC induces apoptosis in cancer cell lines, with marginal cytotoxicity for non-transformed cells, via the mitochondrial cytochrome c/Apaf-1/caspase-9 pathway.
    Keywords: Cancer ; Apoptosis ; Mitochondria ; Caspase ; Myrtucommulone
    ISSN: 1360-8185
    E-ISSN: 1573-675X
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  • 6
    Language: English
    Description: Empirical thesis. "Australian Research Council Centre of Excellence for Core and Crust Fluid Systems (CCFS) and GEMOC Department of Earth and Planetary Sciences, Macquarie University, Sydney, Australia" -- at foot of title. Bibliography: pages 295-316. Chapter 1. Introduction -- Chapter 2. The Siberian Craton : literature overview -- Chapter 3. Samples, analytical methods and techniques -- 4. The Magan terrane -- 5. The Markha terrane -- 6. The Daldyn terrane -- 7. The Khapchan terrane -- 8. The Birekta terrane -- 9. Discussion -- Chapter 10. Conclusions -- References -- Appendices. The lower continental crust and subcontinental lithospheric mantle (SCLM) are very interesting and important part of the Earth planet that has influenced significantly processes, which are continually altering surface of the Earth. Knowledge of the nature, structure and evolution of these layers may lead to understanding of the deep Earth’s processes. The Siberian craton is one of a few regions where samples of lower crust and underlying subcontinental lithospheric mantle can be found. Many geological and geophysical studies were carried out in this region but the role of crust and SCLM in the Earth’s evolution is not completely understood yet. Modern analytical techniques allow solving problems that were outstanding up to now. For example, isotopic and trace-element studies on zircon can specify not only the age of rock but also the source of melts and thus identify different stages in the craton evolution. The Siberian craton has experienced widespread Phanerozoic kimberlite magmatism. Besides diamonds, kimberlites also carry up a unique set of xenogenic material (xenoliths and xenocrysts) derived from depths of the lithosphere-asthenosphere transition zone (230-250 km) to the upper crust. Thus, kimberlitic pipes are natural drill holes, supplying with upper-mantle and crustal xenoliths and allowing us to investigate and reconstruct the structure of the deeper sections of the lithosphere. More than 1000 zircon grains from five terranes (Magan, Markha, Daldyn, Khapchan and Birekta) of the Siberian craton were analysed for U-Pb ages, trace-element characteristics, hafnium and oxygen isotopes composition. These data were supplemented by Re-Os isotope information collected on sulphide inclusion in silicate minerals from the mantle xenoliths. This combined isotopic information show that there were several events that involved both reworking of older crust and some addition of mantle-derived material. Moreover, integration of U-Pb age and Hf-isotopic data for zircons from different terranes indicates that the main magmatic-tectonic events are coeval for all studied terranes. For kimberlitic fields located within the Magan and Markha terranes the results of U-Pb and model ages show a good agreement with previous data. However, the ages from the eastern part of the craton (Khapchanand Birekta terranes) are much older than those reported previously. This implies that the amalgamation of the Siberian craton happened much earlier than it was previously suggested,which might have a significant impact on the diamond-bearing potential of the eastern part of the craton. Mode of access: World wide web 1 online resource (405 pages) illustrations (some colour), maps
    Keywords: Lithosphere ; Cratons -- Russia -- Siberia ; Zircon -- Analysis
    Source: National Library of Australia (Trove)〈img src=https://exlibris-pub.s3.amazonaws.com/Trove_reload.gif style="vertical-align:middle;margin-left:7px"〉
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  • 7
    Dissertation
    Dissertation
    Language: German
    Description: Universiẗat, Diss., 2007--Frankfurt (Main). Zsfassung in dt. und engl. Sprache.
    Keywords: Lipoxygenase Caspasen. Genregulation.
    Source: Networked Digital Library of Theses and Dissertations
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  • 8
    Dissertation
    Dissertation
    Language: German
    Description: Frankfurt (Main), Univ., Diss., 2007 Erscheinungsjahr an der Haupttitelstelle: 2006
    Source: Networked Digital Library of Theses and Dissertations
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  • 9
    Language: English
    Description: The Phase I project was very successful in demonstrating the feasibility of using a superelastic Nitinol shape memory alloy to improve cut, tear, and puncture resistance of military Battle Dress Uniform (BDU) fabric. The Nitinol reinforcement increased cut-resistance by 20 times and tear resistance by 2.5 times the values for current BDU fabric. Cotton/Nylon plain weave fabrics were fabricated in small lots with excellent quality for testing. Various reinforcements were added to demonstrate enhanced mechanical performance. The force-displacement tensile curves from the Modified Grab Test results show that the addition of Nitinol to the fabric doesn't significantly alter flexibility level. The fabrics experienced a 50 to 60 percent increase in breaking strength over the plain fabric with the 5 and 10 Nitinol fibers per inch. Calculations of areal density do not show significant difference between reinforced fabric and plain fabric. Fabric does not kink unless subjected to very severe loads. Wrinkles cannot develop because the shape memory effect returns the Nitinol reinforcement to original shape. Nitinol provides an electrical conduit in the uniform that minimizes shock and static discharge. The Phase I effort has positively demonstrated the feasibility of gaining improved protection in textiles without sacrificing fabric flexibility.
    Keywords: Logistics, Military Facilities and Supplies ; Protective Equipment ; Damping ; Fabrics ; High Strength ; Protective Clothing ; Uniforms ; Cotton ; Density ; Elastic Properties ; Nylon ; Reinforcing Materials ; Shape Memory Alloys ; Static Electricity ; Tensile Properties ; Test And Evaluation ; Textiles ; Threats ; Puncture Resistant ; Nitinol ; Sbir(Small Business Innovation Research) ; Sbir Program ; Multithreats ; Bdu(Battle Dress Uniform) ; Modified Grab Test
    Source: United States Defense Technical Information Center
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  • 10
    In: Frontiers in Physiology, 2018, Vol.9
    ISSN: Frontiers in Physiology
    E-ISSN: 1664-042X
    Source: CrossRef
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