Format:
Online-Ressource
,
v.: digital
Edition:
Online-Ausg. Springer eBook Collection. Biomedical and Life Sciences Electronic reproduction; Available via World Wide Web
ISBN:
9781441906380
Content:
Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1)
Note:
Includes bibliographical references and index
,
Preface; Contents; Contributors; Epigenetics and the Aging Process; Introduction; DNA Methylation and Histone Modifications in Aging; Other Epigenetic Processes and Aging; Impact of Epigenetics on Aging; Epigenetics of Age-Related Diseases; Epigenetic Interventions and Aging; Future Directions/Perspectives; Conclusion; References; Part I DNA Methylation and Histone Modifications in Aging; Age-Related Genomic Hypomethylation; Introduction; Aging and Genomic Hypomethylation; Mechanism of DNA Hypomethylation During Aging; DNA Methyltrasferases and Age-Dependent DNA Hypomethylation
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One-Carbon Metabolism and Age-Dependent DNA HypomethylationDNA Integrity and Age-Dependent DNA Hypomethylation; Age-Related Diseases and DNA Hypomethylation; Cancer; Atherosclerosis; Alzheimer's Disease; Autoimmunity; Age-Related Macular Degeneration; Concluding Remarks; References; Gene-Specific Hypermethylation in Aging; Hypermethylation of Promoter Elements: Regulation of Gene Expression; Methods to Detect Methylation Status; Aging: Global Methylation; Aging: Gene-Specific Methylation; Liver; Gastrointestinal Tract; Other Organs; Conclusions; References
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Aging and Non-sirtuin Histone ModificationsReferences; Sirtuins and Aging; Introduction; Distribution of Sirtuins in Model Organisms; Functions of Sirtuins; Sirtuins and Lifespan; Sirtuins and Calorie Restriction; Sirtuins and Transcriptional Regulation; Sirtuins and Apoptosis; Sirtuins and Metabolism; Sirtuins and Genomic Integrity; Sirtuins and Degenerative Diseases; Sirtuin Activators and Suppressors; Conclusion and Future Directions; References; Chromatin in Senescent Cells: A Conduit for the Anti-AgingEffects of Wnt Signaling?; An Overview of Cellular Senescence
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Senescence, Aging, and Tumor SuppressionMolecular Features of Senescence; Senescence-Inducing Pathways; Chromatin Remodeling in Senescent Cells; Description of SAHF; Formation of SAHF Is a Multi-step Process; Chromosome Condensation Is Driven by Histone Chaperones HIRA and ASF1a; Activation of the HIRA/ASF1a Pathway by Wnt Signaling; Wnt Signaling, SAHF, and Tissue Aging; Summary; References; S -Adenosylmethionine: Simple Agent of Methylation and Secret to Aging and Metabolism?; Introduction; SAM-Dependent Enzymes; The SAM Domain/Rossmann Fold; Other SAM-Binding Domains
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SAM and Radical Formation: The Iron--Sulfur ClusterSAM and RNA Riboswitches; The Central Role of SAM in Metabolism; The Methionine Cycle; SAM and the Transsulfuration Pathway; SAM and the Polyamine Pathway; SAM and Aging; SAM, Mitochondria, and Life Span; The Yin and Yang of SAM in Real Life; SAM and Neurodegenerative Disease: Alzheimer and Cognitive Dysfunction; SAM and Dopamine Metabolism in Parkinson's Disease; SAM and Down's Syndrome; SAM and the Ames Dwarf Mouse; SAM and Mutations in DNA Repair Genes; Conclusion; References; Part II Other Epigenetic Processes and Aging
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Polycomb Group of Genes and the Epigenetics of Aging
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Electronic reproduction; Available via World Wide Web
Additional Edition:
ISBN 9781441906397
Additional Edition:
ISBN 9781441906380
Language:
English
Subjects:
Biology
DOI:
10.1007/978-1-4419-0639-7
URL:
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