Kooperativer Bibliotheksverbund

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Format: 1 Online-Ressource (XV, 584 Seiten) : , Illustrationen.

ISBN: 978-1-4899-7654-3

Additional Edition: Erscheint auch als Druck-Ausgabe, Hardcover ISBN 978-1-4899-7652-9

Additional Edition: Erscheint auch als Druck-Ausgabe, Paperback

Language: English

Subjects: Biology

DOI: 10.1007/978-1-4899-7654-3

URL: Volltext  (URL des Erstveröffentlichers)

URL: http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028962316&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA

URL: Volltext  (URL des Erstveröffentlichers)

URL: Abstract

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Format: 1 online resource (523 p.)

Edition: 2nd ed.

ISBN: 1-281-14479-7 , 9786611144791 , 0-08-055698-1

Content: This second edition updates the burgeoning field of regeneration in the Central Nervous System (CNS) from molecular, systems, and disease-based perspective. While the book covers numerous areas in detail, special emphasis is given to discussions of movement disorders such as Parkinson's disease, Alzheimer's disease, and spinal cord injury.* Incorporates information gained from cutting-edge photomicroscopy techniques* Includes current information on clinical trials* Presents chapters on stem cells and other novel treatments for diseases of the CNS

Note: Previous ed.: 1999. , Front Cover; CNS Regeneration; Copyright Page; Contents; Introduction; List of Contributors; Part I: Responses to Injury; Chapter 1. Intrinsic Determinants of Axon Regeneration; Introduction; Axon Regeneration in the PNS; Axon Regeneration in the CNS; Conclusions; Acknowledgements; References; Chapter 2. Axonal Responses to Injury; Communication of Injury Information by Retrograde; The Cell Body Response to Axonal Injury-Mobilizing Growth Programs; Axonal Regeneration-How Do Axons Re-grow?; Axonal Maintenance and Segment Fusion as an Alternative to Re-growth?; Summary; Acknowledgements , ReferencesChapter 3. Glial Cells, Inflammation, and CNS Trauma Modulation of the Inflammatory Environment After Injury Can Lead to Long-Distance Regeneration Beyond the Glial Scar; Introduction; Are Adult CNS Axons Capable of Robust Regeneration?; Do Glial Cells Contribute to CNS Regenerative Failure?; What Causes Astrocyte Gliosis and Increases in Inhibitory Molecules?; Triggers for Inhibitory Molecules; What is the Role of Inflammation in CNS Injury?; Can Glial Responses be Modified to Enhance Regeneration?; References; Part II: Stem Cells and Trophic Factors in CNS Repair , Chapter 4. Neurotrophic FactorsIntroduction; The Classic Neurotrophin Family; Neurotrophin Roles in the PNS; Neurotrophin Roles in the CNS; ""GDNF Family of Ligands"" Neurotrophic Factors; Other Members of the TGFB-superfamily; Summary of Growth Factor Effects and Potential Uses; Considerations and Future Directions; Acknowledgments; References; Chapter 5. Stem Cell Therapy for Brain Tumors; Neural Stem Cells; Exogenous and Endogenous NSCs Respond to Gliomas; Mechanisms for NSC Homing to Gliomas; Exploiting NSCs as Vehicles for Delivering Toxic Payloads; Horizon; References , Chapter 6. Stem Cell Therapies for Parkinson's DiseaseTransplanting Dopamine Neurons in Parkinson's Disease; Imaging and Current Treatment Options; Ex Vivo and In Vivo Stem Cells in PD; References; Chapter 7. Adult Neural Progenitor Cells in CNS Function and Disease; Introduction; Biology of Neural Stem Cells; Neurogenesis in the Adult Brain; Adult Neurogenesis and Disease; Conclusions; Acknowledgments; References; Chapter 8. Neurotrophic Factors in Alzheimer's Disease; Introduction; Rationale for Growth Factor Approaches; Preclinical Studies of Ex Vivo NGF Gene Therapy , Other Growth Factors for ADConclusions; Acknowledgements; References; Part III: Novel Therapies for Parkinson's and Huntington's Disease; Chapter 9. Direct Delivery of GDNF Into the Non-Human Primate and Human Parkinsonian Brain: Success and Road Blocks; Introduction; Effects of GDNF in Non-human Primates; Direct Brain Delivery of GDNF in Human Parkinsonian Subjects; Point Source Concentration of GDNF May Explain Failure of Phase-2 Clinical Trial; Concerns Over Two Safety Issues Derail all GDNF Trials; Future Directions; Summary; Acknowledgments; References , Chapter 10. Stimulating and Ablative Treatment for Parkinson's Disease , English

Additional Edition: ISBN 0-12-373994-2

Language: English

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Format: 1 online resource (713 p.)

ISBN: 1-281-05446-1 , 9786611054465 , 0-08-052921-6 , 1-4356-0517-9

Content: CNS Regeneration focuses on some of the leading current neurological disease models and methods for promoting central nervous system regeneration. Editors and authors are experts in the field, with experience in basic as well as applied neuroscience. In a comprehensive, logical manner, the book unites important basic science advances in neuroscience with novel medical strategies.Key Features* The first comprehensive, authoritative volume on the topic of CNS regeneration* Reviews current therapeutic approaches* Editors and authors are experts in the field* Appeals

Note: Description based upon print version of record. , Front Cover; CNS Regeneration: Basic Science and Clinical Advances; Copyright Page; Contents; Contributors; Introduction; PART I: CNS Responses to Injury; Chapter 1. Neuronal Responses to Axotomy; Chapter 2. Axonal Responses to Injury; Chapter 3. Beyond the Glial Scar; Chapter 4. Excitotoxins and Free Radicals; PART II: Promoting CNS Recovery; Chapter 5. Neurotrophic Factors; Chapter 6. Fetal Neuronal Grafting for CNS Regeneration; Chapter 7. The Use of Neural Progenitor Cells for Therapy in the CNS Disorders; Chapter 8. Neural Stem Cell Lines for CNS Repair , Chapter 9. Genetic Engineering for CNS RegenerationPART III: Promoting Recovery in Neurological Disease; Chapter 10. Introduction to Parkinson's and Huntington's Disease; Chapter 11. Grafts of Embryonic Dopamine Neurons in Rodent Models of Parkinson's Disease; Chapter 12. Fetal Grafts in Parkinson's Disease; Chapter 13. Immunobiology and Neuroscience of Xenotransplantation in Neurological Disease; Chapter 14. Restorative Surgical Therapies for Parkinson's Disease; Chapter 15. Functional Effects of GDNF in Normal and Parkinsonian Rats and Monkeys , Chapter 16. Genetic Engineering for Parkinson's DiseaseChapter 17. Fetal Neural Grafts for the Treatment of Huntington's Disease; Chapter 18. Cellular Delivery of Neurotrophic Factors as a Potential Treatment for Huntington's Disease; Chapter 19. Regenerative Strategies for Alzheimer's Disease; Chapter 20. Neurotrophic Factors, Gene Therapy, and Alzheimer's Disease; Chapter 21. Trophic Factors and Cell Adhesion Molecules Can Drive Dysfunctional Plasticity and Senile Plaque Formation in Alzheimer's Disease through a Breakdown in Spatial and Temporal Regulation , Chapter 22. Cholinergic Basal Forebrain Grafts in Rodent and Nonhuman Primate Models of Alzheimer's DiseaseChapter 23. Neurotrophic Factors, Encapsulated Cells, and ALS; Chapter 24. Spinal Cord Regeneration; Chapter 25. Neurotrophins and Neuroprotection Improve Axonal Regeneration into Schwann Cell Transplants Placed in Transected Adult Rat Spinal Cord; Chapter 26. Designing Clinical Trials for Neural Repair; Index; Color Plate Section , English

Additional Edition: ISBN 0-12-705070-1

Language: English

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Format: XVI, 678 S. : Ill., graph. Darst.

ISBN: 0-12-705070-1

Language: English

Subjects: Medicine

Keywords: Zentralnervensystem ; Krankheit ; Regeneration ; Nervenregeneration ; Aufsatzsammlung

URL: Inhaltsverzeichnis

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Format: xvi, 678 p., [16] p. of plates : , ill. (some col.)

Edition: Electronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries.

Language: English

Keywords: Electronic books.

URL: Click to View

UID:

Format: xv, 584 Seiten : , Illustrationen, Diagramme.

ISBN: 978-1-4899-7652-9

Additional Edition: Erscheint auch als Online-Ausgabe ISBN 978-1-4899-7654-3

Language: English

Subjects: Biology

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Edition: 2008

ISBN: 9780123739940 , 0123739942

Language: English

URL: Volltext