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  • 1
    In: Journal of the American Geriatrics Society, March 2014, Vol.62(3), pp.512-517
    Description: Byline: Eva Kiesswetter, Stefanie Pohlhausen, Katrin Uhlig, Rebecca Diekmann, Stephanie Lesser, Wolfgang Uter, Helmut Heseker, Peter Stehle, Cornel C. Sieber, Dorothee Volkert Keywords: Mini Nutritional Assessment; physical function; functional decline; mortality; home care Objectives To compare the prognostic value of the revised Mini Nutritional Assessment short form (MNA-SF) classification with that of the long form (MNA-LF) in relation to mortality and functional change in community-dwelling older adults receiving home care in Germany. Design Multicenter, 1-year prospective observational study. Setting Community. Participants Older adults (a[yen]65) receiving home care (n = 309). Measurements Nutritional status (well nourished, at risk of malnutrition, malnourished) was classified using the MNA-SF and MNA-LF at baseline. Functional status was determined according to the Barthel Index of activities of daily living (ADLs) at baseline and after 1 year. Hazard ratios (HRs) and 95% confidence intervals (CIs) of mortality were calculated for MNA-SF and MNA-LF categories using stepwise Cox regression analyses. Repeated-measurements analysis of covariance was used to examine changes in ADL scores over time for MNA-SF and MNA-LF categories. Results MNA-SF classified 15% of the sample as malnourished and 41% as being at risk of malnutrition, whereas the MNA-LF classified 14% and 58%, respectively. During the follow-up year, 15% of participants died. The estimated hazard ratios (HR) for 1-year mortality were lower for MNA-SF than for MNA-LF categories (at risk of malnutrition: HR = 2.21, 95% confidence interval (CI) = 1.02-4.75 vs HR = 5.05, 95% CI = 1.53-16.58; malnourished: HR = 3.27, 95% CI = 1.34-8.02 vs HR = 8.75, 95% CI = 2.45-31.18). For MNA-SF categories, no differences in functional change were found. According to the MNA-LF, ADL decline tended to be greater in those at risk of malnutrition (7.1 [+ or -] 10.1 points) than in those who were well nourished (3.7 [+ or -] 10.1 points) and malnourished (4.9 [+ or -] 10.1 points). Conclusion In this sample of older adults receiving home care, the MNA-LF was superior to the MNA-SF in predicting mortality and differentiating functional decline during 1 year of follow-up. Supporting information: Additional Supporting Information may be found in the online version of this article CAPTION(S): Figure S1. One-year mortality of home cared older adults stratified according to the Mini Nutritional Assessment (a) short form and (b) long form (Kaplan-Meier-curve; results of both log rank tests P .001; MN = malnutrition). Figure S2. Means and standard errors of activity of daily living scores (range 0-100 points) at baseline (t1) and 1-year follow-up (t2) categorized according to Mini Nutritional Assessment (a) short form and (b) long form and adjusted for age. MN = malnutrition.
    Keywords: Mini Nutritional Assessment ; Physical Function ; Functional Decline ; Mortality ; Home Care
    ISSN: 0002-8614
    E-ISSN: 1532-5415
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  • 2
    Language: English
    In: Journal of Chromatography A, 2011, Vol.1218(33), pp.5688-5693
    Description: The congener profile of samples contaminated with dioxin and dioxin-like compounds allows identifying sources of contamination. This article studies the statistical methods of congener profile analysis reported in the literature with respect to the reliability of obtained results. The performance of customary analysis methods regarding raw data transformation and applied TEF (toxic equivalency factor) values is discussed. In particular, the method of principal component analysis and -means cluster is taken as an example and examined in detail. Reasons for occurring inconsistencies such as the dependence of results on raw data transformation and the disregard of measurement uncertainty are described, and it is shown that they also explain inconsistencies in other methods of cluster analysis such as hierarchical cluster analysis and neural networks. It is concluded that these methods cannot be employed to reach court-proof decisions, i.e. decisions which meet court evidentiary standards. An alternative approach to analyzing congener profiles based on mathematical statistics is briefly presented, allowing reliable, court-proof decisions.
    Keywords: Dioxin and Dioxin-Like Compounds ; Congener Profiles ; Clustering Algorithm ; Principle Component Analysis ; Court-Proof ; Validity ; Chemistry
    ISSN: 0021-9673
    E-ISSN: 18733778
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  • 3
    Language: English
    In: Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, November 2018, Vol.45(6), pp.413-422
    Description: During storage of red blood cell (RBC) concentrates, the plasticizer di-2-ethylhexylphthalate (DEHP) that keeps the blood bags soft leaches out and can be taken up by the RBCs. DEHP is known to be beneficial for the RBC storage quality, but the molecular mechanisms of the action are unknown. Aqueous suspensions of DEHP were added to RBCs in buffer. The morphological effects were observed on RBCs from 5 donors. Flow cytometry with annexin A5 binding was used to measure the exposed phosphatidylserine. DEHP induced the formation of stomatocytes at concentrations as low as ng/ml, provided that the cell suspension was also sufficiently dilute. Some spherocytes, which were susceptible to lysis, were also formed; after lysis, RBC ghosts were seen to continue the transition to the cup-shaped stomatocyte form. Incubation with DEHP increased the exposed phosphatidylserine, an effect that was also observed in the presence of vanadate, which inhibits the ATP-dependent translocases that maintain the membrane's lipid asymmetry. DEHP can have an active effect on RBC shape, instead of just preventing the storage-related shape changes. The effect appears to be mediated by increased flip-flop of lipids between the leaflets of the RBC membrane.
    Keywords: Di-Ethylhexylphthalate ; Erythrocytes ; Lipid Bilayers ; Plasticizer ; Storage
    ISSN: 1660-3796
    E-ISSN: 16603818
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  • 4
    Language: English
    In: Platelets, 02 January 2016, Vol.27(1), pp.43-50
    Description: In our previous investigations we have shown that platelets and their precursors express nicotinic α7 acetylcholine receptors (nAChRα7) that are involved in platelet function and in vitro differentiation of the megakaryoblastic cell line MEG-01. In this study, we were interested in the expression...
    Keywords: Megakaryocytic Differentiation ; Nicotine ; Nicotinic Acetylcholine Receptors ; Anatomy & Physiology
    ISSN: 0953-7104
    E-ISSN: 1369-1635
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  • 5
    Language: English
    In: Nature medicine, August 2018, Vol.24(8), pp.1192-1203
    Description: The oncometabolite (R)-2-hydroxyglutarate (R-2-HG) produced by isocitrate dehydrogenase (IDH) mutations promotes gliomagenesis via DNA and histone methylation. Here, we identify an additional activity of R-2-HG: tumor cell-derived R-2-HG is taken up by T cells where it induces a perturbation of nuclear factor of activated T cells transcriptional activity and polyamine biosynthesis, resulting in suppression of T cell activity. IDH1-mutant gliomas display reduced T cell abundance and altered calcium signaling. Antitumor immunity to experimental syngeneic IDH1-mutant tumors induced by IDH1-specific vaccine or checkpoint inhibition is improved by inhibition of the neomorphic enzymatic function of mutant IDH1. These data attribute a novel, non-tumor cell-autonomous role to an oncometabolite in shaping the tumor immune microenvironment.
    Keywords: Immunity ; Glutarates -- Metabolism ; T-Lymphocytes -- Immunology
    ISSN: 10788956
    E-ISSN: 1546-170X
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  • 6
    Language: English
    In: Journal of neuroinflammation, 21 November 2019, Vol.16(1), pp.232
    Description: Echovirus 30 (E-30) is one of the most frequently isolated pathogens in aseptic meningitis worldwide. To gain access to the central nervous system (CNS), E-30 and immune cells have to cross one of the two main barriers of the CNS, the epithelial blood-cerebrospinal fluid barrier (BCSFB) or the endothelial... In this study we investigated the migration of different T cell subpopulations, naive and effector T cells, through HIBCPP cells during E-30 infection. Effects of E-30 infection and the migration process were evaluated via immunofluorescence and flow cytometry analysis, as well as transepithelial resistance... Th1 effector cells and enterovirus-specific effector T cells migrated through HIBCPP cells more efficiently than naive CD4 T cells following E-30 infection of HIBCPP cells. Among the different naive T cell populations, CD8 T cells crossed the E-30-infected HIBCPP cell layer in a significantly higher... Taken together these results suggest that naive CD8 and Th1 effector cells are highly efficient to migrate through the BCSFB in an inflammatory environment. The T cell phenotype is modified during the migration process through HIBCPP cells.
    Keywords: Blood–Cerebrospinal Fluid Barrier ; Effector T Cells ; Enterovirus ; Meningitis ; Naive T Cells ; T Cell Migration
    E-ISSN: 1742-2094
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 7
    Language: English
    In: Critical care (London, England), 09 January 2014, Vol.18(1), pp.R10
    Description: In patients with acute respiratory distress syndrome (ARDS) fluid therapy might be necessary. The aim of this systematic review and meta-analysis is to determine the effects of colloid therapy compared to crystalloids on mortality and oxygenation in adults with ARDS. Randomized controlled trials (RCTs) were identified through a systematic literature search of MEDLINE, EMBASE, CENTRAL and LILACS. Articles published up to 15th February 2013 were independently screened, abstracted, and assessed (Cochrane Risk of Bias Tool) to provide evidence-based therapy recommendations. RCTs were eligible if they compared colloid versus crystalloid therapy on lung function, inflammation, damage or mortality in adults with ARDS. Primary outcome parameters were respiratory mechanics, gas exchange lung inflammation and damage as well as hospital mortality. Kidney function, need for renal replacement therapy, hemodynamic stabilization and intensive care unit (ICU) length of stay served as secondary outcomes. A total of 3 RCTs out of 4130 potential trials found in the databases were selected for qualitative and quantitative analysis totaling 206 patients who received either albumin or saline. Overall risk of bias was unclear to high in the identified trials. Calculated pooled risk of death was not statistically significant (albumin 34 of 100 (34.0%) versus 40 of 104 (38.5%), relative risk (RR) = 0.89, 95% confidence interval (CI) 0.62 to 1.28, P = 0.539). Weighted mean difference (WMD) in PaO2/FiO2 (mmHg) improved in the first 48 hours (WMD = 62, 95% CI 47 to 77, P 〈0.001, I2 = 0%) after therapy start and remained stable after 7 days (WMD = 20, 95% CI 4 to 36, P = 0.017, I2 = 0%). There is a high need for RCTs investigating the effects of colloids in ARDS patients. Based on the findings of this review, colloid therapy with albumin improved oxygenation but did not affect mortality.
    Keywords: Albumins -- Administration & Dosage ; Colloids -- Administration & Dosage ; Fluid Therapy -- Methods ; Isotonic Solutions -- Administration & Dosage ; Respiratory Distress Syndrome, Adult -- Therapy
    ISSN: 13648535
    E-ISSN: 1466-609X
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  • 8
    Language: English
    In: Journal of AOAC International, 2013, Vol.96(2), pp.466-70
    Description: Precision data, such as laboratory-to-laboratory SD (SL) and repeatability SD, obtained from interlaboratory tests are needed to assess analytical test methods. These precision data describing random error are subject to random variation. In order to avoid distorted assessments of test methods, interlaboratory tests must fulfill minimal requirements for achieving, e.g., a desired reliability in S(L). In 2009, McClure and Lee considered reliability of S(L) as a characteristic of an interlaboratory study. They developed an approach to approximate that reliability to make it possible to adapt the study design of an interlaboratory study to a desired reliability in S(L). The McClure and Lee approach introduces the "margin of relative error" to arrive at the magnitude of the uncertainty in S(L). This article discusses their approach and presents a generalized approach. The limitations of McClure and Lee's approximation are shown to result in underestimation of the actual variability of S(L) due to the disregard of the inherent negative bias of S(L). This bias corresponds to the fact that the expected value of the obtained S(L) lies below the true value sigmaL one would obtain in an interlaboratory study with an infinite number of laboratories and replicates. In order to achieve the reported level of reliability in S(L), the actual number of laboratories required is typically approximately 25% higher than that calculated by McClure and Lee. We present a generalized approach using "margins of relative random error," which takes the impact of the bias of the S(L) into account, resulting in a more realistic estimation of the variability of the precision parameter S(L).
    Keywords: Observer Variation ; Laboratories -- Standards
    ISSN: 1060-3271
    E-ISSN: 19447922
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  • 9
    Language: English
    In: Langmuir : the ACS journal of surfaces and colloids, 02 March 2010, Vol.26(5), pp.3462-7
    Description: Thermoresponsive polymer-coated surfaces based on poly(2-(2-methoxyethoxy)ethyl methacrylate-co-oligo(ethylene glycol) methacrylate) [P(MEO(2)MA-co-OEGMA)] allow switching between cell attachment and detachment. Here, we investigate the temperature-dependent surface interactions between the polymer coating and a colloidal probe in an aqueous medium by means of atomic force microscopy (AFM) force-distance measurements. The analysis of the adhesion forces from AFM retraction curves identifies two kinds of regimes for the copolymer at temperatures below and above the lower critical solution temperature (LCST). Whereas at 25 degrees C the surface interactions with the polymer in the swollen state are dominated by repulsive forces, at 37 degrees C the surface interactions switch to attractive forces and a stronger adhesion is detected by AFM. Running several heating/cooling cycles repeatedly shows that switching the surface properties provides reproducible adhesion force values. Time-dependent measurements give insight into the switching kinetics, demonstrating that the cell response is coupled to the polymer kinetics but probably limited by the cellular rearrangements.
    Keywords: Microscopy, Atomic Force ; Temperature ; Biocompatible Materials -- Chemistry ; Methacrylates -- Chemistry ; Polyethylene Glycols -- Chemistry
    ISSN: 07437463
    E-ISSN: 1520-5827
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  • 10
    Language: English
    In: Microsystem Technologies, 2015, Vol.21(6), pp.1363-1369
    Description: For printing the front side metallization of solar cells using the non-contact aerosol printer different silver inks with different rheological properties and silver components were tested. Both atomization methods of the aerosol printer are introduced and the optimized printing parameters are discussed. With the most suitable inks and printing parameters it was possible to achieve high aspect ratios within 2:1 up to 4:1 with small lateral resolutions. A particle-free ink and several particle-containing inks for example diluted screen printing pastes were tested as aerosol ink to evaluate the most feasible ink. According to these results it was possible to assess the most important properties for aerosol inks, which are necessary to obtain a good printability and well defined printed structures. High aspect ratios (AR) of 2:1 were achieved by aerosol printing with the pneumatic atomizer for the front side metallization grid of solar cells and efficiencies of 14–17 % were achieved.
    Keywords: Printing Inks;
    ISSN: 0946-7076
    E-ISSN: 1432-1858
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