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  • 1
    Online Resource
    Online Resource
    Basel, Switzerland : MDPI - Multidisciplinary Digital Publishing Institute
    UID:
    gbv_1794561633
    Format: 1 Online-Ressource (224 p.)
    ISBN: 9783036512624 , 9783036512631
    Content: This book is an embodiment of a series of articles that were published as part of a Special Issue of Biomolecules. It is dedicated to exploring the role of intrinsically disordered proteins (IDPs) in various chronic diseases. The main goal of the articles is to describe recent progress in elucidating the mechanisms by which IDPs cause various human diseases, such as cancer, cardiovascular disease, amyloidosis, neurodegenerative diseases, diabetes, and genetic diseases, to name a few. Contributed by leading investigators in the field, this compendium serves as a valuable resource for researchers, clinicians as well as postdoctoral fellows and graduate students
    Note: English
    Language: English
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  • 2
    Online Resource
    Online Resource
    New York, NY : Springer
    UID:
    gbv_1652497633
    Format: Online-Ressource (LVII, 2574 p. 1108 illus., 777 illus. in color. eReference, digital)
    ISBN: 9781461415336
    Series Statement: SpringerLink
    Content: In biochemistry, a metalloprotein is a generic term for a protein that contains a metal cofactor. The metal may be an isolated ion or may be coordinated with a nonprotein organic compound, such as the porphyrin found in hemoproteins. In some cases, the metal is co-coordinated with a side chain of the protein and an inorganic nonmetallic ion. This kind of protein-metal-nonmetal structure is seen in iron-sulfur clusters Metalloproteins deals with all aspects related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The biological roles of metal cations and metal-binding proteins are endless. They are involved in all crucial cellular activities. Many pathological conditions are related to the problematic metal metabolism. Research in metalloprotein-related topics is therefore rapidly growing, and different aspects of metal-binding proteins progressively enter curricula at Universities and even at the High School level on occasion. However, no key resource providing basic, but comprehensible knowledge on this rapidly expanding field exists. The Encyclopedia of Metalloproteins aims to bridge this gap, and will attempt to cover various aspects of metalloprotein/metalloproteomics and will deal with the different issues related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The goal is to cover exhaustively all catalytically and biologically crucial metal ions and to find at least one interacting protein for other metal ions. The Encyclopedia of Metalloproteins will provide a key resource for advanced undergraduate and graduate students, researchers, instructors, and professors interested in protein science, biochemistry, cell biology, and genetics
    Additional Edition: ISBN 9781461415329
    Additional Edition: Druckausg. ISBN 978-1-461-41532-9
    Language: English
    Keywords: Proteom ; Biopolymere
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  • 3
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    UID:
    gbv_1659044448
    Format: Online-Ressource (XV, 61 p. 13 illus., 10 illus. in color, online resource)
    ISBN: 9783319089218
    Series Statement: SpringerBriefs in Molecular Science
    Content: In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas
    Note: Description based upon print version of record , Introducing the phenomenon of protein intrinsic disorderPeculiar amino acid sequences of soluble IDPs -- Natural abundance of IDPs/IDPRs -- Wavy evolution of intrinsic disorder: Reinventing the wheel -- Structural heterogeneity of IDPs: When almost everything is possible -- Typical functions of IDPs and IDPRs -- Binding promiscuity and multitude of the disorder-based binding modes -- IDPs/IDPRs in human diseases -- IDPs as potential drug targets -- Concluding remarks: Intrinsic disorder as a universal tool for solving protein mysteries and riddles.
    Additional Edition: ISBN 9783319089201
    Additional Edition: Druckausg. Uverskij, Vladimir N. Intrinsically disordered proteins Cham : Springer, 2014 ISBN 9783319089201
    Language: English
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 4
    Book
    Book
    Hoboken [u.a.] : Wiley
    UID:
    b3kat_BV039871921
    Format: XXI, 494 S. , Ill., graph. Darst.
    ISBN: 9780470618318 , 0470618310
    Series Statement: Wiley series in protein and peptide science
    Language: English
    Subjects: Biology
    RVK:
    RVK:
    Keywords: Viren ; Proteine
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  • 5
    Book
    Book
    Amsterdam [u.a.] : Elsevier, Academic Press
    UID:
    b3kat_BV042142322
    Format: XIX, 526 S. , Ill., graph. Darst.
    ISBN: 9780123944313
    Language: English
    Subjects: Biology
    RVK:
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  • 6
    Book
    Book
    Cham [u.a.] : Springer
    UID:
    b3kat_BV042067901
    Format: XV, 61 S. , Ill., graph. Darst.
    ISBN: 9783319089201
    Series Statement: SpringerBriefs in molecular science: Protein folding and structure
    Language: English
    Subjects: Biology
    RVK:
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  • 7
    UID:
    b3kat_BV036111285
    Format: XXiX, 744 S. , Ill., graph. Darst.
    ISBN: 978-0-470-34341-8
    Series Statement: Wiley series on protein and peptide science
    Language: English
    Subjects: Biology
    RVK:
    RVK:
    Keywords: Unfolded Proteins ; Biochemische Analyse ; Aufsatzsammlung
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  • 8
    Book
    Book
    New York, NY : Nova Biomedical Books
    UID:
    gbv_515844632
    Format: VI, 372 S. , graph. Darst.
    ISBN: 1600214045 , 9781600214042
    Series Statement: Methods in protein structure and stability analysis / Vladimir N. Uversky ..., ed. Pt. A
    Note: Literaturangaben
    Language: English
    Keywords: Lumineszenzspektroskopie ; Fluoreszenzspektroskopie ; Zirkulardichroismus
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  • 9
    UID:
    gbv_529604620
    Format: XXV, 537 S. , Ill., graph. Darst.
    ISBN: 038736529X , 0387365346 , 9780387365299 , 9780387365343
    Series Statement: Protein misfolding, aggregation and conformational diseases / ed. by Vladimir N. Uversky; Anthony L. Fink Part B
    Note: Literaturangaben
    Language: English
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  • 10
    UID:
    b3kat_BV040130555
    Format: XIV, 511 S. , Ill., graph. Darst.
    ISBN: 9781617799266
    Series Statement: Methods in molecular biology 895
    In: 1
    Language: German
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