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  • 1
    Language: English
    In: Pediatric Allergy and Immunology, Dec, 2010, Vol.21(8), p.1146(5)
    Description: To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1399-3038.2010.01015.x Byline: Ivy Y. Z. Wong, S. E. Soh, Seo Y. Chng, Lynette P.-C. Shek, Daniel Y. T. Goh, Hugo P. S. Van Bever, B. W. Lee Keywords: rhinitis; topical nasal medication; children; acceptance Abstract: Wong IYZ, Soh SE, Chng SY, Shek LP-C, Goh DYT, Van Bever HPS, Lee BW. Compliance with topical nasal medication - An evaluation in children with rhinitis.Pediatr Allergy Immunol 2010: 21: 1146-1150.[c] 2010 John Wiley & Sons A/S It is our impression that children with rhinitis often dislike or struggle with the administration of topical nasal sprays and drops. This study aims to investigate children's acceptance of topical nasal sprays/drops, and to identify patient factors that may affect their acceptance. An interview (by WYZI) questionnaire survey was carried out on parents/guardians of children aged 1-15 with rhinitis, where information on the diagnosis and treatment, patients' use and responses to these medications, and their preferred treatment routes were collected. Two hundred questionnaires were completed, of which 194 were valid for analysis. The mean age of patients was 7.54 yr; male to female ratio was 1:1.6, and Chinese made up the majority (62.4%). About one quarter (24.7%) of children disliked the use of topical nasal sprays/drops sufficiently to affect compliance with the medication. Furthermore, of those who could indicate their preferred route of drug administration (n = 75), 73% indicated a preference for oral medication, while only 11% preferred the nasal route. Topical nasal sprays/drops were more acceptable in older children (7-15 yr) compared to the younger ones (1-6 yr) (OR = 2.383, CI 1.223-4.644). The acceptance of nasal sprays/drops was not associated with gender, ethnic group, concurrent use by other family members, length and amount of usage, and the response to therapy. A substantial proportion of children prescribed topical nasal sprays/drops did not find it acceptable. Age played a significant factor to the acceptance of the use of topical nasal sprays/drops. Article History: Accepted 6 February 2010 Article note: Dr Bee W. Lee, Department of Paediatrics, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074, Tel.: +65 6772 4420, Fax: +65 6779 7486, E-mail: paeleebw@nus.edu.sg
    Keywords: Drugs -- Analysis ; Patient Compliance -- Analysis ; Pediatric Pharmacology -- Analysis ; Children -- Analysis ; Nasal Sprays -- Analysis ; Rhinitis -- Analysis
    ISSN: 0905-6157
    E-ISSN: 13993038
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  • 2
    Language: English
    In: The Journal of Allergy and Clinical Immunology, April 2015, Vol.135(4), pp.1061-1063.e4
    Description: References1 Respir Med 103 2009 895 901 Co-morbid association of depression and COPD: a population-based study Ng T.P. Niti M. Fones C. Yap K.B. Tan W.C. 2 J Allergy Clin Immunol 113 2004 59 65 Development of the asthma control test: a survey for assessing asthma control Nathan R.A. Sorkness C.A. Kosinski M. Schatz M. Li J.T. Marcus P. 3 Respirology 16 2011 688 697 Relationship between asthma control status, the Asthma Control Test and urgent health-care utilization in Asia Lai C.K. Ko F.W. Bhome A. De Guia T.S. Wong G.W. Zainudin B.M. 4 Thorax 47 1992 76 83 Evaluation of impairment of health related quality of life in asthma: development of a questionnaire for use in clinical trials Juniper E.F. Guyatt G.H. Epstein R.S. Ferrie P.J. Jaeschke R. Hiller T.K. 5 Am Rev Respir Dis 147 1993 832 838 Measuring quality of life in asthma Juniper E.F. Guyatt G.H. Ferrie P.J. Griffith L.E. 6 Am J Epidemiol 160 2004 34 45 Imputations of missing values in practice: results from imputations of serum cholesterol in 28 cohort studies Barzi F. Woodward M. 7 J Psychosom Res 11 1967 213 218 The Social Readjustment Rating Scale Holmes T.H. Rahe R.H. 8 J Eur Acad Dermatol Venereol 18 2004 560 565 Stressful major life events are associated with a higher frequency of cutaneous sensory symptoms: an empirical study of non-clinical subjects Gupta M.A. Gupta A.K. 9 J Health Soc Behav 24 1983 385 396 A global measure of perceived stress Cohen S. Kamarck T. Mermelstein R. 10 Oskamp S.S.S. 1988 Sage Publications Thousand Oaks (CA) The social psychology of health 31 67 Perceived stress in a probability sample of the United States Cohen S. 11 Acta Psychiatr Scand 67 1983 361 370 The hospital anxiety and depression scale Zigmond A.S. Snaith R.P. 12 Health Qual Life Outcomes 3 2005 82 Assessment of the structure of the Hospital Anxiety and Depression Scale in musculoskeletal patients Pallant J.F. Bailey C.M. 13 Health Qual Life Outcomes 7 2009 42 Factor structure of the Hospital Anxiety and Depression Scale in Japanese psychiatric outpatient and student populations Matsudaira T. Igarashi H. Kikuchi H. Kano R. Mitoma H. Ohuchi K. 14 1992 Psychological Assessment Resources Odessa (FL) Revised NEO Personality Inventory and NEO Five-Factor Inventory: Professional manual Costa P.T. MaCrae R.R. 15 J Res Personality 35 2001 353 374 The relationship between coping and personality among police officers in Singapore Bishop G.D. Tong E.M.W. Diong S.M. Enkelmann H.C. Why Y.P. Khader M. 16 J Allergy Clin Immunol 125 2010 116 122 Lower cortisol levels in children with asthma exposed to recurrent maternal distress from birth Dreger L.C. Kozyrskyj A.L. HayGlass K.T. Becker A.B. MacNeil B.J. 17 J Gen Intern Med 21 2006 267 275 Mortality prediction with a single general self-rated health question. A meta-analysis DeSalvo K.B. Bloser N. Reynolds K. He J. Muntner P. 18 Pediatrics 130 2012 e1512 e1519 Hypothalamic-pituitary-adrenal axis suppression in asthmatic school children Zollner E.W. Lombard C.J. Galal U. Hough F.S. Irusen E.M. Weinberg E.
    Keywords: Medicine
    ISSN: 0091-6749
    E-ISSN: 1097-6825
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  • 3
    Language: English
    In: The Journal of Allergy and Clinical Immunology, July 2018, Vol.142(1), pp.86-95
    Description: Dynamic establishment of the nasal microbiota in early life influences local mucosal immune responses and susceptibility to childhood respiratory disorders. The aim of this case-control study was to monitor, evaluate, and compare development of the nasal microbiota of infants with rhinitis and wheeze in the first 18 months of life with those of healthy control subjects. Anterior nasal swabs of 122 subjects belonging to the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) birth cohort were collected longitudinally over 7 time points in the first 18 months of life. Nasal microbiota signatures were analyzed by using 16S rRNA multiplexed pair-end sequencing from 3 clinical groups: (1) patients with rhinitis alone (n = 28), (2) patients with rhinitis with concomitant wheeze (n = 34), and (3) healthy control subjects (n = 60). Maturation of the nasal microbiome followed distinctive patterns in infants from both rhinitis groups compared with control subjects. Bacterial diversity increased over the period of 18 months of life in control infants, whereas infants with rhinitis showed a decreasing trend (  〈 .05). An increase in abundance of the Oxalobacteraceae family (Proteobacteria phylum) and Aerococcaceae family (Firmicutes phylum) was associated with rhinitis and concomitant wheeze (adjusted  〈 .01), whereas the Corynebacteriaceae family (Actinobacteria phylum) and early colonization with the Staphylococcaceae family (Firmicutes phylum; 3 weeks until 9 months) were associated with control subjects (adjusted  〈 .05). The only difference between the rhinitis and control groups was a reduced abundance of the Corynebacteriaceae family (adjusted  〈 .05). Determinants of nasal microbiota succession included sex, mode of delivery, presence of siblings, and infant care attendance. Our results support the hypothesis that the nasal microbiome is involved in development of early-onset rhinitis and wheeze in infants.
    Keywords: Rhinitis ; Wheeze ; Eczema ; Infant ; Cesarean Section ; Nasal Microbiota ; 16s Rrna Gene ; Aerococcaceae ; Corynebacteriaceae ; Oxalobacteraceae ; Staphylococcaceae ; Moraxellaceae ; Medicine
    ISSN: 0091-6749
    E-ISSN: 1097-6825
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  • 4
    Language: English
    In: The Journal of Allergy and Clinical Immunology, February 2018, Vol.141(2), pp.AB131-AB131
    Description: Rationale Short chain fatty acids (SCFAs) are intermediate and end products of metabolism of dietary fibre by intestinal commensal bacteria, and regulate the host’s immune function. Longitudinal multivariate analysis was employed to study the dynamic trends of SCFAs, while adjusted for possible confounders...
    Keywords: Medicine
    ISSN: 0091-6749
    E-ISSN: 1097-6825
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  • 5
    Language: English
    In: Journal of Adolescent Health, August 2014, Vol.55(2), pp.267-275
    Description: Psychiatric comorbidity is reported to be common among adolescents with asthma, but little is known about its underlying psychological factors. This study explored the profile of anxiety and depressive comorbidities among adolescents with well-controlled and poorly controlled asthma and the contribution of neuroticism and perceived stress. The Revised Child Anxiety and Depression Scale, Neuroticism subscale of Big Five Inventory, Perceived Stress Scale, and Asthma Control Test were administered to 198 adolescents (aged 12–19 years) with well-controlled (n = 137) and poorly controlled asthma (n = 61) as well as 171 healthy neighborhood controls. Adolescents with poorly controlled asthma, compared with well-controlled asthma patients and healthy controls, had higher scores of depression (  = .006), panic attacks (  = .002), total anxiety (  = .038), and total internalizing symptoms (  = .017), after adjusting for gender, age, ethnicity, smoking status, and family housing type. Adolescents with asthma had higher neuroticism (  = .025), perceived stress (  = .022), and body mass index (  = .006) and lower self-rated health ( 〈 .001) than healthy controls. No significant differences in psychiatric comorbidity scores were observed after accounting for differences in underlying psychological and physical factors. Among asthma patients, increased asthma control was associated with decreased scores of psychiatric comorbidity ( 〈 .01), but the association was not significant after allowing for decreased neuroticism and perceived stress. The diagnosis of asthma and poor asthma control in adolescents is associated with excess psychiatric comorbidity, which is likely due to increased neuroticism and perceived stress.
    Keywords: Asthma Control ; Psychiatric Comorbidity ; Risk Factors ; Perceived Stress ; Neuroticism ; Adolescent ; Medicine ; Social Welfare & Social Work
    ISSN: 1054-139X
    E-ISSN: 1879-1972
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  • 6
    Language: English
    In: Neuropeptides, October 2016, Vol.59, pp.117-121
    Description: Neuropeptide Y, a widely circulating neurotransmitter, plays a pivotal role in energy balance, immunomodulation and asthma, and several NPY polymorphisms are promising genetic risk factors for asthma and obesity. We explored the associations of candidate NPY gene polymorphisms with prevalent asthma and its relationship with obesity in young adult asthma patients free of other chronic medical morbidity. Five common gene variants of NPY (rs16147 (− 399T/C), rs17149106 (− 602G/T), rs16140 (+ 1000C/G), rs5573 (+ 1201A/G), rs5574 (+ 5327C/T)) previously validated to account for most of the NPY expression in vitro and in vivo were investigated in 126 physician-diagnosed asthma patients without other chronic medical morbidity and 182 healthy controls (21–35 years). Plasma levels of NPY, adiponectin, and CRP were determined using ELISA, and IL-6 was measured by Luminex in a subgroup of 70 patients and 69 age- and sex-matched healthy controls. In logistic regression models controlling for gender and obesity, the CT genotype of rs5574 (OR = 0.54, 95%CI: 0.30–0.89) and the GT genotype of rs17149106 (OR = 5.58, 95%CI: 1.09–28.54) were significantly associated with asthma. No significant interaction between NPY SNP polymorphisms and obesity were detected. Plasma NPY level was correlated with adiponectin levels ( 〈 0.05). Compared with the healthy controls, patients with asthma had higher BMI ( 〈 0.001), adiponectin ( 〈 0.05), IL-6 ( = 0.001) and CRP ( 〈 0.001), and lower NPY levels ( 〈 0.01). The CT genotype of rs5574 and the GT genotype of rs17149106 are significantly associated with prevalent asthma.
    Keywords: Neuropeptide Y Polymorphism ; Adiposity ; Asthma Control ; Chemistry ; Anatomy & Physiology
    ISSN: 0143-4179
    E-ISSN: 1532-2785
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  • 7
    Language: English
    In: The Journal of Allergy and Clinical Immunology: In Practice, March 2018, Vol.6(2), pp.466-475.e1
    Description: There is mounting evidence that early introduction of allergenic food decreases the risk of food allergy development, especially in high-risk infants with eczema. However, there is a lack of data to suggest whether this association holds true in Asian populations. To investigate the relationship between the timing of introduction of allergenic foods and food allergy outcomes in infants in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) study. The GUSTO cohort recruited 1152 mothers of Chinese, Malay, and Indian ethnicity who had singleton, naturally conceived pregnancies and followed their offspring prospectively. Information on demographic characteristics, child health, infant feeding practices, and a convincing history of IgE-mediated food allergy was obtained from interviewer-administered questionnaires at multiple time points. Corroborative skin prick tests to food allergens were performed at 18 and 36 months. Most of the infants were introduced to egg (49.6%), peanut (88.7%), and shellfish (90.2%) after age 10 months. Food allergy prevalence was, however, very low between age 12 and 48 months: egg, 0.35% to 1.8%; peanut allergy, 0.1% to 0.3%; and shellfish, 0.2% to 0.9%. There were no significant associations between the timing of introduction of allergenic foods and the development of food allergy, adjusted for confounders including breast-feeding and eczema. Food allergy rates in Singapore are low despite delayed introduction of allergenic foods. Early introduction of allergenic foods may thus not be necessary in populations in which overall food allergy prevalence is low, and thus infant feeding recommendations should be carefully tailored to individual populations.
    Keywords: Food Allergy ; Allergy Prevention ; Solids Introduction ; Allergenic Food Introduction ; Complementary Feeding ; Egg ; Milk ; Peanut ; Medicine
    ISSN: 2213-2198
    E-ISSN: 2213-2201
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  • 8
    Language: English
    In: Pediatric Allergy and Immunology, Feb, 2012, Vol.23(1), p.5(6)
    Description: To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1399-3038.2011.01245.x Byline: Hugo P. S. Van Bever, Bee Wah Lee, Lynette Shek Keywords: allergy; pediatrics; asthma; eczema; rhinitis; viewpoint Abstract: To cite this article: Van Bever HPS, Lee BW, Shek L. Viewpoint: The future of research in pediatric allergy: What should the focus be? Pediatric Allergy Immunology 2012: 23: 5-10. Abstract Allergic diseases have been increasing during the last three decades, and exact reasons for this are still debated. Despite intense ongoing research, a lot of aspects of allergic diseases are still poorly understood, resulting in limitations in current therapeutic approach to allergies. In this viewpoint, important unanswered research questions are raised mainly on novel therapeutic approaches to allergic children, and suggestions for future research are raised. Three aspects of pediatric allergy are distinguished: the prevention, control, and cure. Article History: Accepted for publication 21 October 2011 Article note: Professor Hugo Van Bever, Department of Paediatrics, NUHS Tower Block Level 12, 1E, Kent Ridge Road, 119288 Singapore, Singapore. , Tel.: +65 6772 4417 , Fax: +65 6779 7486 , E-mail: hugo_van_bever@nuhs.edu.sg
    Keywords: Pediatrics ; Pediatric Allergy
    ISSN: 0905-6157
    E-ISSN: 13993038
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