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  • 1
    Language: English
    In: Virchows Archiv, 2011, Vol.459(2), pp.221-226
    Description: Carcinoma showing thymus-like elements (CASTLE) is a rare neoplasm of the thyroid gland resembling lymphoepithelioma-like and squamous cell carcinoma of the thymus and is thought to arise from ectopic thymic tissue within the thyroid gland or rudimentary branchial pouches along the thymic line. Using comparative genomic hybridization (CGH), chromosomal imbalances have been detected in several types of thymomas and thymic carcinomas. To evaluate whether there are hints of an underlying sequence in the pathogenesis of CASTLE analogue to those found in thymomas and thymic carcinomas, we evaluated four of these rare neoplasms for chromosomal imbalances using CGH. The most frequent gains were seen on chromosomal arm 1q (3/4), and losses were most frequently detected on 6p (4/4), 6q (3/4) and 16q (3/4). These CGH data show that CASTLE is characterized by chromosomal imbalances similar to those found in thymomas and thymic carcinomas and indicate a similar sequence in tumour development.
    Keywords: CASTLE ; Carcinoma showing thymus-like elements ; Chromosomal imbalances ; CGH
    ISSN: 0945-6317
    E-ISSN: 1432-2307
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  • 2
    Language: English
    In: Gastroenterology, April 2016, Vol.150(4), pp.S958-S958
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0016-5085(16)33236-X Byline: Lothar Veits, Andreas Poetzl, Johannes Schumacher, Nils Kosiol, Jessica Becker, Ines Gockel, Ralf J. Rieker, Michael Vieth
    Keywords: Medicine
    ISSN: 0016-5085
    E-ISSN: 1528-0012
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  • 3
    Language: English
    In: Gastroenterology, May 2013, Vol.144(5), pp.S-499-S-499
    Keywords: Medicine
    ISSN: 0016-5085
    E-ISSN: 1528-0012
    Source: ScienceDirect Journals (Elsevier)
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  • 4
    Language: English
    In: Australasian Medical Journal, 01 July 2017, Vol.10(7), pp.575-580
    Description: Background Rotator cuff defects are frequently occurring shoulder pathologies associated with pain and movement impairment. Aims The aim of the study was to analyse the pathologies that lead to operative revisions after primary open rotator cuff repair. Methods In 216 patients who underwent primary rotator cuff repair and later required operative revision between 1996 to 2005, pathologies found intraoperatively during the primary operation and during revision surgery were collected, analysed and compared. Results The average age at the time of revision surgery was 54.3 years. The right shoulder (61.6 per cent) was more often affected than the left, males (63.4 per cent) more often than females. At primary operation – apart from rotator cuff repair – there were the following surgical procedures performed: 190 acromioplasty, 86 Acromiclavicular joint resections, 68 tenodesis, 40 adhesiolysis and 1 tenotomy. If an ACJ-resection had been performed in the primary operation, ACJ-problems were rare in revision surgery (p〈0.01). Primary gleno-humeral adhesions were associated with a significant rise in re-tearing rate (p=0.049). Primary absence of adhesions went along with a significant lower rate of adhesions found at revision (p=0.018). Primary performed acromioplasty had no influence on re-tearing rate (p=0.408) or on the rate of subacromial impingement at revision surgery (p=0.709). Conclusion To avoid operative revision after rotator cuff repair relevant copathologies of the shoulder have to be identified before or during operation and treated accordingly. Therefore, even during open rotator cuff repair, the surgeon should initially start with arthroscopy of the shoulder joint and subacromial space to recognise co-pathologies.
    Keywords: Rotator Cuff ; Failed Surgery ; Repair ; Medicine
    E-ISSN: 1836-1935
    E-ISSN: 19361935
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  • 5
    In: Indian Journal of Pathology and Microbiology, 2018, Vol.61(2), p.187-191
    Description: Background: The prognostic significance and clinico-pathological characterization of mucin (MUC) expression in non-small cell lung cancer (NSCLC) is controversial and little studied. Aims: This study aims at elucidating this issue on the largest and most detailed cohort so far. Settings and Design: We examined the expression of MUC 1, 2, 4, 5AC and 6 on 371, well documented, surgically resected NSCLC cases. Materials and Methods: Immunohistochemical results were correlated with several of our previously studied, relevant parameters on this cohort including a follow-up period of up to 20 years. An additional point we examined for practical reasons that has not been addressed so far, was the possible assistance of MUC expression for the differentiation between a primary lung adenocarcinoma and metastasis from a known pancreatobiliary primary tumor. Statistical Analysis Used: Cronbach's Alpha reliability correlation, Spearman's correlation, ANOVA means of comparison with additional Kruskall–Wallis H-test, and Kaplan–Meier survival analysis were employed as statistical analyses in this study. Results and Conclusions: MUCs were associated with histologic subtypes, tumor differentiation and members of the epidermal growth factor receptor signaling pathway, although they were not found to be significant for prognosis. Expression of MUC1 correlated with certain other markers and may point to a group of patients relevant for upcoming treatment strategies involving MUC1. According to our findings, we also recommend additional MUC5AC staining for a thyroid transcription factor 1-negative adenocarinoma in the lung for the differentiation of a possible metastasis in the presence of a pancreatic ductal adenocarcinoma.
    Keywords: Immunohistochemistry; mucin expression; non-small cell lung cancer; pancreatic ductal adenocarcinoma; prognosis
    ISSN: 0377-4929
    E-ISSN: 09745130
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  • 6
    In: Transplantation, 2012, Vol.93(2), pp.207-213
    Description: BACKGROUND.: Although percutaneous biopsies are considered to be the gold standard in diagnosing pancreas graft rejection, they are not performed routinely because of their association with severe complications. On the other hand, correct diagnosis of rejection is essential but may be difficult in cases of enteric drainage, particularly in patients with a pancreas transplant alone or a pancreas after kidney transplant. METHODS.: Pancreas recipients who underwent enteroscopy between May 2005 and September 2009 were included in this retrospective analysis. Biopsies were graded 0 to 4 for interstitial and vascular changes. RESULTS.: During the study period a total of 65 simultaneous pancreas-kidney transplants, 13 pancreas after kidney transplants and 4 pancreas transplants alone were performed. Sixty-three patients underwent a single enteroscopy, 10 had two, and 6 had three or more. Indications were protocol graft monitoring (n=73), graft dysfunction (n=17), enteric hemorrhage (n=9), or other (n=3). The duodenal segment was accessed in 76 instances (75%) with abnormal findings in 23. A total of 69 biopsies were obtained and revealed normal mucosa in 49 cases (71%). Histology showed signs of acute rejection in 11 cases. The upper gastrointestinal tract was also assessed, and, in 13 cases, additional pathologies were identified including gastroduodenitis (n=10), gastric/duodenal ulcer (n=2), and hemorrhagic esophagitis (n=1). No procedure-related complication occurred. CONCLUSIONS.: This series of enteroscopies demonstrates that the duodenal segment of a pancreatic graft is accessible using our implant technique, and thus permitting biopsies to be obtained and endoscopic interventions to be performed.
    Keywords: Esophagitis ; Graft Rejection ; Ulcers ; Drainage ; Kidney Transplantation ; Pancreas ; Mucosa ; Biopsy ; Gastrointestinal Tract ; Hemorrhage ; Pancreas Transplantation ; Biopsy ; Drainage ; Esophagitis ; Gastrointestinal Tract ; Graft Rejection ; Hemorrhage ; Kidney Transplantation ; Mucosa ; Pancreas ; Pancreas Transplantation ; Ulcers ; Transplantation;
    ISSN: 0041-1337
    E-ISSN: 15346080
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  • 7
    Language: English
    In: Gastroenterology, April 2017, Vol.152(5), pp.S1028-S1028
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0016-5085(17)33478-9 Byline: Marino Venerito, Friederike Weise, Elisabetta Goni, Dirk Reinhold, Karsten Ridwelski, Philipp Lingohr, Hanno Matthaei, Claus Schildberg, Martin Kruschewski, Iurii Krasniuk, Peter P. Grimminger, Markus Moehler, Stefanie Wolff, Hans Lippert, Michael Vieth, Lothar Veits, Christiane Bruns, Florian Lordick, Ines Gockel, Peter Malfertheiner, Johannes Schumacher
    Keywords: Medicine
    ISSN: 0016-5085
    E-ISSN: 1528-0012
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  • 8
    Language: German
    In: Visceral Medicine, April 2012, Vol.28(2), pp.103-112
    Description: Der Barrett-Ösophagus ist und bleibt eine verwirrende Herausforderung, da man sich noch immer nicht über die genaue Bedeutung der zugrunde liegenden Faktoren im Klaren ist. Neben der bekannten Interobserver-Variation in der Neoplasie-Diagnostik bei Barrett-Ösophagus ist die ansteigende Zahl an Diskrepanzen zwischen bioptischen Diagnosen und Befunden, die am OP-Präparat oder endoskopischen Resektat gestellt wurden, ein relativ neues Phänomen. Die histologische Diagnose ist jedoch weiterhin vor und nach interventionellen Eingriffen sehr wichtig, um das weitere Therapie-Prozedere entsprechend auszurichten und abzustimmen.
    Keywords: Hauptthema · Main Topic ; Barrett-Ösophagus ; Ösophaguskarzinom ; Intraepitheliale Neoplasie
    ISBN: 9783318020946
    ISBN: 331802094X
    ISSN: 2297-4725
    ISSN: 16626664
    E-ISSN: 2297-475X
    E-ISSN: 16626672
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  • 9
    Language: English
    In: American journal of clinical pathology, April 2011, Vol.135(4), pp.611-8
    Description: The increasing incidence of lung cancer in women and their supposed survival advantage over men requires clarification of the significance of sex. Age, stage, histologic features, differentiation grade, and Ki-67 index were assessed in 405 surgically resected non-small cell lung cancers (NSCLCs) using a standardized tissue microarray platform. Women were associated with well/moderate tumor differentiation, a Ki-67 index of 3% or less, and adenocarcinoma histologic features. Female sex predicted increased survival time only by univariate analysis. Stratified by sex, increased survival was noted for women older than 64 years, with a tumor at postsurgical International Union Against Cancer stage I, with adenocarcinoma histologic features, with well- or moderately differentiated tumors, or with a Ki-67 index of 3% or less. Sex is not an independent prognostic parameter for patients with surgically resected NSCLC. Sex-linked differences are associated with other factors, thus simulating a prognostic impact of sex. This study elucidates sex-specific interactions between patient and tumor characteristics, which are pivotal toward improving prognostic accuracy, individualized therapies, and screening efforts.
    Keywords: Carcinoma, Non-Small-Cell Lung -- Diagnosis ; Lung Neoplasms -- Diagnosis
    ISSN: 00029173
    E-ISSN: 1943-7722
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  • 10
    In: Case Reports in Clinical Medicine, 2014, Vol.03(08), pp.457-459
    Description: SIR, Syphilis is a sexually-transmitted infectious disease caused by the bacteria Treponemapallidum. A characteristic manifestation of the third stage is arteritis of the aorta, which leads to necrosis and loss of tissue. Here, we report on a 48-year-old woman admitted with suspected Takayasu’s arteritis (TA) due to localized inflammation confined to the aortic root and valve, which could be diagnosed as syphilitic aortitis.
    ISSN: 2325-7075
    E-ISSN: 2325-7083
    Source: CrossRef
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