Format:
Online-Ressource
ISSN:
1860-7187
Content:
Abstract: Antibiotics are becoming gradually ineffective due to drug resistance, leading to greater difficulty in the treatment of infectious diseases. Therefore, the development of new chemical entities with different mechanisms of action is essential in the fight against resistant microorganisms. Various studies have shown that quinoline hydrazide/hydrazone derivatives possess several biological activities, such as antimalarial, antitubercular, anticancer, anti‐inflammatory, and antimicrobial. Among these activities, the antibacterial activity of quinoline hydrazide/hydrazone derivatives is noteworthy. The synthetic flexibility of the quinoline ring has led to the development of a wide range of structurally diverse quinoline hydrazide/hydrazone derivatives, which can act at various bacterial targets such as DNA gyrase, glucosamine‐6‐phosphate synthase, enoyl ACP reductase, and 3‐ketoacyl ACP reductase. This review emphasizes the antibacterial potential of various reported quinoline hydrazide/hydrazone derivatives based on substitution in the quinoline ring. The antibacterial activity of various metal‐quinoline hydrazide/hydrazone complexes is also discussed. The aim of this review is to assemble and scrutinize the latest reports in this promising area of drug development.
In:
day:20
In:
month:01
In:
year:2023
In:
extent:23
In:
ChemMedChem, Weinheim : Wiley-VCH, [2006]-, (20.01.2023) (gesamt 23), 1860-7187
Language:
English
DOI:
10.1002/cmdc.202200571
URN:
urn:nbn:de:101:1-2023012114245266093252
URL:
https://doi.org/10.1002/cmdc.202200571
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023012114245266093252
URL:
https://d-nb.info/1278811060/34
URL:
https://doi.org/10.1002/cmdc.202200571
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