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  • 1
    Online Resource
    Online Resource
    MDPI - Multidisciplinary Digital Publishing Institute
    UID:
    almafu_9959145853402883
    Format: 1 electronic resource (452 p.)
    Content: Starting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Structural and biophysical insights have greatly contributed to a molecular understanding of this kinase. From good old protein biochemistry to modern approaches, such as systems biology and advanced microscopy, all disciplines have provided important information. Thus, multiple links to cellular events and subcellular localizations have been established. Moreover, the crucial involvement of AMPK in human health and disease has been evidenced. AMPK accordingly has moved from an interesting enzyme to a pharmacological target. However, despite our extensive current knowledge about AMPK, the growing community is busier than ever. This book provides a snapshot of recent and current AMPK research with an emphasis on work providing molecular insight, including but not limited to novel physiological and pathological functions, or regulatory mechanisms. Up-to-date reviews and research articles are included.
    Note: English
    Additional Edition: ISBN 3-03897-662-8
    Language: English
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  • 2
    Online Resource
    Online Resource
    New York, NY :Springer New York :
    UID:
    almahu_9949251257502882
    Format: 1 online resource (XVII, 626 p. 119 illus., 76 illus. in color.)
    Edition: 1st ed. 2018.
    ISBN: 1-4939-7598-6
    Series Statement: Methods in Molecular Biology, 1732
    Content: This volume explores the latest methods used to study AMPK by computational, biochemical, biophysical, cellular, and ex vivo and in vivo approaches. The chapters in this book cover specific topics, such as methods to measure change in cellular energy metabolism and analyze metabolic pathways regulated by AMPK; bioinformatics tools to identify AMPK targets; knockdown of AMPK by CRISPR-Cas9; production and crystallization of full-length human AMP-activated protein kinase; cell-free assays to measure the effects of regulatory ligands on AMPK; use of sensors of AMPK activity; AMPK protein interaction by yeast two-hybrid; the role of AMPK in inflammation and autophagy; analyzing the AMPK function in C. elegans and mammals (with special focus on skeletal muscle, blood vessels, kidneys, pancreatic islets and hypothalamus); and human γ2 AMPK mutations. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and thorough, AMPK: Methods and Protocols is a valuable resource for graduate students, postdoctoral researchers, and established investigators who are interested in the richly diverse AMPK field.
    Additional Edition: ISBN 1-4939-7597-8
    Language: English
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  • 3
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    UID:
    gbv_1794540369
    Format: 1 Online-Ressource (134 p.)
    ISBN: 9782889634071
    Content: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Note: English
    Language: English
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  • 4
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    UID:
    b3kat_BV046294232
    Format: 1 Online-Ressource (X, 523 p. 55 illus., 42 illus. in color)
    ISBN: 9783319435893
    Series Statement: Experientia Supplementum 107
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-319-43587-9
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-319-43588-6
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-319-82864-0
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
    Library Location Call Number Volume/Issue/Year Availability
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  • 5
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : MDPI - Multidisciplinary Digital Publishing Institute
    UID:
    gbv_1778498760
    Format: 1 Online-Ressource (452 p.)
    ISBN: 9783038976622
    Content: Starting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Structural and biophysical insights have greatly contributed to a molecular understanding of this kinase. From good old protein biochemistry to modern approaches, such as systems biology and advanced microscopy, all disciplines have provided important information. Thus, multiple links to cellular events and subcellular localizations have been established. Moreover, the crucial involvement of AMPK in human health and disease has been evidenced. AMPK accordingly has moved from an interesting enzyme to a pharmacological target. However, despite our extensive current knowledge about AMPK, the growing community is busier than ever. This book provides a snapshot of recent and current AMPK research with an emphasis on work providing molecular insight, including but not limited to novel physiological and pathological functions, or regulatory mechanisms. Up-to-date reviews and research articles are included
    Note: English
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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  • 6
    UID:
    edocfu_9960412698102883
    Format: 1 electronic resource (134 p.)
    Content: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Note: English
    Additional Edition: ISBN 2-88963-407-8
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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  • 7
    UID:
    almahu_9949282028902882
    Format: 1 electronic resource (134 p.)
    Content: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Note: English
    Additional Edition: ISBN 2-88963-407-8
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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  • 8
    UID:
    edoccha_9960412698102883
    Format: 1 electronic resource (134 p.)
    Content: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Note: English
    Additional Edition: ISBN 2-88963-407-8
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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  • 9
    Book
    Book
    New York, NY :Humana Press,
    UID:
    almahu_BV045266942
    Format: xvii, 626 Seiten : , Illustrationen, Diagramme.
    ISBN: 978-1-4939-7597-6
    Series Statement: Methods in molecular biology 1732
    Additional Edition: Erscheint auch als Online-Ausgabe AMPK New York, NY : Humana Press, 2018 ISBN 978-1-4939-7598-3
    Additional Edition: ISBN 9781493975983
    Language: English
    Subjects: Biology
    RVK:
    RVK:
    Keywords: Aufsatzsammlung
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  • 10
    Online Resource
    Online Resource
    Basel ; Beijing ; Wuhan ; Barcelona ; Belgrade : MDPI
    UID:
    b3kat_BV045523949
    Format: 1 Online-Ressource
    ISBN: 9783038976639
    Note: This is a reprint of articles from the special issue published online in the open access journal International Journal of Molecular Sciences (ISSN 1422-0067) from 2018 to 2019 (available at: https://www.mdpi.com/journal/ijms/special_issues/AMPK).
    Additional Edition: Erscheint auch als Druck-Ausgabe, paperback ISBN 978-3-03897-662-2
    Language: English
    Keywords: AMP ; Proteinkinasen ; Aufsatzsammlung
    URL: Volltext  (kostenfrei)
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