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  • 1
    Language: English
    In: Toxicon, August 2012, Vol.60(2), pp.139-139
    Keywords: Pharmacy, Therapeutics, & Pharmacology ; Anatomy & Physiology
    ISSN: 0041-0101
    E-ISSN: 1879-3150
    Source: ScienceDirect Journals (Elsevier)
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  • 2
    Language: English
    In: Toxicon, August 2012, Vol.60(2), pp.140-141
    Keywords: Pharmacy, Therapeutics, & Pharmacology ; Anatomy & Physiology
    ISSN: 0041-0101
    E-ISSN: 1879-3150
    Source: ScienceDirect Journals (Elsevier)
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  • 3
    Language: English
    In: Toxicon, 2010, Vol.56(7), pp.1198-1222
    Description: Cobra venom factor (CVF) is the complement-activating protein in cobra venom. This manuscript reviews the structure and function of CVF, how it interacts with the complement system, the structural and functional homology to complement component C3, and the use of CVF as an experimental tool to decomplement laboratory animals to study the functions of complement in host defense and immune response as well as in the pathogenesis of diseases. This manuscript also reviews the recent progress in using the homology between CVF and C3 to study C3 structure and function, and to develop human C3 derivatives with the complement-depleting function of CVF. These human C3 derivatives represent humanized CVF, and are a conceptually different concept for pharmacological intervention of the complement system, therapeutic complement depletion. The use of humanized CVF for therapeutic complement depletion in several pre-clinical models of human diseases is also reviewed.
    Keywords: Complement ; Cobra Venom Factor ; Cvf ; Convertase ; Protein Humanization ; Therapeutic Complement Depletion ; Pharmacy, Therapeutics, & Pharmacology ; Anatomy & Physiology
    ISSN: 0041-0101
    E-ISSN: 1879-3150
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  • 4
    Language: English
    In: Molecular Immunology, October 2014, Vol.61(2), pp.191-203
    Description: The complement system is an integral component of both innate and adaptive immunity. However, complement is also a pathogenetic factor in many diseases. The development of agents for therapeutic complement inhibition is the topic of intense investigations by many investigators. We have developed a distinctly different therapeutic approach: complement depletion rather than inhibition. This approach is based on cobra venom factor (CVF), a C3 analog known to be able to safely deplete complement. This manuscript will briefly review the structure and activity of CVF, along with its similarities and differences to C3. Exploiting the knowledge of the structure/function relationship of CVF and C3, we created derivatives of human C3 which display the CVF-like activity of depleting complement, referred to as humanized CVF (hCVF). This review describes the structure and activity of hCVF, including the important property of not cleaving C5. The efficacy of hCVF for therapeutic complement depletion in nine preclinical models diseases with complement pathology is reviewed, including reperfusion injury, age-related macular degeneration (AMD), paroxysmal nocturnal hemoglobinuria (PNH), and immunogenicity of Factor VIII in hemophilia A. Complement depletion is characterized by the absence of toxicity, even after intra-arterial injection into the pulmonary artery of primates. No immunogenicity has been observed.
    Keywords: Cobra Venom Factor (Cvf) ; Humanized Cobra Venom Factor ; Complement Depletion ; Complement Therapeutics ; Medicine ; Biology ; Chemistry
    ISSN: 0161-5890
    E-ISSN: 1872-9142
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  • 5
    Language: English
    In: Toxicon, July 2016, Vol.117, pp.107-107
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.toxicon.2016.04.017 Byline: Carl-Wilhelm Vogel, David C. Fritzinger Author Affiliation: (1) University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA (2) Department of Pathology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA Article Note: (miscellaneous) 4. Drug Discovery and Development
    Keywords: Pharmacy, Therapeutics, & Pharmacology ; Anatomy & Physiology
    ISSN: 0041-0101
    E-ISSN: 1879-3150
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  • 6
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 20 December 1994, Vol.91(26), pp.12775-12779
    Description: Cobra venom factor (CVF) is the complement-activating protein in cobra venom. Like C3b, CVF forms with factor B and factor D in human and mammalian serum the bimolecular C3/C5 convertase. This functional similarity of CVF and C3 correlates with many structural similarities, which led to the suggestion that CVF is evolutionally related to C3. We report here the molecular cloning and derived primary structure of CVF. CVF mRNA is 〉5924 nucleotides in length. It contains a single open reading frame of 4926 nucleotides, coding for a pre-pro-protein of 1642 amino acids. The deduced amino acid sequence reveals ≈70% protein similarity to mammalian and human C3 and exceeds 91% in the case of cobra C3. The single-chain pre-pro-CVF consists of a 22-amino acid signal sequence, a 627-amino acid α-chain, and a 989-amino acid precursor chain for the CVF γ- and β-chains. The processing of pro-CVF involves the removal of 4 arginine residues between the α- and precursor chains as well as of the C3a-like and C3d-like domains from the precursor chain, thereby confirming the predicted chain homologies to C3. Pro-CVF contains five potential N-glycosylation sites, of which only three can be expected to be glycosylated in mature CVF. Like C3, pro-CVF contains 27 cysteine residues and a homologous thioester site in the C3d-like region.
    Keywords: Physical sciences -- Physics -- Microphysics ; Physical sciences -- Chemistry -- Chemical compounds ; Physical sciences -- Chemistry -- Chemical compounds ; Biological sciences -- Biology -- Physiology ; Physical sciences -- Chemistry -- Chemical compounds ; Biological sciences -- Biochemistry -- Enzymology ; Physical sciences -- Physics -- Microphysics ; Biological sciences -- Biology -- Genetics ; Behavioral sciences -- Anthropology -- Applied anthropology ; Biological sciences -- Biology -- Genetics
    ISSN: 00278424
    E-ISSN: 10916490
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  • 7
    Language: English
    In: Toxicon, August 2012, Vol.60(2), pp.107-107
    Keywords: Pharmacy, Therapeutics, & Pharmacology ; Anatomy & Physiology
    ISSN: 0041-0101
    E-ISSN: 1879-3150
    Source: ScienceDirect Journals (Elsevier)
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  • 8
    Language: English
    In: Cancer Epidemiology Biomarkers & Prevention, 10/2012, Vol.21(10 Supplement), pp.B24-B24
    ISSN: 1055-9965
    E-ISSN: 1538-7755
    Source: CrossRef
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  • 9
    Language: English
    In: Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health, January 2014, Vol.73(1), pp.37-8
    Keywords: Cooperative Behavior ; Health Status Disparities ; Biological Specimen Banks -- Organization & Administration ; Colorectal Neoplasms -- Diagnosis
    E-ISSN: 2165-8242
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 10
    Language: English
    In: Cancer Epidemiology Biomarkers & Prevention, 09/2011, Vol.20(10 Supplement), pp.B26-B26
    ISSN: 1055-9965
    E-ISSN: 1538-7755
    Source: CrossRef
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