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  • 1
    Language: English
    In: Analytical and Bioanalytical Chemistry, 2016, Vol.408(29), pp.8255-8256
    Keywords: Chemistry ; Analytical Chemistry ; Biochemistry, General ; Laboratory Medicine ; Characterization and Evaluation of Materials ; Food Science ; Monitoring/Environmental Analysis ; Chemistry;
    ISSN: 1618-2642
    E-ISSN: 1618-2650
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  • 2
    Language: English
    In: Analytical and Bioanalytical Chemistry, 2012, Vol.403(2), p.333(2)
    Keywords: Mass Spectrometry – Methods ; Electrochemistry – Methods ; Electrochemical Reactions – Methods
    ISSN: 1618-2642
    Source: Cengage Learning, Inc.
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  • 3
    Language: English
    In: Analytical and Bioanalytical Chemistry, April, 2012, Vol.403(2), p.333(2)
    Description: Byline: Martin Vogel (1), Uwe Karst (1) Author Affiliation: (1) Institut fur Anorganische und Analytische Chemie, Westfalische Wilhelms-Universitat Munster, Wilhelm-Klemm-Str. 8, 48149, Munster, Germany Article History: Registration Date: 11/02/2012 Online Date: 28/02/2012 Article note: Published in the special paper collection Electrochemistry--Mass Spectrometry with guest editors Uwe Karst and Martin Vogel.
    Keywords: Mass Spectrometry -- Methods ; Spectroscopy -- Methods ; Electrochemistry -- Methods
    ISSN: 1618-2642
    ISSN: 16182650
    E-ISSN: 16182650
    Source: Cengage Learning, Inc.
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  • 4
    Language: English
    In: Analytical and Bioanalytical Chemistry, 2012, Vol.404(6), pp.1621-1622
    Description: Merges the basics of drug metabolism and disposition, liquid chromatography (LC) in combination with modern mass-spectrometric techniques, and, finally, the application of LC-mass spectrometry (MS) in current drug metabolism studies. In contrast to many other textbooks, it does not focus on drug metabolism in general, pharmacokinetics, biochemical pathways, or MS only. In fact, it takes the reader by the hand from the fundamentals of chemical reactions involved in metabolic processes, via advanced topics such as drug transporters, experimental absorption, distribution, metabolism, excretion (ADME) models, or drug development to the basics of MS, tandem MS experiments, sample preparation techniques, and fast LC separation-to mention only some of the topics described. Finally, recent applications of LC-MS in the investigation of drug metabolism and disposition are described, e.g., quantitative mass-spectrometric approaches and high-resolution MS for metabolite identification as well as biomarker discovery. Each chapter provides a detailed summary of references, allowing the reader to easily consult original articles whenever necessary.
    Keywords: Mathematical Models ; Liquid Chromatography ; Readers ; Metabolites ; Excretion ; Drugs ; Metabolism ; Mathematical Analysis ; Instruments and Measurements (So) ; Analysis (MD) ; Chemical Analysis (Ep) ; Chemical Analysis (Ed) ; Chemical Analysis (EC);
    ISSN: 1618-2642
    E-ISSN: 1618-2650
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  • 5
    Language: English
    In: The Lancet, May 6, 2006, Vol.367(9521), p.1486(1)
    Keywords: Periodical Editors -- Practice ; Periodical Editors -- Ethical Aspects ; Medical Publishing -- Officials And Employees ; Medical Publishing -- Ethical Aspects
    ISSN: 0140-6736
    Source: Cengage Learning, Inc.
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  • 6
    Language: English
    In: Analytical and bioanalytical chemistry, April 2012, Vol.403(2), pp.333-4
    Keywords: Electrochemistry -- Methods ; Mass Spectrometry -- Methods
    ISSN: 16182642
    E-ISSN: 1618-2650
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  • 7
    Language: English
    In: Journal of Chromatography A, 29 July 2016, Vol.1457, pp.59-65
    Description: The removal of the anti-inflammatory drug diclofenac, which can be determined in concentrations up to 1 μg/mL in the aquatic environment, from water samples by the use of UV light is investigated by liquid chromatography/mass spectrometry (LC/MS). It is very important to find out whether diclofenac is fully mineralized into non-toxic products or if the UV treatment leads to other potentially bioactive products. The irradiation of an aqueous solution of diclofenac with light in the wavelength range of 220 nm⿿500 nm provides a fast degradation of diclofenac in less than four minutes. Eleven transformation products have been detected by means of reversed-phase LC/MS, seven of which have not been described in literature before. Fragmentation experiments allowed their characterization and lead to proposed structures for most of them. Some of the structures may explain the increased toxicity, which was observed after irradiation of diclofenac solution by other groups.
    Keywords: Diclofenac ; Photodegradation ; Ultraviolet Light ; Liquid Chromatography/Mass Spectrometry ; Tandem Mass Spectrometry ; Chemistry
    ISSN: 0021-9673
    E-ISSN: 18733778
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  • 8
    Language: English
    In: Communications in Mathematical Physics, 2017, Vol.350(1), pp.31-78
    Description: We consider a non-selfadjoint h -differential model operator P h in the semiclassical limit ( $${h\rightarrow 0}$$ h → 0 ) subject to random perturbations with a small coupling constant δ . Assume that $${{\rm e}^{-\frac{1}{Ch}} {\text{ 〈 }} \delta \ll h^{\kappa}}$$ e - 1 C h 〈 δ ≪ h κ for constants $${C,\kappa 〉 0}$$ C , κ 〉 0 suitably large. Let Σ be the closure of the range of the principal symbol. We study the 2-point intensity measure of the random point process of eigenvalues of the randomly perturbed operator $${P_h^{\delta}}$$ P h δ and prove an h -asymptotic formula for the average 2-point density of eigenvalues. With this we show that two eigenvalues of $${P_h^{\delta}}$$ P h δ in the interior of Σ exhibit close range repulsion and long range decoupling. Nous considérons un opérateur différentiel non-autoadjoint P h dans la limite semiclassique ( $${h\rightarrow 0}$$ h → 0 ) soumis à de petites perturbations aléatoires. De plus, nous imposons que la constant de couplage δ vérifie $${{\rm e}^{-\frac{1}{Ch}} {\text{ 〈 }} \delta \ll h^{\kappa}}$$ e - 1 C h 〈 δ ≪ h κ pour certaines constantes $${C,\kappa 〉 0}$$ C , κ 〉 0 choisies assez grandes. Soit Σ l’adhérence de l’image du symbole principal de P h . Dans cet article, nous donnons une formule h -asymptotique pour la 2-points densité des valeurs propres en étudiant la mesure de comptage aléatoire des valeurs propres à l’intérieur de Σ . En étudiant cette densité, nous prouvons que deux valeurs propres sont répulsives à distance courte et indépendantes à long distance.
    Keywords: Physics ; Theoretical, Mathematical and Computational Physics ; Mathematical Physics ; Quantum Physics ; Complex Systems ; Classical and Quantum Gravitation, Relativity Theory ; Applied Sciences ; Physics ; Mathematics;
    ISSN: 0010-3616
    E-ISSN: 1432-0916
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  • 9
    Language: English
    In: Analytica Chimica Acta, 27 June 2014, Vol.834, pp.9-21
    Description: The combination of electrochemistry (EC) and mass spectrometry (MS) has become a more and more frequently used approach in metabolism studies in the last decade. This review provides insight into the importance of metabolism studies during the drug development process and gives a short overview about the conventionally used methods since electrochemistry is often intended to substitute or minimize animal-based studies. The optimization of the electrochemical conditions is of great importance for a successful comparison with approaches. The type of metabolism reactions, which can be simulated by EC, has been extended with new cell types and working electrodes. Although the mechanism differs from the enzyme-catalyzed turnover, electrochemistry can be used to simulate a significant number of the respective reactions. An expanded set-up consisting of EC, a chromatographic separation and MS allows to distinguish between an electrospray ionization (ESI) in-source and an electrochemical oxidation and provides information on the polarity of the electrogenerated compounds. A main advantage of EC for metabolite generation is the possibility to isolate reactive species because of the purely instrumental approach. Especially when a preparative electrochemical cell with a larger working electrode surface is used, metabolites can be generated in sufficient quantities for their subsequent structure elucidation. Besides, the compounds can also be used for selective trapping experiments with different cell components such as small peptides, proteins or DNA bases. Current and possible future developments and applications of EC are presented and discussed as well.
    Keywords: Electrochemistry ; Drug Metabolism ; Mass Spectrometry ; Liquid Chromatography ; Chemistry
    ISSN: 0003-2670
    E-ISSN: 1873-4324
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  • 10
    Language: English
    In: Cell, 20 June 2013, Vol.153(7), pp.1526-1536
    Description: Cytoplasmic dynein is a motor protein that exerts force on microtubules. To generate force for the movement of large organelles, dynein needs to be anchored, with the anchoring sites being typically located at the cell cortex. However, the mechanism by which dyneins target sites where they can generate large collective forces is unknown. Here, we directly observe single dyneins during meiotic nuclear oscillations in fission yeast and identify the steps of the dynein binding process: from the cytoplasm to the microtubule and from the microtubule to cortical anchors. We observed that dyneins on the microtubule move either in a diffusive or directed manner, with the switch from diffusion to directed movement occurring upon binding of dynein to cortical anchors. This dual behavior of dynein on the microtubule, together with the two steps of binding, enables dyneins to self-organize into a spatial pattern needed for them to generate large collective forces. Visualizing single dyneins in vivo reveals that, upon initial microtubule binding, dyneins exhibit bidirectional diffusive motion, and only upon binding to proteins known to anchor dynein at the cortex does the motor’s motion become directional.
    Keywords: Biology
    ISSN: 0092-8674
    E-ISSN: 1097-4172
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