Analytical and Bioanalytical Chemistry, 2012, Vol.404(6), pp.1621-1622
Merges the basics of drug metabolism and disposition, liquid chromatography (LC) in combination with modern mass-spectrometric techniques, and, finally, the application of LC-mass spectrometry (MS) in current drug metabolism studies. In contrast to many other textbooks, it does not focus on drug metabolism in general, pharmacokinetics, biochemical pathways, or MS only. In fact, it takes the reader by the hand from the fundamentals of chemical reactions involved in metabolic processes, via advanced topics such as drug transporters, experimental absorption, distribution, metabolism, excretion (ADME) models, or drug development to the basics of MS, tandem MS experiments, sample preparation techniques, and fast LC separation-to mention only some of the topics described. Finally, recent applications of LC-MS in the investigation of drug metabolism and disposition are described, e.g., quantitative mass-spectrometric approaches and high-resolution MS for metabolite identification as well as biomarker discovery. Each chapter provides a detailed summary of references, allowing the reader to easily consult original articles whenever necessary.
Mathematical Models ; Liquid Chromatography ; Readers ; Metabolites ; Excretion ; Drugs ; Metabolism ; Mathematical Analysis ; Instruments and Measurements (So) ; Analysis (MD) ; Chemical Analysis (Ep) ; Chemical Analysis (Ed) ; Chemical Analysis (EC);
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