Format:
Online-Ressource (IX, 178p. 58 illus., 21 illus. in color, digital)
ISBN:
9783764389277
Series Statement:
Milestones in Drug Therapy
Content:
Influenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge. This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the haemagglutinin, the interactions wi
Note:
Includes bibliographical references and index
,
Influenza Virus Sialidase - A Drug Discovery Target; Preface; References; Contents; Influenza Virology; 8.4.2 Fusion; 8.5 Neuraminidase; 8.6 Influenza C Virus HEF; 8.10 Nuclear Export Protein NEP/NS2; 9 Prophylaxis and Therapy; References; Investigating the Interaction Between Influenza and Sialic Acid: Making and Breaking the Link; 1 Influenza Virus and Haemagglutination; References; Enzymology of Influenza Virus Sialidase; 2 Mechanistic Tools; 2.3 Comparisons Between Sialosides and Glucosides: Intrinsic Reactivity; 2.4 Oxacarbenium Ion Lifetimes; 4 Conclusions; References; References
,
The Development of Carbohydrate-Based Influenza Virus Sialidase Inhibitors1 Introduction; 2 Interactions of N-acetylneuraminic Acid with Influenza Virus Sialidase; 3.3 Neu5Ac2en and Derivatives: Mimics of the Putative Sialidase Sialosyl Cation Transition State Intermediate; 4 Structure-Based Inhibitor Design on the Neu5Ac2en Template: The Development of the Anti-influenza Drug, Zanamivir (RelenzaTM); 4.1 Biological and Structural Evaluation of 4-Amino- (22) and 4-Guanidino- (23) 4-Deoxy-Neu5Ac2en; 4.1.3 The Development of Zanamivir (RelenzaTM)
,
5 Further Developments of Carbohydrate-Based Influenza Virus Sialidase Inhibitors5.2.1 Modification of 4-Amino/Guanidino-Neu5Ac2en: Towards Inhibitors Interacting with the Extended Active Site of Influenza A Group-1Sialidases; References; 2 Non-carbohydrate-Based Influenza Virus Sialidase Inhibitors Structurally Related to Sialic Acids and Designed to Mimic Sialic Acids; References; Clinical Experience with Influenza Virus Sialidase Inhibitors; References; References; Index;
Additional Edition:
ISBN 9783764389260
Additional Edition:
Buchausg. u.d.T. Influenza virus sialidase - a drug discovery target Basel : Springer, 2012 ISBN 9783764389260
Additional Edition:
ISBN 3764389265
Language:
English
Keywords:
Influenzaviren
;
Neuraminidase
;
Arzneimittelentwicklung
DOI:
10.1007/978-3-7643-8927-7
URL:
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