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  • 1
    Language: English
    In: International Journal of Project Management, July 2012, Vol.30(5), pp.567-581
    Description: The growing number of company projects requires comprehensive management, project portfolio management (PPM), for strategic alignment and efficient use of resources. In parallel, companies face customers demanding higher value, and joint value creation with customers is considered a key success factor in the future. Project portfolios delivering products and services for customers implicate a link between PPM and an increased customer focus. Combining the research fields of marketing and PPM for the first time, this study proposes customer integration into PPM. I develop a framework describing the impact of customer integration into PPM on project portfolio success mediated through relationship value. Furthermore, the study describes relevant aspects for customer integration on the project portfolio level and identifies interfaces for cross-functional integration of a customer portfolio representative within the PPM process. The findings and limitations of this study are discussed, and further research is suggested. ► Framework links customer integration and project portfolio management (PPM). ► Customer relationship portfolio management identified as relevant process for PPM. ► Relationship value as mediator between customer integration and portfolio success. ► Links and interfaces between PPM and customer relationship management discovered. ► Marketing and PPM research enhanced by connecting relationship portfolios to PPM.
    Keywords: Project Portfolios ; Project Portfolio Management ; Customer Integration ; Project Portfolio Success ; Customer Relationship Management ; Engineering
    ISSN: 0263-7863
    E-ISSN: 1873-4634
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  • 2
    Language: English
    In: International Journal of Project Management, August 2013, Vol.31(6), pp.847-861
    Description: Companies today need project portfolio management (PPM) to cope with the increasing number of projects and use it to ensure comprehensive management, strategic alignment, and efficient use of resources. Moreover, customers are demanding more value from their suppliers. The management of a project portfolio and the corresponding customer relationship portfolio implies a link between PPM and relationship management. By combining the fields of PPM and marketing, this study hypothesizes a connection between relationship value and project portfolio success. Because both parties need to extract value from a relationship, relationship value is divided into relationship value for the customer and relationship value from the customer. The results are based on a cross-industry sample of 174 German, Swiss, and Austrian medium-sized and large companies and rely on two informants from each firm. We find a significant relationship between relationship value and project portfolio success as well as moderating effects of portfolio interdependency, portfolio size, and technological turbulence.
    Keywords: Project Portfolio Management ; Relationship Value ; Customer Integration ; Project Portfolio Success ; Engineering
    ISSN: 0263-7863
    E-ISSN: 1873-4634
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  • 3
    Language: English
    In: PLoS ONE, 01 January 2011, Vol.6(11), p.e28170
    Description: The pathway of molybdenum cofactor biosynthesis has been studied in detail by using proteins from Mycobacterium species, which contain several homologs associated with the first steps of Moco biosynthesis. While all Mycobacteria species contain...
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 4
    Language: English
    In: Schizophrenia Research, January 2014, Vol.152(1), pp.33-40
    Description: The feeling of being the source and controller of one's actions and their effects in the outside world is an important aspect of our sense of self. Disturbances in this sense of agency (SoA) were observed in schizophrenia and have been linked to impairments in sensorimotor integration. We used a virtual-world action-monitoring paradigm to investigate the SoA in 20 schizophrenic patients and 18 healthy subjects. Participants continuously moved a virtual pen displayed on a computer screen using a touchpad device. The control they exceeded over the virtual pen was switched periodically between the participant and the computer. Participants were requested to monitor their actions and the effects on the virtual pen, and indicate loss or regain of control over the pen's movement by button presses. The numbers of erroneous external attribution of action effects (false negative agency judgements) and erroneous self-attribution (false positive agency judgements) were not significantly different in patients and healthy subjects. However, patients showed a significant increase in the duration of . Moreover, the number of as well as the number and the duration of were negatively correlated with the performance in cognitive tests (BACS) in the patient group only. Our findings indicate that the evaluation system to detect a mismatch between actions and their effects in the outside world is probably more rigid in schizophrenic patients, which leads to an increased self-attribution bias for action effects, as commonly found in delusions of control. The impairment in sensorimotor integration may be compensated for by stronger cognitive control.
    Keywords: Sense of Agency ; Schizophrenia ; Action Monitoring ; Self-Attribution ; Delusions of Influence ; Cue Integration
    ISSN: 0920-9964
    E-ISSN: 1573-2509
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  • 5
    Language: English
    In: PLoS ONE, 2011, Vol.6(11), p.e28170
    Description: The pathway of molybdenum cofactor biosynthesis has been studied in detail by using proteins from Mycobacterium species, which contain several homologs associated with the first steps of Moco biosynthesis. While all Mycobacteria species contain a MoeZR, only some strains have acquired an additional homolog, MoeBR, by horizontal gene transfer. The role of MoeBR and MoeZR was studied in detail for the interaction with the two MoaD-homologs involved in Moco biosynthesis, MoaD1 and MoaD2, in addition to the CysO protein involved in cysteine biosynthesis. We show that both proteins have a role in Moco biosynthesis, while only MoeZR, but not MoeBR, has an additional role in cysteine biosynthesis. MoeZR and MoeBR were able to complement an E. coli moeB mutant strain, but only in conjunction with the Mycobacterial MoaD1 or MoaD2 proteins. Both proteins were able to sulfurate MoaD1 and MoaD2 in vivo , while only MoeZR additionally transferred the sulfur to CysO. Our in vivo studies show that Mycobacteria have acquired several homologs to maintain Moco biosynthesis. MoeZR has a dual role in Moco- and cysteine biosynthesis and is involved in the sulfuration of MoaD and CysO, whereas MoeBR only has a role in Moco biosynthesis, which is not an essential function for Mycobacteria .
    Keywords: Research Article ; Biology ; Medicine ; Infectious Diseases ; Biochemistry
    E-ISSN: 1932-6203
    Source: PLoS
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  • 6
    Language: English
    In: PLoS ONE, Sept 10, 2010, Vol.5(9), p.e12686
    Description: Our nervous system continuously combines new information from our senses with information it has acquired throughout life. Numerous studies have found that human subjects manage this by integrating their observations with their previous experience (priors) in a way that is close to the statistical optimum. However, little is known about the way the nervous system acquires or learns priors. Here we present results from experiments where the underlying distribution of target locations in an estimation task was switched, manipulating the prior subjects should use. Our experimental design allowed us to measure a subject's evolving prior while they learned. We confirm that through extensive practice subjects learn the correct prior for the task. We found that subjects can rapidly learn the mean of a new prior while the variance is learned more slowly and with a variable learning rate. In addition, we found that a Bayesian inference model could predict the time course of the observed learning while offering an intuitive explanation for the findings. The evidence suggests the nervous system continuously updates its priors to enable efficient behavior.
    ISSN: 1932-6203
    Source: Cengage Learning, Inc.
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  • 7
    Language: English
    In: Clinical cancer research : an official journal of the American Association for Cancer Research, 15 May 2016, Vol.22(10), pp.2320-2
    Description: mTORC1 inhibitors were first approved for the use in metastatic kidney cancer. However, observed treatment benefit was highly heterogeneous among patients. Through case-based cancer genomic sequencing of therapeutic outliers, we can begin to appreciate the convergent evolution of given cancer pathways/phenotypes beyond genes in kidney cancer, like a braided river. Clin Cancer Res; 22(10); 2320-2. ©2016 AACRSee related article by Kwiatkowski et al., p. 2445.
    Keywords: Antineoplastic Agents -- Therapeutic Use ; Kidney Neoplasms -- Drug Therapy ; Protein Kinase Inhibitors -- Therapeutic Use ; Tor Serine-Threonine Kinases -- Antagonists & Inhibitors
    ISSN: 1078-0432
    E-ISSN: 15573265
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  • 8
    In: Pacing and Clinical Electrophysiology, February 2014, Vol.37(2), pp.242-248
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/pace.12274/abstract Byline: ANDREW MARTIN, JAMIE VOSS, DUNCAN SHANNON, PETER RUYGROK, NIGEL LEVER Keywords: heart transplantation; lead extraction; implantable cardioverter defibrillator; defibrillation lead Background Cardiac implantable electronic devices (CIEDs) have now become common therapeutic adjuncts for patients prior to orthotopic heart transplantation (OHT). Removal of the generator and the intracardiac components occurs at time of transplantation but removal of the intravascular portion of leads may be unsuccessful without specialized extraction equipment. Methods We performed a retrospective audit of chest radiographs and clinical records of patients undergoing OHT at Green Lane and Auckland City Hospitals between 2002 and 2012. Results At the time of transplant surgery, 56 of 100 patients had a CIED in situ. Hardware was retained postoperatively in 22 (39%), and the CIED had been in situ for 47 (interquartile range [IQR] 16-68) months for these cases, compared to 14 (IQR 3-24) months in those without. In two (9%) patients, the device generator was electively explanted during the week following OHT. There were no subsequent procedures undertaken to remove retained lead fragments. One (4%) had lead fragment embolization, one (4%) had endoluminal fragment migration, and one (4%) had lead fragment erosion into the mediastinum; all were asymptomatic and without adverse clinical sequelae. There was no infection associated with this hardware. The presence of retained lead fragments was not associated with additional mortality. Conclusions Retained lead fragments following OHT occur commonly, without adverse clinical events for this cohort; however, the long-term clinical implications remain uncertain. Complete removal of all CIED hardware should be attempted at the time of OHT, and when this is not possible leads should be left in a state that facilitates their removal at a later date if required. Article Note: Disclosures: There were no external funding sources or relationships with industry related to this work.
    Keywords: Heart Transplantation ; Lead Extraction ; Implantable Cardioverter Defibrillator ; Defibrillation Lead
    ISSN: 0147-8389
    E-ISSN: 1540-8159
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  • 9
    Language: English
    In: Natural Hazards, 2010, Vol.55(3), pp.657-669
    Description: In this article, disasters are understood as processes that have different impacts on social routines in terms of scale, scope and duration. The extent of adaptive processes in society can provide the ground for a rough classification of disaster types. Such classification has, on the one hand, practical and analytical advantages. On the other hand, they harbour the danger of overlooking transitions of scale and discourage comprehensive scale-related learning forms. Based on the disaster scale by Fischer (Int J Mass Emerg Disasters 1:91–107, 2003), flash floods in mountain rivers and torrents are described as extreme emergencies or small-town disasters. Three given examples will clearly show that learning rarely takes place within an institutional setting that is subjected to small disasters, because the stakeholder’s focus remains on only one level. Therefore, we propose to implement a system of self-organised and scale-independent learning, so called deutero learning, within the political subsystem. Following a damaging event, participative processes that involve all levels should be initialised. Their task would be to assess the combination of causes and draw conclusions for mitigation measures. An aggregation of these assessments would help the responsible political subsystems to adapt the current natural disasters policy to the changing environmental conditions.
    Keywords: Single-loop learning ; Double-loop learning ; Deutero learning ; Natural hazards ; Disaster ; Resilience
    ISSN: 0921-030X
    E-ISSN: 1573-0840
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  • 10
    Language: English
    In: British Journal of Sports Medicine, 14 September 2012, Vol.46(11), p.810
    Description: To identify the relationship between field performance in a hot environment and individual heat acclimatisation responses in football players.
    Keywords: Germany ; Qatar ; Temperature ; Physiology ; Exercise ; Artificial Turf ; Athletes ; Urine ; Heat ; Laboratories ; Soccer;
    ISSN: 0306-3674
    ISSN: 03063674
    E-ISSN: 1473-0480
    E-ISSN: 14730480
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