Format:
Online-Ressource
ISSN:
2699-4445
Content:
Abstract: Aims: Diffuse intrinsic pontine glioma (DIPG) is a childhood brainstem tumor with a median overall survival of eleven months. Lack of chemotherapy efficacy may be related to an intact blood-brain barrier (BBB). In this study we aim to investigate the neurovascular unit (NVU) in DIPG patients. Methods: DIPG biopsy (n = 4) and autopsy samples (n = 6) and age-matched healthy pons samples (n = 20) were immunohistochemically investigated for plasma protein extravasation, and the expression of tight junction proteins claudin-5 and zonula occludens-1 (ZO-1), basement membrane component laminin, pericyte marker PDGFR-β, and efflux transporters P-gp and BCRP. The mean vascular density and diameter were also assessed. Results: DIPGs show a heterogeneity in cell morphology and evidence of BBB leakage. Both in tumor biopsy and autopsy samples, expression of claudin-5, ZO-1, laminin, PDGFR-β and P-gp was reduced compared to healthy pontine tissues. In DIPG autopsy samples, vascular den.... https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/3341
In:
volume:2
In:
day:05
In:
month:07
In:
year:2021
In:
Free Neuropathology, Muenster : Prof. Dr. Werner Paulus, University of Muenster, Institute of Neuropathology, [2020]-, 2 (05.07.2021), 2699-4445
Language:
English
URN:
urn:nbn:de:hbz:6:3-freeneuropathology-2021-34408
URL:
https://nbn-resolving.org/urn:nbn:de:hbz:6:3-freeneuropathology-2021-34408
URL:
https://d-nb.info/1240635001/34
URL:
https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/3341/3440
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