Kooperativer Bibliotheksverbund

Berlin Brandenburg


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  • 1
    Language: English
    In: Medical science monitor : international medical journal of experimental and clinical research, 29 December 2014, Vol.20, pp.2811-6
    Description: The results of studies on association between ABCB1 gene polymorphisms and glucocorticoid-induced avascular necrosis of the femoral head (GANFH) are controversial. This study aimed to assess the association of ABCB1 gene polymorphisms with the risk of GANFH by conducting a meta-analysis. The PubMed, Cochrane Library, and Embase databases were searched for papers that describe the association between ABCB1 polymorphisms and GANFH risk. Summary odds ratios and 95% confidence intervals (CI) were estimated based on a fixed-effects model or random-effects model, depending on the absence or presence of significant heterogeneity. A total of 5 studies and 833 patients were included in the final analysis. Significant differences were found for rs1045642 polymorphism in the comparisons of CC vs. CT+TT (OR, 1.462; 95% CI, 1.066-2.007; P=0.019), and rs2032582 polymorphism in the comparisons of GG vs. G(TA)+(TA)(TA) (OR, 1.548; 95% CI,1.063-2.255; P=0.023). The study demonstrated that the ABCB1 polymorphisms (rs1045642 and rs2032582) significantly reduced the risk of GANFH.
    Keywords: Genetic Predisposition to Disease ; Femur Head Necrosis -- Chemically Induced ; Glucocorticoids -- Adverse Effects ; Polymorphism, Single Nucleotide -- Genetics
    E-ISSN: 1643-3750
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  • 2
    In: Clinical Orthopaedics and Related Research, 2010, Vol.468(5), pp.1316-1324
    Description: BACKGROUND: Various head-preserving procedures have been used for young patients with osteonecrosis of the femoral head (ONFH) to avert the need for THA. However, none of these techniques are accepted universally because of the technical difficulties, complications, or mixed results that often are difficult to reproduce. QUESTIONS/PURPOSES: We describe a technique using vascularized bone grafting for treating ONFH in Stages II-IV (Ficat and Arlet) disease, describe our indications, and report the survival of this technique and the functional scores. METHODS: We retrospectively reviewed 191 patients (195 hips) who underwent vascularized greater trochanter grafting for osteonecrosis of the femoral head (Ficat and Arlet Stages II-IV) from 1995 to 2006. The mean age of the patients was 44 years (range, 19-59 years). The minimum followup was 2 years (mean, 8 years; range, 2-11 years). RESULTS: Twenty patients (23 hips) had conversion surgery to THA. The mean Harris hip scores for the patients who did not have conversion surgery to THA improved from 53 to 88 points. Kaplan-Meier survival analysis showed no difference in the 11-year survival rate between patients with Stage II and Stage III disease (THA as an end point). However, the survival rate was lower for patients with Stage IV disease compared with patients with Stages II and III disease. The survival rate for patients in the steroid group was lower compared with the rates for patients in the idiopathic, alcoholic, trauma, and hyperlipidemia groups. At last followup, the stage of necrosis remained unchanged in 118 hips. CONCLUSIONS: We believe vascularized greater trochanter bone grafting is appropriate for young selected patients with mild to moderate collapse of the femoral head. LEVEL OF EVIDENCE: Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
    Keywords: Political Corruption -- Health Aspects ; Political Corruption -- Analysis;
    ISSN: 0009-921X
    E-ISSN: 15281132
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  • 3
    Language: English
    In: Materials Letters, 15 September 2016, Vol.179, pp.166-169
    Description: The bioactive metallic tantalum coating was successfully deposited on the surface of porous SiC by means of chemical vapor deposition (CVD). The morphology and phase composition of tantalum coating were characterized by SEM, EDS and XRD. The cell adhesion test was employed with pre-osteoblast to evaluate the cytocompatibility of Ta coating. The results showed an impact and adherent Ta film was coated on the surface of SiC. The MC3T3-E1 cells showed good adhesion and spreading on the surface of Ta coating, which indicated excellent bioactivity and cytocompatibility. It was proved that the porous SiC with Ta coating could be a potential material for the application as bone substitutes.
    Keywords: Tantalum Coating ; Silicon Carbide ; Chemical Vapor Deposition ; Scaffold ; Engineering ; Physics
    ISSN: 0167-577X
    E-ISSN: 1873-4979
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  • 4
    Language: English
    In: Biochemical and Biophysical Research Communications, 18 November 2016, Vol.480(3), pp.309-313
    Description: Collagen type Ⅱ (col Ⅱ) and aggrecan, the main components of the extracellular matrix (ECM) in human joint cartilage, have been reported to be reduced by chronic production of inflammatory cytokine interleukin (IL)-1β in arthritic joints. Carvedilol, a licensed medicine, has been used for treatment of hypertension, congestive heart failure and coronary disease in clinics. In this study, we investigated the effects of Carvedilol on the expression of col Ⅱ and aggrecan. Our results demonstrate that treatment with Carvedilol didn't change the expression of aggrecan or col Ⅱ at mRNA levels in SW1353 chondrocytes. However, the expression of aggrecan and Col II at protein levels were significantly reduced by IL-1β treatment, which were reversed by Carvedilol in a dose dependent manner, suggesting the inhibitory effects of Carvedilol on the expression of aggrecan and Col II are at post-translational modification levels. In addition, it was shown that IL-1β treatment highly induced MMP-1 and MMP-13 expression in SW1353 chondrocytes at both gene and protein expression levels, which were restored by Carvedilol in a dose dependent manner. Mechanistically, exposure to IL-1β increased phosphorylation of IKK-α/β and degradation of IκB-α in SW1353 chondrocytes, which were suppressed by pretreatment with Carvedilol. Administration of Carvedilol inhibited IL-1β-induced translocation of NF-κB p65 from cytosol to nucleus manner. Notably, a luciferase reporter assay showed that IL-1β severely increased NF-κB luciferase activity, which was markedly suppressed by Carvedilol treatment. Our results suggest that Carvedilol might be a potential therapeutic agent for chondro-protective therapy.
    Keywords: Carvedilol ; Nf-Κb ; Collagen Type Ⅱ ; Mmp-1 ; Osteoarthritis (Oa) ; Biology ; Chemistry ; Anatomy & Physiology
    ISSN: 0006-291X
    E-ISSN: 1090-2104
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  • 5
    In: Microsurgery, November 2013, Vol.33(8), pp.593-599
    Description: The use of the bone flap transfer has been reported to be successful in treatment of patients with early to medium stage (Ficat and Arlet stage I‐III) osteonecrosis of the femoral head (ONFH). We examined the vascular anatomy and blood supply of the greater trochanter area and evaluated the feasibility of revascularization of the femoral head by using the bone flap pedicled with transverse and gluteus medius branches of the lateral circumflex femoral artery. Based on the anatomy study, from January 2002 to May 2004, 32 ONFH patients were treated with the greater trochanteric bone flap pedicled with double blood vessels. Fifteen femoral heads were Ficat and Arlet stage II and 17 were stage III. The mean follow‐up was 99.5 months. Two of the 32 patients required a total hip replacement due to severe hip pain after surgery. The overall Harris hip score improved from a mean of 55.2 points to 85 points. Our data suggest the procedure is relatively easy to perform, less donor‐site morbidity and useful for young patients with stages II to III disease with or without mild collapse of the femoral head. © 2013 Wiley Periodicals, Inc. Microsurgery 33:593–599, 2013.
    Keywords: Osteonecrosis – Care and Treatment ; Osteonecrosis – Usage;
    ISSN: 0738-1085
    E-ISSN: 1098-2752
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  • 6
    Language: Japanese
    In: M&M材料力学カンファレンス, 2017, Vol.2017(0), pp.PS01
    Description: 〈p〉In order to inspect the inside of a small diameter metal pipe easily, an endoscope using a camera or a visual observation has been put into practical use. But there are a lot of problems to inspect a pip, for example, internal scratches can not be judged. Therefore, an ultrasonic probe installed in a pip using an electromagnetic acoustic transducer has been studied.〈/p〉
    Keywords: pipe ; electromagnetic acoustic transducer ; non-destructive inspection ; guide wave ; Pipe ; Electromagnetic Acoustic Transducer ; Non-Destructive Inspection ; Guide Wave
    ISSN: 2424-2845
    ISSN: The Proceedings of the Materials and Mechanics Conference
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  • 7
    In: Biomedical Chromatography, March 2014, Vol.28(3), pp.348-353
    Description: Glucuronidation plays critical role in the elimination of bergenin; however the metabolic mechanism of UDP‐glucuronosyltransferases (UGTs) in the process remains to be investigated. In this study, the kinetics of bergenin glucuronidation by pooled human liver microsomes (HLMs) and 12 recombinat UGT isozymes were investigated. The glucuronidation of bergenin can be shown in HLMs with a value of 231.62 ± 14.08 µ and a value of 2.17 ± 0.21 nmol/min/(mg protein). Among the 12 human UGTs investigated, UGT1A1 was identified as the major isoform catalyzing the glucuronidation of bergenin [ value of 200.37 ± 26.73 µ and value of 1.88 ± 0.26 nmol/min/(mg protein)]. The bergenin glucuronosyltransferase activities in HLMs and UGT1A1 were inhibited by phenylbutazone, estradiol and bilirubin. The results demonstrate that bergenin glucuronidation in HLMs is specifically catalyzed by UGT1A1. Copyright © 2013 John Wiley & Sons, Ltd.
    Keywords: Bergenin ; Udp‐Glucuronosyltransferases ; Human Liver Microsomes ; Ugt1a1 ; In Vitro
    ISSN: 0269-3879
    E-ISSN: 1099-0801
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  • 8
    In: Journal of Clinical & Experimental Orthopaedics, 2017, Vol.03(04)
    ISSN: Journal of Clinical & Experimental Orthopaedics
    E-ISSN: 24718416
    Source: CrossRef
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  • 9
    Language: English
    In: Open Medicine, 01 January 2015, Vol.10(1)
    Description: The objective of this study was to explore the correlation between bone marrow edema, stage of necrosis, and area ratio of necrosis with the hip pain grading in non-traumatic osteonecrosis of the femoral head. Bone marrow edema grading at all levels and the hip pain grade differences were statistically significant (P 〈 0.001). Bone marrow edema grading increased by levels of 0, 1, and 2, whereas average pain rating increased as well to 40.73, 104.66 and 143.49. I ~ III period stage of necrosis and the hip pain grade difference was statistically significant (P 〈 0.001), with the average grade progress pain stage by the death of a rank gradually increased, I period, II period, III period was 57.00, 88.58 and 120.62, respectively. Area ratio of necrosis between 0 ~ 3 were positively correlated with pain, compared the two was statistically significant (P 〈 0.001), and with the degree of pathological changes is aggravating, increase the average rank of levels of pain. 0, 1, 2 and 3 are 36.88, 98.03, 123.87 and 151.93 respectively. We can choose the treatment method and evaluate treatment effect by considering a patients’ degree of bone marrow edema, stage of necrosis and area ratio of necrosis.
    Keywords: Pain Grading ; Bone Marrow Edema ; Stage of Necrosis ; Area Ratio of Necrosis ; Medicine
    E-ISSN: 2391-5463
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  • 10
    Language: English
    In: Open Medicine, 2015, Vol.10
    Keywords: Necrosis – Usage ; Edema – Care and Treatment
    ISSN: 2391-5463
    Source: Cengage Learning, Inc.
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