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  • 1
    In: PLoS ONE, 2015, Vol.10(4)
    Description: The occlusion of dentinal tubules is an effective method to alleviate the symptoms caused by dentin hypersensitivity, a significant health problem in dentistry and daily life. The in situ mineralization within dentinal tubules is a promising treatment for dentin hypersensitivity as it induces the formation of mineral on the sensitive regions and occludes the dentinal tubules. This study was carried out to evaluate the in vitro effect of a whole generation poly(amidoamine) (PAMAM) dendrimer (G3.0) on dentinal tubule occlusion by inducing mineralization within dentinal tubules. Dentin discs were treated with PAMAM dendrimers using two methods, followed by the in vitro characterization using Attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy (FE-SEM) and Energy-Dispersive X-ray Spectroscopy (EDS). These results showed that G3.0 PAMAM dendrimers coated on dentin surface and infiltrated in dentinal tubules could induce hydroxyapatite formation and resulted in effective dentinal tubule occlusion. Moreover, crosslinked PAMAM dendrimers could induce the remineralization of demineralized dentin and thus had the potential in dentinal tubule occlusion. In this in vitro study, dentinal tubules occlusion could be achieved by using PAMAM dendrimers. This could lead to the development of a new therapeutic technique for the treatment of dentin hypersensitivity.
    Keywords: Research Article
    E-ISSN: 1932-6203
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  • 2
    Language: English
    In: Tetrahedron, 11 March 2013, Vol.69(10), pp.2296-2301
    Description: New eunicellin-base diterpenoids, hirsutalins I–M ( – ), were isolated from the soft coral . Their structures were elucidated by spectroscopic methods, particularly in 1D and 2D NMR experiments. The absolute configuration of was determined by Mosher's method. These compounds did not exhibit cytotoxicity toward a limited panel of cancer cell lines but showed nitric oxide inhibitory activity in LPS-stimulated RAW264.7 macrophage cells. Among them, compound was found to possess the strongest NO inhibitory activity with an IC value of 9.8 μg/mL. Furthermore, was shown to significantly reduce the expression iNOS protein in the same cells. New eunicellin-based diterpenoids, were isolated from the soft coral, .
    Keywords: Eunicellin-Base Diterpenoids ; Hirsutalins I–M ; Cytotoxicity ; No Inhibitory Activity ; Chemistry
    ISSN: 0040-4020
    E-ISSN: 1464-5416
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  • 3
    Language: English
    In: Journal of agricultural and food chemistry, 09 March 2011, Vol.59(5), pp.1667-72
    Description: In this study, we discovered that an ethanol (EtOH) extract of Solanum nigrum inhibited spore germination of Alternaria brassicicola, the causative agent of cabbage black leaf spot disease. At a concentration of 500 mg/L, this ethanol extract also caused the germ tubes to become completely swollen. Detached cabbage leaves were then used to evaluate the effects of the extract in controlling the disease. It was observed that the extract-induced swelling of A. brassicicola germ-tube spores did not cause the symptoms of black spot disease on cabbage leaves. Furthermore, an n-butanol fraction of the EtOH extract exhibited strong antifungal activity; at a concentration of 25 mg/L, a derived subfraction (Bu-11-13) showed complete inhibition of spore germination. A white powder was collected from fraction Bu-11-13, and its minimum inhibitory concentration was determined to be 8 mg/L. Using NMR and LC-MS/MS analysis, this white powder compound was identified as degalactotigonin.
    Keywords: Alternaria -- Drug Effects ; Brassica -- Microbiology ; Plant Diseases -- Prevention & Control ; Plant Extracts -- Chemistry ; Saponins -- Pharmacology ; Solanum Nigrum -- Chemistry ; Steroids -- Pharmacology
    ISSN: 00218561
    E-ISSN: 1520-5118
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  • 4
    Language: English
    In: Journal of agricultural and food chemistry, 20 November 2013, Vol.61(46), pp.11008-15
    Description: Activity-directed fractionation and purification processes were employed to identify the anti-inflammatory active compounds using lipopolysaccharide (LPS)-stimulated mouse macrophage (RAW264.7) in vitro. Air-dried roots of Ficus formosana were extracted with methanol and separated into n-hexane, chloroform, ethyl acetate, n-butanol, and water layers. Among them, the chloroform layer showed strong activity and was subjected to separation and purification by using various chromatographic techniques. Five compounds showing potent activity were identified by comparing spectral data to be β-sitosterol, stigmasterol, psoralen, kaempferol, carpachromene, and syringic aldehyde. When macrophages were treated with psoralen and kaempferol together with LPS, a concentration-dependent inhibition of nitric oxide (NO) and tumor necrosis factor (TNF-α) productions were detected. Western blotting revealed that kaempferol, psoralen, and carpachromene blocked protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in LPS-stimulated macrophages. The results confirmed that the traditional use of F. formosana could be a potential anti-inflammatory agent.
    Keywords: Anti-Inflammatory Agents -- Chemistry ; Ficus -- Chemistry ; Plant Extracts -- Chemistry ; Plant Roots -- Chemistry
    ISSN: 00218561
    E-ISSN: 1520-5118
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  • 5
    Language: English
    In: Journal of agricultural and food chemistry, 08 March 2017, Vol.65(9), pp.1874-1886
    Description: Antodia cinnamomea, a precious brown-rot fungus endemic to Taiwan, has pharmaceutical applications due to its diverse array of metabolites. The terpenoids found in A. cinnamomea contribute to its most important bioactivities. We identified several terpenoid compounds in A. cinnamomea and revealed that their content in mycelium and fruiting body were significantly different. Using next-generation sequencing and an in-house transcriptome database, we identified several terpene synthase (TPS) candidates. After sequence analysis and functional characterization, 10 out of 12 candidates were found to have single or multiple terpene synthesis functions. Most of the terpenoid compounds were found to confer important bioactivities. RT-PCR results showed a positive correlation between terpene synthase expression pattern and terpenoid content. In addition, we identified several modification enzyme candidates that may be involved in the postmodification of terpenoid compounds with a genomic DNA scaffold, and a putative genetic network.
    Keywords: Antrodia Cinnamomea ; Genetic Network ; Next-Generation Sequencing ; Terpenoid Synthase ; Transcriptome ; Gene Regulatory Networks ; Antrodia -- Metabolism ; Fruiting Bodies, Fungal -- Metabolism ; Mycelium -- Genetics ; Terpenes -- Metabolism
    ISSN: 00218561
    E-ISSN: 1520-5118
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  • 6
    Language: English
    In: The journal of trading, 2012, Vol.7(2), pp. 37-43
    ISSN: 15593967
    E-ISSN: 21688427
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  • 7
    Language: English
    In: Phytomedicine, 15 March 2013, Vol.20(5), pp.394-400
    Description: Obesity is associated with an increased risk of development of numerous diseases including type 2 diabetes, hypertension, hyperlipidemia, and cardiovascular disease. In this study, we investigated the effects of lucidone on gene expression during adipogenesis in 3T3-L1 cells and on high-fat diet induced obesity in C57BL/6 mice. Lucidone at 40 μmol/L suppressed adipogenesis in 3T3-L1 cells by reducing transcription levels of adipogenic genes, including PPARγ, C/EBPα, LXR-α, LPL, aP2, GLUT4 and adiponectin. Five-week-old male C57BL/6 mice fed a high fat diet (60% energy from fat) supplemented with lucidone at a dosage of 1250 mg/kg of diet for 12 weeks had reduced body and liver weight, reduced epididymal and perirenal adipose tissue, decreased food efficiency (percentage of weight gain divided by food intake), and lowered plasma cholesterol, triglyceride, glucose, and insulin levels. Dissection of adipose tissue from lucidone-treated mice showed a reduction in the average fat-cell size and percentage of large adipocytes. These results provide evidence that dietary intake of lucidone alleviates high fat diet-induced obesity in C57BL/6 mice and reveals the potential of lucidone as a nutraceutical to prevent obesity and consequent metabolic disorders.
    Keywords: Lucidone ; Lindera Erythrocarpa ; Adipogenesis ; High-Fat Diet ; Obesity ; Medicine ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0944-7113
    E-ISSN: 1618-095X
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  • 8
    Language: English
    In: PLoS ONE, 01 January 2015, Vol.10(2), p.e0117111
    Description: Epithelial-to-mesenchymal transition (EMT) is a crucial event involved metastasis of certain tumors. Thus, identifying chemical agents that can block EMT is highly warranted for the development of anti-cancer chemoprevention/chemotherapies....
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 9
    Language: English
    In: Journal of the American Chemical Society, April 29, 2015, Vol.137(16), pp.5576-5581
    Description: The article demonstrates a bottom-up approach toward the assembly of electrochemically exfoliated graphene (EEG) sheets with a series of functional nanoparticles (Si, [Fe.sub.3][O.sub.4], and Pt NPs) into two-dimensional sandwich-like hybrid nanostructures. Polyaniline in the emeraldine base form acts as a versatile dopant to couple NPs onto EEG through either electrostatic interactions or hydrogen bonding. This procedure allows processing and assembly of EEG using an economical pathway.
    Keywords: Graphene – Chemical Properties ; Graphene – Electric Properties ; Nanoparticles – Research
    ISSN: 0002-7863
    Source: Cengage Learning, Inc.
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  • 10
    Language: English
    In: Journal of agricultural and food chemistry, 22 February 2012, Vol.60(7), pp.1673-81
    Description: In this study, we have investigated the anti-inflammatory effects of imperatorin, a compound isolated from the roots of Glehnia littoralis, using a lipopolysaccharide (LPS)-stimulated mouse macrophage (RAW264.7) in vitro and a carrageenan (Carr)-induced mouse paw edema model in vivo. When RAW264.7 macrophages were treated with imperatorin together with LPS, a significant concentration-dependent inhibition of NO production was detected. Western blotting revealed that imperatorin blocked the protein expression of iNOS and cyclooxygenase-2 (COX-2) in LPS-stimulated RAW264.7 macrophages significantly. In the anti-inflammatory test, imperatorin decreased the paw edema at 4 and 5 h after Carr administration and increased the activities of catalase, superoxide dismutase, and glutathione peroxidase in paw edema. We also demonstrated that imperatorin significantly attenuated the malondialdehyde level in the edema paw at the fifth hour after Carr injection. Imperatorin decreased the NO and tumor necrosis factor and prostaglandin E2 levels on serum at 5 h after Carr injection. Western blotting revealed that imperatorin decreased Carr-induced iNOS and COX-2 expressions at 5 h in edema paw. An intraperitoneal injection treatment with imperatorin also diminished neutrophil infiltration into sites of inflammation as did indomethacin. The results suggested that imperatorin had anti-inflammatory effects in LPS-stimulated RAW 264.7 cells and Carr-injected mice, respectively. In addition, inhibition of elevated iNOS and COX-2 protein expression as well as neutrophil infiltration of Carr-injected paws may be involved in the beneficial effects of imperatorin.
    Keywords: Anti-Inflammatory Agents -- Pharmacology ; Apiaceae -- Chemistry ; Cyclooxygenase 2 -- Metabolism ; Furocoumarins -- Pharmacology ; Nitric Oxide Synthase Type II -- Analysis
    ISSN: 00218561
    E-ISSN: 1520-5118
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