Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Type of Material
Type of Publication
Consortium
Language
  • 1
    Book
    Book
    St. Louis, Mo. : Churchill Livingstone Elsevier
    UID:
    (DE-605)HT014467781
    Format: XI, 596 S. : Ill., graph. Darst.
    ISBN: 9780443067327 , 0443067325
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Inst för medicin, Solna / Dept of Medicine, Solna
    UID:
    (DE-627)1803869305
    Content: Elevated level of LDL is the most important risk factor for atherosclerosis. ApoB100 is the only unexchangeable protein in LDL particle. Recent reports have shown that native peptides of ApoB100 trigger activation of adaptive immune responses. Whether ApoB100 can activate innate immune response is unknown. In this thesis, we identified a native ApoB100 peptide from human ApoB100, named ApoB100 danger associated signal-1 (ApoBDS-1), given its biological nature totrigger innate proinflammatory responses in monocytes and macrophages. Besides macrophages, ApoBDS-1 can also activate platelets and endothelial cells, eliciting proinflammatory mediators and promoting platelet-leukocyte aggregates through complex molecular mechanisms involving Ca2+ flux, ROS production, MAPKs activation, PI3K-Akt activation, and microRNA regulations. ApoBDS-1 contributes to the activation of inflammatory signaling in human atherosclerotic plaque. We showed that ApoBDS-1 exists in human carotid plaques by immunofluorescence staining. Size-exclusion chromatography and Western blot confirmed that some low molecular weight fractions isolated from plaque contain ApoBDS-1 epitopes and possess ApoBDS-1-like bioactivity for induction of IL-8. These findings suggest that active ApoBDS-1 presents in atherosclerotic lesions. Analysis of BiKE database indicates that inflammasome pathways are involved in atherosclerosis and associated with the disease severity. Our studies show that ApoBDS-1 is an endogenous activator of NLRP3 inflammasome, inducing IL-1β in monocytes and macrophagesvia NLRP3-dependent caspase-1 activation. We also found that ApoBDS-1 could induce NLRP3 inflammasome complex formation in vivo, and activate NLRP3 inflammasome by induction of K+ efflux. Lastly, we explored the receptor/interacting protein for ApoBDS-1 using far Western blot and 2-D electrophoresis and identified TNF receptor associated protein 1 (Trap1) as an ApoBDS-1 specific interacting protein. Trap1 and ApoBDS-1 are colocalised mainly in cytoplasm and also on cell surface membrane. Biacore SPR analysis suggests that ApoBDS-1 binds toTrap1 with a medium affinity depending on the last 5 amino acids in its C-terminal domain. Trap1 is indispensable for ApoBDS-1 function since ApoBDS-1 induced cytokine secretion and reactive oxygen species can be inhibited by Geldanamycin, an inhibitor of Trap1 or by knocking down of Trap1 using specific shRNA. Taken together, we have identified ApoBDS-1 as the innate immune activator in ApoB100. Blocking the interaction of ApoBDS-1 and Trap1, or inhibition of ApoBDS-1 induced signaling pathways may represent new therapeutic options for atherosclerosis treatment.
    Note: Dissertation Inst för medicin, Solna / Dept of Medicine, Solna 2014
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Online Resource
    Online Resource
    St. Louis : Churchill Livingstone/Elsevier
    UID:
    (DE-604)BV042300838
    Format: 1 Online-Ressource (xi, 596 p.)
    ISBN: 9780702036095 , 0702036099 , 9780443067327 , 0443067325
    Note: Unique and comprehensive, this resource thoroughly discusses the various micro-acupuncture systems with clear and clinically useful information for practice, including styles of practice throughout the world, overviews of each system, and treatment for common disorders. All micro systems are covered, including information on point locations and functions. Treatment protocols are given for more than 50 common diseases and conditions, providing the tools necessary for the most effective treatment of patients. The books readability, evidence-based approach, excellent organization, detailed illustrations, comprehensive coverage of all micro-systems, and practical therapeutic treatment guidelines for commonly seen conditions make it an essential for anyone treating patients with acupuncture. Covers all micro-acupuncture systems, including point locations and functions, providing you with a wide variety of clinical tools: all in one reference. Treatment protocols for more than 50 conditions, listed alphabetically for quick reference. Logically organized, with consistent coverage of introductory material, micro-systems, and treatment protocols. Clear and detailed illustrations and photos that show locations of acupuncture points and each micro-system's relationship to the body, enhancing your understanding of treatment techniques. Based on current research with evidence behind the systems to ensure you are using the most authoritative information in the field. Author Yajuan Wang, an instructor at a major naturopathic university, has more than 20 years of clinical experience , Includes bibliographical references (p. 569-570) and index , Chinese characters included for key terms
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    UID:
    (DE-627)1833695550
    ISBN: 9781713845096
    In: International Conference on Logistics and Systems Engineering (11. : 2022 : Changsha), 11th International Conference on Logistics and Systems Engineering 2021, Red Hook, NY : Curran Associates, Inc., 2022, (2022), Seite 224-233, 9781713845096
    In: year:2022
    In: pages:224-233
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Online Resource
    Online Resource
    Churchill Livingstone
    UID:
    (DE-605)HT021645188
    Format: 1 Online-Ressource
    ISBN: 9780443067327
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    UID:
    (DE-605)TT003776535
    In: Atmospheric environment, Oxford [u.a.], 2003, ISSN 1352-2310. - 37. 2003,21, S. 2893 - 2902
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Online Resource
    Online Resource
    St. Louis : Churchill Livingstone/Elsevier
    UID:
    (DE-627)648861589
    Format: Online-Ressource (xi, 596 p) , ill , 29 cm
    Edition: Online-Ausg. Amsterdam Elsevier Science & Technology 2009 Electronic reproduction; Mode of access: World Wide Web
    ISBN: 0443067325 , 0702036099 , 9780702036095 , 9780443067327
    Content: Unique and comprehensive, this resource thoroughly discusses the various micro-acupuncture systems with clear and clinically useful information for practice, including styles of practice throughout the world, overviews of each system, and treatment for common disorders. All micro systems are covered, including information on point locations and functions. Treatment protocols are given for more than 50 common diseases and conditions, providing the tools necessary for the most effective treatment of patients. The books readability, evidence-based approach, excellent organization, detailed illustrations, comprehensive coverage of all micro-systems, and practical therapeutic treatment guidelines for commonly seen conditions make it an essential for anyone treating patients with acupuncture. Covers all micro-acupuncture systems, including point locations and functions, providing you with a wide variety of clinical tools: all in one reference. Treatment protocols for more than 50 conditions, listed alphabetically for quick reference. Logically organized, with consistent coverage of introductory material, micro-systems, and treatment protocols. Clear and detailed illustrations and photos that show locations of acupuncture points and each micro-system's relationship to the body, enhancing your understanding of treatment techniques. Based on current research with evidence behind the systems to ensure you are using the most authoritative information in the field. Author Yajuan Wang, an instructor at a major naturopathic university, has more than 20 years of clinical experience
    Content: Unique and comprehensive, this resource thoroughly discusses the various micro-acupuncture systems with clear and clinically useful information for practice, including styles of practice throughout the world, overviews of each system, and treatment for common disorders. All micro systems are covered, including information on point locations and functions. Treatment protocols are given for more than 50 common diseases and conditions, providing the tools necessary for the most effective treatment of patients. The books readability, evidence-based approach, excellent organization, detailed illustrations, comprehensive coverage of all micro-systems, and practical therapeutic treatment guidelines for commonly seen conditions make it an essential for anyone treating patients with acupuncture. Covers all micro-acupuncture systems, including point locations and functions, providing you with a wide variety of clinical tools: all in one reference. Treatment protocols for more than 50 conditions, listed alphabetically for quick reference. Logically organized, with consistent coverage of introductory material, micro-systems, and treatment protocols. Clear and detailed illustrations and photos that show locations of acupuncture points and each micro-system's relationship to the body, enhancing your understanding of treatment techniques. Based on current research with evidence behind the systems to ensure you are using the most authoritative information in the field. Author Yajuan Wang, an instructor at a major naturopathic university, has more than 20 years of clinical experience
    Note: Includes bibliographical references (p. 569-570) and index , Unit 1: Introduction to Micro-Acupuncture1. Introduction to Micro-Acupuncture: History and Theory -- 2. Micro System Techniques -- 3. Micro-Acupuncture Method of Point Selection and Combination -- 4. Acupuncture Practice Tips -- Unit 2: Systems of Micro-Acupuncture -- 5. Scalp Acupuncture -- 6. Face Acupuncture -- 7. Ear Acupuncture -- 8. Eye Acupuncture -- 9. Nose Acupuncture -- 10. Philtrum Acupuncture -- 11. Mouth Acupuncture -- 12. Tongue Acupuncture -- 13. Neck Acupuncture -- 14. Back Shu Acupuncture -- 15. Jia Ji Acupuncture -- 16. Spinal Acupuncture -- 17. Chest Acupuncture -- 18. Abdominal Acupuncture -- 19. Hand Acupuncture -- 20. Foot Acupuncture -- 21. Wrist and Ankle Acupuncture -- 22. Holographic Acupuncture -- Unit 3: Micro-Acupuncture Therapeutics -- 23. Micro-Acupuncture Therapeutics -- Unit 4: Therapeutic Massage -- 24. Therapeutic Massage. , Electronic reproduction; Mode of access: World Wide Web , Chinese characters included for key terms
    Additional Edition: 0443067325
    Additional Edition: Print version Micro-Acupuncture in Practice
    Language: English
    Keywords: Electronic books ; Electronic book
    URL: Volltext  (An electronic book accessible through the World Wide Web; click for information)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    UID:
    (DE-627)885227417
    ISSN: 0219-8770
    In: International journal of innovation and technology management, Singapore [u.a.] : World Scientific Publishing, 2004, 13(2016), 6 vom: Dez., Seite 1640014-1-20, 0219-8770
    In: volume:13
    In: year:2016
    In: number:6
    In: month:12
    In: pages:1640014-1-20
    Language: English
    Keywords: Aufsatz in Zeitschrift
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    UID:
    (DE-627)1040219365
    ISSN: 0263-7863
    In: International journal of project management, Amsterdam [u.a.] : Elsevier, 1983, 36(2018), 7 vom: Okt., Seite 980-991, 0263-7863
    In: volume:36
    In: year:2018
    In: number:7
    In: month:10
    In: pages:980-991
    Language: English
    Keywords: Aufsatz in Zeitschrift
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    UID:
    (DE-101)1309253072
    Format: Online-Ressource
    ISSN: 2193-5815
    Content: Abstract: Vinyl sulfones are conjugated systems composed of C=C and S=O, which are considered to be significant building blocks in organic synthesis and as coupling agents because they can serve as Michael acceptors as well as 2π‐partners in cycloaddition reactions. The attractive bioactivity and unique chemical properties of the vinyl sulfone skeleton have led to its extensive study in organic synthesis and pharmaceutical chemistry. However, a systematic and comprehensive review of the routes for the catalytic synthesis of vinyl sulfones have not been carried out so far. In this paper, the applications of vinyl sulfone structures in biomolecular and organic syntheses are briefly investigated, and the current methods for the synthesis of vinyl sulfone structures in recent years using different catalysts are systematically reviewed and analyzed. Finally, the future opportunities and challenges for the synthesis and application of vinyl sulfone compounds are discussed.
    In: day:08
    In: month:11
    In: year:2023
    In: extent:30
    In: Asian journal of organic chemistry, Weinheim : Wiley-VCH, [2012]-, (08.11.2023) (gesamt 30), 2193-5815
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages