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  • 1
    Language: English
    In: Cancer research, 01 December 2012, Vol.72(23), pp.6079-88
    Description: A broad range of human malignancies is associated with nonrandom 1p36 deletions, suggesting the existence of tumor suppressors encoded in this region. Evidence for tumor-specific inactivation of 1p36 genes in the classic "two-hit" manner is scarce; however, many tumor suppressors do not require complete inactivation but contribute to tumorigenesis by partial impairment. We discuss recent data derived from both human tumors and functional cancer models indicating that the 1p36 genes CHD5, CAMTA1, KIF1B, CASZ1, and miR-34a contribute to cancer development when reduced in dosage by genomic copy number loss or other mechanisms. We explore potential interactions among these candidates and propose a model where heterozygous 1p36 deletion impairs oncosuppressive pathways via simultaneous downregulation of several dosage-dependent tumor suppressor genes.
    Keywords: Chromosome Disorders -- Genetics ; Neoplasms -- Genetics
    ISSN: 00085472
    E-ISSN: 1538-7445
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  • 2
    Language: German
    In: Die Zukunft der Wohlfahrtsgesellschaft : Festschrift für Hans-Werner Sinn, 2013, pp. 17-37
    Keywords: Finanzmarktkrise ; Bubbles ; Systemrisiko ; Wirtschaftswachstum ; Vergleich ; Lateinamerika ; Südostasien ; Usa ; Europa ; 1994-2008
    Source: Deutsche Zentralbibliothek für Wirtschaftswissenschaften
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  • 3
    Language: English
    In: Review of Quantitative Finance and Accounting, 2013, Vol.41(1), pp.111-129
    Description: In this note we propose an alternative test specification for Basu’s (1997) time series measure of conservatism that is related to the threshold unit root test of Enders and Granger (1998). We argue that a regression of changes in earnings on the lagged levels —rather than lagged changes— , including an interaction term for negative values, has three conceptual advantages compared to the conventional setup: (1) a smooth, non-oscillating impulse-response pattern to an unexpected shock in earnings (2) a more efficient estimate of persistence in the long run and (3) it can be extended to higher order autoregressive processes. We apply both approaches to a common dataset of firms from the S&P500 index. We confirm the conventional finding that negative shocks are transitory and display stronger mean reversion than positive shocks. However, while most of the literature reports mixed evidence on positive shocks, we find clear evidence that positive shocks are transitory as well. In a Monte Carlo simulation we explain this finding by documenting that larger standard errors in the Basu specification can lead to incorrect inference when the decision between persistent and transitory shocks is close.
    Keywords: Timely loss recognition ; Asymmetric persistence ; Conservatism
    ISSN: 0924-865X
    E-ISSN: 1573-7179
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  • 4
    Language: English
    In: PLoS ONE, 01 January 2016, Vol.11(8), p.e0161283
    Description: In the present report we describe the establishment of a spontaneous immortalized skin keratinocyte cell line derived from the skin of the multimammate rodent Mastomys coucha. These animals are used in preclinical studies for a variety of human diseases such as infections with nematodes, bacteria and papillomaviruses, especially regarding cutaneous manifestations such as non-melanoma skin cancer. Here we characterize the cells in terms of their origin and cytogenetic features. Searching for genomic signatures, a spontaneous mutation in the splicing donor sequence of Trp53 (G to A transition at the first position of intron 7) could be detected. This point mutation leads to alternative splicing and to a premature stop codon, resulting in a truncated and, in turn, undetectable form of p53, probably contributing to the process of immortalization. Mastomys coucha-derived skin keratinocytes can be used as an in vitro system to investigate molecular and immunological aspects of infectious agent interactions with their host cells.
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 5
    Language: English
    In: Cancer Research, 07/01/2017, Vol.77(13 Supplement), pp.1426-1426
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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  • 6
    Language: German
    In: Ifo-Schnelldienst, 2018, Vol.71(18), pp. 54-56
    ISSN: 0018974X
    Source: Deutsche Zentralbibliothek für Wirtschaftswissenschaften
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  • 7
    Language: English
    In: Economics Letters, April 2014, Vol.123(1), pp.26-32
    Description: We point out that fiscal multipliers derived from SVAR-models include the predicted future path of policy instruments. After the initial shock, net taxes and government expenditures react to each other and are autocorrelated. In a counterfactual simulation, we report fiscal multipliers that abstract from these dynamic responses.
    Keywords: Fiscal Policy ; Government Spending ; Net Revenues ; Structural Vector Autoregression ; Economics
    ISSN: 0165-1765
    E-ISSN: 1873-7374
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  • 8
    Language: English
    In: PLoS ONE, 01 January 2013, Vol.8(7), p.e68859
    Description: Retinoic acid (RA) has paradoxical effects on cancer cells: promoting cell death, differentiation and cell cycle arrest, or cell survival and proliferation. Arachidonic acid (AA) release occurs in response to RA treatment and, therefore, AA and its downstream metabolites may be involved in cell survival signalling. To test this, we inhibited phospholipase A2-mediated AA release, cyclooxygenases and lipoxygenases with small-molecule inhibitors to determine if this would sensitise cells to cell death after RA treatment. The data suggest that, in response to RA, phospholipase A2-mediated release of AA and subsequent metabolism by lipoxygenases is important for cell survival. Evidence from gene expression reporter assays and PPARδ knockdown suggests that lipoxygenase metabolites activate PPARδ. The involvement of PPARδ in cell survival is supported by results of experiments with the PPARδ inhibitor GSK0660 and siRNA-mediated knockdown. Quantitative reverse transcriptase PCR studies demonstrated that inhibition of 5-lipoxygenase after RA treatment resulted in a strong up-regulation of mRNA for PPARδ2, a putative inhibitory PPARδ isoform. Over-expression of PPARδ2 using a tetracycline-inducible system in neuroblastoma cells reduced proliferation and induced cell death. These data provide evidence linking lipoxygenases and PPARδ in a cell survival-signalling mechanism and suggest new drug-development targets for malignant and hyper-proliferative diseases.
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 9
    Language: English
    In: Economic policy : a European forum, 2014, pp. 495-552
    Keywords: Schuldenkrise ; Öffentliche Anleihe ; Zins ; Geldpolitik ; Europäischer Stabilitätsmechanismus ; Iwf-Kredit ; Europa ; Welt
    ISSN: 02664658
    Source: Deutsche Zentralbibliothek für Wirtschaftswissenschaften
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  • 10
    In: Financial History Review, 2012, Vol.19(2), pp.149-174
    Description: In this article we re-evaluate the hypothesis that the development of the financial sector was an essential factor behind economic growth in nineteenth-century Germany. We apply a structural VAR framework to a new annual data set from 1870 to 1912 that was initially compiled by Walther Hoffmann (1965). With respect to the literature, the distinguishing characteristic of our analysis is the focus on different sectors in the economy and the interpretation of the findings in the context of a two-sector growth model. We find that all sectors were affected significantly by shocks from the banking system. Interestingly, this link is the strongest in sectors with small or non-tradable-goods-producing firms, such as construction, services, transportation and agriculture. In this regard, the growth patterns in nineteenth-century Germany are similar to those in today's emerging markets.
    Keywords: Economic Growth; Financial Development; Sectoral Asymmetries; C22; N13; N23; 011
    ISSN: 0968-5650
    E-ISSN: 1474-0052
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