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  • 1
    Article
    Article
    BMJ Publishing Group Ltd and British Society of Gastroenterology
    Language: English
    In: Gut May 2010, Vol.59(5), p.692
    Description: The purpose of this article is to review recent developments in the role of CT colonography with an emphasis on colorectal cancer screening. An introduction to the concept and method of CT colonography is given as well as a summary of the data on performance of CT colonography. Furthermore, details on side effects, efficacy and cost-effectiveness and the possible role of extracolonic findings are provided. The impact CTC could have on colonoscopy and other possible indications of the method are also mentioned.
    Keywords: CT-Colonography ; Colorectal Cancer Screening ; CT
    ISSN: 0017-5749
    ISSN: 00175749
    E-ISSN: 1468-3288
    E-ISSN: 14683288
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  • 2
    Language: English
    In: Gastroenterology, June 2012, Vol.142(7), pp.1460-1467.e2
    Description: Screening colonoscopy examinations for colorectal cancer are offered in the United States and some European countries. Data on results and adverse effects of screening colonoscopy are limited. In autumn 2002, colonoscopy was introduced as part of a nationwide cancer screening program in Germany; it was offered to the general population for individuals 55 years of age or older. We collected and analyzed data from this program. We performed a prospective cross-sectional study, collecting results from 2,821,392 screening colonoscopies performed at more than 2100 practices by highly qualified endoscopists in Germany from January 2003 to December 2008. Data on participation, colorectal adenoma and cancer detection, and complications were collected using standardized documentation forms. The data generated were centrally processed and evaluated. The cumulative participation rate was 17.2% of eligible women and 15.5% of eligible men 55–74 years old. The adenoma detection rate (ADR) was 19.4%, with a higher rate in men (25.8% vs 16.7% in women). Advanced adenomas were found in 6.4% of patients. Carcinomas were detected in 25,893 subjects (0.9%); most were of an early UICC stage (I, 47.3%; II, 22.3%; III, 20.7%; IV, 9.6%). The ADRs for gastroenterologists and nongastroenterologists were 25.1% and 22.3%, respectively (adjusted odds ratio, 1.18; 95% confidence interval, 1.16–1.21). The overall complication rate was 2.8/1000 colonoscopies, and the rate of serious complications was 0.58/1000 colonoscopies. A nationwide colonoscopy screening program that uses highly qualified endoscopists can detect a significant number of adenomas and early-stage carcinomas. The ADR for gastroenterologists was higher than for nongastroenterologists.
    Keywords: Early Detection ; Tumor ; Colon Cancer ; Crc ; Medicine
    ISSN: 0016-5085
    E-ISSN: 1528-0012
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  • 3
    Language: German
    In: Zeitschrift für Gastroenterologie, 2016, Vol.54(06), pp.521-522
    ISSN: 0044-2771
    E-ISSN: 1439-7803
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  • 4
    Language: German
    In: Forum, 2016, Vol.31(1), pp.7-7
    Keywords: Medicine;
    ISSN: 0947-0255
    E-ISSN: 2190-9784
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  • 5
    Article
    Article
    Language: German
    In: Deutsches Aerzteblatt Online, 2010
    Keywords: Medicine;
    ISSN: Deutsches Aerzteblatt Online
    E-ISSN: 1866-0452
    Source: CrossRef
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  • 6
    Language: English
    In: European Oncology & Haematology, 2011, Vol.07(04), p.240
    ISSN: 2045-5275
    Source: CrossRef
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  • 7
    Language: English
    In: Digestive Diseases, June 2016, Vol.34(5), pp.574-579
    Description: Background: Colorectal cancer (CRC) is the third most common cancer type in Western countries. Significant progress has been made in the last decade in the therapy of metastatic CRC (mCRC) with a median overall survival (OS) of patients exceeding 30 months. The integration of biologic targeted therapies and anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (MABs) in the treatment of patients with genomically selected all-RAS wild-type mCRC leads to a significant progress in advanced incurable disease state. After the introduction of the anti-VEGF MAB bevacizumab, the FDA approved with ramucirumab the second antiangiogenic MAB for the mCRC treatment. Further new drugs are on the horizon and new diagnostic tools will be introduced soon. Key Messages: Molecular heterogeneity of mCRC has been recognized as pivotal in the evolution of clonal populations during anti-EGFR therapies. Mutations in RAS genes predict a lack of response to anti-EGFR MABs. Mutations in the mitogen-activated protein kinase-phosphoinositide 3-kinase pathways like BRAF or PIK3CA mutations or HER2/ERBB2 or MET amplifications bypass EGFR signaling and also may confer resistance to anti-EGFR MABs. HER2/ERBB2 amplification is a further driver of resistance to anti-EGFR MABs in mCRC. The phase II study of HER2 Amplification for Colo-Rectal Cancer Enhanced Stratification (HERACLES) discovers that a dual HER2-targeted therapy may be an option for HER2-amplified mCRC. The mismatch repair deficiency predicts responsiveness to an immune checkpoint blockade with the anti-PD-1 immune checkpoint inhibitor pembrolizumab. Conclusions: The understanding of primary (de novo) and secondary (acquired) resistance to anti-EGFR therapies, new targeted therapies, immuno-oncology and about predictive biomarkers in mCRC is guiding the development of rational therapeutic strategies. Combinations of targeted therapies are necessary to effectively treat drug-resistant cancers. Liquid biopsy is an upcoming new tool in the primary diagnosis and follow-up analysis of mutations in circulating tumor DNA.
    Keywords: Small and Large Bowel ; Colorectal Cancer ; Acquired Resistance ; Targeted Therapies  ; Mismatch Repair ; Medicine
    ISBN: 9783318058741
    ISBN: 3318058742
    ISSN: 0257-2753
    E-ISSN: 1421-9875
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  • 8
    Language: English
    In: World journal of gastroenterology, 07 February 2015, Vol.21(5), pp.1666-9
    Description: Bleeding of peptic ulcer at the posterior duodenal bulb still is a particular endoscopic challenge with increased risk of treatment failure and worse outcome. In this article, we report successful treatment of an actively bleeding peptic ulcer located at the posterior duodenal wall, using an over-the-scope-clip in the case of a 54-year-old male patient with hemorrhagic shock. Incident primary hemostasis was achieved and no adverse events occurred during a follow-up of 60 d.
    Keywords: Duodenal Ulcer ; Over-the-Scope-Clip ; Upper Gastrointestinal Bleeding ; Endoscopes, Gastrointestinal ; Surgical Instruments ; Duodenal Ulcer -- Surgery ; Hemostasis, Endoscopic -- Instrumentation ; Peptic Ulcer Hemorrhage -- Surgery
    ISSN: 10079327
    E-ISSN: 2219-2840
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  • 9
    Language: English
    In: Visceral Medicine, August 2011, Vol.27(4), pp.316-321
    Description: Zwei bis fünf Prozent aller kolorektalen Karzinome (KRK) entstehen auf dem Boden einer erblichen Krebsdisposition. Hierbei ist die häufigste Form das HNPCC(hereditäres nichtpolypöses kolorektales Karzinom)-Syndrom (Lynch-Syndrom). Seltener sind die familiären adenomatösen Polyposis-Syndrome. Neben erhöhten Risiken für KRK besteht bei fast allen Formen ein erhöhtes Risiko weiterer extrakolonischer Neoplasien. Für die Diagnosestellung ist wesentlich, dass der untersuchende Kliniker phänotypische Hinweise für ein hereditäres Tumordispositonssyndrom erkennt und mit dem Patienten diskutiert sowie die nächsten Schritte zur Diagnosesicherung initiiert. Eine weitere wesentliche Rolle spielt die Befundung durch den Pathologen, der ebenfalls in vielen Fällen Auffälligkeiten erkennen kann und diese dem Kliniker im Befund mitteilen sollte.
    Keywords: Hauptthema · Main Topic ; Polyposis ; Hereditäres Nichtpolypöses Kolorektales Karzinom, Hnpcc ; Lynch-Syndrom ; Adenom ; Krebsrisiko
    ISBN: 9783805597531
    ISBN: 3805597533
    ISSN: 2297-4725
    ISSN: 16626664
    E-ISSN: 2297-475X
    E-ISSN: 16626672
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  • 10
    Language: English
    In: PLoS ONE, 01 January 2014, Vol.9(3), p.e90461
    Description: In pancreatic cancer, there is a clear unmet need to identify new serum markers for either early diagnosis, therapeutic stratification or patient monitoring. Proteomic analysis of tumor cell secretomes is a promising approach to indicate proteins released from tumor cells in vitro. Ectodomain shedding of transmembrane proteins has previously been shown to contribute significant fractions the tumor cell secretomes and to generate valuable serum biomarkers. Here we introduce a soluble form of the giant cadherin Fat1 as a novel biomarker candidate. Fat1 expression and proteolytic processing was analyzed by mass spectrometry and Western blotting using pancreatic cancer cell lines as compared to human pancreatic ductal epithelial cells. RNA expression in cancer tissues was assessed by in silico analysis of publically available microarray data. Involvement of ADAM10 (A Disintegrin and metalloproteinase domain-containing protein 10) in Fat1 ectodomain shedding was analyzed by chemical inhibition and knockdown experiments. A sandwich ELISA was developed to determine levels of soluble Fat1 in serum samples. In the present report we describe the release of high levels of the ectodomain of Fat1 cadherin into the secretomes of human pancreatic cancer cells in vitro, a process that is mediated by ADAM10. We confirm the full-length and processed heterodimeric form of Fat1 expressed on the plasma membrane and also show the p60 C-terminal transmembrane remnant fragment corresponding to the shed ectodomain. Fat1 and its sheddase ADAM10 are overexpressed in pancreatic adenocarcinomas and ectodomain shedding is also recapitulated in vivo leading to increased Fat1 serum levels in some pancreatic cancer patients. We suggest that soluble Fat1 may find an application as a marker for patient monitoring complementing carbohydrate antigen 19-9 (CA19-9). In addition, detailed analysis of the diverse processed protein isoforms of the candidate tumor suppressor Fat1 can also contribute to our understanding of cell biology and tumor behavior.
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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