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  • 1
    Online Resource
    Online Resource
    Cham : Springer International Publishing | Cham : Springer
    UID:
    b3kat_BV048637769
    Format: 1 Online-Ressource (VII, 317 p. 1 illus)
    Edition: 1st ed. 2022
    ISBN: 9783031083563
    Series Statement: Advances in Experimental Medicine and Biology 1385
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-08355-6
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-08357-0
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-08358-7
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 2
    UID:
    b3kat_BV039543619
    Format: XXXII, 290 S. , Ill., graph. Darst.
    ISBN: 9781461404774 , 9781461404781
    Language: English
    Subjects: Biology , Mathematics
    RVK:
    RVK:
    RVK:
    Keywords: Systembiologie ; Stochastik
    Author information: Wolkenhauer, Olaf 1966-
    Author information: Ullah, Mukhtar 1975-
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  • 3
    Online Resource
    Online Resource
    New York, NY [u.a.] : Springer
    UID:
    b3kat_BV039526373
    Format: 1 Online-Ressource
    ISBN: 9781461404774 , 9781461404781
    Language: English
    Subjects: Biology
    RVK:
    Keywords: Systembiologie ; Stochastik
    URL: Volltext  (lizenzpflichtig)
    Author information: Wolkenhauer, Olaf 1966-
    Author information: Ullah, Mukhtar 1975-
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  • 4
    Book
    Book
    Taunton : Research Studies Press [u.a.]
    UID:
    b3kat_BV012055504
    Format: XXVII, 261 S. , Ill., graph. Darst.
    ISBN: 086380229X , 0471981613
    Series Statement: Control Systems Centre 〈Manchester〉: UMIST Control Systems Centre series 5
    Language: English
    Subjects: Mathematics
    RVK:
    Keywords: Wahrscheinlichkeitstheorie ; Fuzzy-Logik
    Author information: Wolkenhauer, Olaf 1966-
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  • 5
    UID:
    b3kat_BV013966209
    Format: XXXII, 263 S. , Ill., graph. Darst.
    ISBN: 0471416568
    Series Statement: A Wiley-Interscience publication
    Language: English
    Subjects: Computer Science , Engineering
    RVK:
    RVK:
    Keywords: Datenbanksystem ; Fuzzy-Logik ; Systemanalyse
    Author information: Wolkenhauer, Olaf 1966-
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  • 6
    UID:
    b3kat_BV040875388
    Format: XII, 346 S. , graph. Darst.
    ISBN: 9789400755895 , 9400755899 , 9789400755901
    Series Statement: Advances in experimental medicine and biology 774
    Additional Edition: Erscheint auch als Online-Ausgabe Schmitz, Ulf MicroRNA cancer regulation
    Language: English
    Subjects: Biology
    RVK:
    Author information: Wolkenhauer, Olaf 1966-
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  • 7
    UID:
    b3kat_BV041200256
    Format: 1 Online-Ressource (xlvii, 2366 Seiten) , Illustrationen
    ISBN: 9781441998637
    Series Statement: Springer reference
    Additional Edition: Erscheint auch als Druck-Ausgabe, Hardcover ISBN 978-1-4419-9862-0
    Additional Edition: Erscheint auch als Print and electronic bundle ISBN 978-1-4419-9864-4
    Language: English
    Subjects: Biology
    RVK:
    Keywords: Systembiologie
    URL: Volltext  (URL des Erstveröffentlichers)
    Author information: Wolkenhauer, Olaf 1966-
    Author information: Dubitzky, Werner 1958-
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  • 8
    UID:
    gbv_1652144536
    Format: Online-Ressource (XII, 346 p. 93 illus., 70 illus. in color, digital)
    ISBN: 9789400755901
    Series Statement: Advances in Experimental Medicine and Biology 774
    Content: This book reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and their applications in combination with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. The use of high-throughput quantitative techniques makes an integrative experimental and computational approach necessary. This book will be a resource for researchers starting out with microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology, and the state-of-the-art in computational microRNA biology
    Note: Description based upon print version of record , MicroRNA Cancer Regulation; Preface; Background; The Systems Perspective on microRNAs in Cancer; Scope of This Book and Target Audience; Structure; How to Read This Book; Biologists and Clinicians; Computational Scientists and Modellers; Acknowledgements; Contents; 1: MicroRNAs in Human Cancer; 1.1 miRNA Overview; 1.2 Methods for Studying miRNA Genetics and Expression; 1.2.1 miRNA Profiling; 1.2.2 miRNA Databases and Validation; 1.3 Mechanisms of Alteration of miRNA Levels in Malignancy; 1.3.1 General Principles of miRNA Genomic Organization , 1.3.2 Alterations in Genomic miRNA Copy Numbers and Location1.3.3 Alterations in miRNA Transcriptional Regulation; 1.3.4 miRNA Biogenesis Pathway in Tumorigenesis; 1.3.4.1 miRNA Biogenesis; 1.3.4.2 Alterations in RNASEN/DGCR8 and DICER1/TARBP2; 1.3.4.3 Alterations in Other Pathway-Related RBPs; 1.4 Dysregulation of miRNA-mRNA Target Recognition; 1.4.1 miRNA Function/Mechanism; 1.4.2 Organization of miRNAs into Sequence Families; 1.4.3 miRNA-mRNA Stoichiometry; 1.4.4 Changes in the miRNA Targets; 1.5 Cancer Tissues Have Distinct miRNA Profiles; 1.5.1 miRNA Cancer Database , 1.5.2 Tissue Heterogeneity1.5.3 miRNAs as Tumor Suppressors and Oncogenes; 1.5.4 miRNA-Regulated Pathways; 1.6 Alterations of miRNA Sequence; 1.7 miRNA Target Identification; 1.8 miRNAs as Diagnostics; 1.9 miRNAs as Therapeutics; References; 2: Bioinformatics, Non-coding RNAs and Its Possible Application in Personalized Medicine; 2.1 Introduction; 2.2 Background; 2.2.1 Types of ncRNAs; 2.2.2 miRNA Function; 2.2.3 miRNA Networks in Cancer; 2.2.4 miRNA Identification; 2.2.5 Deep Sequencing; 2.2.5.1 NGS Data Analysis; 2.2.5.2 NGS and ncRNAs; 2.3 miRNA Gene Prediction; 2.3.1 Prediction Factors , 2.3.2 Prediction Methods2.4 miRNA Target Prediction; 2.5 miRNAs in Clinical Practice; 2.5.1 Cancer Predisposition and Development; 2.5.1.1 Diagnosis, Prognosis and Metastasis; 2.6 Conclusion; References; 3: MicroRNA Target Prediction and Validation; 3.1 Introduction; 3.2 Computational Methods to Identify microRNA Targets; 3.2.1 Thermodynamic Stability of the microRNA:mRNA Duplex; 3.2.2 Sequence Conservation of the Target Site Between Multiple Species; 3.2.3 Multiple Targets in the Same 3'UTR; 3.2.4 Functional Category of Targets; 3.2.5 Combining microRNA and mRNA Expression Data , 3.2.6 Concluding Remarks Regarding Computational Methods3.2.7 Future Directions; 3.3 Experimental Identification and Validation of microRNA Targets; 3.3.1 Reporter Assays; 3.3.2 Proteomics Methods; 3.3.3 Biochemical Approaches; 3.3.4 Molecular Methods; 3.3.5 Concluding Remarks; References; 4: MicroRNA-Regulated Networks: The Perfect Storm for Classical Molecular Biology, the Ideal Scenario for Systems Biology; 4.1 Introduction; 4.2 Systems Biology in a Nutshell; 4.2.1 Network Construction; 4.2.2 Mathematical Model Construction; 4.2.3 Model Calibration; 4.2.4 Model Analysis , 4.3 MicroRNAs as Components of Complex Network Motifs , Preface -- 1 MicroRNAs in human cancer -- 2 Bioinformatics, non-coding RNAs and its possible application in personalized medicine -- 3 MicroRNA target prediction and validation -- 4 MicroRNA-regulated networks: the perfect storm for classical molecular biology, the ideal scenario for systems biology -- 5 The p53/microRNA network in cancer: experimental and bioinformatics approaches.-6 MicroRNAs in melanoma biology -- 7 MicroRNA in the lung -- 8 The E2F1-miRNA cancer progression network -- 9 Modeling of microRNA-transcription factor networks in cancer -- 10 Coordinated networks of microRNAs and transcription factors with evolutionary perspectives -- 11 Mathematical modeling of microRNA-mediated mechanisms of translation repression -- 12 Web resources for microRNA research -- 13 Discovery of microRNA regulatory networks by integrating multidimensional high-throughput data -- 14 Discovering the functional microRNA-mRNA regulatory modules in heterogeneous data -- 15 Elucidating the role of microRNAs in cancer through data mining techniques -- 16 Working together: Combinatorial regulation by microRNAs.  .
    Additional Edition: ISBN 9789400755895
    Additional Edition: Buchausg. u.d.T. ISBN 978-94-007-5589-5
    Additional Edition: Erscheint auch als Druck-Ausgabe MicroRNA cancer regulation Dordrecht [u.a.] : Springer, 2013 ISBN 9400755899
    Additional Edition: ISBN 9789400755895
    Language: English
    Subjects: Biology
    RVK:
    Keywords: Krebs ; Small RNA ; Genexpression ; Regulierung ; Bioinformatik
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
    Author information: Wolkenhauer, Olaf 1966-
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  • 9
    UID:
    gbv_1652959181
    Format: Online-Ressource (XLVII, 2367 p. 830 illus., 530 illus. in color. eReference, online resource)
    ISBN: 9781441998637
    Series Statement: SpringerLink
    Content: Applications in drug discovery -- Aritificial life -- Artificial intelligence and machine learning -- Cancer -- Cell cycle -- Computational microRNA biology -- Functional imaging -- Gene regulatory networks: modeling, reconstruction and analysis -- Large-scale and high-performance computing -- Mathematical theory and methods -- Metabolic networks -- Model databases -- Philosophical and foundational issues -- Quantitative experiment design -- Resources -- Single cell experiments -- Standards, exchange formats, guidelines and ontologies -- Statistical theory and methods -- Structural network analysis -- Systems approaches to translational biomedical research: focus on diagnostic and prognostic applications -- Systems immunology -- Text mining -- Toponomics -- Transcriptional regulation -- Translational control and systems biology.
    Content: Systems biology refers to the quantitative analysis of the dynamic interactions among several components of a biological system and aims to understand the behavior of the system as a whole. Systems biology involves the development and application of systems theory concepts for the study of complex biological systems through iteration over mathematical modeling, computational simulation and biological experimentation. Systems biology could be viewed as a tool to increase our understanding of biological systems, to develop more directed experiments, and to allow accurate predictions. The Encyclopedia of Systems Biology is conceived as a comprehensive reference work covering all aspects of systems biology, in particular the investigation of living matter involving a tight coupling of biological experimentation, mathematical modeling and computational analysis and simulation. The main goal of the Encyclopedia is to provide a complete reference of established knowledge in systems biology – a ‘one-stop shop’ for someone seeking information on key concepts of systems biology. As a result, the Encyclopedia comprises a broad range of topics relevant in the context of systems biology. The audience targeted by the Encyclopedia includes researchers, developers, teachers, students and practitioners who are interested or working in the field of systems biology. Keeping in mind the varying needs of the potential readership, we have structured and presented the content in a way that is accessible to readers from wide range of backgrounds. In contrast to encyclopedic online resources, which often rely on the general public to author their content, a key consideration in the development of the Encyclopedia of Systems Biology was to have subject matter experts define the concepts and subjects of systems biology.
    Note: Applications in drug discoveryAritificial life -- Artificial intelligence and machine learning -- Cancer -- Cell cycle -- Computational microRNA biology -- Functional imaging -- Gene regulatory networks: modeling, reconstruction and analysis -- Large-scale and high-performance computing -- Mathematical theory and methods -- Metabolic networks -- Model databases -- Philosophical and foundational issues -- Quantitative experiment design -- Resources -- Single cell experiments -- Standards, exchange formats, guidelines and ontologies -- Statistical theory and methods -- Structural network analysis -- Systems approaches to translational biomedical research: focus on diagnostic and prognostic applications -- Systems immunology -- Text mining -- Toponomics -- Transcriptional regulation -- Translational control and systems biology.
    Additional Edition: ISBN 9781441998620
    Additional Edition: Druckausg. ISBN 978-1-441-99862-0
    Additional Edition: Druckausg. Encyclopedia of systems biology New York, NY [u.a.] : Springer Reference, 2013 ISBN 9781441998620
    Language: English
    Keywords: Systembiologie
    URL: Volltext  (lizenzpflichtig)
    Author information: Wolkenhauer, Olaf 1966-
    Author information: Dubitzky, Werner 1958-
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  • 10
    UID:
    kobvindex_VBRD-i97838765137750160
    Format: 160 Seiten
    Edition: 2. Auflage
    ISBN: 9783876513775
    Content: Dieses Konversationshandbuch widmet sich der Anwendung des Plattdeutschen im Alltag und das nicht nur beim lütten Schnack över`n Tuun in`t Dörp un ok in de Stadt. Auch Kennenlernen kannst di op Platt. mit dien Leevste(n) schnacken und Diskussionen op Platt maakt jüst so veel Spooß! Olaf Wolkenhauer bietet in diesem Buch neben praktischen Hilfen auch einen umfangreichen Fundus an typischen Formulierungen und Ausdruckformen, die die Vielschichtigkeit der plattdeutschen Sprache widerspiegeln.
    Language: German
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