Format:
Online-Ressource
ISSN:
1862-8354
Content:
Abstract: The dopaminergic neurotoxin 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) replicates many of the pathological hallmarks of Parkinson's disease (PD) in mice via selective destruction of dopamine neurons of the substantia nigra and striatum. Although MPTP has been widely used to study downstream effects following the degeneration of dopaminergic neurons, the underlying mechanisms of MPTP action remain poorly understood. To determine the underlying mechanisms of MPTP action at the protein level, a 2‐DE‐based proteomics approach was used to evaluate the changes in protein expression in substantia nigra and striatal tissue in C57BL/6 mice after MPTP administration. We identified nine proteins that were markedly altered and are likely to be involved in mitochondrial function, heat shock protein activity, and which contribute enzyme activities for energy metabolism and protein degradation.
In:
volume:1
In:
number:12
In:
year:2007
In:
pages:1559-1569
In:
extent:11
In:
Proteomics / Clinical applications. Clinical applications, Weinheim : Wiley VCH, 2007-, 1, Heft 12 (2007), 1559-1569 (gesamt 11), 1862-8354
Language:
English
DOI:
10.1002/prca.200700077
URN:
urn:nbn:de:101:1-2023072616212432596689
URL:
https://doi.org/10.1002/prca.200700077
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023072616212432596689
URL:
https://d-nb.info/1297372301/34
URL:
https://doi.org/10.1002/prca.200700077
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