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  • 1
    Language: English
    In: Pediatrics, January 2011, Vol.127(1), pp.e245-9
    Description: Propylthiouracil, a drug commonly used to treat hyperthyroidism, is known to cause antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis as a rare complication. The wide clinical spectrum of propylthiouracil-induced vasculitis ranges from mild forms with rash and/or arthralgia to severe forms with renal or pulmonary involvement, which can be critical and life-threatening if left unrecognized and untreated. Given its rarity and exceedingly variable clinical presentations, diagnosis may be challenging, and delayed diagnosis is not uncommon without a high index of suspicion, as illustrated by this report of a 17-year-old girl with Graves' disease who developed occult pulmonary hemorrhage as an overlooked rare presentation of ANCA-associated vasculitis after administration of propylthiouracil. Associated clinical features included fever, fatigue, palpable purpura, polyarthritis, and nephritis. Positive findings on chest radiography prompted the bronchoalveolar lavage procedure, which led to the identification of pulmonary hemorrhage. Skin biopsy showed leukocytoclastic vasculitis. Serologic test results were positive for perinuclear ANCA, cytoplasmic ANCA, myeloperoxidase-ANCA, proteinase 3-ANCA, and cryoglobulins but negative for antinuclear antibody, anti-double-stranded DNA, rheumatoid factor, and anti-hepatitis C virus antibody. The symptoms resolved after discontinuation of propylthiouracil and a few months of corticosteroids and azathioprine. This report highlights the necessity for physicians to keep alert for the protean manifestations of propylthiouracil-induced vasculitis.
    Keywords: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis -- Chemically Induced ; Antithyroid Agents -- Adverse Effects ; Hemorrhage -- Etiology ; Lung Diseases -- Etiology ; Propylthiouracil -- Adverse Effects
    ISSN: 00314005
    E-ISSN: 1098-4275
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  • 2
    Language: English
    In: The Journal of Allergy and Clinical Immunology, February 2018, Vol.141(2), pp.AB153-AB153
    Description: Methods We utilized medical claims data from the National Health Insurance Research Database in Taiwan. Among 2,496 patients, 1,696 (68.0%) patients were identified only from outpatient or emergency department (ED) visits, 495 (19.8%) patients were hospitalized, and 305 (12.2%) hospitalized patients were admitted to intensive care units.
    Keywords: Medicine
    ISSN: 0091-6749
    E-ISSN: 1097-6825
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  • 3
    Language: English
    In: PLoS ONE, Dec 18, 2014, Vol.9(12)
    Description: Objectives Leukotrienes play a central pathophysiological role in allergic asthma. The aim of this study was to investigate the utility of measuring urinary leukotriene E.sub.4 (LTE.sub.4) levels in the diagnosis of atopic diseases in early childhood. Methods Children aged 0 through 4 years from a birth cohort in the Prediction of Allergies in Taiwanese Children (PATCH) study were enrolled. Urinary LTE.sub.4 levels were measured and its association between total serum IgE levels, allergen-specific IgE sensitization and atopic diseases were assessed. Results A total of 182 children were regular followed up at clinics for a four-year follow-up period. Urinary LTE.sub.4 levels appeared to be elevated in children with total serum IgE levels exceeding 100 kU/L, allergen-specific IgE sensitization after 2 years of age. Elevation of urinary LTE.sub.4 levels ([greater than or equal to]500 pg/mg of creatinine) significantly discriminated high serum total IgE levels ([greater than or equal to]100 kU/L) at age 2 (P = 0.027). A higher level of total serum IgE or urinary LTE.sub.4 was significantly associated with the risk of developing allergic rhinitis and asthma at age 3. A significantly higher urinary LTE.sub.4 level was found in children with a combination of IgE sensitization and asthma at age 4. Conclusions Urinary LTE.sub.4 levels appear to be highly associated with IgE sensitization and its related allergic airway diseases after age 2. The measurement of urinary LTE.sub.4 ([greater than or equal to]500 pg/mg of creatinine) could not only be a non-invasive method for atopic predisposition but also potentially provide a strategy for the diagnosis and management of asthma in preschool children.
    Keywords: Childhood Asthma -- Diagnosis ; Childhood Asthma -- Analysis ; Immunoglobulin E -- Analysis ; Allergens -- Analysis
    ISSN: 1932-6203
    Source: Cengage Learning, Inc.
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  • 4
    Language: English
    In: PLoS ONE, 01 January 2014, Vol.9(7), p.e102809
    Description: A correct interpretation of sensitization to common allergens is critical in determining susceptibility to allergic diseases. The aim of this study was to investigate the patterns of sensitization to food and inhalant allergens, and their relation...
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 5
    Language: English
    In: Immunological Reviews, July, 2011, Vol.242, p.10(21)
    Description: To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1600-065X.2011.01029.x Byline: Carole Ober (1), Tsung-Chieh Yao (2) Keywords: association studies; linkage studies; genome-wide association studies; asthma; allergic disease; atopy Abstract: Summary: Asthma and allergy are common conditions with complex etiologies involving both genetic and environmental contributions. Recent genome-wide association studies (GWAS) and meta-analyses of GWAS have begun to shed light on both common and distinct pathways that contribute to asthma and allergic diseases. Associations with variation in genes encoding the epithelial cell-derived cytokines, interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP), and the IL1RL1 gene encoding the IL-33 receptor, ST2, highlight the central roles for innate immune response pathways that promote the activation and differentiation of T-helper 2 cells in the pathogenesis of both asthma and allergic diseases. In contrast, variation at the 17q21 asthma locus, encoding the ORMDL3 and GSDML genes, is specifically associated with risk for childhood onset asthma. These and other genetic findings are providing a list of well-validated asthma and allergy susceptibility genes that are expanding our understanding of the common and unique biological pathways that are dysregulated in these related conditions. Ongoing studies will continue to broaden our understanding of asthma and allergy and unravel the mechanisms for the development of these complex traits. Author Affiliation: (1)Department of Human Genetics, The University of Chicago, Chicago, IL, USA. (2)Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan. Article note: Carole Ober, Department of Human Genetics, The University of Chicago, 920 E. 58th Street, CLSC 425, Chicago, IL 60637, USA, Tel.: +1 773 834 0735, Fax: +1 773 834 0505, e-mail: c-ober@genetics.uchicago.edu
    Keywords: Childhood Asthma -- Genetic Aspects ; Allergy -- Genetic Aspects ; Disease Susceptibility -- Genetic Aspects ; Genomics
    ISSN: 0105-2896
    Source: Cengage Learning, Inc.
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  • 6
    Language: English
    In: Immunological Reviews, July, 2011, Vol.242, p.10(21)
    Description: To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1600-065X.2011.01029.x Byline: Carole Ober (1), Tsung-Chieh Yao (2) Keywords: association studies; linkage studies; genome-wide association studies; asthma; allergic disease; atopy Abstract: Summary: Asthma and allergy are common conditions with complex etiologies involving both genetic and environmental contributions. Recent genome-wide association studies (GWAS) and meta-analyses of GWAS have begun to shed light on both common and distinct pathways that contribute to asthma and allergic diseases. Associations with variation in genes encoding the epithelial cell-derived cytokines, interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP), and the IL1RL1 gene encoding the IL-33 receptor, ST2, highlight the central roles for innate immune response pathways that promote the activation and differentiation of T-helper 2 cells in the pathogenesis of both asthma and allergic diseases. In contrast, variation at the 17q21 asthma locus, encoding the ORMDL3 and GSDML genes, is specifically associated with risk for childhood onset asthma. These and other genetic findings are providing a list of well-validated asthma and allergy susceptibility genes that are expanding our understanding of the common and unique biological pathways that are dysregulated in these related conditions. Ongoing studies will continue to broaden our understanding of asthma and allergy and unravel the mechanisms for the development of these complex traits. Author Affiliation: (1)Department of Human Genetics, The University of Chicago, Chicago, IL, USA. (2)Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan. Article note: Carole Ober, Department of Human Genetics, The University of Chicago, 920 E. 58th Street, CLSC 425, Chicago, IL 60637, USA, Tel.: +1 773 834 0735, Fax: +1 773 834 0505, e-mail: c-ober@genetics.uchicago.edu
    Keywords: Childhood Asthma -- Genetic Aspects ; Allergy -- Genetic Aspects ; Disease Susceptibility -- Genetic Aspects ; Genomics
    ISSN: 0105-2896
    Source: Cengage Learning, Inc.
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  • 7
    Language: English
    In: The Journal of Allergy and Clinical Immunology, February 2018, Vol.141(2), pp.AB5-AB5
    Description: Methods A cohort of 385 children (201 boys, 54.5%) born in 2010 in Taiwan attended a 6-year follow-up visit including a questionnaire, an interview by physicians, fractional exhaled nitric oxide (FeNO), and serum testing for total and allergen-specific immunoglobulin E. Asthma, allergic rhinitis, and atopic dermatitis were defined on the basis of physician’s diagnosis. Results The rate of physician-diagnosed asthma was significantly higher in children with a history of neonatal jaundice (OR:2.722; 95% CI:1.192-6.214; p=0.017), after adjustment for gender, maternal age, maternal education, and family economic status.
    Keywords: Medicine
    ISSN: 0091-6749
    E-ISSN: 1097-6825
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  • 8
    Language: English
    In: The Journal of Allergy and Clinical Immunology, February 2018, Vol.141(2), pp.AB5-AB5
    Description: Methods We used data for 385 Asian children (201 boys, 54.5%) from the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort to determine the association of birth weight with lung function parameters and FeNO levels at 6 years of age, adjusted for gestation age, sex,...
    Keywords: Medicine
    ISSN: 0091-6749
    E-ISSN: 1097-6825
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  • 9
    Language: English
    In: Immunological reviews, July 2011, Vol.242(1), pp.10-30
    Description: Asthma and allergy are common conditions with complex etiologies involving both genetic and environmental contributions. Recent genome-wide association studies (GWAS) and meta-analyses of GWAS have begun to shed light on both common and distinct pathways that contribute to asthma and allergic diseases. Associations with variation in genes encoding the epithelial cell-derived cytokines, interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP), and the IL1RL1 gene encoding the IL-33 receptor, ST2, highlight the central roles for innate immune response pathways that promote the activation and differentiation of T-helper 2 cells in the pathogenesis of both asthma and allergic diseases. In contrast, variation at the 17q21 asthma locus, encoding the ORMDL3 and GSDML genes, is specifically associated with risk for childhood onset asthma. These and other genetic findings are providing a list of well-validated asthma and allergy susceptibility genes that are expanding our understanding of the common and unique biological pathways that are dysregulated in these related conditions. Ongoing studies will continue to broaden our understanding of asthma and allergy and unravel the mechanisms for the development of these complex traits.
    Keywords: Asthma -- Genetics ; Gene Expression Regulation -- Immunology ; Hypersensitivity, Immediate -- Genetics ; Th2 Cells -- Immunology
    ISSN: 01052896
    E-ISSN: 1600-065X
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  • 10
    Language: English
    In: PLoS ONE, 01 January 2014, Vol.9(12), p.e115216
    Description: Leukotrienes play a central pathophysiological role in allergic asthma. The aim of this study was to investigate the utility of measuring urinary leukotriene E4 (LTE4) levels in the diagnosis of atopic diseases in early childhood.Children aged...
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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