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  • 1
    Language: English
    In: PLoS ONE, 01 January 2014, Vol.9(8), p.e105236
    Description: BACKGROUND: Kawasaki disease (KD) is a systemic vasculitis with unknown etiology mainly affecting children in Asian countries. Dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN, CD209) in humans was showed to trigger an anti-inflammatory cascade and associated...
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 2
    Language: English
    In: Life Sciences, July 1, 2015, Vol.132, p.41(8)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.lfs.2015.04.005 Byline: Jiunn-Ming Sheen, Hong-Ren Yu, Mao-Meng Tiao, Chih-Cheng Chen, Li-Tung Huang, Hsin-Yu Chang, You-Lin Tain Abstract: Antenatal glucocorticoids can induce long-term effects on offspring health, including hypertension. Programmed hypertension has been observed in a prenatal dexamethasone (DEX) exposure model. However, how renal programming responds to prenatal DEX at different stages of development and the impact of DEX on programmed hypertension remain unclear. Therefore, we utilized RNA next-generation sequencing (NGS) to analyze the renal transcriptome in the offspring to examine whether key genes and pathways are responsible for DEX-induced renal programming and hypertension. Article History: Received 16 January 2015; Revised 8 April 2015; Accepted 11 April 2015
    Keywords: Dexamethasone ; Pregnant Women ; Hypertension
    ISSN: 0024-3205
    Source: Cengage Learning, Inc.
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  • 3
    Language: English
    In: Bioresource Technology, December 2015, Vol.198, pp.437-444
    Description: In this study, the optimization of working cathode position in sleeve-type bioelectrochemical system (BES) was evaluated with inner/outer chamber for azo dye decolorization. Results showed that the working position in outer chamber performed better with decolorization efficiencies of 97.8 ± 2.1% (7 h) and 94.0 ± 2.3% (16 h) than that in inner chamber as the volume ratio : = 1:1 and 3:1, respectively. The current and electrochemical impedance spectroscopy (EIS) analysis indicated that the proton/electron transfer and anolyte diffusion could be improved using outer chamber as working position. The decolorization with increased volume ratio could be further improved through the strategy of increasing substrate concentration, which would provide enough electrons and decrease diffusion resistance, further improving the whole performance with increased outer cathode volume. It has the great potential in sleeve-type configuration application and would create more challenges for process optimization and maintenance.
    Keywords: Bioelectrochemical System (Bes) ; Sleeve-Type Configuration ; Working Position ; Decolorization ; Azo Dye ; Agriculture ; Engineering ; Chemistry
    ISSN: 0960-8524
    E-ISSN: 1873-2976
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  • 4
    Language: English
    In: Bioresource Technology, 2015, Vol.192, p.486(8)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.biortech.2015.06.001 Byline: Fanying Kong, Aijie Wang, Hong-Yu Ren Abstract: Display Omitted Article History: Received 6 May 2015; Revised 29 May 2015; Accepted 1 June 2015
    Keywords: Sludge ; Azo Compounds
    ISSN: 0960-8524
    Source: Cengage Learning, Inc.
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  • 5
    Language: English
    In: Water Research, Nov 15, 2015, Vol.85, p.404(9)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.watres.2015.08.057 Byline: Hong-Yu Ren, Bing-Feng Liu, Fanying Kong, Lei Zhao, Nanqi Ren Abstract: Anaerobic sludge (AS) and microalgae were co-cultured to enhance the energy conversion and nutrients removal from starch wastewater. Mixed ratio, starch concentration and initial pH played critical roles on the hydrogen and lipid production of the co-culture system. The maximum hydrogen production of 1508.3 mL L.sup.-1 and total lipid concentration of 0.36 g L.sup.-1 were obtained under the optimized mixed ratio (algae:AS) of 30:1, starch concentration of 6 g L.sup.-1 and initial pH of 8. The main soluble metabolites in dark fermentation were acetate and butyrate, most of which can be consumed in co-cultivation. When sweet potato starch wastewater was used as the substrate, the highest COD, TN and TP removal and energy conversion efficiencies reached 80.5%, 88.7%, 80.1% and 34.2%, which were 176%, 178%, 200% and 119% higher than that of the control group (dark fermentation), respectively. This research provided a novel approach and achieved efficient simultaneous energy recovery and nutrients removal from starch wastewater by the co-culture system. Author Affiliation: State Key Laboratory of Urban Water Resource and Environment, School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090, China Article History: Received 2 April 2015; Revised 12 August 2015; Accepted 30 August 2015
    Keywords: Sludge ; Esters ; Wastewater ; Hydrogen
    ISSN: 0043-1354
    Source: Cengage Learning, Inc.
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  • 6
    Language: English
    In: PLoS ONE, 01 January 2014, Vol.9(12), p.e115554
    Description: Prenatal dexamethasone exposure has been reported to increase allergy potential in childhood possibly by interference with normal immunological development in utero. This study investigated the effects of prenatal dexamethasone on T helper cell...
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 7
    In: NeuroReport, 2016, Vol.27(11), pp.818-825
    Description: Synthetic glucocorticoids are frequently used in clinical practice for treating pregnant women at risk of preterm delivery, but their long-term effects on the infant brain are largely unknown. Pregnant Sprague–Dawley rats were administered vehicle or dexamethasone between gestational days 14 and 21. Male offspring were then weaned onto either a standard chow or a high-fat diet. The postnatal levels of insulin-like growth factor I (IGF-1), tumor necrosis factor-α (TNF-α), and asymmetric dimethylarginine (ADMA) in the plasma, liver, and brain were examined, as well as the possible effects of prenatal dexamethasone on cognition. We found that a postnatal high-fat diet led to spatial deficits detected by the Morris water maze in adult offspring administered dexamethasone prenatally. The spatial deficit was accompanied by decreased IGF-1 mRNA and increased ADMA levels in the dorsal hippocampus. In peripheral systems, a postnatal high-fat diet resulted in decreased plasma IGF-1, increased plasma corticosterone, increased concentrations of transaminases, TNF-α mRNA, and ADMA in the liver, and associated obesity in adult offspring administered prenatal dexamethasone. In conclusion, a postnatal high-fat diet led to spatial deficits, obesity, and altered levels of IGF-1, TNF-α, and ADMA in the plasma, liver, or brain.
    Keywords: Diet, High-Fat ; Inflammation -- Etiology ; Obesity -- Chemically Induced ; Prenatal Exposure Delayed Effects -- Physiopathology ; Sensation Disorders -- Chemically Induced ; Space Perception -- Physiology;
    ISSN: 0959-4965
    E-ISSN: 1473558X
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  • 8
    Language: English
    In: Life Sciences, 01 July 2015, Vol.132, pp.41-48
    Description: Antenatal glucocorticoids can induce long-term effects on offspring health, including hypertension. Programmed hypertension has been observed in a prenatal dexamethasone (DEX) exposure model. However, how renal programming responds to prenatal DEX at different stages of development and the impact of DEX on programmed hypertension remain unclear. Therefore, we utilized RNA next-generation sequencing (NGS) to analyze the renal transcriptome in the offspring to examine whether key genes and pathways are responsible for DEX-induced renal programming and hypertension. Pregnant rats received intraperitoneal dexamethasone from gestational day 16 to 22. Prenatal DEX-induced programmed hypertension was examined in male offspring at 16 weeks of age. Prenatal DEX modified 431 renal transcripts from the nephrogenesis stage to adulthood in a constant manner. At the pre-hypertensive and established hypertension stages, we identified 11 and 13 differentially expressed genes related to blood pressure regulation, respectively. Among these genes, , , , , , , and are associated with endothelium-derived hyperpolarizing and contractile factors (EDHF and EDCF). Genes in the arachidonic acid metabolism pathway may potentially be key genes contributing to programmed hypertension. In addition, DEX induced soluble epoxide hydrolase expression ( gene encoding protein). Prenatal DEX elicits an imbalance between EDHFs and EDCFs that might lead to renal programming and hypertension. The arachidonic acid metabolism pathway is a common pathway contributing to programmed hypertension. Our results highlight candidate genes and pathways involved in renal programming as targets for therapeutic approaches to prevent programmed hypertension in children exposed to antenatal corticosteroids.
    Keywords: Arachidonic Acid ; Endothelium-Derived Contractile Factor ; Endothelium-Derived Hyperpolarizing Factor ; Glucocorticoid ; Hypertension ; Next-Generation Sequencing ; Sciences (General) ; Biology
    ISSN: 0024-3205
    E-ISSN: 1879-0631
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  • 9
    Language: English
    In: International Journal of Hydrogen Energy, 22 November 2013, Vol.38(35), pp.15100-15104
    Description: Enzymatically treated cornstalk hydrolysate was tested as substrate for H production by W16 in a continuous stirred tank reactor. The performance of strain W16 to ferment the main components of hydrolysate, mixture of glucose and xylose, in continuous culture was conducted at first, and then W16 was evaluated to ferment fully enzymatically hydrolysed cornstalk to produce H in continuous operation mode. At the dilution rate of 0.020 h , the H yield and production rate reached a maximum of 1.9 mol H  mol sugars and 8.4 mmol H  L  h , respectively, accompanied with the maximum glucose and xylose utilizations of 86.3% and 77.6%. Continuous H production from enzymatically treated cornstalk hydrolysate in this research provides a new direction for economic, efficient, and harmless H production.
    Keywords: Continuous H2 Production ; Thermoanaerobacterium Thermosaccharolyticum W16 ; Cornstalk Hydrolysate ; Engineering
    ISSN: 0360-3199
    E-ISSN: 1879-3487
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  • 10
    Language: English
    In: PLoS ONE, 2011, Vol.6(4), p.e17370
    Description: Kawasaki disease (KD) is characterized by systemic vasculitis with unknown etiology. Previous studies from Japan indicated that a gene polymorphism of ITPKC (rs28493229) is responsible for susceptibility to KD. We collected DNA samples from 1,531 Taiwanese subjects (341 KD patients and 1,190 controls) for genotyping ITPKC . In this study, no significant association was noted for the ITPKC polymorphism (rs28493229) between the controls and KD patients, although the CC genotype was overrepresented. We further combined our data with previously published case/control KD studies in the Taiwanese population and performed a meta-analysis. A significant association between rs28493229 and KD was found (Odds Ratio:1.36, 95% Confidence Interval 1.12–1.66). Importantly, a significant association was obtained between rs28493229 and KD patients with aneurysm formation ( P  = 0.001, under the recessive model). Taken together, our results indicated that C-allele of ITPKC SNP rs28493229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population.
    Keywords: Research Article ; Medicine ; Genetics And Genomics ; Pediatrics And Child Health
    E-ISSN: 1932-6203
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