Mutation Research - Genetic Toxicology and Environmental Mutagenesis, June 17, 2011, Vol.722(2), p.94(12)
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.mrgentox.2010.05.006 Byline: Igor Koturbash (a), Franz J. Zemp (a), Igor Pogribny (b), Olga Kovalchuk (a) Keywords: MicroRNA; Cancer; Carcinogenesis; Genome instability Abbreviations: miRNA, microRNA; AGO, argonaute; miRNP, miRNA/AGO ribonucleoprotein; RISC, RNA-induced silencing complex; MRE, miRNA recognition element; CLL, chronic lymphocytic leukemia; BCL2, B-cell lymphoma 2; oncomiR, oncogenic miRNA; HOXD10, homeobox protein D10; TICs, tumor initiating cells; DHFR, dihydrofolate reductase gene; IR, ionizing radiation Abstract: Small non-coding RNAs-microRNAs, are potent negative regulators of gene expression. MicroRNAs are involved in multiple biological processes, metabolic regulation, including cell proliferation, differentiation, and programmed cell death. Since the dysregulation of these processes is a hallmark of cancer, microRNAs can be viewed as major contributors to the pathogenesis of cancer, including initiation and progression of cancer. This review focuses on microRNA biogenesis and function, and their role in cancer, metastasis, drug resistance, and tumorigenesis. Author Affiliation: (a) Department of Biological Sciences, University of Lethbridge, AB, Canada T1K3M4 (b) Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States Article History: Received 28 April 2010; Accepted 8 May 2010 Article Note: (footnote) [star] The views expressed in this paper do not necessarily represent those of the U.S. Food and Drug Administration.
Lymphomas -- Development And Progression ; Drug Resistance -- Development And Progression ; Leukemia -- Development And Progression ; Carcinogenesis -- Development And Progression ; Cancer Metastasis -- Development And Progression ; Gene Expression ; Biosynthesis ; Tetrahydrofolate Dehydrogenase ; Cancer Treatment
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