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  • 1
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 13 August 2013, Vol.110(33), pp.13564-9
    Description: Vaccines are among the most effective approaches to prevent and control many infectious diseases. Because of safety and reproducibility concerns, whole-cell vaccines (WCVs), made from live or killed microorganisms and including hundreds of antigenic components, have been mostly replaced by acellular or subunit vaccines composed of well-defined, purified antigen components. The efficacy of acellular vaccines is inferior to that of WCVs, however, for two major reasons: limited antigen diversity and reduced immunogenicity, especially in a lack of activation of antigen-specific T-cell immunity, which plays an important role in protection against mucosal and intracellular pathogens. Here we present the multiple antigen-presenting system (MAPS), which enables the creation of a macromolecular complex that mimics the properties of WCVs by integrating various antigen components, including polysaccharides and proteins, in the same construct and that induces multipronged immune responses, including antibody, Th1, and Th17 responses. Using antigens from various pathogens (Streptococcus pneumoniae, Salmonella typhi, and Mycobacterium tuberculosis), we demonstrate the versatility of the MAPS system and its feasibility for the design of unique defined-structure subunit vaccines to confer comprehensive protection via multiple immune mechanisms. Moreover, MAPS can serve as a tool for structure-activity analysis of cellular immunogens.
    Keywords: Drug Design ; Antigen Presentation -- Immunology ; Antigens, Bacterial -- Immunology ; Immunity, Cellular -- Immunology ; Macromolecular Substances -- Immunology ; Vaccines, Acellular -- Immunology
    ISSN: 00278424
    E-ISSN: 1091-6490
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  • 2
    Language: English
    In: Journal of the American College of Cardiology, 20 October 2015, Vol.66(16), pp.C167-C168
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jacc.2015.06.639 Byline: Zhang Lu, Xiaoping Yu Author Affiliation: Department of Cardiology, The Second People Hospital of Shenzhen
    Keywords: Medicine
    ISSN: 0735-1097
    E-ISSN: 1558-3597
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  • 3
    Language: English
    In: Chemistry - A European Journal, July 8, 2013, Vol.19(28), p.9242(9)
    Description: Byline: Lu Zhang, Peng Cui, Baocheng Zhang, Feng Gao Keywords: aptamers; biosensors; quantum dots; phosphorescence; energy transfer Abstract This paper presents the first example of a sensitive, selective, and stable phosphorescent sensor based on phosphorescence energy transfer (PET) for thrombin that functions through thrombin-aptamer recognition events. In this work, an efficient PET donor-acceptor pair using Mn-doped ZnS quantum dots labeled with thrombin-binding aptamers (TBA QDs) as donors, and carbon nanodots (CNDs) as acceptors has been constructed. Due to the I-I stacking interaction between aptamer and CNDs, the energy donor and acceptor are taken into close proximity, leading to the phosphorescence quenching of donors, TBA QDs. A maximum phosphorescence quenching efficiency as high as 95.9% is acquired. With the introduction of thrombin to the "off state" of the TBA-QDs-CNDs system, the phosphorescence is "turned on" due to the formation of quadruplex-thrombin complexes, which releases the energy acceptor CNDs from the energy donors. Based on the restored phosphorescence, an aptamer-based turn-on thrombin biosensor has been demonstrated by using the phosphorescence as a signal transduction method. The sensor displays a linear range of 0-40anM for thrombin, with a detection limit as low as 0.013anM in pure buffers. The proposed aptasensor has also been used to monitor thrombin in complex biological fluids, including serum and plasma, with satisfactory recovery ranging from 96.8 to 104.3%. This is the first time that Mn-doped ZnS quantum dots and CNDs have been employed as a donor-acceptor pair to construct PET-based biosensors, which combines both the photophysical merits of phosphorescence QDs and the superquenching ability of CNDs and thus affords excellent analytical performance. We believe this proposed method could pave the way to a new design of biosensors using PET systems. Author Affiliation: Laboratory of Optical Probes and Bioelectrocatalysis (LOPAB), Anhui Key Laboratory of Chemo/Biosensing, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000 (P.R. China), Fax: (+86)553-3869302 Laboratory of Optical Probes and Bioelectrocatalysis (LOPAB), Anhui Key Laboratory of Chemo/Biosensing, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000 (P.R. China), Fax: (+86)553-3869302 Supporting information: Additional Supporting Information may be found in the online version of this article As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
    Keywords: Nanotechnology ; Detection Equipment ; Thrombin
    ISSN: 0947-6539
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  • 4
    Language: English
    In: Journal of Business and Psychology, 2012, Vol.27(3), pp.345-362
    Description: The purpose of this study is to explore whether different aspects of corporate social responsibility (i.e., economic, legal, and ethical) have independent association with job applicants’ attraction to organizations and how applicants combine the information. Further, from a person–organization fit perspective, we examine whether applicants are attracted to organizations whose corporate social responsibility (CSR) reflects their differences in ethical predispositions (i.e., utilitarianism and formalism) and Machiavellianism. Using factorial design, we created scenarios manipulating CSR and pay level. Participants read each scenario and answered questions about their attraction to the organization depicted in the scenario. We found that each aspect of CSR had an independent relationship with organizational attraction and the probability of accepting a job offer. Participants combined information from each type of CSR in an interactive, configural manner. Applicants with different ethical predispositions and Machiavellianism personality were affected by CSR to different extents. Understanding how job applicants evaluate CSR information may give managers an opportunity to influence applicant attraction. Further, our study shows that organizations may be able to maximize the utility of their CSR investments by selectively conveying CSR information in recruitment brochures that are attractive to their ideal applicants. This is the first study to examine how job applicants form their perception based upon different configurations of the multiple aspects of CSR. In addition, this is the first study to examine the moderating effect of individual differences in ethical predispositions and Machiavellianism on the relationship between CSR and applicant attraction.
    Keywords: Corporate social responsibility ; Applicant attraction ; Person–organization fit ; Ethical predispositions ; Machiavellianism
    ISSN: 0889-3268
    E-ISSN: 1573-353X
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  • 5
    Language: English
    In: Materials Letters, 2011, Vol.65(1), pp.38-40
    Description: We have provided an effective, environmentally benign approach for the synthesis of hybrid platinum-carbon nanotubes (Pt-CNTs) composite via a CNTs-guided carbothermal reduction. The materials were characterized by transmission electron microscopy (TEM), Raman spectroscopy and X-ray photoelectron spectroscopy (XPS). The results revealed that CNTs acted as both support and reducing agent, and therefore the Pt nanoparticles with an average particle size of 3.5 nm could uniformly disperse onto the surface of CNTs. Moreover, as-fabricated Pt-CNTs exhibited the enhanced electrocatalytic activity and stability for ethanol oxidation in both acidic and alkaline media, in comparison to that prepared by electrochemical deposition. This approach greatly enlarges the practical application areas of hybrid Pt-CNTs composite materials. ► Pt nanoparticles were obtained by carbon nanotubes-guided carbothermal reduction. ► Pt nanoparticles were highly dispersed on the surface of carbon nanotubes. ► Hybrid Pt-CNTs showed excellent electrocatalytic property for ethanol oxidation.
    Keywords: Carbon Nanotubes ; Pt Nanoparticles ; Carbothermal Reduction ; Electrocatalytic Oxidation ; Engineering ; Physics
    ISSN: 0167-577X
    E-ISSN: 1873-4979
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  • 6
    Language: English
    In: Bioresource Technology, July, 2014, Vol.163, p.112(11)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.biortech.2014.04.041 Byline: Lu Zhang, Xiangyang Sun Abstract: acents Effects of rhamnolipid (RL) and particle size (IPS) on composting were studied. acents RL at 0.15% and IPS of 15mm reduced the two-stage composting time to 24days. acents Physico-chemical and biological characteristics explain the rapid decomposition. acents Microbial communities, nutrient contents, and cellulose degradation are optimized. Article History: Received 10 March 2014; Revised 8 April 2014; Accepted 11 April 2014
    Keywords: Cellulose -- Analysis
    ISSN: 0960-8524
    Source: Cengage Learning, Inc.
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  • 7
    Language: English
    In: Materials Science & Engineering A, Feb 1, 2012, Vol.534, p.228(6)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.msea.2011.11.063 Byline: Pi Jinhong (a)(b), Pan Ye (a), Zhang Hui (a)(c), Zhang Lu (a) Keywords: Microstructure; Properties; High-entropy alloy Abstract: a* The content of nickel has a significant effect on microstructure and properties of AlCrFeCuNi.sub.x HEAs. a* Results show that high entropy alloys (HEAs) with equal molar components do not always show the best properties. a* The tested HEAs are composed of three phases, which are one BCC phase, one FCC phase and one compound phase, respectively. Author Affiliation: (a) School of Materials Science and Engineering, Southeast University, Jiangsu Key Laboratory of Advanced Metallic Materials, Nanjing 211189, China (b) School of Material Engineering, Nanjing Institute of Technology, Nanjing 211167, China (c) School of Material Science and Engineering, AnHui University of Technology, Maanshan 243002, China Article History: Received 23 July 2011; Revised 18 November 2011; Accepted 19 November 2011
    Keywords: Alloys -- Analysis
    ISSN: 0921-5093
    Source: Cengage Learning, Inc.
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  • 8
    Language: English
    In: Journal of Power Sources, Dec 1, 2013, Vol.243, p.147(5)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jpowsour.2013.05.093 Byline: Zhang Lu, Kang Xueya, Tuerdi Wumair, Dou Junqing, Han Ying Abstract: The composite materials of B-doped LiFeP.sub.1-x B.sub.x O.sub.4-[delta] /C (x = 0.00, 0.05, 0.10 and 0.15) at P-site are synthesized in flowing N.sub.2 atmosphere by liquid phase reduction method with heat treatment. The synthesized products are characterized by X-ray diffraction, SEM, cyclic voltammetry and galvanostatic charge/discharge tests. The results show that the samples all have well-regulated olivine-type structures, high crystallinity, moderate and uniform particle size, while B-doping improves the conductivity of composite materials, decreases the polarization of electrode, and enhances the cycling performance and high rate capability effectively. The LiFeP.sub.0.9B.sub.0.1O.sub.4-[delta] /C composite exhibits the best electrochemical performance in the all samples. The discharge capacities of LiFeP.sub.0.9B.sub.0.1O.sub.4-[delta] /C are 155.2 mAh g.sup.-1, 146.2 mAh g.sup.-1, 139.4 mAh g.sup.-1, 132.4 mAh g.sup.-1, 119.1 mAh g.sup.-1 and 102.6 mAh g.sup.-1 at the rate of 0.2C, 0.5C, 1.0C, 2.0C, 5.0C, and 10.0C. Author Affiliation: (a) Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China (b) Graduate University of Chinese Academy of Sciences, Beijing 100049, China (c) Xinjiang Key Laboratory of Electronic Information Materials and Devices, Urumqi 830011, China Article History: Received 25 December 2012; Revised 20 May 2013; Accepted 20 May 2013
    Keywords: Electrochemistry -- Chemical Properties ; Electrochemistry -- Analysis ; Electrochemistry -- Electric Properties
    ISSN: 0378-7753
    Source: Cengage Learning, Inc.
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  • 9
    Language: English
    In: Bioresource Technology, Nov, 2014, Vol.171, p.274(11)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.biortech.2014.08.079 Byline: Lu Zhang, Xiangyang Sun Abstract: acents Spent mushroom compost (SMC) and/or biochar (BC) were added to green waste composting. acents Physico-chemical and microbiological properties explained the rapid decomposition. acents Particle sizes, microorganisms, enzymes, nitrification, and nutrients were optimized. acents Combination of 35% SMC and 20% BC reduced two-stage co-composting time to 24days. acents Two-stage co-composting enhanced the humification and decomposition of organic wastes. Article History: Received 9 July 2014; Revised 15 August 2014; Accepted 17 August 2014
    Keywords: Nitrification ; Microbiology
    ISSN: 0960-8524
    Source: Cengage Learning, Inc.
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  • 10
    Language: English
    In: Bioresource Technology, March, 2013, Vol.131, p.68(8)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.biortech.2012.10.059 Byline: Lu Zhang, Xiangyang Sun, Yun Tian, Xiaoqiang Gong Keywords: Green waste; Secondary fermentation; Compost; Brown sugar; Calcium superphosphate Abstract: a* A two-stage composting (with primary and secondary fermentations) is described. a* Brown sugar and calcium superphosphate are evaluated as fermentation additives. a* Maturity time is shortened and maximum of fermentation temperature is attained twice. a* Physico-chemical characteristics explain the rapid decomposition of green waste. a* pH, C/N ratio, organic matter, GI value, void ratio, and particle size are optimized. Author Affiliation: Faculty of Soil and Water Conservation, Key Laboratory of Soil and Water Conservation and Desertification Combating, Ministry of Education, Beijing Forestry University, Beijing 100083, PR China Article History: Received 31 July 2012; Revised 12 October 2012; Accepted 13 October 2012
    Keywords: Phosphate Fertilizers ; Forest Management ; Calcium Phosphate
    ISSN: 0960-8524
    Source: Cengage Learning, Inc.
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